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Items: 10


Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.

Gillis A, Gondin AB, Kliewer A, Sanchez J, Lim HD, Alamein C, Manandhar P, Santiago M, Fritzwanker S, Schmidel F, Katte TA, Reekie T, Grimsey NL, Kassiou M, Kellam B, Krasel C, Halls ML, Connor M, Lane JR, Schulz S, Christie MJ, Canals M.

Sci Signal. 2020 Mar 31;13(625). pii: eaaz3140. doi: 10.1126/scisignal.aaz3140.


Opioid pharmacology under the microscope.

Jullé D, Gondin AB, Von Zastrow ME, Canals M.

Mol Pharmacol. 2020 Mar 20. pii: mol.119.119321. doi: 10.1124/mol.119.119321. [Epub ahead of print]


Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks.

Civciristov S, Huang C, Liu B, Marquez EA, Gondin AB, Schittenhelm RB, Ellisdon AM, Canals M, Halls ML.

J Biol Chem. 2019 Nov 1;294(44):16198-16213. doi: 10.1074/jbc.RA119.008685. Epub 2019 Sep 12.


GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization.

Gondin AB, Halls ML, Canals M, Briddon SJ.

Front Mol Neurosci. 2019 May 1;12:104. doi: 10.3389/fnmol.2019.00104. eCollection 2019.


Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.

DiCello JJ, Rajasekhar P, Eriksson EM, Saito A, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G79-G89. doi: 10.1152/ajpgi.00085.2019. Epub 2019 May 15.


Agonist-dependent development of delta opioid receptor tolerance in the colon.

DiCello JJ, Saito A, Rajasekhar P, Sebastian BW, McQuade RM, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP.

Cell Mol Life Sci. 2019 Aug;76(15):3033-3050. doi: 10.1007/s00018-019-03077-6. Epub 2019 Mar 23.


G protein-coupled receptor trafficking and signaling: new insights into the enteric nervous system.

Carbone SE, Veldhuis NA, Gondin AB, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G446-G452. doi: 10.1152/ajpgi.00406.2018. Epub 2019 Jan 31. Review.


Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.

Miess E, Gondin AB, Yousuf A, Steinborn R, Mösslein N, Yang Y, Göldner M, Ruland JG, Bünemann M, Krasel C, Christie MJ, Halls ML, Schulz S, Canals M.

Sci Signal. 2018 Jul 17;11(539). pii: eaas9609. doi: 10.1126/scisignal.aas9609.


Fluorescently Labeled Morphine Derivatives for Bioimaging Studies.

Lam R, Gondin AB, Canals M, Kellam B, Briddon SJ, Graham B, Scammells PJ.

J Med Chem. 2018 Feb 8;61(3):1316-1329. doi: 10.1021/acs.jmedchem.7b01811. Epub 2018 Jan 10.


Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.

Halls ML, Yeatman HR, Nowell CJ, Thompson GL, Gondin AB, Civciristov S, Bunnett NW, Lambert NA, Poole DP, Canals M.

Sci Signal. 2016 Feb 9;9(414):ra16. doi: 10.1126/scisignal.aac9177.


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