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Items: 22

1.

Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction.

Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ.

Mol Pharmacol. 2016 Jan;89(1):176-86. doi: 10.1124/mol.115.100222. Epub 2015 Oct 22.

2.

S1P signaling: new therapies and opportunities.

Gonzalez-Cabrera PJ, Brown S, Studer SM, Rosen H.

F1000Prime Rep. 2014 Dec 1;6:109. doi: 10.12703/P6-109. eCollection 2014. Review.

3.

The organization of the sphingosine 1-phosphate signaling system.

Rosen H, Germana Sanna M, Gonzalez-Cabrera PJ, Roberts E.

Curr Top Microbiol Immunol. 2014;378:1-21. doi: 10.1007/978-3-319-05879-5_1. Review.

PMID:
24728591
4.

Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist.

Cahalan SM, Gonzalez-Cabrera PJ, Nguyen N, Guerrero M, Cisar EA, Leaf NB, Brown SJ, Roberts E, Rosen H.

Mol Pharmacol. 2013 Feb;83(2):316-21. doi: 10.1124/mol.112.082958. Epub 2012 Nov 30.

5.

Real-time differential labeling of blood, interstitium, and lymphatic and single-field analysis of vasculature dynamics in vivo.

Sarkisyan G, Cahalan SM, Gonzalez-Cabrera PJ, Leaf NB, Rosen H.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1460-8. doi: 10.1152/ajpcell.00382.2011. Epub 2012 Feb 22.

6.

S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.

Gonzalez-Cabrera PJ, Cahalan SM, Nguyen N, Sarkisyan G, Leaf NB, Cameron MD, Kago T, Rosen H.

Mol Pharmacol. 2012 Feb;81(2):166-74. doi: 10.1124/mol.111.076109. Epub 2011 Oct 26.

7.

Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice.

Cahalan SM, Gonzalez-Cabrera PJ, Sarkisyan G, Nguyen N, Schaeffer MT, Huang L, Yeager A, Clemons B, Scott F, Rosen H.

Nat Chem Biol. 2011 May;7(5):254-6. doi: 10.1038/nchembio.547. Epub 2011 Mar 27.

8.

Sphingosine 1-phosphate receptor signaling.

Rosen H, Gonzalez-Cabrera PJ, Sanna MG, Brown S.

Annu Rev Biochem. 2009;78:743-68. doi: 10.1146/annurev.biochem.78.072407.103733. Review.

PMID:
19231986
9.

Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions.

Gonzalez-Cabrera PJ, Jo E, Sanna MG, Brown S, Leaf N, Marsolais D, Schaeffer MT, Chapman J, Cameron M, Guerrero M, Roberts E, Rosen H.

Mol Pharmacol. 2008 Nov;74(5):1308-18. doi: 10.1124/mol.108.049783. Epub 2008 Aug 15.

10.

Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.

Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H.

ACS Chem Biol. 2008 Aug 15;3(8):486-98. doi: 10.1021/cb800051m. Epub 2008 Jul 1.

11.

Tipping the gatekeeper: S1P regulation of endothelial barrier function.

Rosen H, Sanna MG, Cahalan SM, Gonzalez-Cabrera PJ.

Trends Immunol. 2007 Mar;28(3):102-7. Epub 2007 Feb 5. Review.

PMID:
17276731
12.

Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.

Gonzalez-Cabrera PJ, Hla T, Rosen H.

J Biol Chem. 2007 Mar 9;282(10):7254-64. Epub 2007 Jan 10.

13.

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H.

Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9.

PMID:
16829954
14.

S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.

Jo E, Sanna MG, Gonzalez-Cabrera PJ, Thangada S, Tigyi G, Osborne DA, Hla T, Parrill AL, Rosen H.

Chem Biol. 2005 Jun;12(6):703-15.

15.

Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.

Gonzalez-Cabrera PJ, Shi T, Yun J, McCune DF, Rorabaugh BR, Perez DM.

Endocrinology. 2004 Nov;145(11):5157-67. Epub 2004 Aug 5.

PMID:
15297446
16.

The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model.

Ross SA, Rorabaugh BR, Chalothorn D, Yun J, Gonzalez-Cabrera PJ, McCune DF, Piascik MT, Perez DM.

Cardiovasc Res. 2003 Dec 1;60(3):598-607.

PMID:
14659805
17.

Gene expression profile of neurodegeneration induced by alpha1B-adrenergic receptor overactivity: NMDA/GABAA dysregulation and apoptosis.

Yun J, Gaivin RJ, McCune DF, Boongird A, Papay RS, Ying Z, Gonzalez-Cabrera PJ, Najm I, Perez DM.

Brain. 2003 Dec;126(Pt 12):2667-81. Epub 2003 Aug 22.

PMID:
12937073
18.

Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130.

Gonzalez-Cabrera PJ, Gaivin RJ, Yun J, Ross SA, Papay RS, McCune DF, Rorabaugh BR, Perez DM.

Mol Pharmacol. 2003 May;63(5):1104-16.

PMID:
12695539
19.
20.

Tonic inhibitory role for cAMP in alpha(1a)-adrenergic receptor coupling to extracellular signal-regulated kinases 1/2.

Jiao X, Gonzalez-Cabrera PJ, Xiao L, Bradley ME, Abel PW, Jeffries WB.

J Pharmacol Exp Ther. 2002 Oct;303(1):247-56.

PMID:
12235258
21.

Selective inhibition of alpha1B-adrenergic receptor expression and function using a phosphorothioate antisense oligodeoxynucleotide.

Gonzalez-Cabrera PJ, Iversen PL, Liu MF, Scofield MA, Jeffries WB.

Mol Pharmacol. 1998 Jun;53(6):1034-9.

PMID:
9614205
22.

Enhanced hypo-osmoregulation induced by warm-acclimation in antarctic fish is mediated by increased gill and kidney Na+/K(+)-ATPase activities.

Gonzalez-Cabrera PJ, Dowd F, Pedibhotla VK, Rosario R, Stanley-Samuelson D, Petzel D.

J Exp Biol. 1995 Nov;198(Pt 11):2279-91.

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