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Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products.

Ting CP, Funk MA, Halaby SL, Zhang Z, Gonen T, van der Donk WA.

Science. 2019 Jul 19;365(6450):280-284. doi: 10.1126/science.aau6232.


The cryo-EM method microcrystal electron diffraction (MicroED).

Nannenga BL, Gonen T.

Nat Methods. 2019 May;16(5):369-379. doi: 10.1038/s41592-019-0395-x. Epub 2019 Apr 29. Review.


MicroED data collection with SerialEM.

de la Cruz MJ, Martynowycz MW, Hattne J, Gonen T.

Ultramicroscopy. 2019 Jun;201:77-80. doi: 10.1016/j.ultramic.2019.03.009. Epub 2019 Mar 19.


Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.

Zee CT, Glynn C, Gallagher-Jones M, Miao J, Santiago CG, Cascio D, Gonen T, Sawaya MR, Rodriguez JA.

IUCrJ. 2019 Jan 24;6(Pt 2):197-205. doi: 10.1107/S2052252518017621. eCollection 2019 Mar 1.


Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size.

Martynowycz MW, Zhao W, Hattne J, Jensen GJ, Gonen T.

Structure. 2019 Mar 5;27(3):545-548.e2. doi: 10.1016/j.str.2018.12.003. Epub 2019 Jan 17.


Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS.

Ma J, Lei HT, Reyes FE, Sanchez-Martinez S, Sarhan MF, Hattne J, Gonen T.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2086-2090. doi: 10.1073/pnas.1806206116. Epub 2019 Jan 18.


YKL-40 is a local marker for inflammation in patients with pseudoexfoliation syndrome.

Gonen T, Guzel S, Keskinbora KH.

Eye (Lond). 2019 May;33(5):772-776. doi: 10.1038/s41433-018-0308-8. Epub 2018 Dec 18.


The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination.

Jones CG, Martynowycz MW, Hattne J, Fulton TJ, Stoltz BM, Rodriguez JA, Nelson HM, Gonen T.

ACS Cent Sci. 2018 Nov 28;4(11):1587-1592. doi: 10.1021/acscentsci.8b00760. Epub 2018 Nov 2.


MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat.

Purdy MD, Shi D, Chrustowicz J, Hattne J, Gonen T, Yeager M.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13258-13263. doi: 10.1073/pnas.1806806115. Epub 2018 Dec 10.


MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter.

Liu S, Gonen T.

Commun Biol. 2018;1:38. doi: 10.1038/s42003-018-0040-8. Epub 2018 May 3.


MicroED: a versatile cryoEM method for structure determination.

Nannenga BL, Gonen T.

Emerg Top Life Sci. 2018 Apr 20;2(1):1-8. doi: 10.1042/ETLS20170082. Epub 2018 Feb 6.


From electron crystallography of 2D crystals to MicroED of 3D crystals.

Martynowycz MW, Gonen T.

Curr Opin Colloid Interface Sci. 2018 Mar;34:9-16. doi: 10.1016/j.cocis.2018.01.010. Epub 2018 Jan 31.


Altered reward-related neural responses in non-manifesting carriers of the Parkinson disease related LRRK2 mutation.

Thaler A, Gonen T, Mirelman A, Helmich RC, Gurevich T, Orr-Urtreger A, Bloem BR, Giladi N, Hendler T; LRRK2 Ashkenazi Jewish consortium.

Brain Imaging Behav. 2019 Aug;13(4):1009-1020. doi: 10.1007/s11682-018-9920-2.


Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state.

Lei HT, Ma J, Sanchez Martinez S, Gonen T.

Nat Struct Mol Biol. 2018 Jun;25(6):522-527. doi: 10.1038/s41594-018-0072-2. Epub 2018 Jun 5.


Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study.

Abend R, Sar-El R, Gonen T, Jalon I, Vaisvaser S, Bar-Haim Y, Hendler T.

Neuromodulation. 2018 May 9. doi: 10.1111/ner.12787. [Epub ahead of print]


Analysis of Global and Site-Specific Radiation Damage in Cryo-EM.

Hattne J, Shi D, Glynn C, Zee CT, Gallagher-Jones M, Martynowycz MW, Rodriguez JA, Gonen T.

Structure. 2018 May 1;26(5):759-766.e4. doi: 10.1016/j.str.2018.03.021. Epub 2018 Apr 26.


Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS.

