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Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport.

Xie C, Takahashi S, Brocker CN, He S, Li C, Xie G, Jang K, Gao X, Krausz KW, Qu A, Levi M, Gonzalez FJ.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun 10. pii: S1388-1981(18)30326-3. doi: 10.1016/j.bbalip.2019.05.014. [Epub ahead of print]


Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ.

Gastroenterology. 2019 May 30. pii: S0016-5085(19)40975-X. doi: 10.1053/j.gastro.2019.05.057. [Epub ahead of print]


Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1.

Zhang B, Yang J, Qin Z, Li S, Xu J, Yao Z, Zhang X, Gonzalez FJ, Yao X.

PLoS One. 2019 May 31;14(5):e0217695. doi: 10.1371/journal.pone.0217695. eCollection 2019.


The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors.

Qin Z, Zhang B, Yang J, Li S, Xu J, Yao Z, Zhang X, Gonzalez FJ, Yao X.

Front Pharmacol. 2019 May 7;10:496. doi: 10.3389/fphar.2019.00496. eCollection 2019.


β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes.

Lalwani A, Warren J, Liuwantara D, Hawthorne WJ, O'Connell PJ, Gonzalez FJ, Stokes RA, Chen J, Laybutt DR, Craig ME, Swarbrick MM, King C, Gunton JE.

Cell Rep. 2019 May 21;27(8):2370-2384.e6. doi: 10.1016/j.celrep.2019.04.086.


Use of Raman spectroscopy in the assessment of skin after CO2 ablative fractional laser surgery on acne scars.

Chiwo FS, Guevara E, Ramírez-Elías MG, Castillo-Martínez CC, Osornio-Martínez CE, Cabrera-Alonso R, Pérez-Atamoros F, González FJ.

Skin Res Technol. 2019 May 22. doi: 10.1111/srt.12722. [Epub ahead of print]


Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer.

Peters JM, Kim DJ, Bility MT, Borland MG, Zhu B, Gonzalez FJ.

Mol Carcinog. 2019 May 6. doi: 10.1002/mc.23033. [Epub ahead of print]


Pregnane X receptor activation potentiates ritonavir hepatotoxicity.

Shehu AI, Lu J, Wang P, Zhu J, Wang Y, Yang D, McMahon D, Xie W, Gonzalez FJ, Ma X.

J Clin Invest. 2019 Apr 30;130. pii: 128274. doi: 10.1172/JCI128274.


Notes from the Field: Multistate Coccidioidomycosis Outbreak in U.S. Residents Returning from Community Service Trips to Baja California, Mexico - July-August 2018.

Toda M, Gonzalez FJ, Fonseca-Ford M, Franklin P, Huntington-Frazier M, Gutelius B, Kawakami V, Lunquest K, McCracken S, Moser K, Oltean H, Ratner AJ, Raybern C, Signs K, Zaldivar A, Chiller TM, Jackson BR, McCotter O.

MMWR Morb Mortal Wkly Rep. 2019 Apr 12;68(14):332-333. doi: 10.15585/mmwr.mm6814a5. No abstract available.


Hepatocyte Nuclear Factor 4-Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver.

Thakur A, Wong JCH, Wang EY, Lotto J, Kim D, Cheng JC, Mingay M, Cullum R, Moudgil V, Ahmed N, Tsai SH, Wei W, Walsh CP, Stephan T, Bilenky M, Fuglerud BM, Karimi MM, Gonzalez FJ, Hirst M, Hoodless PA.

Hepatology. 2019 Apr 1. doi: 10.1002/hep.30631. [Epub ahead of print]


Writing Gender with Sexuality: Reflections on the Diaries of Lou Sullivan.

González FJ.

J Am Psychoanal Assoc. 2019 Feb;67(1):59-82. doi: 10.1177/0003065119826626.


Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity.

Zhao Q, Zhang T, Xiao XR, Huang JF, Wang Y, Gonzalez FJ, Li F.

Br J Pharmacol. 2019 Jul;176(13):2162-2178. doi: 10.1111/bph.14664. Epub 2019 May 7.


Altered erythrocyte morphology in Mexican adults with prediabetes and type 2 diabetes mellitus evaluated by scanning electron microscope.

Loyola-Leyva A, Loyola-Rodríguez JP, Terán Figueroa Y, González FJ, Atzori M, Barquera Cervera S.

Microscopy (Oxf). 2019 Jun 1;68(3):261-270. doi: 10.1093/jmicro/dfz011.


Experience of Using an App in HIV Patients Older Than 60 Years: Pilot Program.

Olalla J, García de Lomas JM, Márquez E, González FJ, Del Arco A, De La Torre J, Prada JL, Cantudo F, Martín MD, Nieto M, Perez Stachowski J, García-Alegría J.

JMIR Mhealth Uhealth. 2019 Mar 6;7(3):e9904. doi: 10.2196/mhealth.9904.


Hepatic metabolic adaptation in a murine model of glutathione deficiency.

Chen Y, Golla S, Garcia-Milian R, Thompson DC, Gonzalez FJ, Vasiliou V.

Chem Biol Interact. 2019 Apr 25;303:1-6. doi: 10.1016/j.cbi.2019.02.015. Epub 2019 Feb 20.


Detection of Histamine Dihydrochloride at Low Concentrations Using Raman Spectroscopy Enhanced by Gold Nanostars Colloids.

Kolosovas-Machuca ES, Cuadrado A, Ojeda-Galván HJ, Ortiz-Dosal LC, Hernández-Arteaga AC, Rodríguez-Aranda MDC, Navarro-Contreras HR, Alda J, González FJ.

Nanomaterials (Basel). 2019 Feb 6;9(2). pii: E211. doi: 10.3390/nano9020211.


The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.

Sartor C, Bachelot L, Godard C, Lager F, Renault G, Gonzalez FJ, Perret C, Gougelet A, Colnot S.

Liver Int. 2019 Apr;39(4):727-739. doi: 10.1111/liv.14068. Epub 2019 Feb 24.


Modulation of Lipid Metabolism by Celastrol.

Zhang T, Zhao Q, Xiao X, Yang R, Hu D, Zhu X, Gonzalez FJ, Li F.

J Proteome Res. 2019 Mar 1;18(3):1133-1144. doi: 10.1021/acs.jproteome.8b00797. Epub 2019 Feb 12.


Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation.

Kim D, Brocker CN, Takahashi S, Yagai T, Kim T, Xie G, Wang H, Qu A, Gonzalez FJ.

Hepatology. 2019 Jan 29. doi: 10.1002/hep.30530. [Epub ahead of print]


In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice.

Hayashi Y, Ito Y, Naito H, Tamada H, Yamagishi N, Kondo T, Ishikawa T, Gonzalez FJ, Nakajima T.

Toxicology. 2019 Mar 1;415:49-55. doi: 10.1016/j.tox.2019.01.008. Epub 2019 Jan 17.


A systemic workflow for profiling metabolome and lipidome in tissue.

Lu D, Xue L, Feng C, Jin Y, Wu C, Xie C, Gonzalez FJ, Wang G, Zhou Z.

J Chromatogr A. 2019 Mar 29;1589:105-115. doi: 10.1016/j.chroma.2018.12.061. Epub 2018 Dec 30.


The Evolution of Carcinogenesis.

Peters JM, Gonzalez FJ.

Toxicol Sci. 2018 Oct 1;165(2):272-276. doi: 10.1093/toxsci/kfy184. No abstract available.


Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.

Zhao Q, Liu F, Cheng Y, Xiao XR, Hu DD, Tang YM, Bao WM, Yang JH, Jiang T, Hu JP, Gonzalez FJ, Li F.

Mol Cell Proteomics. 2019 Mar;18(3):520-533. doi: 10.1074/mcp.RA118.000817. Epub 2019 Jan 7.


Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis.

Konstandi M, Sotiropoulos I, Matsubara T, Malliou F, Katsogridaki A, Andriopoulou CE, Gonzalez FJ.

Psychopharmacology (Berl). 2019 Jan 6. doi: 10.1007/s00213-018-5149-4. [Epub ahead of print]


Endothelial Cell-Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue.

Akiyama TE, Skelhorne-Gross GE, Lightbody ED, Rubino RE, Shi JY, McNamara LA, Sharma N, Zycband EI, Gonzalez FJ, Liu H, Woods JW, Chang CH, Berger JP, Nicol CJB.

J Pharmacol Exp Ther. 2019 Mar;368(3):514-523. doi: 10.1124/jpet.118.250985. Epub 2019 Jan 3.


An automated method for the evaluation of breast cancer using infrared thermography.

Morales-Cervantes A, Kolosovas-Machuca ES, Guevara E, Maruris Reducindo M, Bello Hernández AB, Ramos García M, González FJ.

EXCLI J. 2018 Oct 26;17:989-998. doi: 10.17179/excli2018-1735. eCollection 2018.


Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ.

Hepatol Commun. 2018 Oct 1;2(12):1567-1582. doi: 10.1002/hep4.1263. eCollection 2018 Dec.


Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice.

Xie G, Yin S, Zhang Z, Qi D, Wang X, Kim D, Yagai T, Brocker CN, Wang Y, Gonzalez FJ, Wang H, Qu A.

Am J Pathol. 2019 Feb;189(2):272-282. doi: 10.1016/j.ajpath.2018.10.009. Epub 2018 Nov 16.


Retraction: Disruption of the NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Gene in Mice Causes Myelogenous Hyperplasia.

Long DJ 2nd, Gaikwad A, Multani A, Pathak S, Montgomery CA, Gonzalez FJ, Jaiswal AK.

Cancer Res. 2018 Nov 15;78(22):6526. doi: 10.1158/0008-5472.CAN-18-2455. No abstract available.


Development and validation of an algorithm to predict the treatment modality of burn wounds using thermographic scans: Prospective cohort study.

Martínez-Jiménez MA, Ramirez-GarciaLuna JL, Kolosovas-Machuca ES, Drager J, González FJ.

PLoS One. 2018 Nov 14;13(11):e0206477. doi: 10.1371/journal.pone.0206477. eCollection 2018.


Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C.

Nat Med. 2018 Dec;24(12):1919-1929. doi: 10.1038/s41591-018-0222-4. Epub 2018 Nov 5.


Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models.

Tu MJ, Ho PY, Zhang QY, Jian C, Qiu JX, Kim EJ, Bold RJ, Gonzalez FJ, Bi H, Yu AM.

Cancer Lett. 2019 Feb 1;442:82-90. doi: 10.1016/j.canlet.2018.10.038. Epub 2018 Oct 30.


Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice.

Mukherjee K, Song CY, Estes AM, Dhodi AN, Ormseth BH, Shin JS, Gonzalez FJ, Malik KU.

J Am Heart Assoc. 2018 Sep 18;7(18):e010065. doi: 10.1161/JAHA.118.010065.


Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice.

Lu Y, Harada M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Kyogashima M, Gonzalez FJ, Aoyama T.

Arch Toxicol. 2019 Jan;93(1):149-161. doi: 10.1007/s00204-018-2335-4. Epub 2018 Oct 19.


Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis.

Wang H, Ge C, Zhou J, Guo Y, Cui S, Huang N, Yan T, Cao L, Che Y, Zheng Q, Zheng X, Gonzalez FJ, Wang G, Hao H.

EBioMedicine. 2018 Nov;37:322-333. doi: 10.1016/j.ebiom.2018.10.028. Epub 2018 Oct 15.


Use of Raman spectroscopy to screen diabetes mellitus with machine learning tools.

Guevara E, Torres-Galván JC, Ramírez-Elías MG, Luevano-Contreras C, González FJ.

Biomed Opt Express. 2018 Sep 26;9(10):4998-5010. doi: 10.1364/BOE.9.004998. eCollection 2018 Oct 1.


The role of hypoxia-inducible factors in metabolic diseases.

Gonzalez FJ, Xie C, Jiang C.

Nat Rev Endocrinol. 2018 Dec;15(1):21-32. doi: 10.1038/s41574-018-0096-z. Review.


PPARα-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling.

Hua H, Yang J, Lin H, Xi Y, Dai M, Xu G, Wang F, Liu L, Zhao T, Huang J, Gonzalez FJ, Liu A.

J Pharm Pharmacol. 2018 Dec;70(12):1630-1642. doi: 10.1111/jphp.13014. Epub 2018 Sep 25.


Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling.

Moreno-Marín N, Merino JM, Alvarez-Barrientos A, Patel DP, Takahashi S, González-Sancho JM, Gandolfo P, Rios RM, Muñoz A, Gonzalez FJ, Fernández-Salguero PM.

iScience. 2018 Jun 29;4:44-63. doi: 10.1016/j.isci.2018.05.006. Epub 2018 May 15.


The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells.

Li S, Xu J, Yao Z, Hu L, Qin Z, Gao H, Krausz KW, Gonzalez FJ, Yao X.

Chem Biol Interact. 2018 Dec 25;296:45-56. doi: 10.1016/j.cbi.2018.09.001. Epub 2018 Sep 17.


Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.

Sasaki S, Urabe M, Maeda T, Suzuki J, Irie R, Suzuki M, Tomaru Y, Sakaguchi M, Gonzalez FJ, Inoue Y.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00213-18. doi: 10.1128/MCB.00213-18. Print 2018 Dec 15.


Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol.

Ghosh J, Chowdhury AR, Srinivasan S, Chattopadhyay M, Bose M, Bhattacharya S, Raza H, Fuchs SY, Rustgi AK, Gonzalez FJ, Avadhani NG.

Toxicol Sci. 2018 Dec 1;166(2):428-440. doi: 10.1093/toxsci/kfy206.


Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.

Brocker CN, Patel DP, Velenosi TJ, Kim D, Yan T, Yue J, Li G, Krausz KW, Gonzalez FJ.

J Lipid Res. 2018 Nov;59(11):2140-2152. doi: 10.1194/jlr.M088419. Epub 2018 Aug 29.


The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation.

Battistelli C, Sabarese G, Santangelo L, Montaldo C, Gonzalez FJ, Tripodi M, Cicchini C.

Cell Death Differ. 2019 May;26(5):890-901. doi: 10.1038/s41418-018-0170-z. Epub 2018 Aug 28.


Molecular Regulation of Carcinogenesis: Friend and Foe.

Patterson AD, Gonzalez FJ, Perdew GH, Peters JM.

Toxicol Sci. 2018 Oct 1;165(2):277-283. doi: 10.1093/toxsci/kfy185.


Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice.

Jiang Y, Feng D, Ma X, Fan S, Gao Y, Fu K, Wang Y, Sun J, Yao X, Liu C, Zhang H, Xu L, Liu A, Gonzalez FJ, Yang Y, Gao B, Huang M, Bi H.

Hepatology. 2019 Jan;69(1):343-358. doi: 10.1002/hep.30131. Epub 2018 Dec 17.


Laparoscopic surgical transmesocolic jejunostomy: A new surgical approach.

Pagan A, Bianchi A, Martínez JA, Jiménez M, Gonzalez FJ.

Turk J Surg. 2018 Jan 3;34(2):155-157. doi: 10.5152/turkjsurg.2017.3211. eCollection 2018.


Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory.

Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7408-E7417. doi: 10.1073/pnas.1802021115. Epub 2018 Jul 16.


The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides.

Malliou F, Andreadou I, Gonzalez FJ, Lazou A, Xepapadaki E, Vallianou I, Lambrinidis G, Mikros E, Marselos M, Skaltsounis AL, Konstandi M.

J Nutr Biochem. 2018 Sep;59:17-28. doi: 10.1016/j.jnutbio.2018.05.013. Epub 2018 Jun 5.


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