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Items: 1 to 50 of 56

1.

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology.

Panigaj M, Johnson MB, Ke W, McMillan J, Goncharova EA, Chandler M, Afonin KA.

ACS Nano. 2019 Nov 5. doi: 10.1021/acsnano.9b06522. [Epub ahead of print]

PMID:
31664817
2.

Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension.

Estephan LE, Genuardi MV, Kosanovich CM, Risbano MG, Zhang Y, Petro N, Watson A, Al Aaraj Y, Sembrat JC, Rojas M, Goncharov DA, Simon MA, Goncharova EA, Vaidya A, Smith A, Mazurek J, Han Y, Chan SY.

Pulm Circ. 2019 Apr-Jun;9(2):2045894019840646. doi: 10.1177/2045894019840646.

3.

A DNA minimachine for selective and sensitive detection of DNA.

Lyalina TA, Goncharova EA, Prokofeva NY, Voroshilina ES, Kolpashchikov DM.

Analyst. 2019 Jan 21;144(2):416-420. doi: 10.1039/c8an02274g. Epub 2019 Jan 2.

PMID:
30600819
4.

TAKling GDF-15 and skeletal muscle atrophy in pulmonary hypertension: are we there yet?

Lai YC, Provencher S, Goncharova EA.

Thorax. 2019 Feb;74(2):103-105. doi: 10.1136/thoraxjnl-2018-212680. Epub 2018 Dec 15. No abstract available.

PMID:
30554140
5.

Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension.

Kudryashova TV, Shen Y, Pena A, Cronin E, Okorie E, Goncharov DA, Goncharova EA.

Int J Mol Sci. 2018 Sep 28;19(10). pii: E2957. doi: 10.3390/ijms19102957.

6.

Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension.

Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H, Cole JE, Sabroe I, Monaco C, Cool CD, Goncharova EA, Lawrie A, Farkas L.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):199-210. doi: 10.1164/rccm.201707-1370OC.

7.

TWISTed HIF: revisiting smooth muscle HIF-1α signaling in pulmonary hypertension.

Shen YS, Goncharova EA.

Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L387-L389. doi: 10.1152/ajplung.00285.2018. Epub 2018 Jul 5. No abstract available.

8.

Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension.

Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):681-684. doi: 10.1164/rccm.201801-0022LE. No abstract available.

9.

Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events In Vivo.

Falabella M, Sun L, Barr J, Pena AZ, Kershaw EE, Gingras S, Goncharova EA, Kaufman BA.

G3 (Bethesda). 2017 Oct 5;7(10):3533-3542. doi: 10.1534/g3.117.300123.

10.

Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats.

Pena A, Kobir A, Goncharov D, Goda A, Kudryashova TV, Ray A, Vanderpool R, Baust J, Chang B, Mora AL, Gorcsan J 3rd, Goncharova EA.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):615-625. doi: 10.1165/rcmb.2016-0364OC.

11.

HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension.

Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, Lampron MC, Lambert C, Breuils-Bonnet S, Nadeau V, Paradis R, Goncharova EA, Provencher S, Bonnet S.

Sci Rep. 2017 Jul 3;7(1):4546. doi: 10.1038/s41598-017-04874-4.

12.

Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation.

Ghouleh IA, Sahoo S, Meijles DN, Amaral JH, de Jesus DS, Sembrat J, Rojas M, Goncharov DA, Goncharova EA, Pagano PJ.

Clin Sci (Lond). 2017 Jul 16;131(15):2019-2035. doi: 10.1042/CS20160812. Print 2017 Aug 1.

13.

Automated Measurement of Blood Vessels in Tissues from Microscopy Images.

Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD.

Curr Protoc Cytom. 2016 Oct 10;78:12.44.1-12.44.13. doi: 10.1002/cpcy.10.

14.

Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs.

Pullamsetti SS, Savai R, Seeger W, Goncharova EA.

Am J Respir Crit Care Med. 2017 Feb 15;195(4):425-437. doi: 10.1164/rccm.201606-1226PP. Review. No abstract available.

15.

mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts.

Romero Y, Bueno M, Ramirez R, Álvarez D, Sembrat JC, Goncharova EA, Rojas M, Selman M, Mora AL, Pardo A.

