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Items: 39


Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization.

Granato M, Gilardini Montani MS, Zompetta C, Santarelli R, Gonnella R, Romeo MA, D'Orazi G, Faggioni A, Cirone M.

Biomolecules. 2019 Sep 12;9(9). pii: E482. doi: 10.3390/biom9090482.


Give me a kiss! An integrative rehabilitative training program with motor imagery and mirror therapy for recovery of facial palsy.

Paolucci T, Cardarola A, Colonnelli P, Ferracuti G, Gonnella R, Murgia M, Santilli V, Paoloni M, Bernetti A, Agostini F, Mangone M.

Eur J Phys Rehabil Med. 2019 Mar 27. doi: 10.23736/S1973-9087.19.05757-5. [Epub ahead of print]


STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation.

Santarelli R, Carillo V, Romeo MA, Gaeta A, Nazzari C, Gonnella R, Granato M, D'Orazi G, Faggioni A, Cirone M.

Virology. 2019 Feb;528:137-143. doi: 10.1016/j.virol.2018.12.015. Epub 2019 Jan 5.


EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation.

Gilardini Montani MS, Santarelli R, Granato M, Gonnella R, Torrisi MR, Faggioni A, Cirone M.

Autophagy. 2019 Apr;15(4):652-667. doi: 10.1080/15548627.2018.1536530. Epub 2018 Oct 23.


EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3.

Gilardini Montani MS, Santarelli R, Falcinelli L, Gonnella R, Granato M, Di Renzo L, Cuomo L, Vitillo M, Faggioni A, Cirone M.

J Leukoc Biol. 2018 Oct;104(4):821-832. doi: 10.1002/JLB.2A0118-029RR. Epub 2018 Jul 24.


Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy.

Granato M, Romeo MA, Tiano MS, Santarelli R, Gonnella R, Gilardini Montani MS, Faggioni A, Cirone M.

Sci Rep. 2017 Oct 12;7(1):13052. doi: 10.1038/s41598-017-13533-7.


Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.

Granato M, Gilardini Montani MS, Romeo MA, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M.

Cell Signal. 2017 Dec;40:239-247. doi: 10.1016/j.cellsig.2017.09.020. Epub 2017 Sep 28.


Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers.

Manyevitch R, Protas M, Scarpiello S, Deliso M, Bass B, Nanajian A, Chang M, Thompson SM, Khoury N, Gonnella R, Trotz M, Moore DB, Harms E, Perry G, Clunes L, Ortiz A, Friedrich JO, Murray IVJ.

Curr Alzheimer Res. 2018;15(2):164-181. doi: 10.2174/1567205014666170921122458. Review.


Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells.

Gonnella R, Yadav S, Gilardini Montani MS, Granato M, Santarelli R, Garufi A, D'Orazi G, Faggioni A, Cirone M.

Free Radic Biol Med. 2017 Nov;112:327-335. doi: 10.1016/j.freeradbiomed.2017.08.005. Epub 2017 Aug 8.


Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.

Granato M, Rizzello C, Gilardini Montani MS, Cuomo L, Vitillo M, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M.

J Nutr Biochem. 2017 Mar;41:124-136. doi: 10.1016/j.jnutbio.2016.12.011. Epub 2017 Jan 5.


KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression.

Santarelli R, Granato M, Pentassuglia G, Lacconi V, Gilardini Montani MS, Gonnella R, Tafani M, Torrisi MR, Faggioni A, Cirone M.

Autophagy. 2016 Dec;12(12):2311-2325. Epub 2016 Oct 7.


The activation of KSHV lytic cycle blocks autophagy in PEL cells.

Granato M, Santarelli R, Filardi M, Gonnella R, Farina A, Torrisi MR, Faggioni A, Cirone M.

Autophagy. 2015 Nov 2;11(11):1978-1986. doi: 10.1080/15548627.2015.1091911.


Small molecules and Alzheimer's disease: misfolding, metabolism and imaging.

Patel V, Zhang X, Tautiva NA, Nyabera AN, Owa OO, Baidya M, Sung HC, Taunk PS, Abdollahi S, Charles S, Gonnella RA, Gadi N, Duong KT, Fawver JN, Ran C, Jalonen TO, Murray IV.

