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Late steps in bacterial translation initiation visualized using time-resolved cryo-EM.

Kaledhonkar S, Fu Z, Caban K, Li W, Chen B, Sun M, Gonzalez RL Jr, Frank J.

Nature. 2019 Jun;570(7761):400-404. doi: 10.1038/s41586-019-1249-5. Epub 2019 May 20.


Bayesian-Estimated Hierarchical HMMs Enable Robust Analysis of Single-Molecule Kinetic Heterogeneity.

Hon J, Gonzalez RL Jr.

Biophys J. 2019 May 21;116(10):1790-1802. doi: 10.1016/j.bpj.2019.02.031. Epub 2019 Apr 2.


Relationship between Selective Serotonin Reuptake Inhibitors and Risk of Dental Implant Failure.

Carr AB, Gonzalez RLV, Jia L, Lohse CM.

J Prosthodont. 2019 Mar;28(3):252-257. doi: 10.1111/jopr.13015. Epub 2019 Jan 28.


Early Implant Failure Associated With Patient Factors, Surgical Manipulations, and Systemic Conditions.

Carr AB, Arwani N, Lohse CM, Gonzalez RLV, Muller OM, Salinas TJ.

J Prosthodont. 2019 Jul;28(6):623-633. doi: 10.1111/jopr.12978. Epub 2018 Oct 22.


d-Amino Acid-Mediated Translation Arrest Is Modulated by the Identity of the Incoming Aminoacyl-tRNA.

Fleisher RC, Cornish VW, Gonzalez RL Jr.

Biochemistry. 2018 Jul 24;57(29):4241-4246. doi: 10.1021/acs.biochem.8b00595. Epub 2018 Jul 12.


Observation and Analysis of RAD51 Nucleation Dynamics at Single-Monomer Resolution.

Subramanyam S, Kinz-Thompson CD, Gonzalez RL Jr, Spies M.

Methods Enzymol. 2018;600:201-232. doi: 10.1016/bs.mie.2017.12.008. Epub 2018 Feb 1.


Increasing the Time Resolution of Single-Molecule Experiments with Bayesian Inference.

Kinz-Thompson CD, Gonzalez RL Jr.

Biophys J. 2018 Jan 23;114(2):289-300. doi: 10.1016/j.bpj.2017.11.3741.


A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria.

Caban K, Pavlov M, Ehrenberg M, Gonzalez RL Jr.

Nat Commun. 2017 Nov 14;8(1):1475. doi: 10.1038/s41467-017-01492-6.


Survivor: Ribosome Edition.

Gonzalez RL Jr.

EMBO J. 2017 Jul 14;36(14):1996-1998. doi: 10.15252/embj.201797518. Epub 2017 Jul 3. No abstract available.


Vasoreactivity in CADASIL: Comparison to structural MRI and neuropsychology.

Moreton FC, Cullen B, Delles C, Santosh C, Gonzalez RL, Dani K, Muir KW.

J Cereb Blood Flow Metab. 2018 Jun;38(6):1085-1095. doi: 10.1177/0271678X17710375. Epub 2017 May 24.


Electrostatic melting in a single-molecule field-effect transistor with applications in genomic identification.

Vernick S, Trocchia SM, Warren SB, Young EF, Bouilly D, Gonzalez RL, Nuckolls C, Shepard KL.

Nat Commun. 2017 May 18;8:15450. doi: 10.1038/ncomms15450.


Precisely and Accurately Inferring Single-Molecule Rate Constants.

Kinz-Thompson CD, Bailey NA, Gonzalez RL Jr.

Methods Enzymol. 2016;581:187-225. doi: 10.1016/bs.mie.2016.08.021. Epub 2016 Oct 7.


Tadalafil for Endometrial Growth in Clomiphene Citrate stimulated cycles in an IUI programma: A pilot study.

Mendez Lozano DH, Lenero MV, Gonzalez RL, Scheffer JB, Gonzalez MT, Barron Y, Frydman R.

Facts Views Vis Obgyn. 2015 Dec 28;7(4):231-237.


Single-Molecule Reaction Chemistry in Patterned Nanowells.

Bouilly D, Hon J, Daly NS, Trocchia S, Vernick S, Yu J, Warren S, Wu Y, Gonzalez RL Jr, Shepard KL, Nuckolls C.

Nano Lett. 2016 Jul 13;16(7):4679-85. doi: 10.1021/acs.nanolett.6b02149. Epub 2016 Jun 7.


A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation.

Ruehle MD, Zhang H, Sheridan RM, Mitra S, Chen Y, Gonzalez RL, Cooperman BS, Kieft JS.

Elife. 2015 Nov 2;4. pii: e08146. doi: 10.7554/eLife.08146.


Protein synthesis during cellular quiescence is inhibited by phosphorylation of a translational elongation factor.

Pereira SF, Gonzalez RL Jr, Dworkin J.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3274-81. doi: 10.1073/pnas.1505297112. Epub 2015 Jun 8.


