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Analysis of Paramyxovirus Transcription and Replication by High-Throughput Sequencing.

Wignall-Fleming EB, Hughes DJ, Vattipally S, Modha S, Goodbourn S, Davison AJ, Randall RE.

J Virol. 2019 Aug 13;93(17). pii: e00571-19. doi: 10.1128/JVI.00571-19. Print 2019 Sep 1.


Species specific differences in use of ANP32 proteins by influenza A virus.

Long JS, Idoko-Akoh A, Mistry B, Goldhill D, Staller E, Schreyer J, Ross C, Goodbourn S, Shelton H, Skinner MA, Sang H, McGrew MJ, Barclay W.

Elife. 2019 Jun 4;8. pii: e45066. doi: 10.7554/eLife.45066.


The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.

Young DF, Wignall-Fleming EB, Busse DC, Pickin MJ, Hankinson J, Randall EM, Tavendale A, Davison AJ, Lamont D, Tregoning JS, Goodbourn S, Randall RE.

PLoS Pathog. 2019 Feb 11;15(2):e1007561. doi: 10.1371/journal.ppat.1007561. eCollection 2019 Feb.


The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells.

James J, Smith N, Ross C, Iqbal M, Goodbourn S, Digard P, Barclay WS, Shelton H.

J Gen Virol. 2019 Mar;100(3):414-430. doi: 10.1099/jgv.0.001220. Epub 2019 Jan 23.


A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features.

Mohamoud HS, Ahmed S, Jelani M, Alrayes N, Childs K, Vadgama N, Almramhi MM, Al-Aama JY, Goodbourn S, Nasir J.

Sci Rep. 2018 Feb 1;8(1):2053. doi: 10.1038/s41598-018-20658-w.


Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells.

Giotis ES, Ross CS, Robey RC, Nohturfft A, Goodbourn S, Skinner MA.

Sci Rep. 2017 Dec 13;7(1):17485. doi: 10.1038/s41598-017-17730-2.


Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses.

Vasou A, Sultanoglu N, Goodbourn S, Randall RE, Kostrikis LG.

Viruses. 2017 Jul 13;9(7). pii: E186. doi: 10.3390/v9070186. Review.


Control of the induction of type I interferon by Peste des petits ruminants virus.

Sanz Bernardo B, Goodbourn S, Baron MD.

PLoS One. 2017 May 5;12(5):e0177300. doi: 10.1371/journal.pone.0177300. eCollection 2017.


Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP.

Barber C, Netherton C, Goatley L, Moon A, Goodbourn S, Dixon L.

Virology. 2017 Apr;504:107-113. doi: 10.1016/j.virol.2017.02.002. Epub 2017 Feb 9.


Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family.

Young DF, Andrejeva J, Li X, Inesta-Vaquera F, Dong C, Cowling VH, Goodbourn S, Randall RE.

J Virol. 2016 Sep 29;90(20):9446-56. doi: 10.1128/JVI.01056-16. Print 2016 Oct 15.


Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α).

Giotis ES, Robey RC, Skinner NG, Tomlinson CD, Goodbourn S, Skinner MA.

Vet Res. 2016 Aug 5;47(1):75. doi: 10.1186/s13567-016-0363-8.


Genome Sequence of the Parainfluenza Virus 5 Strain That Persistently Infects AGS Cells.

Wignall-Fleming E, Young DF, Goodbourn S, Davison AJ, Randall RE.

Genome Announc. 2016 Jul 21;4(4). pii: e00653-16. doi: 10.1128/genomeA.00653-16.


Sensitivity of African swine fever virus to type I interferon is linked to genes within multigene families 360 and 505.

Golding JP, Goatley L, Goodbourn S, Dixon LK, Taylor G, Netherton CL.

Virology. 2016 Jun;493:154-61. doi: 10.1016/j.virol.2016.03.019. Epub 2016 Apr 1.


LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA.

Childs KS, Randall RE, Goodbourn S.

PLoS One. 2013 May 9;8(5):e64202. doi: 10.1371/journal.pone.0064202. Print 2013.


Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction.

Killip MJ, Young DF, Gatherer D, Ross CS, Short JA, Davison AJ, Goodbourn S, Randall RE.

J Virol. 2013 May;87(9):4798-807. doi: 10.1128/JVI.03383-12. Epub 2013 Feb 28.


Genetic screen of a mutant poxvirus library identifies an ankyrin repeat protein involved in blocking induction of avian type I interferon.

Laidlaw SM, Robey R, Davies M, Giotis ES, Ross C, Buttigieg K, Goodbourn S, Skinner MA.

J Virol. 2013 May;87(9):5041-52. doi: 10.1128/JVI.02736-12. Epub 2013 Feb 20.


Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response.

Buttigieg K, Laidlaw SM, Ross C, Davies M, Goodbourn S, Skinner MA.

J Virol. 2013 May;87(9):5028-40. doi: 10.1128/JVI.02738-12. Epub 2013 Feb 20.


STAT2 deficiency and susceptibility to viral illness in humans.

Hambleton S, Goodbourn S, Young DF, Dickinson P, Mohamad SM, Valappil M, McGovern N, Cant AJ, Hackett SJ, Ghazal P, Morgan NV, Randall RE.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3053-8. doi: 10.1073/pnas.1220098110. Epub 2013 Feb 7.


ISG56/IFIT1 is primarily responsible for interferon-induced changes to patterns of parainfluenza virus type 5 transcription and protein synthesis.

Andrejeva J, Norsted H, Habjan M, Thiel V, Goodbourn S, Randall RE.