Curr Alzheimer Res. 2015;12(5):445-61.


PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.

Gonnella R, Granato M, Farina A, Santarelli R, Faggioni A, Cirone M.

Biochim Biophys Acta. 2015 Jul;1853(7):1586-95. doi: 10.1016/j.bbamcr.2015.03.011. Epub 2015 Mar 27.


Targeting of prosurvival pathways as therapeutic approaches against primary effusion lymphomas: past, present, and Future.

Granato M, Santarelli R, Gonnella R, Farina A, Trivedi P, Faggioni A, Cirone M.

Biomed Res Int. 2015;2015:104912. doi: 10.1155/2015/104912. Epub 2015 Jan 28. Review.


Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.

Granato M, Santarelli R, Farina A, Gonnella R, Lotti LV, Faggioni A, Cirone M.

J Virol. 2014 Nov;88(21):12715-26. doi: 10.1128/JVI.02199-14. Epub 2014 Aug 20.


STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells.

Santarelli R, Gonnella R, Di Giovenale G, Cuomo L, Capobianchi A, Granato M, Gentile G, Faggioni A, Cirone M.

Sci Rep. 2014 Feb 28;4:4241. doi: 10.1038/srep04241.


Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line.

Gonnella R, Santarelli R, Farina A, Granato M, D'Orazi G, Faggioni A, Cirone M.

J Exp Clin Cancer Res. 2013 Oct 23;32:79. doi: 10.1186/1756-9966-32-79.


JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

Granato M, Santarelli R, Lotti LV, Di Renzo L, Gonnella R, Garufi A, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M.

PLoS One. 2013 Sep 26;8(9):e75965. doi: 10.1371/journal.pone.0075965. eCollection 2013.


HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.

Granato M, Lacconi V, Peddis M, Lotti LV, Di Renzo L, Gonnella R, Santarelli R, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M.

Cell Death Dis. 2013 Jul 18;4:e730. doi: 10.1038/cddis.2013.263. Erratum in: Cell Death Dis. 2014;5:e2154. Renzo, L D [corrected to Di Renzo, L].


KSHV ORF67 encoded lytic protein localizes on the nuclear membrane and alters emerin distribution.

Farina A, Santarelli R, Bloise R, Gonnella R, Granato M, Bei R, Modesti A, Cirone M, Bengtsson L, Angeloni A, Faggioni A.

Virus Res. 2013 Aug;175(2):143-50. doi: 10.1016/j.virusres.2013.04.001. Epub 2013 Apr 23.


Activation of dendritic cells by tumor cell death.

Cirone M, Di Renzo L, Lotti LV, Conte V, Trivedi P, Santarelli R, Gonnella R, Frati L, Faggioni A.

Oncoimmunology. 2012 Oct 1;1(7):1218-1219.


Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91.

Cirone M, Di Renzo L, Lotti LV, Conte V, Trivedi P, Santarelli R, Gonnella R, Frati L, Faggioni A.

PLoS One. 2012;7(3):e31732. doi: 10.1371/journal.pone.0031732. Epub 2012 Mar 7.


Identification and characterization of the product encoded by ORF69 of Kaposi's sarcoma-associated herpesvirus.

Santarelli R, Farina A, Granato M, Gonnella R, Raffa S, Leone L, Bei R, Modesti A, Frati L, Torrisi MR, Faggioni A.

J Virol. 2008 May;82(9):4562-72. doi: 10.1128/JVI.02400-07. Epub 2008 Feb 27.


Deletion of Epstein-Barr virus BFLF2 leads to impaired viral DNA packaging and primary egress as well as to the production of defective viral particles.

Granato M, Feederle R, Farina A, Gonnella R, Santarelli R, Hub B, Faggioni A, Delecluse HJ.

J Virol. 2008 Apr;82(8):4042-51. doi: 10.1128/JVI.02436-07. Epub 2008 Feb 20.


Regulation of the expression of the Epstein-Barr virus early gene BFRF1.

