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Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells.

Wolf B, Busso C, Gönczy P.

Nat Commun. 2019 Jun 28;10(1):2859. doi: 10.1038/s41467-019-10446-z.


Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans.

Klinkert K, Levernier N, Gross P, Gentili C, von Tobel L, Pierron M, Busso C, Herrman S, Grill SW, Kruse K, Gönczy P.

Elife. 2019 Feb 26;8. pii: e44552. doi: 10.7554/eLife.44552.


Centriole assembly at a glance.

Gönczy P, Hatzopoulos GN.

J Cell Sci. 2019 Feb 20;132(4). pii: jcs228833. doi: 10.1242/jcs.228833. Review.


Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment.

Bezler A, Braukmann F, West SM, Duplan A, Conconi R, Schütz F, Gönczy P, Piano F, Gunsalus K, Miska EA, Keller L.

PLoS Genet. 2019 Feb 8;15(2):e1007905. doi: 10.1371/journal.pgen.1007905. eCollection 2019 Feb.


Multicolor single-particle reconstruction of protein complexes.

Sieben C, Banterle N, Douglass KM, Gönczy P, Manley S.

Nat Methods. 2018 Oct;15(10):777-780. doi: 10.1038/s41592-018-0140-x. Epub 2018 Oct 1.


Correction: PI(4,5)P2 forms dynamic cortical structures and directs actin distribution as well as polarity in Caenorhabditis elegans embryos (doi: 10.1242/dev.164988).

Scholze MJ, Barbieux KS, De Simone A, Boumasmoud M, Süess CCN, Wang R, Gönczy P.

Development. 2018 Jul 3;145(13). pii: dev169144. doi: 10.1242/dev.169144. No abstract available.


Integrated Microfluidic Device for Drug Studies of Early C. Elegans Embryogenesis.

Dong L, Jankele R, Cornaglia M, Lehnert T, Gönczy P, Gijs MAM.

Adv Sci (Weinh). 2018 Mar 8;5(5):1700751. doi: 10.1002/advs.201700751. eCollection 2018 May.


High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6.

Nievergelt AP, Banterle N, Andany SH, Gönczy P, Fantner GE.

Nat Nanotechnol. 2018 Aug;13(8):696-701. doi: 10.1038/s41565-018-0149-4. Epub 2018 May 21.


Reconstruction From Multiple Particles for 3D Isotropic Resolution in Fluorescence Microscopy.

Fortun D, Guichard P, Hamel V, Sorzano COS, Banterle N, Gonczy P, Unser M.

IEEE Trans Med Imaging. 2018 May;37(5):1235-1246. doi: 10.1109/TMI.2018.2795464.


PI(4,5)P2 forms dynamic cortical structures and directs actin distribution as well as polarity in Caenorhabditis elegans embryos.

Scholze MJ, Barbieux KS, De Simone A, Boumasmoud M, Süess CCN, Wang R, Gönczy P.

Development. 2018 May 30;145(11). pii: dev164988. doi: 10.1242/dev.164988. Erratum in: Development. 2018 Jul 3;145(13):.


The Rise of the Cartwheel: Seeding the Centriole Organelle.

Guichard P, Hamel V, Gönczy P.

Bioessays. 2018 Apr;40(4):e1700241. doi: 10.1002/bies.201700241. Epub 2018 Mar 6. Review.


Uncovering the balance of forces driving microtubule aster migration in C. elegans zygotes.

De Simone A, Spahr A, Busso C, Gönczy P.

Nat Commun. 2018 Mar 5;9(1):938. doi: 10.1038/s41467-018-03118-x.


Interaction between the Caenorhabditis elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly.

Bianchi S, Rogala KB, Dynes NJ, Hilbert M, Leidel SA, Steinmetz MO, Gönczy P, Vakonakis I.

Mol Biol Cell. 2018 Mar 15;29(6):722-735. doi: 10.1091/mbc.E17-06-0412. Epub 2018 Jan 24.


ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage.

Wolf B, Balestra FR, Spahr A, Gönczy P.

Dev Biol. 2018 Feb 15;434(2):221-230. doi: 10.1016/j.ydbio.2018.01.001. Epub 2018 Jan 4.


Centriole Biogenesis: From Identifying the Characters to Understanding the Plot.

Banterle N, Gönczy P.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:23-49. doi: 10.1146/annurev-cellbio-100616-060454. Epub 2017 Aug 16. Review.


Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.

Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano COS, Steinmetz MO, Guichard P, Gönczy P.

