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Genomic instability and innate immune responses to self-DNA in progeria.

Gonzalo S, Coll-Bonfill N.

Geroscience. 2019 Jul 6. doi: 10.1007/s11357-019-00082-2. [Epub ahead of print] Review.


Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and Bedside.

Kreienkamp R, Gonzalo S.

Subcell Biochem. 2019;91:435-451. doi: 10.1007/978-981-13-3681-2_15. Review.


Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet.

Kreienkamp R, Billon C, Bedia-Diaz G, Albert CJ, Toth Z, Butler AA, McBride-Gagyi S, Ford DA, Baldan A, Burris TP, Gonzalo S.

Aging Cell. 2019 Feb;18(1):e12852. doi: 10.1111/acel.12852. Epub 2018 Dec 12.


Tissue Non-Specific Alkaline Phosphatase and Vascular Calcification: A Potential Therapeutic Target.

Azpiazu D, Gonzalo S, Villa-Bellosta R.

Curr Cardiol Rev. 2019;15(2):91-95. doi: 10.2174/1573403X14666181031141226. Review.


Factors associated with poor anticoagulation control with vitaminK antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study.

Contreras Muruaga MM, Reig G, Vivancos J, González A, Cardona P, Ramírez-Moreno JM, Martí-Fábregas J, Suárez Fernández C; en nombre de los investigadores del estudio ALADIN; Listado de investigadores del estudio ALADIN.

Rev Clin Esp. 2018 Oct;218(7):327-335. doi: 10.1016/j.rce.2018.04.020. Epub 2018 Jul 6. English, Spanish.


Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.

Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemaçon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A.

Nucleic Acids Res. 2019 Feb 20;47(3):1294-1310. doi: 10.1093/nar/gky519.


Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response.

Graziano S, Kreienkamp R, Coll-Bonfill N, Gonzalo S.

Nucleus. 2018 Jan 1;9(1):258-275. doi: 10.1080/19491034.2018.1454168.


A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.

Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.

Cell Rep. 2018 Feb 20;22(8):2006-2015. doi: 10.1016/j.celrep.2018.01.090.


Role of pyrophosphate in vascular calcification in chronic kidney disease.

Azpiazu D, Gonzalo S, González-Parra E, Egido J, Villa-Bellosta R.

Nefrologia. 2018 May - Jun;38(3):250-257. doi: 10.1016/j.nefro.2017.07.005. Epub 2017 Nov 11. Review. English, Spanish.


Environmental exposure to low-doses of ionizing radiation. Effects on early nephrotoxicity in mice.

Bellés M, Gonzalo S, Serra N, Esplugas R, Arenas M, Domingo JL, Linares V.

Environ Res. 2017 Jul;156:291-296. doi: 10.1016/j.envres.2017.03.034. Epub 2017 Apr 3.


Mechanisms of oncogene-induced genomic instability.

Graziano S, Gonzalo S.

Biophys Chem. 2017 Jun;225:49-57. doi: 10.1016/j.bpc.2016.11.008. Epub 2016 Nov 24. Review.


Hidden drivers of low-dose pharmaceutical pollutant mixtures revealed by the novel GSA-QHTS screening method.

Rodea-Palomares I, Gonzalez-Pleiter M, Gonzalo S, Rosal R, Leganes F, Sabater S, Casellas M, Muñoz-Carpena R, Fernández-Piñas F.

Sci Adv. 2016 Sep 7;2(9):e1601272. doi: 10.1126/sciadv.1601272. eCollection 2016 Sep.


Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.

Gonzalo S, Kreienkamp R, Askjaer P.

Ageing Res Rev. 2017 Jan;33:18-29. doi: 10.1016/j.arr.2016.06.007. Epub 2016 Jun 29. Review.


The nuclear lamina in health and disease.

Dobrzynska A, Gonzalo S, Shanahan C, Askjaer P.

Nucleus. 2016 May 3;7(3):233-48. doi: 10.1080/19491034.2016.1183848. Epub 2016 May 9. Review.


Methods to Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina.

Gonzalo S, Kreienkamp R.

