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Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity.

Lopez-Pastor AR, Gomez-Hernandez A, Diaz-Castroverde S, Gonzalez-Aseguinolaza G, Gonzalez-Rodriguez A, Garcia G, Fernandez S, Escribano O, Benito M.

Dis Model Mech. 2019 Jan 14. pii: dmm.036186. doi: 10.1242/dmm.036186. [Epub ahead of print]


CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I.

Zabaleta N, Barberia M, Martin-Higueras C, Zapata-Linares N, Betancor I, Rodriguez S, Martinez-Turrillas R, Torella L, Vales A, Olagüe C, Vilas-Zornoza A, Castro-Labrador L, Lara-Astiaso D, Prosper F, Salido E, Gonzalez-Aseguinolaza G, Rodriguez-Madoz JR.

Nat Commun. 2018 Dec 21;9(1):5454. doi: 10.1038/s41467-018-07827-1.


Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.

Torralba D, Baixauli F, Villarroya-Beltri C, Fernández-Delgado I, Latorre-Pellicer A, Acín-Pérez R, Martín-Cófreces NB, Jaso-Tamame ÁL, Iborra S, Jorge I, González-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enríquez JA, Mittelbrunn M, Sánchez-Madrid F.

Nat Commun. 2018 Jul 9;9(1):2658. doi: 10.1038/s41467-018-05077-9.


Brain copper storage after genetic long-term correction in a mouse model of Wilson disease.

Uerlings R, Moreno D, Murillo O, Gazquez C, Hernández-Alcoceba R, González-Aseguinolaza G, Weiskirchen R.

Neurol Genet. 2018 May 18;4(3):e243. doi: 10.1212/NXG.0000000000000243. eCollection 2018 Jun. No abstract available.


Erratum to "A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-β induction" [J Hepatol 67 (2017) 669-679].

Suárez-Amarán L, Usai C, Di Scala M, Godoy C, Ni Y, Hommel M, Palomo L, Segura V, Olagüe C, Vales A, Ruiz-Ripa A, Buti M, Salido E, Prieto J, Urban S, Rodríguez-Frias F, Aldabe R, González-Aseguinolaza G.

J Hepatol. 2018 Jul;69(1):262-264. doi: 10.1016/j.jhep.2018.04.003. No abstract available.


Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry.

Moreno D, Murillo O, Gazquez C, Hernandez-Alcoceba R, Uerlings R, Gonzalez-Aseguinolaza G, Weiskirchen R.

J Hepatol. 2018 May;68(5):1088-1090. doi: 10.1016/j.jhep.2017.12.022. Epub 2018 Jan 6. No abstract available.


Erratum for Martínez-Florensa et al., "Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis".

Martínez-Florensa M, Consuegra-Fernández M, Aranda F, Armiger-Borràs N, Di Scala M, Carrasco E, Pachón J, Vila J, González-Aseguinolaza G, Lozano F.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01997-17. doi: 10.1128/AAC.01997-17. Print 2017 Nov. No abstract available.


Successful Repeated Hepatic Gene Delivery in Mice and Non-human Primates Achieved by Sequential Administration of AAV5ch and AAV1.

Majowicz A, Salas D, Zabaleta N, Rodríguez-Garcia E, González-Aseguinolaza G, Petry H, Ferreira V.

Mol Ther. 2017 Aug 2;25(8):1831-1842. doi: 10.1016/j.ymthe.2017.05.003. Epub 2017 Jun 5.


A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-β induction.

Suárez-Amarán L, Usai C, Di Scala M, Godoy C, Ni Y, Hommel M, Palomo L, Segura V, Olagüe C, Vales A, Ruiz-Ripa A, Buti M, Salido E, Prieto J, Urban S, Rodríguez-Frias F, Aldabe R, González-Aseguinolaza G.

J Hepatol. 2017 Oct;67(4):669-679. doi: 10.1016/j.jhep.2017.05.010. Epub 2017 May 18. Erratum in: J Hepatol. 2018 May 15;:.


Improvement of Adeno-Associated Virus-Mediated Liver Transduction Efficacy by Regional Administration in Macaca fascicularis.