Curr Biol. 2017 Aug 21;27(16):2486-2498.e6. doi: 10.1016/j.cub.2017.07.011. Epub 2017 Aug 3.


TRACMIT: An effective pipeline for tracking and analyzing cells on micropatterns through mitosis.

Burri O, Wolf B, Seitz A, Gönczy P.

PLoS One. 2017 Jul 26;12(7):e0179752. doi: 10.1371/journal.pone.0179752. eCollection 2017.


Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes.

De Simone A, Gönczy P.

Mol Biol Cell. 2017 Nov 7;28(23):3165-3170. doi: 10.1091/mbc.E16-12-0823. Epub 2017 Jul 12.


Cell-free reconstitution reveals centriole cartwheel assembly mechanisms.

Guichard P, Hamel V, Le Guennec M, Banterle N, Iacovache I, Nemčíková V, Flückiger I, Goldie KN, Stahlberg H, Lévy D, Zuber B, Gönczy P.

Nat Commun. 2017 Mar 23;8:14813. doi: 10.1038/ncomms14813.


Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning.

Wolf B, Diop F, Ferraris P, Wichit S, Busso C, Missé D, Gönczy P.

Open Biol. 2017 Jan;7(1). pii: 160231. doi: 10.1098/rsob.160231.


Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number.

Graciotti M, Fang Z, Johnsson K, Gönczy P.

Chembiochem. 2016 Nov 3;17(21):2063-2074. doi: 10.1002/cbic.201600327. Epub 2016 Sep 23.


KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.

Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, Gönczy P, Tora L.

Nat Commun. 2016 Oct 31;7:13227. doi: 10.1038/ncomms13227.


The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.

Kraatz S, Guichard P, Obbineni JM, Olieric N, Hatzopoulos GN, Hilbert M, Sen I, Missimer J, Gönczy P, Steinmetz MO.

Structure. 2016 Aug 2;24(8):1358-1371. doi: 10.1016/j.str.2016.06.011. Epub 2016 Jul 28.


Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.

Afshar K, Werner ME, Tse YC, Glotzer M, Gönczy P.

Development. 2016 Jul 15;143(14):2689. doi: 10.1242/dev.141515. No abstract available.


Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.

Kilchmann F, Marcaida MJ, Kotak S, Schick T, Boss SD, Awale M, Gönczy P, Reymond JL.

J Med Chem. 2016 Aug 11;59(15):7188-211. doi: 10.1021/acs.jmedchem.6b00709. Epub 2016 Jul 20.


Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.

Kotak S, Afshar K, Busso C, Gönczy P.

J Cell Sci. 2016 Aug 1;129(15):3015-25. doi: 10.1242/jcs.184416. Epub 2016 Jun 22.


Computational support for a scaffolding mechanism of centriole assembly.

Klein HC, Guichard P, Hamel V, Gönczy P, Schwarz US.

Sci Rep. 2016 Jun 8;6:27075. doi: 10.1038/srep27075.


Corrigendum: SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.

Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Flückiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, Müller DJ, Kammerer RA, Gönczy P, Hirono M, Steinmetz MO.

Nat Cell Biol. 2016 May 27;18(6):709. doi: 10.1038/ncb3362. No abstract available.


Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth.

Sharma A, Aher A, Dynes NJ, Frey D, Katrukha EA, Jaussi R, Grigoriev I, Croisier M, Kammerer RA, Akhmanova A, Gönczy P, Steinmetz MO.

Dev Cell. 2016 May 23;37(4):362-376. doi: 10.1016/j.devcel.2016.04.024.


Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes.

Borrego-Pinto J, Somogyi K, Karreman MA, König J, Müller-Reichert T, Bettencourt-Dias M, Gönczy P, Schwab Y, Lénárt P.

J Cell Biol. 2016 Mar 28;212(7):815-27. doi: 10.1083/jcb.201510083. Epub 2016 Mar 21.


SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.

Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Flückiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, Müller DJ, Kammerer RA, Gönczy P, Hirono M, Steinmetz MO.

Nat Cell Biol. 2016 Apr;18(4):393-403. doi: 10.1038/ncb3329. Epub 2016 Mar 21. Erratum in: Nat Cell Biol. 2016 May 27;18(6):709.


Basal body structure in Trichonympha.

Guichard P, Gönczy P.

Cilia. 2016 Mar 1;5:9. doi: 10.1186/s13630-016-0031-7. eCollection 2016. Review.


Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation.

De Simone A, Nédélec F, Gönczy P.

