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Items: 1 to 50 of 170

1.

Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion.

Lluch A, González-Angulo AM, Casadevall D, Eterovic AK, Martínez de Dueñas E, Zheng X, Guerrero-Zotano Á, Liu S, Pérez R, Chen K, Chacón JI, Mills GB, Antolín S, Blancas I, López-Serra P, Carrasco E, Caballero R, Prat A, Rojo F, Gonzalez-Perez A, Meric-Bernstam F, Albanell J.

Eur J Cancer. 2019 Sep 3;120:54-64. doi: 10.1016/j.ejca.2019.07.003. [Epub ahead of print]

PMID:
31491604
2.

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.

Moreno-Grau S, de Rojas I, Hernández I, Quintela I, Montrreal L, Alegret M, Hernández-Olasagarre B, Madrid L, González-Perez A, Maroñas O, Rosende-Roca M, Mauleón A, Vargas L, Lafuente A, Abdelnour C, Rodríguez-Gómez O, Gil S, Santos-Santos MÁ, Espinosa A, Ortega G, Sanabria Á, Pérez-Cordón A, Cañabate P, Moreno M, Preckler S, Ruiz S, Aguilera N, Pineda JA, Macías J, Alarcón-Martín E, Sotolongo-Grau O; GR@ACE consortium; DEGESCO consortium; Alzheimer's Disease Neuroimaging Initiative, Marquié M, Monté-Rubio G, Valero S, Benaque A, Clarimón J, Bullido MJ, García-Ribas G, Pástor P, Sánchez-Juan P, Álvarez V, Piñol-Ripoll G, García-Alberca JM, Royo JL, Franco E, Mir P, Calero M, Medina M, Rábano A, Ávila J, Antúnez C, Real LM, Orellana A, Carracedo Á, Sáez ME, Tárraga L, Boada M, Ruiz A.

Alzheimers Dement. 2019 Aug 13. pii: S1552-5260(19)35117-9. doi: 10.1016/j.jalz.2019.06.4950. [Epub ahead of print]

3.

LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.

Cebrià-Costa JP, Pascual-Reguant L, Gonzalez-Perez A, Serra-Bardenys G, Querol J, Cosín M, Verde G, Cigliano RA, Sanseverino W, Segura-Bayona S, Iturbide A, Andreu D, Nuciforo P, Bernado-Morales C, Rodilla V, Arribas J, Yelamos J, de Herreros AG, Stracker TH, Peiró S.

Oncogene. 2019 Aug 28. doi: 10.1038/s41388-019-0969-1. [Epub ahead of print]

PMID:
31462706
4.

OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers.

Arnedo-Pac C, Mularoni L, Muiños F, Gonzalez-Perez A, Lopez-Bigas N.

Bioinformatics. 2019 Aug 1. pii: btz588. doi: 10.1093/bioinformatics/btz588. [Epub ahead of print] No abstract available.

PMID:
31369060
5.

Bullous pemphigoid and DPP4 inhibitors.

García Castro R, Godoy Gijón E, González Pérez AM, Román Curto C.

Med Clin (Barc). 2019 Jul 18. pii: S0025-7753(19)30407-5. doi: 10.1016/j.medcli.2019.04.031. [Epub ahead of print] English, Spanish. No abstract available.

PMID:
31327556
6.

OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers.

Arnedo-Pac C, Mularoni L, Muiños F, Gonzalez-Perez A, Lopez-Bigas N.

Bioinformatics. 2019 Jun 22. pii: btz501. doi: 10.1093/bioinformatics/btz501. [Epub ahead of print]

PMID:
31228182
7.

PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes.

Ogando J, Sáez ME, Santos J, Nuevo-Tapioles C, Gut M, Esteve-Codina A, Heath S, González-Pérez A, Cuezva JM, Lacalle RA, Mañes S.

J Immunother Cancer. 2019 Jun 13;7(1):151. doi: 10.1186/s40425-019-0628-7.

8.