Zabaleta N, Salas D, Paramo M, Hommel M, Sier-Ferreira V, Hernandez-Alcoceba R, Prieto J, Bilbao JI, Gonzalez-Aseguinolaza G.

Hum Gene Ther Clin Dev. 2017 Jun;28(2):68-73. doi: 10.1089/humc.2016.183. Epub 2017 Mar 10.


Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System.

Pignataro D, Sucunza D, Vanrell L, Lopez-Franco E, Dopeso-Reyes IG, Vales A, Hommel M, Rico AJ, Lanciego JL, Gonzalez-Aseguinolaza G.

Front Neuroanat. 2017 Feb 10;11:2. doi: 10.3389/fnana.2017.00002. eCollection 2017.


Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis.

Martínez-Florensa M, Consuegra-Fernández M, Aranda F, Armiger-Borràs N, Di Scala M, Carrasco E, Pachón J, Vila J, González-Aseguinolaza G, Lozano F.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01391-16. doi: 10.1128/AAC.01391-16. Print 2017 Jan. Erratum in: Antimicrob Agents Chemother. 2017 Oct 24;61(11):.


Interferon alpha bioactivity critically depends on Scavenger receptor class B type I function.

Vasquez M, Fioravanti J, Aranda F, Paredes V, Gomar C, Ardaiz N, Fernandez-Ruiz V, Méndez M, Nistal-Villan E, Larrea E, Gao Q, Gonzalez-Aseguinolaza G, Prieto J, Berraondo P.

Oncoimmunology. 2016 Jun 29;5(8):e1196309. doi: 10.1080/2162402X.2016.1196309. eCollection 2016 Aug.


Prevalent role of the insulin receptor isoform A in the regulation of hepatic glycogen metabolism in hepatocytes and in mice.

Diaz-Castroverde S, Baos S, Luque M, Di Scala M, González-Aseguinolaza G, Gómez-Hernández A, Beneit N, Escribano O, Benito M.

Diabetologia. 2016 Dec;59(12):2702-2710. Epub 2016 Sep 7.


Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.

Diaz-Castroverde S, Gómez-Hernández A, Fernández S, García-Gómez G, Di Scala M, González-Aseguinolaza G, Fernández-Millán E, González-Rodríguez Á, García-Bravo M, Chambon P, Álvarez C, Perdomo L, Beneit N, Escribano O, Benito M.

Dis Model Mech. 2016 Nov 1;9(11):1271-1281. Epub 2016 Aug 24.


Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis.

Gil-Farina I, Di Scala M, Salido E, López-Franco E, Rodríguez-García E, Blasi M, Merino J, Aldabe R, Prieto J, Gonzalez-Aseguinolaza G.

J Immunol. 2016 Sep 15;197(6):2145-56. doi: 10.4049/jimmunol.1600228. Epub 2016 Aug 10.


Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice.

Di Scala M, Otano I, Gil-Fariña I, Vanrell L, Hommel M, Olagüe C, Vales A, Galarraga M, Guembe L, Ortiz de Solorzano C, Ghosh I, Maini MK, Prieto J, González-Aseguinolaza G.

J Virol. 2016 Sep 12;90(19):8563-74. doi: 10.1128/JVI.01030-16. Print 2016 Oct 1.


Identification of IFN-γ-producing T cells as the main mediators of the side effects associated to mouse interleukin-15 sustained exposure.

Di Scala M, Gil-Fariña I, Olagüe C, Vales A, Sobrevals L, Fortes P, Corbacho D, González-Aseguinolaza G.

Oncotarget. 2016 Aug 2;7(31):49008-49026. doi: 10.18632/oncotarget.10264.


Generation and characterization of human iPSC lines derived from a Primary Hyperoxaluria Type I patient with p.I244T mutation.

Zapata-Linares N, Rodriguez S, Salido E, Abizanda G, Iglesias E, Prosper F, Gonzalez-Aseguinolaza G, Rodriguez-Madoz JR.

Stem Cell Res. 2016 Jan;16(1):116-9. doi: 10.1016/j.scr.2015.12.014. Epub 2015 Dec 28.


Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria.