Methods Mol Biol. 2016;1411:419-37. doi: 10.1007/978-1-4939-3530-7_26.


Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes.

Kreienkamp R, Croke M, Neumann MA, Bedia-Diaz G, Graziano S, Dusso A, Dorsett D, Carlberg C, Gonzalo S.

Oncotarget. 2016 May 24;7(21):30018-31. doi: 10.18632/oncotarget.9065.


Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence.

Graziano S, Johnston R, Deng O, Zhang J, Gonzalo S.

Oncogene. 2016 Oct 13;35(41):5362-5376. doi: 10.1038/onc.2016.77. Epub 2016 Apr 4.


Tying up loose ends: telomeres, genomic instability and lamins.

Gonzalo S, Eissenberg JC.

Curr Opin Genet Dev. 2016 Apr;37:109-118. doi: 10.1016/j.gde.2016.03.003. Epub 2016 Mar 21. Review.


Electrospun cellulose acetate composites containing supported metal nanoparticles for antifungal membranes.

Quirós J, Gonzalo S, Jalvo B, Boltes K, Perdigón-Melón JA, Rosal R.

Sci Total Environ. 2016 Sep 1;563-564:912-20. doi: 10.1016/j.scitotenv.2015.10.072. Epub 2015 Oct 31.


Loss of lamin A function increases chromatin dynamics in the nuclear interior.

Bronshtein I, Kepten E, Kanter I, Berezin S, Lindner M, Redwood AB, Mai S, Gonzalo S, Foisner R, Shav-Tal Y, Garini Y.

Nat Commun. 2015 Aug 24;6:8044. doi: 10.1038/ncomms9044.


Different mechanisms of actions of genistein, quercetin on spontaneous contractions of rabbit duodenum.

Santos-Fagundes D, Grasa L, Gonzalo S, Valero MS, Castro M, Arruebo MP, Plaza MÁ, Murillo MD.

Rev Esp Enferm Dig. 2015 Jul;107(7):413-6.


DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.

Gonzalo S, Kreienkamp R.

Curr Opin Cell Biol. 2015 Jun;34:75-83. doi: 10.1016/ Epub 2015 Jun 12. Review.


Effect of PFOA/PFOS pre-exposure on the toxicity of the herbicides 2,4-D, Atrazine, Diuron and Paraquat to a model aquatic photosynthetic microorganism.

Rodea-Palomares I, Makowski M, Gonzalo S, González-Pleiter M, Leganés F, Fernández-Piñas F.

Chemosphere. 2015 Nov;139:65-72. doi: 10.1016/j.chemosphere.2015.05.078. Epub 2015 Jun 9.


Roles of Toll-Like Receptor 4, IκB Kinase, and the Proteasome in the Intestinal Alterations Caused by Sepsis.

Gonzalo S, Valero MS, Martínez de Salinas F, Vergara C, Arruebo MP, Plaza MÁ, Murillo MD, Grasa L.

Dig Dis Sci. 2015 May;60(5):1223-31. doi: 10.1007/s10620-014-3418-6. Epub 2014 Nov 5.


A colloidal singularity reveals the crucial role of colloidal stability for nanomaterials in-vitro toxicity testing: nZVI-microalgae colloidal system as a case study.

Gonzalo S, Llaneza V, Pulido-Reyes G, Fernández-Piñas F, Bonzongo JC, Leganes F, Rosal R, García-Calvo E, Rodea-Palomares I.

PLoS One. 2014 Oct 23;9(10):e109645. doi: 10.1371/journal.pone.0109645. eCollection 2014.


First evidences of PAMAM dendrimer internalization in microorganisms of environmental relevance: A linkage with toxicity and oxidative stress.

Gonzalo S, Rodea-Palomares I, Leganés F, García-Calvo E, Rosal R, Fernández-Piñas F.

Nanotoxicology. 2015;9(6):706-18. doi: 10.3109/17435390.2014.969345. Epub 2014 Oct 17.


[Down syndrome maternal serum screening: results' comments recommended by accredited biologists].