Deciphering the Origin of Enantioselectivity on the Cis-Cyclopropanation of Styrene with Enantiopure Di-chloro,Di-gold(I)-SEGPHOS Carbenoids Generated from Propargylic Esters.

Villar P, González-Pérez AB, de Lera AR.

J Org Chem. 2019 Jun 21;84(12):7664-7673. doi: 10.1021/acs.joc.9b00250. Epub 2019 May 31.

PMID:
31095390
9.

Risk of bleeding events among patients with systemic sclerosis and the general population in the UK: a large population-based cohort study.

Michel A, González-Pérez A, Sáez ME, García Rodríguez LA.

Clin Rheumatol. 2019 May 14. doi: 10.1007/s10067-019-04588-0. [Epub ahead of print]

PMID:
31087225
10.

Tension subcutaneous haematomas associated with anticoagulants in the elderly: Do they have earlier morbidity and mortality than hip fractures?

Galán-Olleros M, Valle-Cruz JA, García-Coiradas J, González-Pérez A, Rodríguez-González FA, Alcobía-Díaz B, Marco F.

Rev Esp Cir Ortop Traumatol. 2019 Sep - Oct;63(5):361-369. doi: 10.1016/j.recot.2019.02.004. Epub 2019 Apr 20. English, Spanish.

PMID:
31014931
11.

Local Determinants of the Mutational Landscape of the Human Genome.

Gonzalez-Perez A, Sabarinathan R, Lopez-Bigas N.

Cell. 2019 Mar 21;177(1):101-114. doi: 10.1016/j.cell.2019.02.051. Review.

12.

NK Cell Infiltrates and HLA Class I Expression in Primary HER2+ Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival.

Muntasell A, Rojo F, Servitja S, Rubio-Perez C, Cabo M, Tamborero D, Costa-García M, Martínez-Garcia M, Menéndez S, Vazquez I, Lluch A, Gonzalez-Perez A, Rovira A, López-Botet M, Albanell J.

Clin Cancer Res. 2019 Mar 1;25(5):1535-1545. doi: 10.1158/1078-0432.CCR-18-2365. Epub 2018 Dec 6.

PMID:
30523021
13.

Contemporary epidemiology of systemic sclerosis: A population-based cohort study in the United Kingdom.

García Rodríguez LA, González-Pérez A, Michel A, Sáez ME.

Semin Arthritis Rheum. 2019 Aug;49(1):105-111. doi: 10.1016/j.semarthrit.2018.11.002. Epub 2018 Nov 10.

PMID:
30470546
14.

Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes.

Pich O, Muiños F, Sabarinathan R, Reyes-Salazar I, Gonzalez-Perez A, Lopez-Bigas N.

Cell. 2018 Nov 1;175(4):1074-1087.e18. doi: 10.1016/j.cell.2018.10.004.

PMID:
30388444
15.

Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response.

Piñero J, Gonzalez-Perez A, Guney E, Aguirre-Plans J, Sanz F, Oliva B, Furlong LI.

Front Genet. 2018 Sep 25;9:412. doi: 10.3389/fgene.2018.00412. eCollection 2018.

16.

A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT).

Mateo J, Chakravarty D, Dienstmann R, Jezdic S, Gonzalez-Perez A, Lopez-Bigas N, Ng CKY, Bedard PL, Tortora G, Douillard JY, Van Allen EM, Schultz N, Swanton C, André F, Pusztai L.

Ann Oncol. 2018 Sep 1;29(9):1895-1902. doi: 10.1093/annonc/mdy263.

17.

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Kwok-Shing Ng P, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortés-Ciriano I, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H; MC3 Working Group; Cancer Genome Atlas Research Network, Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L.

Cell. 2018 Aug 9;174(4):1034-1035. doi: 10.1016/j.cell.2018.07.034. No abstract available.

18.

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.

López-Arribillaga E, Rodilla V, Colomer C, Vert A, Shelton A, Cheng JH, Yan B, Gonzalez-Perez A, Junttila MR, Iglesias M, Torres F, Albanell J, Villanueva A, Bigas A, Siebel CW, Espinosa L.