Aging Cell. 2016 Dec;15(6):1103-1112. doi: 10.1111/acel.12514. Epub 2016 Aug 26.

16.

HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.

Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):866-877.

17.

SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.

Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT.

Circulation. 2016 Feb 23;133(8):717-31. doi: 10.1161/CIRCULATIONAHA.115.018935. Epub 2016 Jan 26.

18.

Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension.

Kudryashova TV, Goncharov DA, Pena A, Ihida-Stansbury K, DeLisser H, Kawut SM, Goncharova EA.

Pulm Circ. 2015 Dec;5(4):667-80. doi: 10.1086/683810.

19.

Update in Pulmonary Vascular Diseases 2014.

Goncharova EA, Gladwin MT, Kawut SM.

Am J Respir Crit Care Med. 2015 Sep 1;192(5):544-50. Review. No abstract available.

20.

VCAM-1 is a TGF-β1 inducible gene upregulated in idiopathic pulmonary fibrosis.

Agassandian M, Tedrow JR, Sembrat J, Kass DJ, Zhang Y, Goncharova EA, Kaminski N, Mallampalli RK, Vuga LJ.

Cell Signal. 2015 Dec;27(12):2467-73. doi: 10.1016/j.cellsig.2015.09.003. Epub 2015 Sep 18.

21.

Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts.

Goncharova EA, James ML, Kudryashova TV, Goncharov DA, Krymskaya VP.

PLoS One. 2014 Oct 31;9(10):e111476. doi: 10.1371/journal.pone.0111476. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0118637.

22.

[Bone marrow mononuclear cells from murine tibia after the space flight on biosatellite "Bion-M1"].

Andreeva ER, Goncharova EA, Gornostaeva AN, Grigor'eva OV, Buravkova LB.

Aviakosm Ekolog Med. 2014;48(2):5-11. Russian.

PMID:
25087405
23.

Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.

Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong SB, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies S, Guttentag S, Schmidt LS, Krymskaya VP.

Cell Rep. 2014 Apr 24;7(2):412-423. doi: 10.1016/j.celrep.2014.03.025. Epub 2014 Apr 13.

24.

Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.

Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA.

Circulation. 2014 Feb 25;129(8):864-74. doi: 10.1161/CIRCULATIONAHA.113.004581. Epub 2013 Nov 22.

25.

mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects.

Goncharova EA.

FASEB J. 2013 May;27(5):1796-807. doi: 10.1096/fj.12-222224. Epub 2013 Jan 25. Review.

26.

Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells.

Goncharova EA, Khavin IS, Goncharov DA, Krymskaya VP.

Respir Res. 2012 Nov 27;13:109. doi: 10.1186/1465-9921-13-109.

27.

Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.

Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP.

PLoS One. 2012;7(11):e47842. doi: 10.1371/journal.pone.0047842. Epub 2012 Nov 6.

28.

Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM).

Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP.

Sci Transl Med. 2012 Oct 3;4(154):154ra134. doi: 10.1126/scitranslmed.3003840.

29.

DHEA-S inhibits human neutrophil and human airway smooth muscle migration.

Koziol-White CJ, Goncharova EA, Cao G, Johnson M, Krymskaya VP, Panettieri RA Jr.

Biochim Biophys Acta. 2012 Oct;1822(10):1638-42. doi: 10.1016/j.bbadis.2012.06.012. Epub 2012 Jul 3.

30.

β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein.

Goncharova EA, Goncharov DA, Zhao H, Penn RB, Krymskaya VP, Panettieri RA Jr.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):48-54. doi: 10.1165/rcmb.2011-0217OC.

31.

mTORC2 is required for proliferation and survival of TSC2-null cells.

Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP.

Mol Cell Biol. 2011 Jun;31(12):2484-98. doi: 10.1128/MCB.01061-10. Epub 2011 Apr 11.

32.

mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia.

Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL, Goncharova EA.

FASEB J. 2011 Jun;25(6):1922-33. doi: 10.1096/fj.10-175018. Epub 2011 Mar 2.

33.

Interferons modulate mitogen-induced protein synthesis in airway smooth muscle.