D'Avola D, López-Franco E, Sangro B, Pañeda A, Grossios N, Gil-Farina I, Benito A, Twisk J, Paz M, Ruiz J, Schmidt M, Petry H, Harper P, de Salamanca RE, Fontanellas A, Prieto J, González-Aseguinolaza G.

J Hepatol. 2016 Oct;65(4):776-783. doi: 10.1016/j.jhep.2016.05.012. Epub 2016 May 17.


A Versatile Vector for In Vivo Monitoring of Type I Interferon Induction and Signaling.

Nistal-Villan E, Poutou J, Rodríguez-Garcia E, Buñuales M, Carte-Abad B, Prieto J, Gonzalez-Aseguinolaza G, Hernandez-Alcoceba R, Larrea E.

PLoS One. 2016 Mar 23;11(3):e0152031. doi: 10.1371/journal.pone.0152031. eCollection 2016.


Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients.

Gil-Farina I, Fronza R, Kaeppel C, Lopez-Franco E, Ferreira V, D'Avola D, Benito A, Prieto J, Petry H, Gonzalez-Aseguinolaza G, Schmidt M.

Mol Ther. 2016 Jun;24(6):1100-1105. doi: 10.1038/mt.2016.52. Epub 2016 Mar 7.


Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model.

Nistal-Villan E, Bunuales M, Poutou J, Gonzalez-Aparicio M, Bravo-Perez C, Quetglas JI, Carte B, Gonzalez-Aseguinolaza G, Prieto J, Larrea E, Hernandez-Alcoceba R.

Mol Cancer. 2015 Dec 16;14:210. doi: 10.1186/s12943-015-0479-x.


Long-term metabolic correction of Wilson's disease in a murine model by gene therapy.

Murillo O, Luqui DM, Gazquez C, Martinez-Espartosa D, Navarro-Blasco I, Monreal JI, Guembe L, Moreno-Cermeño A, Corrales FJ, Prieto J, Hernandez-Alcoceba R, Gonzalez-Aseguinolaza G.

J Hepatol. 2016 Feb;64(2):419-426. doi: 10.1016/j.jhep.2015.09.014. Epub 2015 Sep 25.


A RIG-I 2CARD-MAVS200 Chimeric Protein Reconstitutes IFN-β Induction and Antiviral Response in Models Deficient in Type I IFN Response.

Nistal-Villán E, Rodríguez-García E, Di Scala M, Ferrero-Laborda R, Olagüe C, Vales Á, Carte-Abad B, Crespo I, García-Sastre A, Prieto J, Larrea E, González-Aseguinolaza G.

J Innate Immun. 2015;7(5):466-81. doi: 10.1159/000375262. Epub 2015 May 5.


Immunosurveillance of the liver by intravascular effector CD8(+) T cells.

Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Ganzer L, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M.

Cell. 2015 Apr 23;161(3):486-500. doi: 10.1016/j.cell.2015.03.005. Epub 2015 Apr 16.


Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I.

Berraondo P, Di Scala M, Korolowicz K, Thampi LM, Otano I, Suarez L, Fioravanti J, Aranda F, Ardaiz N, Yang J, Kallakury BV, Tucker RD, Vasquez M, Menne S, Prieto J, González-Aseguinolaza G.

J Hepatol. 2015 Aug;63(2):329-36. doi: 10.1016/j.jhep.2015.02.048. Epub 2015 Mar 12.


Chronic exposure to IFNα drives medullar lymphopoiesis towards T-cell differentiation in mice.

Di Scala M, Gil-Fariña I, Vanrell L, Sánchez-Bayona R, Alignani D, Olagüe C, Vales A, Berraondo P, Prieto J, González-Aseguinolaza G.

Haematologica. 2015 Aug;100(8):1014-22. doi: 10.3324/haematol.2014.115410. Epub 2015 Feb 24.


Animal models of chronic hepatitis delta virus infection host-virus immunologic interactions.

Aldabe R, Suárez-Amarán L, Usai C, González-Aseguinolaza G.

Pathogens. 2015 Feb 12;4(1):46-65. doi: 10.3390/pathogens4010046. Review.


Characterization and genotyping of the DRB1 gene of the major histocompatibility complex (MHC) in the Marmota monax, animal model of hepatitis B.