Nat Commun. 2018 Jul 31;9(1):2992. doi: 10.1038/s41467-018-05385-0.

19.

Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia.

Genescà E, Lazarenkov A, Morgades M, Berbis G, Ruíz-Xivillé N, Gómez-Marzo P, Ribera J, Juncà J, González-Pérez A, Mercadal S, Guardia R, Artola MT, Moreno MJ, Martínez-López J, Zamora L, Barba P, Gil C, Tormo M, Cladera A, Novo A, Pratcorona M, Nomdedeu J, González-Campos J, Almeida M, Cervera J, Montesinos P, Batlle M, Vives S, Esteve J, Feliu E, Solé F, Orfao A, Ribera JM.

J Hematol Oncol. 2018 Jul 24;11(1):96. doi: 10.1186/s13045-018-0639-8.

20.

Author Correction: Reduced mutation rate in exons due to differential mismatch repair.

Frigola J, Sabarinathan R, Mularoni L, Muiños F, Gonzalez-Perez A, López-Bigas N.

Nat Genet. 2018 Aug;50(8):1196. doi: 10.1038/s41588-018-0123-y.

PMID:
29973711
21.

Hormonal contraception is not associated with increased risk for seizures in the general population: results from a cohort study using The Health Improvement Network.

Beier CP, García Rodríguez LA, Sáez ME, Gaist D, González-Pérez A.

Eur J Clin Pharmacol. 2018 Sep;74(9):1175-1180. doi: 10.1007/s00228-018-2494-5. Epub 2018 May 31.

PMID:
29855657
22.

A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations.

Tamborero D, Rubio-Perez C, Muiños F, Sabarinathan R, Piulats JM, Muntasell A, Dienstmann R, Lopez-Bigas N, Gonzalez-Perez A.

Clin Cancer Res. 2018 Aug 1;24(15):3717-3728. doi: 10.1158/1078-0432.CCR-17-3509. Epub 2018 Apr 17.

23.

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Ng PK, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortés-Ciriano I, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H; MC3 Working Group; Cancer Genome Atlas Research Network, Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L.

Cell. 2018 Apr 5;173(2):371-385.e18. doi: 10.1016/j.cell.2018.02.060. Erratum in: Cell. 2018 Aug 9;174(4):1034-1035.

24.

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations.

Tamborero D, Rubio-Perez C, Deu-Pons J, Schroeder MP, Vivancos A, Rovira A, Tusquets I, Albanell J, Rodon J, Tabernero J, de Torres C, Dienstmann R, Gonzalez-Perez A, Lopez-Bigas N.

Genome Med. 2018 Mar 28;10(1):25. doi: 10.1186/s13073-018-0531-8.

25.

Liberal red blood cell transfusions impair quality of life after cardiac surgery.

González-Pérez A, Al-Sibai JZ, Álvarez-Fernández P, Martínez-Camblor P, Argüello-Junquera M, García-Gala JM, Martínez-Revuelta E, Silva J, Morís C, Albaiceta GM.

Med Intensiva. 2019 Apr;43(3):156-164. doi: 10.1016/j.medin.2018.01.014. Epub 2018 Mar 12. English, Spanish.

26.

Low-Dose Aspirin after an Episode of Haemorrhagic Stroke Is Associated with Improved Survival.

González-Pérez A, Gaist D, de Abajo FJ, Sáez ME, García Rodríguez LA.

Thromb Haemost. 2017 Dec;117(12):2396-2405. doi: 10.1160/TH17-05-0342. Epub 2017 Dec 6.

PMID:
29212127
27.

Reduced mutation rate in exons due to differential mismatch repair.

Frigola J, Sabarinathan R, Mularoni L, Muiños F, Gonzalez-Perez A, López-Bigas N.

Nat Genet. 2017 Dec;49(12):1684-1692. doi: 10.1038/ng.3991. Epub 2017 Nov 6. Erratum in: Nat Genet. 2018 Aug;50(8):1196.

28.