Goncharova EA, Lim PN, Chisolm A, Fogle HW 3rd, Taylor JH, Goncharov DA, Eszterhas A, Panettieri RA Jr, Krymskaya VP.

Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L25-35. doi: 10.1152/ajplung.00228.2009. Epub 2010 Apr 9.

34.

Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1.

Damera G, Fogle HW, Lim P, Goncharova EA, Zhao H, Banerjee A, Tliba O, Krymskaya VP, Panettieri RA Jr.

Br J Pharmacol. 2009 Nov;158(6):1429-41. doi: 10.1111/j.1476-5381.2009.00428.x. Epub 2009 Oct 8.

35.

Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis.

Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.

Mol Pharmacol. 2009 Oct;76(4):766-77. doi: 10.1124/mol.109.057042. Epub 2009 Jul 13.

36.

PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects.

Krymskaya VP, Goncharova EA.

Cell Cycle. 2009 Feb 1;8(3):403-13. Epub 2009 Feb 6. Review.

37.

Ecological-genetic organization of plant quantitative traits and mapping of the loci determining agronomically important traits in soft wheat.

Chesnokov YV, Pochepnya NV, Börner A, Lohwasser U, Goncharova EA, Dragavtsev VA.

Dokl Biochem Biophys. 2008 Jan-Feb;418:36-9. No abstract available.

PMID:
18429603
38.

Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation.

Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.

Mol Pharmacol. 2008 Mar;73(3):778-88. Epub 2007 Dec 19.

PMID:
18094073
39.

Pulmonary lymphangioleiomyomatosis (LAM): progress and current challenges.

Goncharova EA, Krymskaya VP.

J Cell Biochem. 2008 Feb 1;103(2):369-82. Review.

PMID:
17541983
40.
41.

Assays for in vitro monitoring of proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells.

Goncharova EA, Lim P, Goncharov DA, Eszterhas A, Panettieri RA Jr, Krymskaya VP.

Nat Protoc. 2006;1(6):2905-8.

PMID:
17406550
42.

Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2.

Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, Eszterhas A, Krymskaya VP.

Am J Respir Cell Mol Biol. 2006 May;34(5):561-72. Epub 2006 Jan 19.

43.

Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis.

Goncharova EA, Goncharov DA, Lim PN, Noonan D, Krymskaya VP.

Am J Respir Cell Mol Biol. 2006 Apr;34(4):473-80. Epub 2005 Dec 30.

44.

Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration.

Krymskaya VP, Goncharova EA, Ammit AJ, Lim PN, Goncharov DA, Eszterhas A, Panettieri RA Jr.

FASEB J. 2005 Mar;19(3):428-30. Epub 2004 Dec 20.

PMID:
15746183
45.

Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent.

Kazi AS, Lotfi S, Goncharova EA, Tliba O, Amrani Y, Krymskaya VP, Lazaar AL.

Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L539-45. Epub 2003 Nov 21.

46.

[A foreign body of the external acoustic meatus].

Marugin IV, Ter-Agopov AE, Borshch GM, Goncharova EA.

Vestn Otorinolaringol. 2003;(5):54. Russian. No abstract available.

PMID:
14627006
47.

Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration.

Goncharova EA, Billington CK, Irani C, Vorotnikov AV, Tkachuk VA, Penn RB, Krymskaya VP, Panettieri RA Jr.

Am J Respir Cell Mol Biol. 2003 Jul;29(1):19-27. Epub 2003 Jan 31.

PMID:
12600820
48.

PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells.

Goncharova EA, Ammit AJ, Irani C, Carroll RG, Eszterhas AJ, Panettieri RA, Krymskaya VP.

Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L354-63.

49.

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM).

Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA Jr, Krymskaya VP.

J Biol Chem. 2002 Aug 23;277(34):30958-67. Epub 2002 Jun 3.

50.

Activation of p38 MAP-kinase and caldesmon phosphorylation are essential for urokinase-induced human smooth muscle cell migration.

Goncharova EA, Vorotnikov AV, Gracheva EO, Wang CL, Panettieri RA Jr, Stepanova VV, Tkachuk VA.

Biol Chem. 2002 Jan;383(1):115-26.

PMID:
11930938

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