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Items: 28


Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.

Braten O, Livneh I, Ziv T, Admon A, Kehat I, Caspi LH, Gonen H, Bercovich B, Godzik A, Jahandideh S, Jaroszewski L, Sommer T, Kwon YT, Guharoy M, Tompa P, Ciechanover A.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4639-47. doi: 10.1073/pnas.1608644113. Epub 2016 Jul 6.


KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.

Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A.

Cell. 2015 Apr 9;161(2):333-47. doi: 10.1016/j.cell.2015.03.001.


Mining level of control in medical organizations.

Çalimli O, Türkeli S, Eken EG, Gönen HE.

Stud Health Technol Inform. 2014;205:328-32.


The effects of different ventilator modes on cerebral tissue oxygen saturation in patients with bidirectional superior cavopulmonary connection.

Türköz A, Balcı ŞT, Gönen H, Çınar Ö, Özker E, Türköz R.

Ann Card Anaesth. 2014 Jan-Mar;17(1):10-5. doi: 10.4103/0971-9784.124122.


X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein.

Bornstein B, Edison N, Gottfried Y, Lev T, Shekhtman A, Gonen H, Rajalingam K, Larisch S.

Int J Biochem Cell Biol. 2012 Mar;44(3):489-95. doi: 10.1016/j.biocel.2011.12.005. Epub 2011 Dec 14.


Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

Herman-Bachinsky Y, Ryoo HD, Ciechanover A, Gonen H.

Cell Death Differ. 2007 Apr;14(4):861-71. Epub 2007 Jan 5.


Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation.

Lotan R, Rotem A, Gonen H, Finberg JP, Kemeny S, Steller H, Ciechanover A, Larisch S.

J Biol Chem. 2005 Jul 8;280(27):25802-10. Epub 2005 Apr 18.


A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1.

Nadav E, Shmueli A, Barr H, Gonen H, Ciechanover A, Reiss Y.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):91-7.


Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

Ryoo HD, Bergmann A, Gonen H, Ciechanover A, Steller H.

Nat Cell Biol. 2002 Jun;4(6):432-8. Erratum in: Nat Cell Biol 2002 Jul;4(7):546.


Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.

Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israël A.

J Biol Chem. 2001 Sep 14;276(37):34371-8. Epub 2001 Jun 25.


Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.

Ciechanover A, Gonen H, Bercovich B, Cohen S, Fajerman I, Israël A, Mercurio F, Kahana C, Schwartz AL, Iwai K, Orian A.

Biochimie. 2001 Mar-Apr;83(3-4):341-9.


SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase.

Orian A, Gonen H, Bercovich B, Fajerman I, Eytan E, Israël A, Mercurio F, Iwai K, Schwartz AL, Ciechanover A.

EMBO J. 2000 Jun 1;19(11):2580-91.


Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A.

J Biol Chem. 1999 May 21;274(21):14823-30.


Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding.

Abu Hatoum O, Gross-Mesilaty S, Breitschopf K, Hoffman A, Gonen H, Ciechanover A, Bengal E.

Mol Cell Biol. 1998 Oct;18(10):5670-7.


Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase.

Yaron A, Gonen H, Alkalay I, Hatzubai A, Jung S, Beyth S, Mercurio F, Manning AM, Ciechanover A, Ben-Neriah Y.

EMBO J. 1997 Nov 3;16(21):6486-94.


On the involvement of calpains in the degradation of the tumor suppressor protein p53.

Gonen H, Shkedy D, Barnoy S, Kosower NS, Ciechanover A.

FEBS Lett. 1997 Apr 7;406(1-2):17-22.


Isolation, characterization, and partial purification of a novel ubiquitin-protein ligase, E3. Targeting of protein substrates via multiple and distinct recognition signals and conjugating enzymes.

Gonen H, Stancovski I, Shkedy D, Hadari T, Bercovich B, Bengal E, Mesilati S, Abu-Hatoum O, Schwartz AL, Ciechanover A.

J Biol Chem. 1996 Jan 5;271(1):302-10.


The 26S proteasome of the yeast Saccharomyces cerevisiae.

Fischer M, Hilt W, Richter-Ruoff B, Gonen H, Ciechanover A, Wolf DH.

FEBS Lett. 1994 Nov 21;355(1):69-75.


Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu.

Gonen H, Smith CE, Siegel NR, Kahana C, Merrick WC, Chakraburtty K, Schwartz AL, Ciechanover A.

Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7648-52.


Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates.

Blumenfeld N, Gonen H, Mayer A, Smith CE, Siegel NR, Schwartz AL, Ciechanover A.

J Biol Chem. 1994 Apr 1;269(13):9574-81.


Degradation of proteins by the ubiquitin-mediated proteolytic pathway.

Ciechanover A, Gonen H, Elias S, Mayer A.

New Biol. 1990 Mar;2(3):227-34. Review.


In vitro transformation of chondroprogenitor cells into osteoblasts and the formation of new membrane bone.

Silbermann M, Lewinson D, Gonen H, Lizarbe MA, von der Mark K.

Anat Rec. 1983 Aug;206(4):373-83.


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