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Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.

Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang YN, Sreekumar A, Li W, Goodell MA.

Blood. 2020 Jan 13. pii: blood.2019003330. doi: 10.1182/blood.2019003330. [Epub ahead of print]


Environmental influences on clonal hematopoiesis.

King KY, Huang Y, Nakada D, Goodell MA.

Exp Hematol. 2019 Dec 29. pii: S0301-472X(19)31240-8. doi: 10.1016/j.exphem.2019.12.005. [Epub ahead of print] Review.


Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies.

Zeng H, He H, Guo L, Li J, Lee M, Han W, Guzman AG, Zang S, Zhou Y, Zhang X, Goodell MA, King KY, Sun D, Huang Y.

Cancer Lett. 2019 Dec 28;467:1-8. doi: 10.1016/j.canlet.2019.09.013. Epub 2019 Sep 26.


Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning.

Rau RE, Goodell MA.

Cell Stem Cell. 2019 Apr 4;24(4):511-512. doi: 10.1016/j.stem.2019.03.001.


Single-cell technology meets hematology: introduction to a review series.

Goodell MA, Bodine DM.

Blood. 2019 Mar 28;133(13):1387-1388. doi: 10.1182/blood-2019-01-887224. Epub 2019 Feb 6. No abstract available.


Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners.

Sandoval JE, Huang YH, Muise A, Goodell MA, Reich NO.

J Biol Chem. 2019 Mar 29;294(13):4898-4910. doi: 10.1074/jbc.RA118.006795. Epub 2019 Jan 31.


Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons.

Luo C, Lee QY, Wapinski O, Castanon R, Nery JR, Mall M, Kareta MS, Cullen SM, Goodell MA, Chang HY, Wernig M, Ecker JR.

Elife. 2019 Jan 15;8. pii: e40197. doi: 10.7554/eLife.40197.


New insights into the biology of acute myeloid leukemia with mutated NPM1.

Brunetti L, Gundry MC, Goodell MA.

Int J Hematol. 2019 Aug;110(2):150-160. doi: 10.1007/s12185-018-02578-7. Epub 2019 Jan 10. Review.


DNA methylation and de-methylation using hybrid site-targeting proteins.

Lei Y, Huang YH, Goodell MA.

Genome Biol. 2018 Nov 6;19(1):187. doi: 10.1186/s13059-018-1566-2. Review.


PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MA.

Cell Stem Cell. 2018 Nov 1;23(5):700-713.e6. doi: 10.1016/j.stem.2018.10.004.


Mutant NPM1 Maintains the Leukemic State through HOX Expression.

Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MA.

Cancer Cell. 2018 Sep 10;34(3):499-512.e9. doi: 10.1016/j.ccell.2018.08.005.


Homeobox oncogene activation by pan-cancer DNA hypermethylation.

Su J, Huang YH, Cui X, Wang X, Zhang X, Lei Y, Xu J, Lin X, Chen K, Lv J, Goodell MA, Li W.

Genome Biol. 2018 Aug 10;19(1):108. doi: 10.1186/s13059-018-1492-3.


DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells.

Gu T, Lin X, Cullen SM, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi LS, Chen JJ, Kyba M, Huang Y, Chen T, Li W, Goodell MA.

Genome Biol. 2018 Jul 12;19(1):88. doi: 10.1186/s13059-018-1464-7.


Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9.

Brunetti L, Gundry MC, Kitano A, Nakada D, Goodell MA.

J Vis Exp. 2018 Apr 10;(134). doi: 10.3791/57278.


Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.

Jeong M, Park HJ, Celik H, Ostrander EL, Reyes JM, Guzman A, Rodriguez B, Lei Y, Lee Y, Ding L, Guryanova OA, Li W, Goodell MA, Challen GA.

Cell Rep. 2018 Apr 3;23(1):1-10. doi: 10.1016/j.celrep.2018.03.025.


Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.

Tan Q, Brunetti L, Rousseaux MWC, Lu HC, Wan YW, Revelli JP, Liu Z, Goodell MA, Zoghbi HY.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1511-E1519. doi: 10.1073/pnas.1716452115. Epub 2018 Jan 30.


DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A.

Huang YH, Su J, Lei Y, Brunetti L, Gundry MC, Zhang X, Jeong M, Li W, Goodell MA.

Genome Biol. 2017 Sep 18;18(1):176. doi: 10.1186/s13059-017-1306-z.


Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS.

Jeong M, Guzman AG, Goodell MA.

Methods Mol Biol. 2017;1633:137-149. doi: 10.1007/978-1-4939-7142-8_9.


Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein.

Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W, Goodell MA.

Nat Commun. 2017 Jul 11;8:16026. doi: 10.1038/ncomms16026.


DNMT3A in Leukemia.

Brunetti L, Gundry MC, Goodell MA.

Cold Spring Harb Perspect Med. 2017 Feb 1;7(2). pii: a030320. doi: 10.1101/cshperspect.a030320. Review.


Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9.

Gundry MC, Brunetti L, Lin A, Mayle AE, Kitano A, Wagner D, Hsu JI, Hoegenauer KA, Rooney CM, Goodell MA, Nakada D.

Cell Rep. 2016 Oct 25;17(5):1453-1461. doi: 10.1016/j.celrep.2016.09.092.


Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.

Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10436-41. doi: 10.1073/pnas.1601650113. Epub 2016 Aug 31.


DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.

Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA.

Cancer Cell. 2016 Aug 8;30(2):363-365. doi: 10.1016/j.ccell.2016.07.015. Epub 2016 Aug 8. No abstract available.


DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.

