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NLRC5 deficiency has a moderate impact on immunodominant CD8+ T cell responses during rotavirus infection of adult mice.

Sun T, Ferrero RL, Girardin SE, Gommerman JL, Philpott DJ.

Immunol Cell Biol. 2019 Feb 15. doi: 10.1111/imcb.12244. [Epub ahead of print]


B-Cell Deficiency Lowers Blood Pressure in Mice.

Dingwell LS, Shikatani EA, Besla R, Levy AS, Dinh DD, Momen A, Zhang H, Afroze T, Chen MB, Chiu F, Simmons CA, Billia F, Gommerman JL, John R, Heximer S, Scholey JW, Bolz SS, Robbins CS, Husain M.

Hypertension. 2019 Mar;73(3):561-570. doi: 10.1161/HYPERTENSIONAHA.118.11828.


Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL.

Cell. 2019 Jan 24;176(3):610-624.e18. doi: 10.1016/j.cell.2018.11.035. Epub 2019 Jan 3.


Generational Patterns of Asthma Incidence among Immigrants to Canada over Two Decades. A Population-based Cohort Study.

Radhakrishnan D, Guttmann A, To T, Reisman JJ, Knight BD, Mojaverian N, Manuel DG, Gommerman JL, Croitoru K, Benchimol EI.

Ann Am Thorac Soc. 2019 Feb;16(2):248-257. doi: 10.1513/AnnalsATS.201803-187OC.


Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity.

Perez-Shibayama C, Gil-Cruz C, Cheng HW, Onder L, Printz A, Mörbe U, Novkovic M, Li C, Lopez-Macias C, Buechler MB, Turley SJ, Mack M, Soneson C, Robinson MD, Scandella E, Gommerman J, Ludewig B.

Sci Immunol. 2018 Aug 10;3(26). pii: eaar4539. doi: 10.1126/sciimmunol.aar4539.


Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in Aicda-/- and Ung-/- Mice.

Galicia G, Lee DSW, Ramaglia V, Ward LA, Yam JY, Leung LYT, Li R, Handy M, Zhang J, Drohomyrecky PC, Lancaster E, Bar-Or A, Martin A, Gommerman JL.

J Immunol. 2018 Aug 15;201(4):1119-1130. doi: 10.4049/jimmunol.1700729. Epub 2018 Jul 6.


Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis.

Touil H, Kobert A, Lebeurrier N, Rieger A, Saikali P, Lambert C, Fawaz L, Moore CS, Prat A, Gommerman J, Antel JP, Itoyama Y, Nakashima I, Bar-Or A; Canadian B Cell Team in MS.

J Neuroinflammation. 2018 Apr 19;15(1):114. doi: 10.1186/s12974-018-1136-2.


The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining.

Li C, Irrazabal T, So CC, Berru M, Du L, Lam E, Ling AK, Gommerman JL, Pan-Hammarström Q, Martin A.

Nat Commun. 2018 Mar 8;9(1):1006. doi: 10.1038/s41467-018-03455-x.


Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.

Onder L, Mörbe U, Pikor N, Novkovic M, Cheng HW, Hehlgans T, Pfeffer K, Becher B, Waisman A, Rülicke T, Gommerman J, Mueller CG, Sawa S, Scandella E, Ludewig B.

Immunity. 2017 Jul 18;47(1):80-92.e4. doi: 10.1016/j.immuni.2017.05.008. Epub 2017 Jul 11.


Three-Dimensional Imaging of Transparent Tissues via Metal Nanoparticle Labeling.

Syed AM, Sindhwani S, Wilhelm S, Kingston BR, Lee DSW, Gommerman JL, Chan WCW.

J Am Chem Soc. 2017 Jul 26;139(29):9961-9971. doi: 10.1021/jacs.7b04022. Epub 2017 Jul 13.


Antibody-Independent Function of Human B Cells Contributes to Antifungal T Cell Responses.

Li R, Rezk A, Li H, Gommerman JL, Prat A, Bar-Or A; Canadian B Cells in MS Team.

J Immunol. 2017 Apr 15;198(8):3245-3254. doi: 10.4049/jimmunol.1601572. Epub 2017 Mar 8.


Stromal Cell Niches in the Inflamed Central Nervous System.

Pikor NB, Cupovic J, Onder L, Gommerman JL, Ludewig B.

J Immunol. 2017 Mar 1;198(5):1775-1781. doi: 10.4049/jimmunol.1601566. Review.


Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.

Sun T, Rojas OL, Li C, Ward LA, Philpott DJ, Gommerman JL.

Mucosal Immunol. 2017 May;10(3):775-788. doi: 10.1038/mi.2016.79. Epub 2016 Sep 7.


Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.

Kowalczyk-Quintas C, Schuepbach-Mallepell S, Vigolo M, Willen L, Tardivel A, Smulski CR, