Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 110

1.

Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites.

Poveda JA, Giudici AM, Renart ML, Millet O, Morales A, González-Ros JM, Oakes V, Furini S, Domene C.

Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):183029. doi: 10.1016/j.bbamem.2019.183029. Epub 2019 Jul 24.

PMID:
31351058
2.

Mechanisms of Blockade of the Muscle-Type Nicotinic Receptor by Benzocaine, a Permanently Uncharged Local Anesthetic.

Cobo R, Nikolaeva-Koleva M, Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Neuroscience. 2019 May 31. pii: S0306-4522(19)30373-2. doi: 10.1016/j.neuroscience.2019.05.043. [Epub ahead of print]

PMID:
31158437
3.

Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies.

Renart ML, Giudici AM, Poveda JA, Fedorov A, Berberan-Santos MN, Prieto M, Díaz-García C, González-Ros JM, Coutinho A.

Sci Rep. 2019 Apr 17;9(1):6215. doi: 10.1038/s41598-019-42405-5.

4.

Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study.

Giudici AM, Renart ML, Díaz-García C, Morales A, Poveda JA, González-Ros JM.

Int J Mol Sci. 2019 Feb 5;20(3). pii: E689. doi: 10.3390/ijms20030689.

5.

Mechanisms Underlying the Strong Inhibition of Muscle-Type Nicotinic Receptors by Tetracaine.

Cobo R, Nikolaeva M, Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Front Mol Neurosci. 2018 Aug 8;11:193. doi: 10.3389/fnmol.2018.00193. eCollection 2018.

6.

Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel.

Renart ML, Montoya E, Giudici AM, Poveda JA, Fernández AM, Morales A, González-Ros JM.

J Biol Chem. 2017 Sep 15;292(37):15552-15560. doi: 10.1074/jbc.M117.795807. Epub 2017 Aug 4.

7.

Towards understanding the molecular basis of ion channel modulation by lipids: Mechanistic models and current paradigms.

Poveda JA, Marcela Giudici A, Lourdes Renart M, Morales A, González-Ros JM.

Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1507-1516. doi: 10.1016/j.bbamem.2017.04.003. Epub 2017 Apr 11. Review.

8.

Differential binding of monovalent cations to KcsA: Deciphering the mechanisms of potassium channel selectivity.

Montoya E, Lourdes Renart M, Marcela Giudici A, Poveda JA, Fernández AM, Morales A, González-Ros JM.

Biochim Biophys Acta Biomembr. 2017 May;1859(5):779-788. doi: 10.1016/j.bbamem.2017.01.014. Epub 2017 Jan 12.

9.

Muscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine.

Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Front Mol Neurosci. 2016 Nov 24;9:127. eCollection 2016.

10.

Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine.

Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Front Mol Neurosci. 2016 Feb 15;9:12. doi: 10.3389/fnmol.2016.00012. eCollection 2016.

11.

Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in the Potassium Channel from Streptomyces lividans (KcsA).

Molina ML, Giudici AM, Poveda JA, Fernández-Ballester G, Montoya E, Renart ML, Fernández AM, Encinar JA, Riquelme G, Morales A, González-Ros JM.

J Biol Chem. 2015 Oct 16;290(42):25745-55. doi: 10.1074/jbc.M115.669598. Epub 2015 Sep 2.

12.

Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation.

Gregorio-Teruel L, Valente P, González-Ros JM, Fernández-Ballester G, Ferrer-Montiel A.

J Gen Physiol. 2014 Mar;143(3):361-75. doi: 10.1085/jgp.201311070.

13.

Lipid modulation of ion channels through specific binding sites.

Poveda JA, Giudici AM, Renart ML, Molina ML, Montoya E, Fernández-Carvajal A, Fernández-Ballester G, Encinar JA, González-Ros JM.

Biochim Biophys Acta. 2014 Jun;1838(6):1560-7. doi: 10.1016/j.bbamem.2013.10.023. Epub 2013 Nov 8. Review.

14.

Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives.

Ibarguren M, López DJ, Encinar JA, González-Ros JM, Busquets X, Escribá PV.

Biochim Biophys Acta. 2013 Nov;1828(11):2553-63. doi: 10.1016/j.bbamem.2013.06.014. Epub 2013 Jun 18.

15.

Highly functionalized 1,2-diamino compounds through reductive amination of amino acid-derived β-keto esters.

Pérez-Faginas P, Aranda MT, García-López MT, Infantes L, Fernández-Carvajal A, González-Ros JM, Ferrer-Montiel A, González-Muñiz R.

PLoS One. 2013;8(1):e53231. doi: 10.1371/journal.pone.0053231. Epub 2013 Jan 7.

16.

Detergent-labile, supramolecular assemblies of KcsA: relative abundance and interactions involved.

Giudici AM, Molina ML, Ayala JL, Montoya E, Renart ML, Fernández AM, Encinar JA, Ferrer-Montiel AV, Poveda JA, González-Ros JM.

Biochim Biophys Acta. 2013 Feb;1828(2):193-200. doi: 10.1016/j.bbamem.2012.09.020. Epub 2012 Sep 27.

17.

Advances in modulating thermosensory TRP channels.

Ferrer-Montiel A, Fernández-Carvajal A, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Messeguer A, González-Muñiz R.

Expert Opin Ther Pat. 2012 Sep;22(9):999-1017. doi: 10.1517/13543776.2012.711320. Epub 2012 Jul 27. Review.

PMID:
22835143
18.

Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant.

Calcutta A, Jessen CM, Behrens MA, Oliveira CL, Renart ML, González-Ros JM, Otzen DE, Pedersen JS, Malmendal A, Nielsen NC.

Biochim Biophys Acta. 2012 Sep;1818(9):2290-301. doi: 10.1016/j.bbamem.2012.04.005. Epub 2012 Apr 14.

19.

Contribution of ion binding affinity to ion selectivity and permeation in KcsA, a model potassium channel.

Renart ML, Montoya E, Fernández AM, Molina ML, Poveda JA, Encinar JA, Ayala JL, Ferrer-Montiel AV, Gómez J, Morales A, González Ros JM.

Biochemistry. 2012 May 8;51(18):3891-900. doi: 10.1021/bi201497n. Epub 2012 Apr 27.

PMID:
22509943
20.

Mutation of Ser-50 and Cys-66 in Snapin modulates protein structure and stability.

Navarro A, Encinar JA, López-Méndez B, Aguado-Llera D, Prieto J, Gómez J, Martínez-Cruz LA, Millet O, González-Ros JM, Fernández-Ballester G, Neira JL, Ferrer-Montiel A.

Biochemistry. 2012 Apr 24;51(16):3470-84. doi: 10.1021/bi201574t. Epub 2012 Apr 11.

PMID:
22471585
21.

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis.

Devesa I, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Ferrer-Montiel A, Fernández-Carvajal A.

J Inflamm Res. 2011;4:67-81. doi: 10.2147/JIR.S12978. Epub 2011 May 24.

22.

Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.

Vidal-Mosquera M, Fernández-Carvajal A, Moure A, Valente P, Planells-Cases R, González-Ros JM, Bujons J, Ferrer-Montiel A, Messeguer A.

J Med Chem. 2011 Nov 10;54(21):7441-52. doi: 10.1021/jm200981s. Epub 2011 Oct 10.

PMID:
21950613
23.

Solid-phase synthesis of a library of amphipatic hydantoins. Discovery of new hits for TRPV1 blockade.

Gerona-Navarro G, González-Muñiz R, Fernández-Carvajal A, González-Ros JM, Ferrer-Montiel A, Carreño C, Albericio F, Royo M.

ACS Comb Sci. 2011 Sep 12;13(5):458-65. doi: 10.1021/co1000986. Epub 2011 Jul 8.

24.

Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.

Alberola-Die A, Martinez-Pinna J, González-Ros JM, Ivorra I, Morales A.

J Neurochem. 2011 Jun;117(6):1009-19. doi: 10.1111/j.1471-4159.2011.07271.x. Epub 2011 May 10.

25.

Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity.

Valente P, Fernández-Carvajal A, Camprubí-Robles M, Gomis A, Quirce S, Viana F, Fernández-Ballester G, González-Ros JM, Belmonte C, Planells-Cases R, Ferrer-Montiel A.

FASEB J. 2011 May;25(5):1628-40. doi: 10.1096/fj.10-174433. Epub 2011 Feb 9.

PMID:
21307333
26.

Ionic channels as targets for drug design: a review on computational methods.

Fernández-Ballester G, Fernández-Carvajal A, González-Ros JM, Ferrer-Montiel A.

Pharmaceutics. 2011 Dec 9;3(4):932-53. doi: 10.3390/pharmaceutics3040932.

27.

New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view.

Fernández-Carvajal A, Fernández-Ballester G, Devesa I, González-Ros JM, Ferrer-Montiel A.

Pharmaceuticals (Basel). 2011 Dec 27;5(1):16-48. doi: 10.3390/ph5010016.

28.

Ion binding to KcsA: implications in ion selectivity and channel gating.

Renart ML, Triano I, Poveda JA, Encinar JA, Fernández AM, Ferrer-Montiel AV, Gómez J, González Ros JM.

Biochemistry. 2010 Nov 9;49(44):9480-7. doi: 10.1021/bi101235v.

PMID:
20925387
29.

Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein.

Triano I, Barrera FN, Renart ML, Molina ML, Fernández-Ballester G, Poveda JA, Fernández AM, Encinar JA, Ferrer-Montiel AV, Otzen D, González-Ros JM.

Biochemistry. 2010 Jun 29;49(25):5397-404. doi: 10.1021/bi1003712.

PMID:
20481584
30.

Interaction of transmembrane-spanning segments of the alpha2-adrenergic receptor with model membranes.

Prades J, Encinar JA, Funari SS, González-Ros JM, Escribá PV, Barceló F.

Mol Membr Biol. 2009 Aug;26(5):265-78. doi: 10.1080/09687680903081610. Epub 2009 Jun 30.

PMID:
19568979
31.

N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.

Molina ML, Barrera FN, Encinar JA, Renart ML, Fernández AM, Poveda JA, Santoro J, Bruix M, Gavilanes F, Fernández-Ballester G, Neira JL, González-Ros JM.

J Biol Chem. 2008 Jun 27;283(26):18076-85. doi: 10.1074/jbc.M710132200. Epub 2008 Apr 22.

32.

Protein-promoted membrane domains.

Poveda JA, Fernández AM, Encinar JA, González-Ros JM.

Biochim Biophys Acta. 2008 Jul-Aug;1778(7-8):1583-90. doi: 10.1016/j.bbamem.2008.01.021. Epub 2008 Feb 11. Review.

33.

Membranes: a meeting point for lipids, proteins and therapies.

Escribá PV, González-Ros JM, Goñi FM, Kinnunen PK, Vigh L, Sánchez-Magraner L, Fernández AM, Busquets X, Horváth I, Barceló-Coblijn G.

J Cell Mol Med. 2008 Jun;12(3):829-75. doi: 10.1111/j.1582-4934.2008.00281.x. Epub 2008 Feb 8. Review.

34.

Protein self-assembly and lipid binding in the folding of the potassium channel KcsA.

Barrera FN, Renart ML, Poveda JA, de Kruijff B, Killian JA, González-Ros JM.

Biochemistry. 2008 Feb 19;47(7):2123-33. doi: 10.1021/bi700778c. Epub 2008 Jan 19.

PMID:
18205389
35.

Interaction of the C-terminal region of the Ggamma protein with model membranes.

Barceló F, Prades J, Encinar JA, Funari SS, Vögler O, González-Ros JM, Escribá PV.

Biophys J. 2007 Oct 1;93(7):2530-41. Epub 2007 Jun 1.

36.

Structural and functional changes induced in the nicotinic acetylcholine receptor by membrane phospholipids.

Fernández-Carvajal AM, Encinar JA, Poveda JA, de Juan E, Martínez-Pinna J, Ivorra I, Ferragut JA, Morales A, González-Ros JM.

J Mol Neurosci. 2006;30(1-2):121-4.

PMID:
17192656
37.

Nicotinic acetylcholine receptor properties are modulated by surrounding lipids: an in vivo study.

Morales A, de Juan E, Fernández-Carvajal AM, Martinez-Pinna J, Poveda JA, Encinar JA, Ivorra I, González-Ros JM.

J Mol Neurosci. 2006;30(1-2):5-6.