Zhang X, Su J, Jeong M, Ko M, Huang Y, Park HJ, Guzman A, Lei Y, Huang YH, Rao A, Li W, Goodell MA.

Nat Genet. 2016 Sep;48(9):1014-23. doi: 10.1038/ng.3610. Epub 2016 Jul 18.


DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.

Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA.

Blood. 2016 Aug 18;128(7):971-81. doi: 10.1182/blood-2015-11-684225. Epub 2016 Jun 22.


DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.

Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA.

Cancer Cell. 2016 Jun 13;29(6):922-934. doi: 10.1016/j.ccell.2016.05.003. Erratum in: Cancer Cell. 2016 Aug 8;30(2):363-365.


Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes.

Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE.

Exp Hematol. 2016 Aug;44(8):740-4. doi: 10.1016/j.exphem.2016.05.003. Epub 2016 May 18.


Noncoding Regulatory RNAs in Hematopoiesis.

Jeong M, Goodell MA.

Curr Top Dev Biol. 2016;118:245-70. doi: 10.1016/bs.ctdb.2016.01.006. Epub 2016 Feb 23. Review.


Stem cells and healthy aging.

Goodell MA, Rando TA.

Science. 2015 Dec 4;350(6265):1199-204. doi: 10.1126/science.aab3388. Review.


Acute loss of TET function results in aggressive myeloid cancer in mice.

An J, González-Avalos E, Chawla A, Jeong M, López-Moyado IF, Li W, Goodell MA, Chavez L, Ko M, Rao A.

Nat Commun. 2015 Nov 26;6:10071. doi: 10.1038/ncomms10071.


Stem Cells and Aging: What's Next?

Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y.

Cell Stem Cell. 2015 Jun 4;16(6):578-81. No abstract available.


Comparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice.

Gibson BW, Boles NC, Souroullas GP, Herron AJ, Fraley JK, Schwiebert RS, Sharp JJ, Goodell MA.

Comp Med. 2015 Jun;65(3):165-72.


Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells.

King KY, Matatall KA, Shen CC, Goodell MA, Swierczek SI, Prchal JT.

Exp Hematol. 2015 Oct;43(10):912-918.e2. doi: 10.1016/j.exphem.2015.05.013. Epub 2015 Jun 11.


Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments.

Goodell MA, Nguyen H, Shroyer N.

Nat Rev Mol Cell Biol. 2015 May;16(5):299-309. doi: 10.1038/nrm3980. Review.


Long non-coding RNAs control hematopoietic stem cell function.

Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA.

Cell Stem Cell. 2015 Apr 2;16(4):426-38. doi: 10.1016/j.stem.2015.02.002. Epub 2015 Mar 12.


Dynamic DNA methylation discovered during HSC differentiation.

Cullen SM, Goodell MA.

Cell Cycle. 2015;14(5):693-4. doi: 10.1080/15384101.2015.1006558. No abstract available.


DNMT3A in haematological malignancies.

Yang L, Rau R, Goodell MA.

Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19. Review.


Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.

Mayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry CV, Challen GA, Li W, Wheeler D, Rebel VI, Goodell MA.

Blood. 2015 Jan 22;125(4):629-38.


Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.

Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA.

Cell Stem Cell. 2014 Sep 4;15(3):350-364. doi: 10.1016/j.stem.2014.06.018. Epub 2014 Aug 14.


New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells.

Jeong M, Goodell MA.

Exp Hematol. 2014 Aug;42(8):609-17. doi: 10.1016/j.exphem.2014.04.008. Epub 2014 Jun 30. Review.


A gallon of sweat to make a pint of blood.

Goodell MA.

J Exp Med. 2014 Jun 30;211(7):1271-2. doi: 10.1084/jem.2117insight2. No abstract available.


mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).

Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA.

Nature. 2014 Jun 19;510(7505):393-6. doi: 10.1038/nature13255. Epub 2014 May 25.


Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.

Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA.

Cell Stem Cell. 2014 May 1;14(5):673-88. doi: 10.1016/j.stem.2014.03.002.


MOABS: model based analysis of bisulfite sequencing data.

Sun D, Xi Y, Rodriguez B, Park HJ, Tong P, Meong M, Goodell MA, Li W.

Genome Biol. 2014 Feb 24;15(2):R38. doi: 10.1186/gb-2014-15-2-r38.


Hematopoietic stem cell development: an epigenetic journey.

Cullen SM, Mayle A, Rossi L, Goodell MA.

Curr Top Dev Biol. 2014;107:39-75. doi: 10.1016/B978-0-12-416022-4.00002-0. Review.


Large conserved domains of low DNA methylation maintained by Dnmt3a.

Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA.

Nat Genet. 2014 Jan;46(1):17-23. doi: 10.1038/ng.2836. Epub 2013 Nov 24.


A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.

Kim SJ, Zhao H, Hardikar S, Singh AK, Goodell MA, Chen T.

Blood. 2013 Dec 12;122(25):4086-9. doi: 10.1182/blood-2013-02-483487. Epub 2013 Oct 28.


Parental permissions: H19 and keeping the stem cell progeny under control.

Goodell MA.

Cell Stem Cell. 2013 Aug 1;13(2):137-8. doi: 10.1016/j.stem.2013.07.008.


Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells.

Shi FT, Kim H, Lu W, He Q, Liu D, Goodell MA, Wan M, Songyang Z.

J Biol Chem. 2013 Jul 19;288(29):20776-84. doi: 10.1074/jbc.M113.460386. Epub 2013 May 31.


Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine.

Cullen SM, Goodell MA.

Genome Biol. 2013 May 28;14(5):116. doi: 10.1186/gb-2013-14-5-116.

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