Mutational landscape of RNA-binding proteins in human cancers.

Neelamraju Y, Gonzalez-Perez A, Bhat-Nakshatri P, Nakshatri H, Janga SC.

RNA Biol. 2018 Jan 2;15(1):115-129. doi: 10.1080/15476286.2017.1391436. Epub 2017 Nov 14.

29.

Synthesis of the octahydronaphthalene core of nahuoic acid A via a B(C6F5)3-catalyzed intramolecular Diels-Alder (IMDA) reaction.

Guillade L, González-Pérez AB, de Lera ÁR.

Org Biomol Chem. 2017 Sep 13;15(35):7430-7438. doi: 10.1039/c7ob01665d.

PMID:
28831488
30.

Rearrangement of vinyl allene oxide geometric isomers to cyclopentenones. Further computational insights with biologically relevant model systems.

González-Pérez AB, Grechkin A, de Lera ÁR.

Org Biomol Chem. 2017 Mar 28;15(13):2846-2855. doi: 10.1039/c6ob02791a.

PMID:
28286893
31.

[Surgical treatment of malignant primary tumors of the pelvis on Ennekings zone II].

González-Pérez AM, Arvinius C, García-Coiradas J, García-Maroto R, Cebrian-Parra JL.

Acta Ortop Mex. 2016 May-Jun;30(3):132-137. Spanish.

32.

Mortality in patients who discontinue low-dose acetylsalicylic acid therapy after upper gastrointestinal bleeding.

González-Pérez A, Sáez ME, Johansson S, Nagy P, García Rodríguez LA.

Pharmacoepidemiol Drug Saf. 2017 Feb;26(2):215-222. doi: 10.1002/pds.4140. Epub 2016 Dec 6.

PMID:
27921360
33.

Rational design of cancer gene panels with OncoPaD.

Rubio-Perez C, Deu-Pons J, Tamborero D, Lopez-Bigas N, Gonzalez-Perez A.

Genome Med. 2016 Oct 3;8(1):98.

34.

From feelings of imprisonment to group cohesion: A qualitative analysis of group analytic psychotherapy with dual diagnosed patients admitted to an acute inpatient psychiatric unit.

Sánchez Morales L, Eiroa-Orosa FJ, Valls Llagostera C, González Pérez A, Alberich C.

Psychother Res. 2018 May;28(3):433-445. doi: 10.1080/10503307.2016.1216623. Epub 2016 Sep 15.

PMID:
27631420
35.

Risk of bleeding after hospitalization for a serious coronary event: a retrospective cohort study with nested case-control analyses.

González-Pérez A, Sáez ME, Johansson S, Himmelmann A, García Rodríguez LA.

BMC Cardiovasc Disord. 2016 Aug 30;16(1):164. doi: 10.1186/s12872-016-0348-6.

36.

Risk of seizure associated with use of acid-suppressive drugs: An observational cohort study.

Sáez ME, González-Pérez A, Gaist D, Johansson S, Nagy P, García Rodríguez LA.

Epilepsy Behav. 2016 Sep;62:72-80. doi: 10.1016/j.yebeh.2016.06.039. Epub 2016 Jul 21.

PMID:
27450309
37.

Solitary electromechanical pulses in lobster neurons.

Gonzalez-Perez A, Mosgaard LD, Budvytyte R, Villagran-Vargas E, Jackson AD, Heimburg T.

Biophys Chem. 2016 Sep;216:51-59. doi: 10.1016/j.bpc.2016.06.005. Epub 2016 Jul 9.

PMID:
27448851
38.

Non-canonical NF-κB pathway activation predicts outcome in borderline oestrogen receptor positive breast carcinoma.

Rojo F, González-Pérez A, Furriol J, Nicolau MJ, Ferrer J, Burgués O, Sabbaghi M, González-Navarrete I, Cristobal I, Serrano L, Zazo S, Madoz J, Servitja S, Tusquets I, Albanell J, Lluch A, Rovira A, Eroles P.

