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Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.

Shiga Y, Shiga A, Mesci P, Kwon H, Brifault C, Kim JH, Jeziorski JJ, Nasamran C, Ohtori S, Muotri AR, Gonias SL, Campana WM.

Sci Rep. 2019 Dec 17;9(1):19291. doi: 10.1038/s41598-019-55132-8.


Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines.

Pontecorvi P, Banki MA, Zampieri C, Zalfa C, Azmoon P, Kounnas MZ, Marchese C, Gonias SL, Mantuano E.

J Neuroinflammation. 2019 Dec 6;16(1):257. doi: 10.1186/s12974-019-1657-3.


Plasminogen Receptors in Human Malignancies: Effects on Prognosis and Feasibility as Targets for Drug Development.

Gonias SL, Zampieri C.

Curr Drug Targets. 2019 Nov 21. doi: 10.2174/1389450120666191122101658. [Epub ahead of print]


Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages.

Das L, Azmoon P, Banki MA, Mantuano E, Gonias SL.

PLoS One. 2019 Nov 7;14(11):e0224738. doi: 10.1371/journal.pone.0224738. eCollection 2019.


Hepatocyte tPA: where have you been hiding?

Gonias SL.

Blood. 2019 Feb 14;133(7):631-632. doi: 10.1182/blood-2018-12-891515. No abstract available.


LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.

Brifault C, Kwon H, Campana WM, Gonias SL.

Glia. 2019 Jun;67(6):1210-1224. doi: 10.1002/glia.23599. Epub 2019 Feb 11.


Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin.

Zalfa C, Azmoon P, Mantuano E, Gonias SL.

J Leukoc Biol. 2019 Apr;105(4):729-740. doi: 10.1002/JLB.3A0818-329RRR. Epub 2019 Jan 28.


Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity.

Gonias SL.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2548-2549. doi: 10.1161/ATVBAHA.118.311882. No abstract available.


PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology.

Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E.

J Cell Sci. 2018 Jul 26;131(14). pii: jcs217083. doi: 10.1242/jcs.217083.


Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury.

Poplawski G, Ishikawa T, Brifault C, Lee-Kubli C, Regestam R, Henry KW, Shiga Y, Kwon H, Ohtori S, Gonias SL, Campana WM.

Glia. 2018 Aug;66(8):1577-1590. doi: 10.1002/glia.23325. Epub 2018 Mar 9.


The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres.

Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL.

Sci Rep. 2018 Feb 14;8(1):2982. doi: 10.1038/s41598-018-21358-1.


Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival.

Gonias SL, Karimi-Mostowfi N, Murray SS, Mantuano E, Gilder AS.

PLoS One. 2017 Oct 31;12(10):e0186649. doi: 10.1371/journal.pone.0186649. eCollection 2017.


Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation.

Brifault C, Gilder AS, Laudati E, Banki M, Gonias SL.

J Biol Chem. 2017 Nov 10;292(45):18699-18712. doi: 10.1074/jbc.M117.798413. Epub 2017 Sep 28.


Tissue-type plasminogen activator regulates macrophage activation and innate immunity.

Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL.

Blood. 2017 Sep 14;130(11):1364-1374. doi: 10.1182/blood-2017-04-780205. Epub 2017 Jul 6.


Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells.

Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL.

FASEB J. 2017 Apr;31(4):1744-1755. doi: 10.1096/fj.201601121R. Epub 2017 Jan 10.


Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion.

Gilder AS, Wang L, Natali L, Karimi-Mostowfi N, Brifault C, Gonias SL.

PLoS One. 2016 Dec 15;11(12):e0168418. doi: 10.1371/journal.pone.0168418. eCollection 2016.


Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells.

Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM.

Neuroreport. 2016 Dec 14;27(18):1305-1311.


mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer.

Hau AM, Leivo MZ, Gilder AS, Hu JJ, Gonias SL, Hansel DE.

Cell Signal. 2017 Jan;29:96-106. doi: 10.1016/j.cellsig.2016.10.010. Epub 2016 Oct 21.


The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains.

Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E.

Mol Cell Neurosci. 2016 Oct;76:42-51. doi: 10.1016/j.mcn.2016.08.006. Epub 2016 Aug 23.


LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response.

Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias SL.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1369-74. doi: 10.1073/pnas.1515480113. Epub 2016 Jan 19.


Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature.

Jones KA, Gilder AS, Lam MS, Du N, Banki MA, Merati A, Pizzo DP, VandenBerg SR, Gonias SL.

Neuro Oncol. 2016 May;18(5):667-78. doi: 10.1093/neuonc/nov243. Epub 2015 Sep 29.


Urokinase receptor and resistance to targeted anticancer agents.

Gonias SL, Hu J.

Front Pharmacol. 2015 Jul 27;6:154. doi: 10.3389/fphar.2015.00154. eCollection 2015. Review.


The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration.

Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL.

J Cell Sci. 2015 Sep 15;128(18):3478-88. doi: 10.1242/jcs.173765. Epub 2015 Aug 13.


Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion.

Gilder AS, Jones KA, Hu J, Wang L, Chen CC, Carter BS, Gonias SL.

J Biol Chem. 2015 Jun 12;290(24):14798-809. doi: 10.1074/jbc.M115.637488. Epub 2015 Apr 2.


A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.

Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB.

Cancer Res. 2015 Jan 15;75(2):394-404. doi: 10.1158/0008-5472.CAN-14-2004. Epub 2014 Nov 28.


Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.

Hu J, Muller KA, Furnari FB, Cavenee WK, VandenBerg SR, Gonias SL.