Granato M, Farina A, Gonnella R, Santarelli R, Frati L, Faggioni A, Angeloni A.

Virology. 2006 Mar 30;347(1):109-16. Epub 2006 Jan 9.


Characterization and intracellular localization of the Epstein-Barr virus protein BFLF2: interactions with BFRF1 and with the nuclear lamina.

Gonnella R, Farina A, Santarelli R, Raffa S, Feederle R, Bei R, Granato M, Modesti A, Frati L, Delecluse HJ, Torrisi MR, Angeloni A, Faggioni A.

J Virol. 2005 Mar;79(6):3713-27.


BFRF1 of Epstein-Barr virus is essential for efficient primary viral envelopment and egress.

Farina A, Feederle R, Raffa S, Gonnella R, Santarelli R, Frati L, Angeloni A, Torrisi MR, Faggioni A, Delecluse HJ.

J Virol. 2005 Mar;79(6):3703-12.


Expression of tumor necrosis factor receptor-associated factor 1 in nasopharyngeal carcinoma: possible upregulation by Epstein-Barr virus latent membrane protein 1.

Siegler G, Meyer B, Dawson C, Brachtel E, Lennerz J, Koch C, Kremmer E, Niedobitek E, Gonnella R, Pilch BZ, Young LS, Niedobitek G.

Int J Cancer. 2004 Nov 1;112(2):265-72.


Intracellular localization of the Epstein-Barr virus BFRF1 gene product in lymphoid cell lines and oral hairy leukoplakia lesions.

Farina A, Cardinali G, Santarelli R, Gonnella R, Webster-Cyriaque J, Bei R, Muraro R, Frati L, Angeloni A, Torrisi MR, Faggioni A.

J Med Virol. 2004 Jan;72(1):102-11.


The BFRF1 gene of Epstein-Barr virus encodes a novel protein.

Farina A, Santarelli R, Gonnella R, Bei R, Muraro R, Cardinali G, Uccini S, Ragona G, Frati L, Faggioni A, Angeloni A.

J Virol. 2000 Apr;74(7):3235-44.


Lack of serologic association between human herpesvirus-8 infection and multiple myeloma and monoclonal gammopathies of undetermined significance.

Santarelli R, Angeloni A, Farina A, Gonnella R, Gentile G, Martino P, Petrucci MT, Mandelli F, Frati L, Faggioni A.

J Natl Cancer Inst. 1998 May 20;90(10):781-2. No abstract available.


Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.

Gires O, Zimber-Strobl U, Gonnella R, Ueffing M, Marschall G, Zeidler R, Pich D, Hammerschmidt W.

EMBO J. 1997 Oct 15;16(20):6131-40.


Human herpesvirus 8 DNA sequences in CD8+ T cells.

Sirianni MC, Vincenzi L, Topino S, Scala E, Angeloni A, Gonnella R, Uccini S, Faggioni A.

J Infect Dis. 1997 Aug;176(2):541. No abstract available.


Transcription of latent and replicative Epstein-Barr-virus genes in bone-marrow and peripheral-blood mononuclear cells of healthy donors.

Gonnella R, Angeloni A, Calogero A, Farina A, Santarelli R, Gentile G, Arcese W, Martino P, Mandelli F, Frati L, Faggioni A, Ragona G.

Int J Cancer. 1997 Mar 4;70(5):524-9.


[Acute amanita phalloides poisoning in the second pregnancy trimester].

Dolfi F, Gonnella R.

Minerva Anestesiol. 1994 Mar;60(3):153-4. Italian.


HHV-6 infection in Italy: characterization of an endemic isolate and seroepidemiologic analysis.

Ragona G, Calogero A, Cirone M, Cuomo L, Gonnella R, Zompetta C, Gentile G, Martino P, Menichella D, Frati L, Faggioni A.

Clin Diagn Virol. 1994 Jan;1(5-6):261-70.


Two genes encoding putative mitochondrial alcohol dehydrogenases are present in the yeast Kluyveromyces lactis.

Saliola M, Gonnella R, Mazzoni C, Falcone C.

Yeast. 1991 May-Jun;7(4):391-400.


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