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Items: 26


Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial.

Tameris M, Mearns H, Penn-Nicholson A, Gregg Y, Bilek N, Mabwe S, Geldenhuys H, Shenje J, Luabeya AKK, Murillo I, Doce J, Aguilo N, Marinova D, Puentes E, Rodríguez E, Gonzalo-Asensio J, Fritzell B, Thole J, Martin C, Scriba TJ, Hatherill M; MTBVAC Clinical Trial Team.

Lancet Respir Med. 2019 Sep;7(9):757-770. doi: 10.1016/S2213-2600(19)30251-6. Epub 2019 Aug 12.


Editorial: Update on the Immune Mechanisms Against Respiratory Pathogens.

Garmendia J, Gonzalo-Asensio J.

Front Immunol. 2019 Jul 23;10:1730. doi: 10.3389/fimmu.2019.01730. eCollection 2019. No abstract available.


Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate.

Díaz C, Pérez Del Palacio J, Valero-Guillén PL, Mena García P, Pérez I, Vicente F, Martín C, Genilloud O, Sánchez Pozo A, Gonzalo-Asensio J.

ACS Infect Dis. 2019 Aug 9;5(8):1317-1326. doi: 10.1021/acsinfecdis.9b00008. Epub 2019 May 30.


MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice.

Broset E, Saubi N, Guitart N, Aguilo N, Uranga S, Kilpeläinen A, Eto Y, Hanke T, Gonzalo-Asensio J, Martín C, Joseph-Munné J.

Mol Ther Methods Clin Dev. 2019 Feb 7;13:253-264. doi: 10.1016/j.omtm.2019.01.014. eCollection 2019 Jun 14.


New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages.

Gonzalo-Asensio J, Pérez I, Aguiló N, Uranga S, Picó A, Lampreave C, Cebollada A, Otal I, Samper S, Martín C.

PLoS Genet. 2018 Apr 12;14(4):e1007282. doi: 10.1371/journal.pgen.1007282. eCollection 2018 Apr.


Vaccination against tuberculosis.

Martin C, Aguilo N, Gonzalo-Asensio J.

Enferm Infecc Microbiol Clin. 2018 Dec;36(10):648-656. doi: 10.1016/j.eimc.2018.02.006. Epub 2018 Apr 5. English, Spanish.


MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic.

Gonzalo-Asensio J, Marinova D, Martin C, Aguilo N.

Front Immunol. 2017 Dec 15;8:1803. doi: 10.3389/fimmu.2017.01803. eCollection 2017. Review.


Breaking Transmission with Vaccines: The Case of Tuberculosis.

Gonzalo-Asensio J, Aguilo N, Marinova D, Martin C.

Microbiol Spectr. 2017 Jul;5(4). doi: 10.1128/microbiolspec.MTBP-0001-2016. Review.


Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis.

Aguilo N, Gonzalo-Asensio J, Alvarez-Arguedas S, Marinova D, Gomez AB, Uranga S, Spallek R, Singh M, Audran R, Spertini F, Martin C.

Nat Commun. 2017 Jul 14;8:16085. doi: 10.1038/ncomms16085.


MTBVAC from discovery to clinical trials in tuberculosis-endemic countries.

Marinova D, Gonzalo-Asensio J, Aguilo N, Martin C.

Expert Rev Vaccines. 2017 Jun;16(6):565-576. doi: 10.1080/14760584.2017.1324303. Epub 2017 May 12. Review.


Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition.

Yruela I, Contreras-Moreira B, Magalhães C, Osório NS, Gonzalo-Asensio J.

Genome Biol Evol. 2016 Dec 1;8(12):3751-3764. doi: 10.1093/gbe/evw279.


(Aminophosphane)gold(I) and silver(I) complexes as antibacterial agents.

Ortego L, Gonzalo-Asensio J, Laguna A, Villacampa MD, Gimeno MC.

J Inorg Biochem. 2015 May;146:19-27. doi: 10.1016/j.jinorgbio.2015.01.007. Epub 2015 Jan 30.


Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator.

Gonzalo-Asensio J, Malaga W, Pawlik A, Astarie-Dequeker C, Passemar C, Moreau F, Laval F, Daffé M, Martin C, Brosch R, Guilhot C.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11491-6. doi: 10.1073/pnas.1406693111. Epub 2014 Jul 21.