Oncogene. 2015 Jul 30;34(31):4078-88. doi: 10.1038/onc.2014.336. Epub 2014 Oct 27.


uPAR induces expression of transforming growth factor β and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.

Hu J, Jo M, Eastman BM, Gilder AS, Bui JD, Gonias SL.

Am J Pathol. 2014 Dec;184(12):3384-93. doi: 10.1016/j.ajpath.2014.08.003. Epub 2014 Oct 11.


Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.

Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR 3rd, Klemke R, Gonias SL, Coppinger JA.

Mol Cell Proteomics. 2015 Jan;14(1):1-14. doi: 10.1074/mcp.M114.037697. Epub 2014 Jul 5.


Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.

Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P.

J Clin Invest. 2014 Mar;124(3):1199-213. doi: 10.1172/JCI70647. Epub 2014 Feb 17.


Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion.

Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE.

PLoS One. 2013 Nov 27;8(11):e81081. doi: 10.1371/journal.pone.0081081. eCollection 2013.


LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.

Mantuano E, Lam MS, Gonias SL.

J Biol Chem. 2013 Nov 22;288(47):34009-18. doi: 10.1074/jbc.M113.509133. Epub 2013 Oct 15.


LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system.

Gonias SL, Campana WM.

Am J Pathol. 2014 Jan;184(1):18-27. doi: 10.1016/j.ajpath.2013.08.029. Epub 2013 Oct 12. Review.


Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors.

Staudt ND, Jo M, Hu J, Bristow JM, Pizzo DP, Gaultier A, VandenBerg SR, Gonias SL.

Cancer Res. 2013 Jul 1;73(13):3902-12. doi: 10.1158/0008-5472.CAN-12-4233. Epub 2013 Apr 30.


Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain.

Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM.

J Neurosci. 2013 Mar 27;33(13):5590-602. doi: 10.1523/JNEUROSCI.3342-12.2013.


Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris.

Fernandez-Castaneda A, Arandjelovic S, Stiles TL, Schlobach RK, Mowen KA, Gonias SL, Gaultier A.

J Biol Chem. 2013 Feb 15;288(7):4538-48. doi: 10.1074/jbc.M112.384693. Epub 2012 Dec 21.


LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.

Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL.

J Cell Sci. 2013 Jan 1;126(Pt 1):209-20. doi: 10.1242/jcs.113191. Epub 2012 Nov 6.


Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.

Bristow JM, Reno TA, Jo M, Gonias SL, Klemke RL.

J Biol Chem. 2013 Jan 4;288(1):123-31. doi: 10.1074/jbc.M112.410910. Epub 2012 Oct 26.


A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen.

Eastman BM, Jo M, Webb DL, Takimoto S, Gonias SL.

Cell Signal. 2012 Sep;24(9):1847-55. doi: 10.1016/j.cellsig.2012.05.011. Epub 2012 May 19.


The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury.

Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM.

J Neurosci. 2011 Sep 21;31(38):13376-85. doi: 10.1523/JNEUROSCI.2850-11.2011.


Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.

Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias SL.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15984-9. doi: 10.1073/pnas.1113416108. Epub 2011 Sep 6.


Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1).

Gonias SL, Gaultier A, Jo M.

Curr Pharm Des. 2011;17(19):1962-9. Review.


Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion.

Endsley MP, Hu Y, Deng Y, He X, Warejcka DJ, Twining SS, Gonias SL, Zhang M.

J Biol Chem. 2011 Jul 15;286(28):24599-607. doi: 10.1074/jbc.M111.235788. Epub 2011 May 23.


Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1.

Shi Y, Yamauchi T, Gaultier A, Takimoto S, Campana WM, Gonias SL.

J Neurosci Res. 2011 Apr;89(4):544-51. doi: 10.1002/jnr.22576. Epub 2011 Feb 2.


Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells.

Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL.

Cancer Res. 2010 Nov 1;70(21):8948-58. doi: 10.1158/0008-5472.CAN-10-1936. Epub 2010 Oct 12.


LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome.

Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt BF 3rd, Gonias SL.

J Proteome Res. 2010 Dec 3;9(12):6689-95. doi: 10.1021/pr1008288. Epub 2010 Oct 28.


Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.

Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL.

J Leukoc Biol. 2010 Oct;88(4):769-78. doi: 10.1189/jlb.0410220. Epub 2010 Jul 7.


Factor XII bridges coagulation and fibrinolysis again.

Gonias SL.

Blood. 2010 Jun 17;115(24):4979-80. doi: 10.1182/blood-2010-03-275263. No abstract available.


Iron control of erythroid development by a novel aconitase-associated regulatory pathway.

Bullock GC, Delehanty LL, Talbot AL, Gonias SL, Tong WH, Rouault TA, Dewar B, Macdonald JM, Chruma JJ, Goldfarb AN.

Blood. 2010 Jul 8;116(1):97-108. doi: 10.1182/blood-2009-10-251496. Epub 2010 Apr 20.


Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration.

Mantuano E, Jo M, Gonias SL, Campana WM.

J Biol Chem. 2010 May 7;285(19):14259-66. doi: 10.1074/jbc.M109.085126. Epub 2010 Mar 2.


LRP1 regulates remodeling of the extracellular matrix by fibroblasts.

Gaultier A, Hollister M, Reynolds I, Hsieh EH, Gonias SL.

Matrix Biol. 2010 Jan;29(1):22-30. doi: 10.1016/j.matbio.2009.08.003. Epub 2009 Aug 20.

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