Br J Cancer. 2016 Jul 26;115(3):322-31. doi: 10.1038/bjc.2016.204. Epub 2016 Jul 12.

39.

OncodriveFML: a general framework to identify coding and non-coding regions with cancer driver mutations.

Mularoni L, Sabarinathan R, Deu-Pons J, Gonzalez-Perez A, López-Bigas N.

Genome Biol. 2016 Jun 16;17(1):128. doi: 10.1186/s13059-016-0994-0.

40.

Bioinspired Materials for Water Purification.

Gonzalez-Perez A, Persson KM.

Materials (Basel). 2016 Jun 3;9(6). pii: E447. doi: 10.3390/ma9060447. Review.

41.

Reply to 'Comment on 'New-onset type 2 diabetes, elevated HbA1c, anti-diabetic medications, and risk of pancreatic cancer''.

Lu Y, Rodríguez LA, Malgerud L, González-Pérez A, Martín-Pérez M, Lagergren J, Bexelius TS.

Br J Cancer. 2016 May 24;114(11):e12. doi: 10.1038/bjc.2016.100. No abstract available.

42.

Paraneoplastic vasculitis associated to pelvic chondrosarcoma: a case report.

Arvinius C, González-Pérez A, García-Coiradas J, García-Maroto R, Cebrián-Parra JL.

SICOT J. 2016 Feb 26;2:8. doi: 10.1051/sicotj/2015042.

43.

Altered oncomodules underlie chromatin regulatory factors driver mutations.

Frigola J, Iturbide A, Lopez-Bigas N, Peiro S, Gonzalez-Perez A.

Oncotarget. 2016 May 24;7(21):30748-59. doi: 10.18632/oncotarget.8752.

44.

Uncovering disease mechanisms through network biology in the era of Next Generation Sequencing.

Piñero J, Berenstein A, Gonzalez-Perez A, Chernomoretz A, Furlong LI.

Sci Rep. 2016 Apr 15;6:24570. doi: 10.1038/srep24570.

45.

Nucleotide excision repair is impaired by binding of transcription factors to DNA.

Sabarinathan R, Mularoni L, Deu-Pons J, Gonzalez-Perez A, López-Bigas N.

Nature. 2016 Apr 14;532(7598):264-7. doi: 10.1038/nature17661.

PMID:
27075101
46.

Exploiting the Multidentate Nature of Chiral Disulfonimides in a Multicomponent Reaction for the Asymmetric Synthesis of Pyrrolo[1,2-a]indoles: A Remarkable Case of Enantioinversion.

Galván A, González-Pérez AB, Álvarez R, de Lera AR, Fañanás FJ, Rodríguez F.

Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3428-32. doi: 10.1002/anie.201511231. Epub 2016 Feb 2.

PMID:
26833640
47.
48.

Association between low-dose acetylsalicylic acid reinitiation and the risk of myocardial infarction or coronary heart disease death.

Sáez ME, González-Pérez A, Johansson S, Himmelmann A, García Rodríguez LA.

Eur J Prev Cardiol. 2016 Jul;23(10):1029-36. doi: 10.1177/2047487315618795. Epub 2015 Nov 24.

PMID:
26603743
49.

New-onset type 2 diabetes, elevated HbA1c, anti-diabetic medications, and risk of pancreatic cancer.

Lu Y, García Rodríguez LA, Malgerud L, González-Pérez A, Martín-Pérez M, Lagergren J, Bexelius TS.

Br J Cancer. 2015 Dec 1;113(11):1607-14. doi: 10.1038/bjc.2015.353. Epub 2015 Nov 17.

50.

[Morphological abnormalities in the cibarium of Lutzomyia evansi (Diptera: Psychodidae, Phlebotominae) caught in Trujillo, Venezuela].

Méndez-de Daboín Y, Oviedo-Araújo M, González-Pérez A, Suárez-Hernández J, Sandoval CM, Cazorla D.

Biomedica. 2015 Apr-Jun;35(2):269-73. doi: 10.1590/S0120-41572015000200015. Spanish.

PMID:
26535549

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