Muller F, Dreux S, Czerkiewicz I, Bernard M, Guibourdenche J, Lacroix I, Moineau MP, Read MH, Sault C, Thibaud D, Veyrat B; ABA, Bidat L.

J Gynecol Obstet Biol Reprod (Paris). 2014 Nov;43(9):671-9. doi: 10.1016/j.jgyn.2014.05.012. Epub 2014 Sep 11. French.


Single-walled carbon nanotubes (SWCNTs) enhance KCl-, acetylcholine-, and serotonin-induced contractions and evoke oxidative stress on rabbit ileum.

Grasa L, Ansón-Casaos A, Martínez MT, Albendea R, De Martino A, Gonzalo S, Murillo MD.

J Biomed Nanotechnol. 2014 Mar;10(3):529-42.


DNA damage and lamins.

Gonzalo S.

Adv Exp Med Biol. 2014;773:377-99. doi: 10.1007/978-1-4899-8032-8_17. Review.


Mechanism of action of Trolox on duodenal contractility.

Fagundes DS, Grasa L, Gonzalo S, Martinez de Salinas F, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Pharmacol. 2013 Dec;64(6):705-10.


Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability.

Das A, Grotsky DA, Neumann MA, Kreienkamp R, Gonzalez-Suarez I, Redwood AB, Kennedy BK, Stewart CL, Gonzalo S.

Nucleus. 2013 Sep-Oct;4(5):410-9. doi: 10.4161/nucl.26873. Epub 2013 Oct 23.


Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.

Croke M, Neumann MA, Grotsky DA, Kreienkamp R, Yaddanapudi SC, Gonzalo S.

Cell Cycle. 2013 Dec 1;12(23):3629-39. doi: 10.4161/cc.26582. Epub 2013 Oct 2.


Novel roles of 1α,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment.

Gonzalo S.

J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:59-64. doi: 10.1016/j.jsbmb.2013.09.009. Epub 2013 Sep 27. Review.


The two faces of DNA repair: disease and therapy.

Vindigni A, Gonzalo S.

Mo Med. 2013 Jul-Aug;110(4):314-9.


Chitosan-gelatin biopolymers as carrier substrata for limbal epithelial stem cells.

de la Mata A, Nieto-Miguel T, López-Paniagua M, Galindo S, Aguilar MR, García-Fernández L, Gonzalo S, Vázquez B, Román JS, Corrales RM, Calonge M.

J Mater Sci Mater Med. 2013 Dec;24(12):2819-29. doi: 10.1007/s10856-013-5013-3. Epub 2013 Jul 28.


Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment.

González-Pleiter M, Gonzalo S, Rodea-Palomares I, Leganés F, Rosal R, Boltes K, Marco E, Fernández-Piñas F.

Water Res. 2013 Apr 15;47(6):2050-64. doi: 10.1016/j.watres.2013.01.020. Epub 2013 Jan 24.


BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells.

Grotsky DA, Gonzalez-Suarez I, Novell A, Neumann MA, Yaddanapudi SC, Croke M, Martinez-Alonso M, Redwood AB, Ortega-Martinez S, Feng Z, Lerma E, Ramon y Cajal T, Zhang J, Matias-Guiu X, Dusso A, Gonzalo S.

J Cell Biol. 2013 Jan 21;200(2):187-202. doi: 10.1083/jcb.201204053.


An insight into the mechanisms of nanoceria toxicity in aquatic photosynthetic organisms.

Rodea-Palomares I, Gonzalo S, Santiago-Morales J, Leganés F, García-Calvo E, Rosal R, Fernández-Piñas F.

Aquat Toxicol. 2012 Oct 15;122-123:133-43. doi: 10.1016/j.aquatox.2012.06.005. Epub 2012 Jun 26.


The variable sensitivity of HIV Ag/Ab combination assays in the detection of p24Ag according to genotype could compromise the diagnosis of early HIV infection.

Ly TD, Plantier JC, Leballais L, Gonzalo S, Lemée V, Laperche S.

J Clin Virol. 2012 Oct;55(2):121-7. doi: 10.1016/j.jcv.2012.06.012. Epub 2012 Jul 13.


