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Minipigs as a neonatal animal model for tuberculosis vaccine efficacy testing.

Ramos L, Obregon-Henao A, Henao-Tamayo M, Bowen R, Izzo A, Lunney JK, Gonzalez-Juarrero M.

Vet Immunol Immunopathol. 2019 Sep;215:109884. doi: 10.1016/j.vetimm.2019.109884. Epub 2019 Jul 26.


Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.

Walz A, Lukka PB, Pearce C, Creissen E, Braunstein M, Hickey AJ, Meibohm B, Gonzalez-Juarrero M.

Tuberculosis (Edinb). 2019 Jul;117:52-55. doi: 10.1016/ Epub 2019 Jun 6.


Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.

Stewart IE, Lukka PB, Liu J, Meibohm B, Gonzalez-Juarrero M, Braunstein MS, Lee RE, Hickey AJ.

Pharm Res. 2019 Jul 18;36(9):136. doi: 10.1007/s11095-019-2666-8.


Direct Inhibition of MmpL3 by Novel Antitubercular Compounds.

Li W, Stevens CM, Pandya AN, Darzynkiewicz Z, Bhattarai P, Tong W, Gonzalez-Juarrero M, North EJ, Zgurskaya HI, Jackson M.

ACS Infect Dis. 2019 Jun 14;5(6):1001-1012. doi: 10.1021/acsinfecdis.9b00048. Epub 2019 Mar 28.


Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.

Rathi C, Lukka PB, Wagh S, Lee RE, Lenaerts AJ, Braunstein M, Hickey A, Gonzalez-Juarrero M, Meibohm B.

Tuberculosis (Edinb). 2019 Jan;114:119-122. doi: 10.1016/ Epub 2018 Dec 31.


Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway.

Upadhyay R, Sanchez-Hidalgo A, Wilusz CJ, Lenaerts AJ, Arab J, Yeh J, Stefanisko K, Tarasova NI, Gonzalez-Juarrero M.

Sci Rep. 2018 Nov 9;8(1):16610. doi: 10.1038/s41598-018-35023-0.


Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent.

De Groote MA, Jarvis TC, Wong C, Graham J, Hoang T, Young CL, Ribble W, Day J, Li W, Jackson M, Gonzalez-Juarrero M, Sun X, Ochsner UA.

Front Microbiol. 2018 Sep 20;9:2231. doi: 10.3389/fmicb.2018.02231. eCollection 2018. Erratum in: Front Microbiol. 2019 Oct 04;10:2298.


Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Mycobacterium tuberculosis.

Santos K, Lukka PB, Grzegorzewicz A, Jackson M, Trivedi A, Pavan F, Chorilli M, Braunstein M, Hickey A, Meibohm B, Gonzalez-Juarrero M.

Front Microbiol. 2018 Aug 21;9:1895. doi: 10.3389/fmicb.2018.01895. eCollection 2018.


Interactions of free-living amoebae with rice bacterial pathogens Xanthomonas oryzae pathovars oryzae and oryzicola.

Long JJ, Jahn CE, Sánchez-Hidalgo A, Wheat W, Jackson M, Gonzalez-Juarrero M, Leach JE.

PLoS One. 2018 Aug 24;13(8):e0202941. doi: 10.1371/journal.pone.0202941. eCollection 2018.


Cell mediated immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence strain Rev. 1.

Higgins JL, Bowen RA, Gonzalez-Juarrero M.

Vet Immunol Immunopathol. 2018 Aug;202:74-84. doi: 10.1016/j.vetimm.2018.06.004. Epub 2018 Jun 18.


Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.

da Silva MB, Portela JM, Li W, Jackson M, Gonzalez-Juarrero M, Hidalgo AS, Belisle JT, Bouth RC, Gobbo AR, Barreto JG, Minervino AHH, Cole ST, Avanzi C, Busso P, Frade MAC, Geluk A, Salgado CG, Spencer JS.

PLoS Negl Trop Dis. 2018 Jun 28;12(6):e0006532. doi: 10.1371/journal.pntd.0006532. eCollection 2018 Jun.


Yersinia pestis Survival and Replication in Potential Ameba Reservoir.

Markman DW, Antolin MF, Bowen RA, Wheat WH, Woods M, Gonzalez-Juarrero M, Jackson M.

Emerg Infect Dis. 2018 Feb;24(2):294-302. doi: 10.3201/eid2402.171065.


The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.

Ramos L, Obregon-Henao A, Henao-Tamayo M, Bowen R, Lunney JK, Gonzalez-Juarrero M.

Tuberculosis (Edinb). 2017 Sep;106:91-98. doi: 10.1016/ Epub 2017 Jul 14.