Nat Struct Mol Biol. 2018 Apr;25(4):311-319. doi: 10.1038/s41594-018-0045-5. Epub 2018 Mar 12.


Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system.

Liu Y, Gonen S, Gonen T, Yeates TO.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3362-3367. doi: 10.1073/pnas.1718825115. Epub 2018 Mar 5.



Berger A, Tellem R, Arad M, Hochberg U, Gonen T, Strauss I.

Harefuah. 2018 Feb;157(2):108-111. Review. Hebrew.


Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS.

Science. 2018 Feb 9;359(6376):698-701. doi: 10.1126/science.aan6398.


Structure-based inhibitors of tau aggregation.

Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS.

Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20.


Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA.

Nat Struct Mol Biol. 2018 Feb;25(2):131-134. doi: 10.1038/s41594-017-0018-0. Epub 2018 Jan 15.


Double Anterior Stereotactic Cingulotomy for Intractable Oncological Pain.

Strauss I, Berger A, Ben Moshe S, Arad M, Hochberg U, Gonen T, Tellem R.

Stereotact Funct Neurosurg. 2017;95(6):400-408. doi: 10.1159/000484613. Epub 2018 Jan 10.


Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS.

J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27.


MicroED Structure of Au146(p-MBA)57 at Subatomic Resolution Reveals a Twinned FCC Cluster.

Vergara S, Lukes DA, Martynowycz MW, Santiago U, Plascencia-Villa G, Weiss SC, de la Cruz MJ, Black DM, Alvarez MM, López-Lozano X, Barnes CO, Lin G, Weissker HC, Whetten RL, Gonen T, Yacaman MJ, Calero G.

J Phys Chem Lett. 2017 Nov 16;8(22):5523-5530. doi: 10.1021/acs.jpclett.7b02621. Epub 2017 Oct 31.


Robust inter-subject audiovisual decoding in functional magnetic resonance imaging using high-dimensional regression.

Raz G, Svanera M, Singer N, Gilam G, Cohen MB, Lin T, Admon R, Gonen T, Thaler A, Granot RY, Goebel R, Benini S, Valente G.

Neuroimage. 2017 Dec;163:244-263. doi: 10.1016/j.neuroimage.2017.09.032. Epub 2017 Sep 20.


The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.

Wright ZVF, McCarthy S, Dickman R, Reyes FE, Sanchez-Martinez S, Cryar A, Kilford I, Hall A, Takle AK, Topf M, Gonen T, Thalassinos K, Tabor AB.

J Am Chem Soc. 2017 Sep 20;139(37):13063-13075. doi: 10.1021/jacs.7b06506. Epub 2017 Sep 7.


Intra-operative multi-site stimulation: Expanding methodology for cortical brain mapping of language functions.

Gonen T, Gazit T, Korn A, Kirschner A, Perry D, Hendler T, Ram Z.

PLoS One. 2017 Jul 10;12(7):e0180740. doi: 10.1371/journal.pone.0180740. eCollection 2017.


Taking the measure of MicroED.

Rodriguez JA, Eisenberg DS, Gonen T.

Curr Opin Struct Biol. 2017 Oct;46:79-86. doi: 10.1016/ Epub 2017 Jun 22. Review.


Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.

de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T.

Nat Methods. 2017 Feb 13;14(4):399-402. doi: 10.1038/nmeth.4178.


Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS.

Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273.


Surgery-Independent Language Function Decline in Patients Undergoing Awake Craniotomy.

Gonen T, Sela G, Yanakee R, Ram Z, Grossman R.

World Neurosurg. 2017 Mar;99:674-679. doi: 10.1016/j.wneu.2016.12.081. Epub 2016 Dec 27.


The role of oxytocin in modulating interpersonal space: A pharmacological fMRI study.

Cohen D, Perry A, Gilam G, Mayseless N, Gonen T, Hendler T, Shamay-Tsoory SG.

Psychoneuroendocrinology. 2017 Feb;76:77-83. doi: 10.1016/j.psyneuen.2016.10.021. Epub 2016 Nov 10.


Corrigendum: Design of a hyperstable 60-subunit protein icosahedron.

Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D.

Nature. 2016 Dec 1;540(7631):150. doi: 10.1038/nature20108. Epub 2016 Oct 19. No abstract available.


Dynamics of FLAIR Volume Changes in Glioblastoma and Prediction of Survival.