PMID:
17192603
38.

Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA.

Renart ML, Barrera FN, Molina ML, Encinar JA, Poveda JA, Fernández AM, Gómez J, González-Ros JM.

J Biol Chem. 2006 Oct 6;281(40):29905-15. Epub 2006 Jun 30.

39.

Clustering and coupled gating modulate the activity in KcsA, a potassium channel model.

Molina ML, Barrera FN, Fernández AM, Poveda JA, Renart ML, Encinar JA, Riquelme G, González-Ros JM.

J Biol Chem. 2006 Jul 7;281(27):18837-48. Epub 2006 May 2.

40.

Antifungal effects and mechanism of action of viscotoxin A3.

Giudici M, Poveda JA, Molina ML, de la Canal L, González-Ros JM, Pfüller K, Pfüller U, Villalaín J.

FEBS J. 2006 Jan;273(1):72-83.

41.

Proteomic analysis of apical microvillous membranes of syncytiotrophoblast cells reveals a high degree of similarity with lipid rafts.

Paradela A, Bravo SB, Henríquez M, Riquelme G, Gavilanes F, González-Ros JM, Albar JP.

J Proteome Res. 2005 Nov-Dec;4(6):2435-41.

PMID:
16335998
42.

Unfolding and refolding in vitro of a tetrameric, alpha-helical membrane protein: the prokaryotic potassium channel KcsA.

Barrera FN, Renart ML, Molina ML, Poveda JA, Encinar JA, Fernández AM, Neira JL, González-Ros JM.

Biochemistry. 2005 Nov 1;44(43):14344-52.

PMID:
16245951
43.

The influence of a membrane environment on the structure and stability of a prokaryotic potassium channel, KcsA.

Encinar JA, Molina ML, Poveda JA, Barrera FN, Renart ML, Fernández AM, González-Ros JM.

FEBS Lett. 2005 Sep 26;579(23):5199-204.

44.

Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel KcsA.

Molina ML, Encinar JA, Barrera FN, Fernández-Ballester G, Riquelme G, González-Ros JM.

Biochemistry. 2004 Nov 30;43(47):14924-31.

PMID:
15554699
45.

Binding of the C-terminal sterile alpha motif (SAM) domain of human p73 to lipid membranes.

Barrera FN, Poveda JA, González-Ros JM, Neira JL.

J Biol Chem. 2003 Nov 21;278(47):46878-85. Epub 2003 Sep 3.

46.

Probing the channel-bound shaker B inactivating peptide by stereoisomeric substitution at a strategic tyrosine residue.

Encinar JA, Fernández AM, Poveda JA, Molina ML, Albar JP, Gavilanes F, Gonzalez-Ros JM.

Biochemistry. 2003 Jul 29;42(29):8879-84.

PMID:
12873149
47.

Intrinsic tyrosine fluorescence as a tool to study the interaction of the shaker B "ball" peptide with anionic membranes.

Poveda JA, Prieto M, Encinar JA, González-Ros JM, Mateo CR.

Biochemistry. 2003 Jun 17;42(23):7124-32.

PMID:
12795608
48.

Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors.

Castro-Galache MD, Ferragut JA, Barbera VM, Martín-Orozco E, Gonzalez-Ros JM, Garcia-Morales P, Saceda M.

Int J Cancer. 2003 May 1;104(5):579-86.

49.

Salmonid viral haemorrhagic septicaemia virus: fusion-related enhancement of virus infectivity by peptides derived from viral glycoprotein G or a combinatorial library.

Mas V, Pérez L, Encinar JA, Pastor MT, Rocha A, Perez-Paya E, Ferrer-Montiel A, Gonzalez Ros JM, Estepa A, Coll JM.

J Gen Virol. 2002 Nov;83(Pt 11):2671-81.

PMID:
12388802
50.

Tyrosine phosphorylation of the inactivating peptide of the shaker B potassium channel: a structural-functional correlate.

Encinar JA, Fernández AM, Molina ML, Molina A, Poveda JA, Albar JP, López-Barneo J, Gavilanes F, Ferrer-Montiel AV, González-Ros JM.

Biochemistry. 2002 Oct 8;41(40):12263-9.

PMID:
12356329

Supplemental Content

Loading ...
Support Center