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Items: 28


Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension.

Estephan LE, Genuardi MV, Kosanovich CM, Risbano MG, Zhang Y, Petro N, Watson A, Al Aaraj Y, Sembrat JC, Rojas M, Goncharov DA, Simon MA, Goncharova EA, Vaidya A, Smith A, Mazurek J, Han Y, Chan SY.

Pulm Circ. 2019 Apr-Jun;9(2):2045894019840646. doi: 10.1177/2045894019840646.


Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension.

Kudryashova TV, Shen Y, Pena A, Cronin E, Okorie E, Goncharov DA, Goncharova EA.

Int J Mol Sci. 2018 Sep 28;19(10). pii: E2957. doi: 10.3390/ijms19102957.


Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension.

Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):681-684. doi: 10.1164/rccm.201801-0022LE. No abstract available.


Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation.

Ghouleh IA, Sahoo S, Meijles DN, Amaral JH, de Jesus DS, Sembrat J, Rojas M, Goncharov DA, Goncharova EA, Pagano PJ.

Clin Sci (Lond). 2017 Jul 16;131(15):2019-2035. doi: 10.1042/CS20160812. Print 2017 Aug 1.


Automated Measurement of Blood Vessels in Tissues from Microscopy Images.

Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD.

Curr Protoc Cytom. 2016 Oct 10;78:12.44.1-12.44.13. doi: 10.1002/cpcy.10.


HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.

Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):866-877.


SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.

Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT.

Circulation. 2016 Feb 23;133(8):717-31. doi: 10.1161/CIRCULATIONAHA.115.018935. Epub 2016 Jan 26.


Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension.

Kudryashova TV, Goncharov DA, Pena A, Ihida-Stansbury K, DeLisser H, Kawut SM, Goncharova EA.

Pulm Circ. 2015 Dec;5(4):667-80. doi: 10.1086/683810.


Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts.

Goncharova EA, James ML, Kudryashova TV, Goncharov DA, Krymskaya VP.

PLoS One. 2014 Oct 31;9(10):e111476. doi: 10.1371/journal.pone.0111476. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0118637.


Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.

Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong SB, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies S, Guttentag S, Schmidt LS, Krymskaya VP.

Cell Rep. 2014 Apr 24;7(2):412-423. doi: 10.1016/j.celrep.2014.03.025. Epub 2014 Apr 13.


Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.

Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA.

Circulation. 2014 Feb 25;129(8):864-74. doi: 10.1161/CIRCULATIONAHA.113.004581. Epub 2013 Nov 22.


Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling.

Atochina-Vasserman EN, Goncharov DA, Volgina AV, Milavec M, James ML, Krymskaya VP.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):704-9. doi: 10.1165/rcmb.2013-0203RC.


Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder.

Parker WE, Orlova KA, Parker WH, Birnbaum JF, Krymskaya VP, Goncharov DA, Baybis M, Helfferich J, Okochi K, Strauss KA, Crino PB.

Sci Transl Med. 2013 Apr 24;5(182):182ra53. doi: 10.1126/scitranslmed.3005271.


Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells.

Goncharova EA, Khavin IS, Goncharov DA, Krymskaya VP.

Respir Res. 2012 Nov 27;13:109. doi: 10.1186/1465-9921-13-109.


Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM).

Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP.

Sci Transl Med. 2012 Oct 3;4(154):154ra134. doi: 10.1126/scitranslmed.3003840.


β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein.

Goncharova EA, Goncharov DA, Zhao H, Penn RB, Krymskaya VP, Panettieri RA Jr.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):48-54. doi: 10.1165/rcmb.2011-0217OC.


mTORC2 is required for proliferation and survival of TSC2-null cells.

Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP.

Mol Cell Biol. 2011 Jun;31(12):2484-98. doi: 10.1128/MCB.01061-10. Epub 2011 Apr 11.


mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia.

Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL, Goncharova EA.

FASEB J. 2011 Jun;25(6):1922-33. doi: 10.1096/fj.10-175018. Epub 2011 Mar 2.


Interferons modulate mitogen-induced protein synthesis in airway smooth muscle.

Goncharova EA, Lim PN, Chisolm A, Fogle HW 3rd, Taylor JH, Goncharov DA, Eszterhas A, Panettieri RA Jr, Krymskaya VP.

Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L25-35. doi: 10.1152/ajplung.00228.2009. Epub 2010 Apr 9.


Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis.

Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.

Mol Pharmacol. 2009 Oct;76(4):766-77. doi: 10.1124/mol.109.057042. Epub 2009 Jul 13.


Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation.

Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.

Mol Pharmacol. 2008 Mar;73(3):778-88. Epub 2007 Dec 19.


Assays for in vitro monitoring of proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells.

Goncharova EA, Lim P, Goncharov DA, Eszterhas A, Panettieri RA Jr, Krymskaya VP.

Nat Protoc. 2006;1(6):2905-8.


Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2.

Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, Eszterhas A, Krymskaya VP.

Am J Respir Cell Mol Biol. 2006 May;34(5):561-72. Epub 2006 Jan 19.


Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis.

Goncharova EA, Goncharov DA, Lim PN, Noonan D, Krymskaya VP.

Am J Respir Cell Mol Biol. 2006 Apr;34(4):473-80. Epub 2005 Dec 30.


Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact.

Thangam EB, Venkatesha RT, Zaidi AK, Jordan-Sciutto KL, Goncharov DA, Krymskaya VP, Amrani Y, Panettieri RA Jr, Ali H.

FASEB J. 2005 May;19(7):798-800. Epub 2005 Mar 9.


Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration.

Krymskaya VP, Goncharova EA, Ammit AJ, Lim PN, Goncharov DA, Eszterhas A, Panettieri RA Jr.

FASEB J. 2005 Mar;19(3):428-30. Epub 2004 Dec 20.


Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM).

Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA Jr, Krymskaya VP.

J Biol Chem. 2002 Aug 23;277(34):30958-67. Epub 2002 Jun 3.

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