Mitogen activated protein kinases blockade improves lipopolysaccharide-induced ileal motor disturbances.

Gonzalo S, Grasa L, Hernández LV, Arruebo MP, Plaza MÁ, Murillo MD.

Rev Esp Enferm Dig. 2012 Jun;104(6):305-9. English, Spanish.


Clinical performance of the carbohydrate-deficient transferrin (CDT) assay by the Sebia Capillarys2 system in case of cirrhosis. Interest of the Bio-Rad %CDT by HPLC test and Siemens N-Latex CDT kit as putative confirmatory methods.

Gonzalo P, Pecquet M, Bon C, Gonzalo S, Radenne S, Augustin-Normand C, Souquet JC.

Clin Chim Acta. 2012 Apr 11;413(7-8):712-8. doi: 10.1016/j.cca.2011.12.022. Epub 2012 Jan 8.


Regulating the levels of key factors in cell cycle and DNA repair: new pathways revealed by lamins.

Redwood AB, Gonzalez-Suarez I, Gonzalo S.

Cell Cycle. 2011 Nov 1;10(21):3652-7. doi: 10.4161/cc.10.21.18201. Epub 2011 Nov 1. Review.


Nuclear factor κB is a key transcription factor in the duodenal contractility alterations induced by lipopolysaccharide.

Hernández LV, Gonzalo S, Castro M, Arruebo MP, Plaza MA, Murillo MD, Grasa L.

Exp Physiol. 2011 Nov;96(11):1151-62. doi: 10.1113/expphysiol.2011.060830. Epub 2011 Sep 2.


Trolox reduces the effect of ethanol on acetylcholine-induced contractions and oxidative stress in the isolated rabbit duodenum.

Fagundes DS, Gonzalo S, Grasa L, Castro M, Arruebo MP, Plaza MA, Murillo MD.

Rev Esp Enferm Dig. 2011 Aug;103(8):396-401. English, Spanish.


A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.

Gonzalez-Suarez I, Redwood AB, Grotsky DA, Neumann MA, Cheng EH, Stewart CL, Dusso A, Gonzalo S.

EMBO J. 2011 Jul 12;30(16):3383-96. doi: 10.1038/emboj.2011.225.


A dual role for A-type lamins in DNA double-strand break repair.

Redwood AB, Perkins SM, Vanderwaal RP, Feng Z, Biehl KJ, Gonzalez-Suarez I, Morgado-Palacin L, Shi W, Sage J, Roti-Roti JL, Stewart CL, Zhang J, Gonzalo S.

Cell Cycle. 2011 Aug 1;10(15):2549-60. Epub 2011 Aug 1.


Chemical and toxicological evolution of the antibiotic sulfamethoxazole under ozone treatment in water solution.

Gómez-Ramos Mdel M, Mezcua M, Agüera A, Fernández-Alba AR, Gonzalo S, Rodríguez A, Rosal R.

J Hazard Mater. 2011 Aug 15;192(1):18-25. doi: 10.1016/j.jhazmat.2011.04.072. Epub 2011 Apr 22.


Role of TLR4 and MAPK in the local effect of LPS on intestinal contractility.

Barona I, Fagundes DS, Gonzalo S, Grasa L, Arruebo MP, Plaza MÁ, Murillo MD.

J Pharm Pharmacol. 2011 May;63(5):657-62. doi: 10.1111/j.2042-7158.2011.01253.x. Epub 2011 Mar 17.


Nurturing the genome: A-type lamins preserve genomic stability.

Gonzalez-Suarez I, Gonzalo S.

Nucleus. 2010 Mar-Apr;1(2):129-35. doi: 10.4161/nucl.1.2.10797. Epub 2009 Nov 29. Review.


The mTOR inhibitor rapamycin suppresses DNA double-strand break repair.

Chen H, Ma Z, Vanderwaal RP, Feng Z, Gonzalez-Suarez I, Wang S, Zhang J, Roti Roti JL, Gonzalo S, Zhang J.

Radiat Res. 2011 Feb;175(2):214-24. Epub 2010 Oct 26.

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