Mycobacterium bovis hosted by free-living-amoebae permits their long-term persistence survival outside of host mammalian cells and remain capable of transmitting disease to mice.

Sanchez-Hidalgo A, Obregón-Henao A, Wheat WH, Jackson M, Gonzalez-Juarrero M.

Environ Microbiol. 2017 Oct;19(10):4010-4021. doi: 10.1111/1462-2920.13810. Epub 2017 Jul 11.


Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.

Li W, Obregón-Henao A, Wallach JB, North EJ, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5198-207. doi: 10.1128/AAC.00826-16. Print 2016 Sep.


Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis.

Man DK, Chow MY, Casettari L, Gonzalez-Juarrero M, Lam JK.

Adv Drug Deliv Rev. 2016 Jul 1;102:21-32. doi: 10.1016/j.addr.2016.04.013. Epub 2016 Apr 22. Review.


Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ.

Upadhyay A, Fontes FL, Gonzalez-Juarrero M, McNeil MR, Crans DC, Jackson M, Crick DC.

ACS Cent Sci. 2015 Sep 23;1(6):292-302. Epub 2015 Aug 12.


Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

Irwin SM, Driver E, Lyon E, Schrupp C, Ryan G, Gonzalez-Juarrero M, Basaraba RJ, Nuermberger EL, Lenaerts AJ.

Dis Model Mech. 2015 Jun;8(6):591-602. doi: 10.1242/dmm.019570. Epub 2015 Mar 30.


Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.

Chamberlain LM, Holt-Casper D, Gonzalez-Juarrero M, Grainger DW.

J Biomed Mater Res A. 2015 Sep;103(9):2864-74. doi: 10.1002/jbm.a.35415. Epub 2015 Feb 27.


Long-term survival and virulence of Mycobacterium leprae in amoebal cysts.

Wheat WH, Casali AL, Thomas V, Spencer JS, Lahiri R, Williams DL, McDonnell GE, Gonzalez-Juarrero M, Brennan PJ, Jackson M.

PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3405. doi: 10.1371/journal.pntd.0003405. eCollection 2014 Dec.


Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice.

Lishnevsky M, Young LC, Woods SJ, Groshong SD, Basaraba RJ, Gilchrist JM, Higgins DM, Gonzalez-Juarrero M, Bass TA, Muller WA, Schenkel AR.

Exp Mol Pathol. 2014 Aug;97(1):128-36. doi: 10.1016/j.yexmp.2014.06.008. Epub 2014 Jun 24.


Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ.

Nat Med. 2014 Feb;20(2):152-158. doi: 10.1038/nm.3458. Epub 2014 Jan 26.


Polar lipids of Burkholderia pseudomallei induce different host immune responses.

Gonzalez-Juarrero M, Mima N, Trunck LA, Schweizer HP, Bowen RA, Dascher K, Mwangi W, Eckstein TM.

PLoS One. 2013 Nov 18;8(11):e80368. doi: 10.1371/journal.pone.0080368. eCollection 2013.


GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus.

De Groote MA, Johnson L, Podell B, Brooks E, Basaraba R, Gonzalez-Juarrero M.

J Antimicrob Chemother. 2014 Apr;69(4):1057-64. doi: 10.1093/jac/dkt451. Epub 2013 Nov 11.


Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.

Silva EB, Goodyear A, Sutherland MD, Podnecky NL, Gonzalez-Juarrero M, Schweizer HP, Dow SW.

Infect Immun. 2013 Dec;81(12):4626-34. doi: 10.1128/IAI.00915-13. Epub 2013 Oct 7.


Experimental aerosol Mycobacterium bovis model of infection in goats.

Gonzalez-Juarrero M, Bosco-Lauth A, Podell B, Soffler C, Brooks E, Izzo A, Sanchez-Campillo J, Bowen R.

Tuberculosis (Edinb). 2013 Sep;93(5):558-64. doi: 10.1016/ Epub 2013 Jul 10.


Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species.

Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel Y, Zhang P, Ojha AK.

J Biol Chem. 2013 Jan 4;288(1):382-92. doi: 10.1074/jbc.M112.419754. Epub 2012 Nov 15.


Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery.

Gonzalez-Juarrero M, Woolhiser LK, Brooks E, DeGroote MA, Lenaerts AJ.

Antimicrob Agents Chemother. 2012 Jul;56(7):3957-9. doi: 10.1128/AAC.00464-12. Epub 2012 Apr 30.


Immunity to TB and targets for immunotherapy.

Gonzalez-Juarrero M.

Immunotherapy. 2012 Feb;4(2):187-99. doi: 10.2217/imt.11.168. Review.


Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.

de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M.

J Biol Chem. 2011 Nov 18;286(46):40219-31. doi: 10.1074/jbc.M111.259440. Epub 2011 Sep 23.


Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry.

Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DW, Lenz LL.

J Vis Exp. 2011 May 2;(51). pii: 2702. doi: 10.3791/2702.


Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice.

Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M.

Tuberculosis (Edinb). 2011 Jan;91(1):98-106. doi: 10.1016/ Epub 2010 Dec 31.


Optimization of inhaled therapies for tuberculosis: the role of macrophages and dendritic cells.

González-Juarrero M, O'Sullivan MP.

Tuberculosis (Edinb). 2011 Jan;91(1):86-92. doi: 10.1016/ Review.


Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.

Ryan GJ, Hoff DR, Driver ER, Voskuil MI, Gonzalez-Juarrero M, Basaraba RJ, Crick DC, Spencer JS, Lenaerts AJ.

PLoS One. 2010 Jun 14;5(6):e11108. doi: 10.1371/journal.pone.0011108.


Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.

Redente EF, Higgins DM, Dwyer-Nield LD, Orme IM, Gonzalez-Juarrero M, Malkinson AM.

J Leukoc Biol. 2010 Jul;88(1):159-68. doi: 10.1189/jlb.0609378. Epub 2010 Apr 1.


Localized immunosuppressive environment in the foreign body response to implanted biomaterials.

Higgins DM, Basaraba RJ, Hohnbaum AC, Lee EJ, Grainger DW, Gonzalez-Juarrero M.

Am J Pathol. 2009 Jul;175(1):161-70. doi: 10.2353/ajpath.2009.080962. Epub 2009 Jun 15.


Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.

Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Lee EJ, Orme IM, Gonzalez-Juarrero M.

Tuberculosis (Edinb). 2009 Mar;89(2):149-57. doi: 10.1016/ Epub 2009 Feb 12.


Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.

Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M.

Am J Respir Cell Mol Biol. 2009 Aug;41(2):136-45. doi: 10.1165/rcmb.2008-0363OC. Epub 2008 Dec 18.


Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.

Beamer GL, Flaherty DK, Assogba BD, Stromberg P, Gonzalez-Juarrero M, de Waal Malefyt R, Vesosky B, Turner J.

J Immunol. 2008 Oct 15;181(8):5545-50.


Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

Gonzalez-Juarrero M, Kingry LC, Ordway DJ, Henao-Tamayo M, Harton M, Basaraba RJ, Hanneman WH, Orme IM, Slayden RA.

Am J Respir Cell Mol Biol. 2009 Apr;40(4):398-409. doi: 10.1165/rcmb.2008-0248OC. Epub 2008 Sep 11.


Animal models of M. tuberculosis Infection.

Orme I, Gonzalez-Juarrero M.

Curr Protoc Microbiol. 2007 Nov;Chapter 10:Unit 10A.5. doi: 10.1002/9780471729259.mc10a05s7.


Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models.

Chamberlain LM, Godek ML, Gonzalez-Juarrero M, Grainger DW.

J Biomed Mater Res A. 2009 Mar 15;88(4):858-71. doi: 10.1002/jbm.a.31930.


Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.

Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Higgins JR, Lee EJ, Orme IM, Gonzalez-Juarrero M.

J Immunol. 2008 Apr 1;180(7):4892-900.


XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability.

Ordway D, Higgins DM, Sanchez-Campillo J, Spencer JS, Henao-Tamayo M, Harton M, Orme IM, Gonzalez Juarrero M.

J Leukoc Biol. 2007 Nov;82(5):1221-9. Epub 2007 Aug 15.


Cross-reaction of anti-human CD monoclonal antibodies on guinea pig cells: a summary of the guinea pig section of the HLDA8 animal homologues data.

Lasco TM, Gonzalez-Juarrero M, Saalmüller A, Lunney JK.

Vet Immunol Immunopathol. 2007 Sep 15;119(1-2):131-6. Epub 2007 Jun 20.


Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis.

Ordway D, Harton M, Henao-Tamayo M, Montoya R, Orme IM, Gonzalez-Juarrero M.

J Immunol. 2006 Apr 15;176(8):4931-9.


Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.

Park JS, Tamayo MH, Gonzalez-Juarrero M, Orme IM, Ordway DJ.

J Leukoc Biol. 2006 Jan;79(1):80-6. Epub 2005 Nov 7.


Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.

Taylor JL, Ordway DJ, Troudt J, Gonzalez-Juarrero M, Basaraba RJ, Orme IM.

Infect Immun. 2005 Aug;73(8):5189-93.

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