18F-FDG PET/CT with unusual bone and CNS metastases from testicular seminoma.

Gómez FJ, Bánez IA, González RL, Jiménez-Granero P, Dorado IB.

Int Braz J Urol. 2015 Mar-Apr;41(2):393-4. doi: 10.1590/S1677-5538.IBJU.2015.02.31. No abstract available.


Structural dynamics of ribosome subunit association studied by mixing-spraying time-resolved cryogenic electron microscopy.

Chen B, Kaledhonkar S, Sun M, Shen B, Lu Z, Barnard D, Lu TM, Gonzalez RL Jr, Frank J.

Structure. 2015 Jun 2;23(6):1097-105. doi: 10.1016/j.str.2015.04.007. Epub 2015 May 21.


The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center.

Englander MT, Avins JL, Fleisher RC, Liu B, Effraim PR, Wang J, Schulten K, Leyh TS, Gonzalez RL Jr, Cornish VW.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6038-43. doi: 10.1073/pnas.1424712112. Epub 2015 Apr 27.


The emerging role of rectified thermal fluctuations in initiator aa-tRNA- and start codon selection during translation initiation.

Caban K, Gonzalez RL Jr.

Biochimie. 2015 Jul;114:30-8. doi: 10.1016/j.biochi.2015.04.001. Epub 2015 Apr 14. Review.


Ribosomal initiation complex-driven changes in the stability and dynamics of initiation factor 2 regulate the fidelity of translation initiation.

Wang J, Caban K, Gonzalez RL Jr.

J Mol Biol. 2015 May 8;427(9):1819-34. doi: 10.1016/j.jmb.2014.12.025. Epub 2015 Jan 14.


Single-molecule dataset (SMD): a generalized storage format for raw and processed single-molecule data.

Greenfeld M, van de Meent JW, Pavlichin DS, Mabuchi H, Wiggins CH, Gonzalez RL Jr, Herschlag D.

BMC Bioinformatics. 2015 Jan 16;16:3. doi: 10.1186/s12859-014-0429-4.


Translation initiation factor 3 regulates switching between different modes of ribosomal subunit joining.

MacDougall DD, Gonzalez RL Jr.

J Mol Biol. 2015 May 8;427(9):1801-18. doi: 10.1016/j.jmb.2014.09.024. Epub 2014 Oct 13.


The ribosome uses cooperative conformational changes to maximize and regulate the efficiency of translation.

Ning W, Fei J, Gonzalez RL Jr.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12073-8. doi: 10.1073/pnas.1401864111. Epub 2014 Aug 1.


smFRET studies of the 'encounter' complexes and subsequent intermediate states that regulate the selectivity of ligand binding.

Kinz-Thompson CD, Gonzalez RL Jr.

FEBS Lett. 2014 Oct 1;588(19):3526-38. doi: 10.1016/j.febslet.2014.07.013. Epub 2014 Jul 24. Review.


Deoxypolypeptides bind and cleave RNA.

Cheng L, Mahendran A, Gonzalez RL Jr, Breslow R.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):7920-4. doi: 10.1073/pnas.1407295111. Epub 2014 May 19.


A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation.

Kim HK, Liu F, Fei J, Bustamante C, Gonzalez RL Jr, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5538-43. doi: 10.1073/pnas.1403457111. Epub 2014 Mar 31.


Empirical Bayes methods enable advanced population-level analyses of single-molecule FRET experiments.

van de Meent JW, Bronson JE, Wiggins CH, Gonzalez RL Jr.

Biophys J. 2014 Mar 18;106(6):1327-37. doi: 10.1016/j.bpj.2013.12.055.


The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.

Boël G, Smith PC, Ning W, Englander MT, Chen B, Hashem Y, Testa AJ, Fischer JJ, Wieden HJ, Frank J, Gonzalez RL Jr, Hunt JF.

Nat Struct Mol Biol. 2014 Feb;21(2):143-51. doi: 10.1038/nsmb.2740. Epub 2014 Jan 5.


EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics.

Chen B, Boël G, Hashem Y, Ning W, Fei J, Wang C, Gonzalez RL Jr, Hunt JF, Frank J.

Nat Struct Mol Biol. 2014 Feb;21(2):152-9. doi: 10.1038/nsmb.2741. Epub 2014 Jan 5.


Robustly passivated, gold nanoaperture arrays for single-molecule fluorescence microscopy.

Kinz-Thompson CD, Palma M, Pulukkunat DK, Chenet D, Hone J, Wind SJ, Gonzalez RL Jr.

ACS Nano. 2013 Sep 24;7(9):8158-66. doi: 10.1021/nn403447s. Epub 2013 Sep 6.


Conformational selection of translation initiation factor 3 signals proper substrate selection.

Elvekrog MM, Gonzalez RL Jr.

Nat Struct Mol Biol. 2013 May;20(5):628-33. doi: 10.1038/nsmb.2554. Epub 2013 Apr 14.


Hierarchically-coupled hidden Markov models for learning kinetic rates from single-molecule data.

van de Meent JW, Bronson JE, Wood F, Gonzalez RL Jr, Wiggins CH.

JMLR Workshop Conf Proc. 2013;28(2):361-369. Epub 2013 May 5.


In vitro and in vivo single-molecule fluorescence imaging of ribosome-catalyzed protein synthesis.

Perez CE, Gonzalez RL Jr.

Curr Opin Chem Biol. 2011 Dec;15(6):853-63. doi: 10.1016/j.cbpa.2011.11.002. Epub 2011 Nov 19. Review.


Molecular imaging: sine labore nihil.

Schepartz A, Gonzalez RL Jr.

Curr Opin Chem Biol. 2011 Dec;15(6):749-51. doi: 10.1016/j.cbpa.2011.11.001. Epub 2011 Nov 19. No abstract available.


Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis.

Fei J, Richard AC, Bronson JE, Gonzalez RL Jr.

Nat Struct Mol Biol. 2011 Aug 21;18(9):1043-51. doi: 10.1038/nsmb.2098.


Biological mechanisms, one molecule at a time.

Tinoco I Jr, Gonzalez RL Jr.

Genes Dev. 2011 Jun 15;25(12):1205-31. doi: 10.1101/gad.2050011. Review.


Selective biomolecular nanoarrays for parallel single-molecule investigations.

Palma M, Abramson JJ, Gorodetsky AA, Penzo E, Gonzalez RL Jr, Sheetz MP, Nuckolls C, Hone J, Wind SJ.

J Am Chem Soc. 2011 May 25;133(20):7656-9. doi: 10.1021/ja201031g. Epub 2011 Apr 29.


Label-free single-molecule detection of DNA-hybridization kinetics with a carbon nanotube field-effect transistor.

Sorgenfrei S, Chiu CY, Gonzalez RL Jr, Yu YJ, Kim P, Nuckolls C, Shepard KL.

Nat Nanotechnol. 2011 Feb;6(2):126-32. doi: 10.1038/nnano.2010.275. Epub 2011 Jan 23.


Graphical models for inferring single molecule dynamics.

Bronson JE, Hofman JM, Fei J, Gonzalez RL Jr, Wiggins CH.

BMC Bioinformatics. 2010 Oct 26;11 Suppl 8:S2. doi: 10.1186/1471-2105-11-S8-S2.


A microfluidic approach for investigating the temperature dependence of biomolecular activity with single-molecule resolution.

Wang B, Ho J, Fei J, Gonzalez RL Jr, Lin Q.

Lab Chip. 2011 Jan 21;11(2):274-81. doi: 10.1039/c0lc00157k. Epub 2010 Oct 27.


A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis.

Fei J, Wang J, Sternberg SH, MacDougall DD, Elvekrog MM, Pulukkunat DK, Englander MT, Gonzalez RL Jr.

Methods Enzymol. 2010;472:221-59. doi: 10.1016/S0076-6879(10)72008-5.


[Asymptomatic Brugada syndrome unmasked by influenza virus subtype H1N1 infection].

González RL, Medrano JC, Castaño AJ, Sánchez FÁ.

Med Clin (Barc). 2011 Feb 26;136(5):226-7. doi: 10.1016/j.medcli.2010.01.023. Epub 2010 Mar 29. Spanish. No abstract available.


Structure and dynamics of a processive Brownian motor: the translating ribosome.

Frank J, Gonzalez RL Jr.

Annu Rev Biochem. 2010;79:381-412. doi: 10.1146/annurev-biochem-060408-173330. Review.


Learning rates and states from biophysical time series: a Bayesian approach to model selection and single-molecule FRET data.

Bronson JE, Fei J, Hofman JM, Gonzalez RL Jr, Wiggins CH.

Biophys J. 2009 Dec 16;97(12):3196-205. doi: 10.1016/j.bpj.2009.09.031.


Natural amino acids do not require their native tRNAs for efficient selection by the ribosome.

Effraim PR, Wang J, Englander MT, Avins J, Leyh TS, Gonzalez RL Jr, Cornish VW.

Nat Chem Biol. 2009 Dec;5(12):947-53. doi: 10.1038/nchembio.255. Epub 2009 Oct 25.


Allosteric collaboration between elongation factor G and the ribosomal L1 stalk directs tRNA movements during translation.

Fei J, Bronson JE, Hofman JM, Srinivas RL, Wiggins CH, Gonzalez RL Jr.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15702-7. doi: 10.1073/pnas.0908077106. Epub 2009 Aug 27.


Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling.

Sternberg SH, Fei J, Prywes N, McGrath KA, Gonzalez RL Jr.

Nat Struct Mol Biol. 2009 Aug;16(8):861-8. doi: 10.1038/nsmb.1622. Epub 2009 Jul 13.


Navigating the RNA folding landscape.

Gonzalez RL Jr.

Nat Chem Biol. 2008 Aug;4(8):451-2. doi: 10.1038/nchembio0808-451.


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