Cell Rep. 2016 Mar 8;14(9):2250-2262. doi: 10.1016/j.celrep.2016.01.077. Epub 2016 Feb 25.


Centrosomes and cancer: revisiting a long-standing relationship.

Gönczy P.

Nat Rev Cancer. 2015 Nov;15(11):639-52. doi: 10.1038/nrc3995. Review.


Isolation, cryotomography, and three-dimensional reconstruction of centrioles.

Guichard P, Hamel V, Neves A, Gönczy P.

Methods Cell Biol. 2015;129:191-209. doi: 10.1016/bs.mcb.2015.04.003. Epub 2015 May 27.


The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.

Rogala KB, Dynes NJ, Hatzopoulos GN, Yan J, Pong SK, Robinson CV, Deane CM, Gönczy P, Vakonakis I.

Elife. 2015 May 29;4:e07410. doi: 10.7554/eLife.07410.


Cellular hallmarks reveal restricted aerobic metabolism at thermal limits.

Neves A, Busso C, Gönczy P.

Elife. 2015 May 1;4:e04810. doi: 10.7554/eLife.04810.


Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos.

Balestra FR, von Tobel L, Gönczy P.

Cell Res. 2015 May;25(5):642-4. doi: 10.1038/cr.2015.49. Epub 2015 Apr 24. No abstract available.


Polarity-dependent asymmetric distribution and MEX-5/6-mediated translational activation of the Era-1 mRNA in C. elegans embryos.

Spiró Z, Gönczy P.

PLoS One. 2015 Mar 30;10(3):e0120984. doi: 10.1371/journal.pone.0120984. eCollection 2015.


Quantitative analysis and modeling probe polarity establishment in C. elegans embryos.

Blanchoud S, Busso C, Naef F, Gönczy P.

Biophys J. 2015 Feb 17;108(4):799-809. doi: 10.1016/j.bpj.2014.12.022.


Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos.

Rose L, Gönczy P.

WormBook. 2014 Dec 30:1-43. doi: 10.1895/wormbook.1.30.2. Review.


SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans.

von Tobel L, Mikeladze-Dvali T, Delattre M, Balestra FR, Blanchoud S, Finger S, Knott G, Müller-Reichert T, Gönczy P.

PLoS Genet. 2014 Nov 20;10(11):e1004777. doi: 10.1371/journal.pgen.1004777. eCollection 2014 Nov.


Correlative multicolor 3D SIM and STORM microscopy.

Hamel V, Guichard P, Fournier M, Guiet R, Flückiger I, Seitz A, Gönczy P.

Biomed Opt Express. 2014 Aug 29;5(10):3326-36. doi: 10.1364/BOE.5.003326. eCollection 2014 Oct 1.


Multiciliogenesis: multicilin directs transcriptional activation of centriole formation.

Balestra FR, Gönczy P.

Curr Biol. 2014 Aug 18;24(16):R746-9. doi: 10.1016/j.cub.2014.07.006.


Centrosomes back in the limelight.

Bornens M, Gönczy P.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130452. doi: 10.1098/rstb.2013.0452. No abstract available.


NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.

Kotak S, Busso C, Gönczy P.

EMBO J. 2014 Aug 18;33(16):1815-30. doi: 10.15252/embj.201488147. Epub 2014 Jul 4.


Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos.

Spiró Z, Thyagarajan K, De Simone A, Träger S, Afshar K, Gönczy P.

Development. 2014 Jul;141(13):2712-23. doi: 10.1242/dev.107508.


A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.

Khan MA, Rupp VM, Orpinell M, Hussain MS, Altmüller J, Steinmetz MO, Enzinger C, Thiele H, Höhne W, Nürnberg G, Baig SM, Ansar M, Nürnberg P, Vincent JB, Speicher MR, Gönczy P, Windpassinger C.

Hum Mol Genet. 2014 Nov 15;23(22):5940-9. doi: 10.1093/hmg/ddu318. Epub 2014 Jun 20.


Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells.

Keller D, Orpinell M, Olivier N, Wachsmuth M, Mahen R, Wyss R, Hachet V, Ellenberg J, Manley S, Gönczy P.

J Cell Biol. 2014 Mar 3;204(5):697-712. doi: 10.1083/jcb.201307049.


NuMA phosphorylation dictates dynein-dependent spindle positioning.

Kotak S, Gönczy P.

Cell Cycle. 2014;13(2):177-8. doi: 10.4161/cc.27040. Epub 2013 Nov 15. No abstract available.

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