Grossman R, Shimony N, Shir D, Gonen T, Sitt R, Kimchi TJ, Harosh CB, Ram Z.

Ann Surg Oncol. 2017 Mar;24(3):794-800. doi: 10.1245/s10434-016-5635-z. Epub 2016 Oct 20.


MicroED opens a new era for biological structure determination.

Nannenga BL, Gonen T.

Curr Opin Struct Biol. 2016 Oct;40:128-135. doi: 10.1016/ Epub 2016 Oct 1. Review.


Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.

Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11232-11236. Epub 2016 Sep 19.


High-Resolution Macromolecular Structure Determination by MicroED, a cryo-EM Method.

Rodriguez JA, Gonen T.

Methods Enzymol. 2016;579:369-92. doi: 10.1016/bs.mie.2016.04.017. Epub 2016 Jun 16. Review.


Treatment of mixed astigmatism: early clinical outcomes withWaveLight and Technolas excimer lasers.

Kilavuzoğlu AE, Gönen T, Çelebi AR, Coşar Yurteri CB, Şener AB.

Turk J Med Sci. 2016 Apr 19;46(3):664-72. doi: 10.3906/sag-1504-35.


Psychophysiological whole-brain network clustering based on connectivity dynamics analysis in naturalistic conditions.

Raz G, Shpigelman L, Jacob Y, Gonen T, Benjamini Y, Hendler T.

Hum Brain Mapp. 2016 Dec;37(12):4654-4672. doi: 10.1002/hbm.23335. Epub 2016 Aug 1.


Accurate design of megadalton-scale two-component icosahedral protein complexes.

Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D.

Science. 2016 Jul 22;353(6297):389-94. doi: 10.1126/science.aaf8818.


Atomic resolution structure determination by the cryo-EM method MicroED.

Liu S, Hattne J, Reyes FE, Sanchez-Martinez S, Jason de la Cruz M, Shi D, Gonen T.

Protein Sci. 2017 Jan;26(1):8-15. doi: 10.1002/pro.2989. Epub 2016 Aug 19. Review.


Design of a hyperstable 60-subunit protein dodecahedron. [corrected].

Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D.

Nature. 2016 Jul 7;535(7610):136-9. doi: 10.1038/nature18010. Epub 2016 Jun 15. Erratum in: Nature. 2016 Dec 1;540(7631):150.


Modeling truncated pixel values of faint reflections in MicroED images.

Hattne J, Shi D, de la Cruz MJ, Reyes FE, Gonen T.

J Appl Crystallogr. 2016 May 11;49(Pt 3):1029-1034. eCollection 2016 Jun 1.


Functional connectivity dynamics during film viewing reveal common networks for different emotional experiences.

Raz G, Touroutoglou A, Wilson-Mendenhall C, Gilam G, Lin T, Gonen T, Jacob Y, Atzil S, Admon R, Bleich-Cohen M, Maron-Katz A, Hendler T, Barrett LF.

Cogn Affect Behav Neurosci. 2016 Aug;16(4):709-23. doi: 10.3758/s13415-016-0425-4.


The collection of MicroED data for macromolecular crystallography.

Shi D, Nannenga BL, de la Cruz MJ, Liu J, Sawtelle S, Calero G, Reyes FE, Hattne J, Gonen T.

Nat Protoc. 2016 May;11(5):895-904. doi: 10.1038/nprot.2016.046. Epub 2016 Apr 14.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


Human mesostriatal response tracks motivational tendencies under naturalistic goal conflict.

Gonen T, Soreq E, Eldar E, Ben-Simon E, Raz G, Hendler T.

Soc Cogn Affect Neurosci. 2016 Jun;11(6):961-72. doi: 10.1093/scan/nsw014. Epub 2016 Feb 1.


Probabilistic machine learning for the evaluation of presurgical language dominance.

Gazit T, Andelman F, Glikmann-Johnston Y, Gonen T, Solski A, Shapira-Lichter I, Ovadia M, Kipervasser S, Neufeld MY, Fried I, Hendler T, Perry D.

J Neurosurg. 2016 Aug;125(2):481-93. doi: 10.3171/2015.7.JNS142568. Epub 2016 Jan 1.


Structure of the toxic core of α-synuclein from invisible crystals.

Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS.

Nature. 2015 Sep 24;525(7570):486-90. doi: 10.1038/nature15368. Epub 2015 Sep 9.

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