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Items: 17


Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly.

Zhao Z, Wang JC, Gonzalez-Gutierrez G, Venkatakrishnan B, Asor R, Khaykelson D, Raviv U, Zlotnick A.

J Virol. 2019 Jun 28;93(14). pii: e00141-19. doi: 10.1128/JVI.00141-19. Print 2019 Jul 15.


Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii.

Wang J, Lonergan ZR, Gonzalez-Gutierrez G, Nairn BL, Maxwell CN, Zhang Y, Andreini C, Karty JA, Chazin WJ, Trinidad JC, Skaar EP, Giedroc DP.

Cell Chem Biol. 2019 May 16;26(5):745-755.e7. doi: 10.1016/j.chembiol.2019.02.011. Epub 2019 Mar 21.


Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.

Bum-Erdene K, Zhou D, Gonzalez-Gutierrez G, Ghozayel MK, Si Y, Xu D, Shannon HE, Bailey BJ, Corson TW, Pollok KE, Wells CD, Meroueh SO.

Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13. doi: 10.1016/j.chembiol.2018.11.010. Epub 2018 Dec 20.


Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System.

Capdevila DA, Edmonds KA, Campanello GC, Wu H, Gonzalez-Gutierrez G, Giedroc DP.

J Am Chem Soc. 2018 Jul 25;140(29):9108-9119. doi: 10.1021/jacs.8b02129. Epub 2018 Jul 16.


Chasing the open-state structure of pentameric ligand-gated ion channels.

Gonzalez-Gutierrez G, Wang Y, Cymes GD, Tajkhorshid E, Grosman C.

J Gen Physiol. 2017 Dec 4;149(12):1119-1138. doi: 10.1085/jgp.201711803. Epub 2017 Oct 31.


The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold.

Gonzalez-Gutierrez G, Grosman C.

J Gen Physiol. 2015 Jul;146(1):15-36. doi: 10.1085/jgp.201411333. Epub 2015 Jun 15.


Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography.

Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18716-21. doi: 10.1073/pnas.1313156110. Epub 2013 Oct 28.


Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals.

Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6331-6. doi: 10.1073/pnas.1119268109. Epub 2012 Apr 2.


Homodimerization of the Src homology 3 domain of the calcium channel β-subunit drives dynamin-dependent endocytosis.

Miranda-Laferte E, Gonzalez-Gutierrez G, Schmidt S, Zeug A, Ponimaskin EG, Neely A, Hidalgo P.

J Biol Chem. 2011 Jun 24;286(25):22203-10. doi: 10.1074/jbc.M110.201871. Epub 2011 Apr 18.


Desensitization of neurotransmitter-gated ion channels during high-frequency stimulation: a comparative study of Cys-loop, AMPA and purinergic receptors.

Papke D, Gonzalez-Gutierrez G, Grosman C.

J Physiol. 2011 Apr 1;589(Pt 7):1571-85. doi: 10.1113/jphysiol.2010.203315. Epub 2011 Feb 7.


Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states.

Gonzalez-Gutierrez G, Grosman C.

J Mol Biol. 2010 Nov 12;403(5):693-705. doi: 10.1016/j.jmb.2010.09.026. Epub 2010 Sep 21.


Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes.

Gonzalez-Gutierrez G, Miranda-Laferte E, Contreras G, Neely A, Hidalgo P.

Channels (Austin). 2010 Jan-Feb;4(1):42-50. Epub 2010 Jan 9.


Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium.

González-Pérez V, Neely A, Tapia C, González-Gutiérrez G, Contreras G, Orio P, Lagos V, Rojas G, Estévez T, Stack K, Naranjo D.

J Gen Physiol. 2008 Dec;132(6):633-50. doi: 10.1085/jgp.200810057.


The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating.

Gonzalez-Gutierrez G, Miranda-Laferte E, Nothmann D, Schmidt S, Neely A, Hidalgo P.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14198-203. doi: 10.1073/pnas.0806558105. Epub 2008 Sep 5.


Mutations of nonconserved residues within the calcium channel alpha1-interaction domain inhibit beta-subunit potentiation.

Gonzalez-Gutierrez G, Miranda-Laferte E, Naranjo D, Hidalgo P, Neely A.

J Gen Physiol. 2008 Sep;132(3):383-95. doi: 10.1085/jgp.200709901.


The Src homology 3 domain of the beta-subunit of voltage-gated calcium channels promotes endocytosis via dynamin interaction.

Gonzalez-Gutierrez G, Miranda-Laferte E, Neely A, Hidalgo P.

J Biol Chem. 2007 Jan 26;282(4):2156-62. Epub 2006 Nov 16.


The alpha1-beta-subunit interaction that modulates calcium channel activity is reversible and requires a competent alpha-interaction domain.

Hidalgo P, Gonzalez-Gutierrez G, Garcia-Olivares J, Neely A.

J Biol Chem. 2006 Aug 25;281(34):24104-10. Epub 2006 Jun 22.

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