A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component.

Solans L, Aguiló N, Samper S, Pawlik A, Frigui W, Martín C, Brosch R, Gonzalo-Asensio J.

Infect Immun. 2014 Aug;82(8):3446-56. doi: 10.1128/IAI.01824-14. Epub 2014 Jun 2.


The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

Solans L, Gonzalo-Asensio J, Sala C, Benjak A, Uplekar S, Rougemont J, Guilhot C, Malaga W, Martín C, Cole ST.

PLoS Pathog. 2014 May 29;10(5):e1004183. doi: 10.1371/journal.ppat.1004183. eCollection 2014 May.


A novel antisense RNA from the Salmonella virulence plasmid pSLT expressed by non-growing bacteria inside eukaryotic cells.

Gonzalo-Asensio J, Ortega AD, Rico-Pérez G, Pucciarelli MG, García-Del Portillo F.

PLoS One. 2013 Oct 31;8(10):e77939. doi: 10.1371/journal.pone.0077939. eCollection 2013.


Recent developments in tuberculosis vaccines.

Marinova D, Gonzalo-Asensio J, Aguilo N, Martin C.

Expert Rev Vaccines. 2013 Dec;12(12):1431-48. doi: 10.1586/14760584.2013.856765. Review.


Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials.

Arbues A, Aguilo JI, Gonzalo-Asensio J, Marinova D, Uranga S, Puentes E, Fernandez C, Parra A, Cardona PJ, Vilaplana C, Ausina V, Williams A, Clark S, Malaga W, Guilhot C, Gicquel B, Martin C.

Vaccine. 2013 Oct 1;31(42):4867-73. doi: 10.1016/j.vaccine.2013.07.051. Epub 2013 Aug 17.


Dynamics of Salmonella small RNA expression in non-growing bacteria located inside eukaryotic cells.

Ortega AD, Gonzalo-Asensio J, García-del Portillo F.

RNA Biol. 2012 Apr;9(4):469-88. doi: 10.4161/rna.19317. Epub 2012 Feb 16.


Identification of three novel antisense RNAs in the fur locus from unicellular cyanobacteria.

Sevilla E, Martín-Luna B, González A, Gonzalo-Asensio JA, Peleato ML, Fillat MF.

Microbiology. 2011 Dec;157(Pt 12):3398-404. doi: 10.1099/mic.0.048231-0. Epub 2011 Sep 15.


High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.

Brodin P, Poquet Y, Levillain F, Peguillet I, Larrouy-Maumus G, Gilleron M, Ewann F, Christophe T, Fenistein D, Jang J, Jang MS, Park SJ, Rauzier J, Carralot JP, Shrimpton R, Genovesio A, Gonzalo-Asensio JA, Puzo G, Martin C, Brosch R, Stewart GR, Gicquel B, Neyrolles O.

PLoS Pathog. 2010 Sep 9;6(9):e1001100. doi: 10.1371/journal.ppat.1001100.


PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.

Gonzalo-Asensio J, Mostowy S, Harders-Westerveen J, Huygen K, Hernández-Pando R, Thole J, Behr M, Gicquel B, Martín C.

PLoS One. 2008;3(10):e3496. doi: 10.1371/journal.pone.0003496. Epub 2008 Oct 23.


The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv.

Gonzalo-Asensio J, Soto CY, Arbués A, Sancho J, del Carmen Menéndez M, García MJ, Gicquel B, Martín C.

J Bacteriol. 2008 Nov;190(21):7068-78. doi: 10.1128/JB.00712-08. Epub 2008 Aug 29.


A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra.

Chesne-Seck ML, Barilone N, Boudou F, Gonzalo Asensio J, Kolattukudy PE, Martín C, Cole ST, Gicquel B, Gopaul DN, Jackson M.

J Bacteriol. 2008 Feb;190(4):1329-34. Epub 2007 Dec 7.


The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis.

Gonzalo Asensio J, Maia C, Ferrer NL, Barilone N, Laval F, Soto CY, Winter N, Daffé M, Gicquel B, Martín C, Jackson M.

J Biol Chem. 2006 Jan 20;281(3):1313-6. Epub 2005 Dec 2.

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