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Items: 20


Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.

Zhang J, Webster JD, Dugger DL, Goncharov T, Roose-Girma M, Hung J, Kwon YC, Vucic D, Newton K, Dixit VM.

Cell Rep. 2019 May 28;27(9):2679-2689.e3. doi: 10.1016/j.celrep.2019.04.111.


Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D.

Mol Cell. 2018 Feb 15;69(4):551-565.e7. doi: 10.1016/j.molcel.2018.01.016.


Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death.

de Almagro MC, Goncharov T, Izrael-Tomasevic A, Duttler S, Kist M, Varfolomeev E, Wu X, Lee WP, Murray J, Webster JD, Yu K, Kirkpatrick DS, Newton K, Vucic D.

Cell Death Differ. 2017 Jan;24(1):26-37. doi: 10.1038/cdd.2016.78. Epub 2016 Aug 12.


Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination.

de Almagro MC, Goncharov T, Newton K, Vucic D.

Cell Death Dis. 2015 Jun 25;6:e1800. doi: 10.1038/cddis.2015.158.


Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

Varfolomeev E, Goncharov T, Vucic D.

Methods Mol Biol. 2015;1280:269-82. doi: 10.1007/978-1-4939-2422-6_15.


Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.

Varfolomeev E, Izrael-Tomasevic A, Yu K, Bustos D, Goncharov T, Belmont LD, Masselot A, Bakalarski CE, Kirkpatrick DS, Vucic D.

Biochem J. 2015 Feb 15;466(1):45-54. doi: 10.1042/BJ20141195.


OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E, Arnott D, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2013 Apr 17;32(8):1103-14. doi: 10.1038/emboj.2013.62. Epub 2013 Mar 22.


Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, Vucic D.

Sci Signal. 2012 Mar 20;5(216):ra22. doi: 10.1126/scisignal.2001878.


TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro.

Menke C, Goncharov T, Qamar L, Korch C, Ford HL, Behbakht K, Thorburn A.

PLoS One. 2011 Jan 14;6(1):e14527. doi: 10.1371/journal.pone.0014527.


c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300. Epub 2010 Nov 26.


Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ.

J Med Chem. 2009 Mar 26;52(6):1723-30. doi: 10.1021/jm801450c.


Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D.

Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885.


c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D.

J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11.


Transcription-controlled gene therapy against tumor angiogenesis.

Greenberger S, Shaish A, Varda-Bloom N, Levanon K, Breitbart E, Goldberg I, Barshack I, Hodish I, Yaacov N, Bangio L, Goncharov T, Wallach D, Harats D.

J Clin Invest. 2004 Apr;113(7):1017-24.


Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants.

Zalcenstein A, Stambolsky P, Weisz L, Müller M, Wallach D, Goncharov TM, Krammer PH, Rotter V, Oren M.

Oncogene. 2003 Aug 28;22(36):5667-76.


How are the regulators regulated? The search for mechanisms that impose specificity on induction of cell death and NF-kappaB activation by members of the TNF/NGF receptor family.

Wallach D, Arumugam TU, Boldin MP, Cantarella G, Ganesh KA, Goltsev Y, Goncharov TM, Kovalenko AV, Rajput A, Varfolomeev EE, Zhang SQ.

Arthritis Res. 2002;4 Suppl 3:S189-96. Epub 2002 May 9. Review.


Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D.

Immunity. 1998 Aug;9(2):267-76.


Exploring cell death mechanisms by analyzing signaling cascades of the TNF/NGF receptor family.

Wallach D, Boldin M, Goncharov T, Goltsev Y, Mett I, Malinin N, Adar R, Kovalenko A, Varfolomeev E.

Behring Inst Mitt. 1996 Oct;(97):144-55. Review.


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