Moreno-Cugnon L, Esparza-Baquer A, Larruskain A, García-Etxebarria K, Menne S, González-Aseguinolaza G, Jugo BM.

Mol Immunol. 2015 Feb;63(2):505-12.


Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice.

Pascual-Lucas M, Viana da Silva S, Di Scala M, Garcia-Barroso C, González-Aseguinolaza G, Mulle C, Alberini CM, Cuadrado-Tejedor M, Garcia-Osta A.

EMBO Mol Med. 2014 Oct;6(10):1246-62. doi: 10.15252/emmm.201404228.


Adenovirus expressing β2-microglobulin recovers HLA class I expression and antitumor immunity by increasing T-cell recognition.

Del Campo AB, Carretero J, Muñoz JA, Zinchenko S, Ruiz-Cabello F, González-Aseguinolaza G, Garrido F, Aptsiauri N.

Cancer Gene Ther. 2014 Aug;21(8):317-32. doi: 10.1038/cgt.2014.32. Epub 2014 Jun 27.


Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver.

Alzuguren P, Hervas-Stubbs S, Gonzalez-Aseguinolaza G, Poutou J, Fortes P, Mancheno U, Bunuales M, Olagüe C, Razquin N, Van Rooijen N, Enguita M, Hernandez-Alcoceba R.

Liver Int. 2015 Apr;35(4):1274-89. doi: 10.1111/liv.12571. Epub 2014 May 10.


Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum.

Sack BK, Miller JL, Vaughan AM, Douglass A, Kaushansky A, Mikolajczak S, Coppi A, Gonzalez-Aseguinolaza G, Tsuji M, Zavala F, Sinnis P, Kappe SH.

Infect Immun. 2014 Feb;82(2):808-17. doi: 10.1128/IAI.01249-13. Epub 2013 Dec 9.


Adeno-associated viral vector serotype 5 poorly transduces liver in rat models.

Montenegro-Miranda PS, Pañeda A, ten Bloemendaal L, Duijst S, de Waart DR, Gonzalez- Aseguinolaza G, Bosma PJ.

PLoS One. 2013 Dec 27;8(12):e82597. doi: 10.1371/journal.pone.0082597. eCollection 2013. Erratum in: PLoS One. 2015;10(3):e0119777. Aseguinolaza, Gloria Gonzalez [corrected to Gonzalez- Aseguinolaza, Gloria].


Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria.

Pañeda A, Lopez-Franco E, Kaeppel C, Unzu C, Gil-Royo AG, D'Avola D, Beattie SG, Olagüe C, Ferrero R, Sampedro A, Mauleon I, Hermening S, Salmon F, Benito A, Gavira JJ, Cornet ME, del Mar Municio M, von Kalle C, Petry H, Prieto J, Schmidt M, Fontanellas A, González-Aseguinolaza G.

Hum Gene Ther. 2013 Dec;24(12):1007-17. doi: 10.1089/hum.2013.166.


IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.

Gil-Fariña I, Di Scala M, Vanrell L, Olagüe C, Vales A, High KA, Prieto J, Mingozzi F, Gonzalez-Aseguinolaza G.

PLoS One. 2013 Jul 2;8(7):e67748. doi: 10.1371/journal.pone.0067748. Print 2013.


Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma.

del Campo AB, Kyte JA, Carretero J, Zinchencko S, Méndez R, González-Aseguinolaza G, Ruiz-Cabello F, Aamdal S, Gaudernack G, Garrido F, Aptsiauri N.

Int J Cancer. 2014 Jan 1;134(1):102-13. doi: 10.1002/ijc.28338. Epub 2013 Jul 16.


Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling.

Hafalla JC, Bauza K, Friesen J, Gonzalez-Aseguinolaza G, Hill AV, Matuschewski K.

PLoS Pathog. 2013 May;9(5):e1003303. doi: 10.1371/journal.ppat.1003303. Epub 2013 May 9.


Cytokines for the treatment of gastrointestinal cancers: clinical experience and new perspectives.

Hernandez-Alcoceba R, Sangro B, Berraondo P, Gonzalez-Aseguinolaza G, Prieto J.

Expert Opin Investig Drugs. 2013 Jul;22(7):827-41. doi: 10.1517/13543784.2013.793307. Epub 2013 Apr 18. Review.


Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium.

Rodríguez D, González-Aseguinolaza G, Rodríguez JR, Vijayan A, Gherardi M, Rueda P, Casal JI, Esteban M.

PLoS One. 2012;7(4):e34445. doi: 10.1371/journal.pone.0034445. Epub 2012 Apr 17.


Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B.

Otano I, Suarez L, Dotor J, Gonzalez-Aparicio M, Crettaz J, Olagüe C, Vales A, Riezu JI, Larrea E, Borras F, Benito A, Hernandez-Alcoceba R, Menne S, Prieto J, González-Aseguinolaza G.

Hepatology. 2012 Aug;56(2):474-83. doi: 10.1002/hep.25667. Epub 2012 Jul 2.


Gene therapy of liver diseases: a 2011 perspective.

Gonzalez-Aseguinolaza G, Prieto J.

Clin Res Hepatol Gastroenterol. 2011 Nov;35(11):699-708. doi: 10.1016/j.clinre.2011.05.016. Epub 2011 Jul 22. Review.


Self-inactivating helper virus for the production of high-capacity adenoviral vectors.

Gonzalez-Aparicio M, Mauleon I, Alzuguren P, Bunuales M, Gonzalez-Aseguinolaza G, San Martín C, Prieto J, Hernandez-Alcoceba R.

Gene Ther. 2011 Nov;18(11):1025-33. doi: 10.1038/gt.2011.58. Epub 2011 Apr 28.


Characterization of woodchuck apolipoprotein A-I: a new tool for drug delivery and identification of altered isoforms in the woodchuck chronic hepatitis model.

Fioravanti J, Gomar C, Medina-Echeverz J, Otano I, Benito A, Prieto J, González-Aseguinolaza G, Berraondo P.

J Med Virol. 2011 Jul;83(7):1221-9. doi: 10.1002/jmv.22104. Epub 2011 Apr 22.


Anchoring interferon alpha to apolipoprotein A-I reduces hematological toxicity while enhancing immunostimulatory properties.

Fioravanti J, González I, Medina-Echeverz J, Larrea E, Ardaiz N, González-Aseguinolaza G, Prieto J, Berraondo P.

Hepatology. 2011 Jun;53(6):1864-73. doi: 10.1002/hep.24306. Epub 2011 May 2.


Electroporation enhances immunogenicity of a DNA vaccine expressing woodchuck hepatitis virus surface antigen in woodchucks.

Liu KH, Ascenzi MA, Bellezza CA, Bezuidenhout AJ, Cote PJ, Gonzalez-Aseguinolaza G, Hannaman D, Luxembourg A, Evans CF, Tennant BC, Menne S.

J Virol. 2011 May;85(10):4853-62. doi: 10.1128/JVI.02437-10. Epub 2011 Mar 9.


Development of a liver-specific Tet-on inducible system for AAV vectors and its application in the treatment of liver cancer.

Vanrell L, Di Scala M, Blanco L, Otano I, Gil-Farina I, Baldim V, Paneda A, Berraondo P, Beattie SG, Chtarto A, Tenenbaum L, Prieto J, Gonzalez-Aseguinolaza G.

Mol Ther. 2011 Jul;19(7):1245-53. doi: 10.1038/mt.2011.37. Epub 2011 Mar 1.


Adeno-associated virus liver transduction efficiency measured by in vivo [18F]FHBG positron emission tomography imaging in rodents and nonhuman primates.

Pañeda A, Collantes M, Beattie SG, Otano I, Snapper J, Timmermans E, Guembe L, Petry H, Lanciego JL, Benito A, Prieto J, Rodriguez-Pena MS, Peñuelas I, Gonzalez-Aseguinolaza G.

Hum Gene Ther. 2011 Aug;22(8):999-1009. doi: 10.1089/hum.2010.190. Epub 2011 Apr 6.


Gene therapy for HCV/HBV-induced hepatocellular carcinoma.

Smerdou C, Menne S, Hernandez-Alcoceba R, Gonzalez-Aseguinolaza G.

Curr Opin Investig Drugs. 2010 Dec;11(12):1368-77. Review.


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