J Gen Virol. 2013 Jan;94(Pt 1):59-68. doi: 10.1099/vir.0.046797-0. Epub 2012 Oct 10.


Viral immune modulators perturb the human molecular network by common and unique strategies.

Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G.

Nature. 2012 Jul 26;487(7408):486-90. doi: 10.1038/nature11289.


Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction.

Childs K, Randall R, Goodbourn S.

J Virol. 2012 Apr;86(7):3411-21. doi: 10.1128/JVI.06405-11. Epub 2012 Feb 1.


Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis.

Killip MJ, Young DF, Precious BL, Goodbourn S, Randall RE.

J Gen Virol. 2012 Feb;93(Pt 2):299-307. doi: 10.1099/vir.0.037531-0. Epub 2011 Nov 2.


Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist.

Killip MJ, Young DF, Ross CS, Chen S, Goodbourn S, Randall RE.

Virology. 2011 Jun 20;415(1):39-46. doi: 10.1016/j.virol.2011.03.027. Epub 2011 Apr 22.


Regulation of transcription of the Aedes albopictus cecropin A1 gene: A role for p38 mitogen-activated protein kinase.

Moon AE, Walker AJ, Goodbourn S.

Insect Biochem Mol Biol. 2011 Aug;41(8):628-36. doi: 10.1016/j.ibmb.2011.04.001. Epub 2011 Apr 8.


Heterocellular induction of interferon by negative-sense RNA viruses.

Chen S, Short JA, Young DF, Killip MJ, Schneider M, Goodbourn S, Randall RE.

Virology. 2010 Nov 25;407(2):247-55. doi: 10.1016/j.virol.2010.08.008. Epub 2010 Sep 15.


The classical swine fever virus Npro product is degraded by cellular proteasomes in a manner that does not require interaction with interferon regulatory factor 3.

Seago J, Goodbourn S, Charleston B.

J Gen Virol. 2010 Mar;91(Pt 3):721-6. doi: 10.1099/vir.0.015545-0. Epub 2009 Nov 11.


The regulation of type I interferon production by paramyxoviruses.

Goodbourn S, Randall RE.

J Interferon Cytokine Res. 2009 Sep;29(9):539-47. doi: 10.1089/jir.2009.0071. Review.


Mechanism of mda-5 Inhibition by paramyxovirus V proteins.

Childs KS, Andrejeva J, Randall RE, Goodbourn S.

J Virol. 2009 Feb;83(3):1465-73. doi: 10.1128/JVI.01768-08. Epub 2008 Nov 19.


The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3.

Seago J, Hilton L, Reid E, Doceul V, Jeyatheesan J, Moganeradj K, McCauley J, Charleston B, Goodbourn S.

J Gen Virol. 2007 Nov;88(Pt 11):3002-6.


Catalytic turnover of STAT1 allows PIV5 to dismantle the interferon-induced anti-viral state of cells.

Precious BL, Carlos TS, Goodbourn S, Randall RE.

Virology. 2007 Nov 10;368(1):114-21. Epub 2007 Jul 19.


Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs.

Hagmaier K, Stock N, Precious B, Childs K, Wang LF, Goodbourn S, Randall RE.

J Gen Virol. 2007 Mar;88(Pt 3):956-66.


NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.

Hayman A, Comely S, Lackenby A, Hartgroves LC, Goodbourn S, McCauley JW, Barclay WS.

J Virol. 2007 Mar;81(5):2318-27. Epub 2006 Dec 20.


mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.

Childs K, Stock N, Ross C, Andrejeva J, Hilton L, Skinner M, Randall R, Goodbourn S.

Virology. 2007 Mar 1;359(1):190-200. Epub 2006 Oct 16.


The NPro product of bovine viral diarrhea virus inhibits DNA binding by interferon regulatory factor 3 and targets it for proteasomal degradation.

Hilton L, Moganeradj K, Zhang G, Chen YH, Randall RE, McCauley JW, Goodbourn S.

J Virol. 2006 Dec;80(23):11723-32. Epub 2006 Sep 13.


Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.

Hayman A, Comely S, Lackenby A, Murphy S, McCauley J, Goodbourn S, Barclay W.

Virology. 2006 Mar 30;347(1):52-64. Epub 2005 Dec 27.


Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1.

Precious B, Childs K, Fitzpatrick-Swallow V, Goodbourn S, Randall RE.

J Virol. 2005 Nov;79(21):13434-41.


Activation of interferon-stimulated response element in huh-7 cells replicating hepatitis C virus subgenomic RNA.

Pai M, Prabhu R, Panebra A, Nangle S, Haque S, Bastian F, Garry R, Agrawal K, Goodbourn S, Dash S.

Intervirology. 2005;48(5):301-11.


The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.

Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S, Randall RE.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17264-9. Epub 2004 Nov 24.


Differential activation of interferon regulatory factors-3 and -7 by non-cytopathogenic and cytopathogenic bovine viral diarrhoea virus.

Baigent SJ, Goodbourn S, McCauley JW.

Vet Immunol Immunopathol. 2004 Aug;100(3-4):135-44.


Identification of novel co-repressor molecules for Interferon Regulatory Factor-2.

Childs KS, Goodbourn S.

Nucleic Acids Res. 2003 Jun 15;31(12):3016-26.


Virus replication in engineered human cells that do not respond to interferons.

Young DF, Andrejeva L, Livingstone A, Goodbourn S, Lamb RA, Collins PL, Elliott RM, Randall RE.

J Virol. 2003 Feb;77(3):2174-81.


The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta.

Poole E, He B, Lamb RA, Randall RE, Goodbourn S.

Virology. 2002 Nov 10;303(1):33-46.


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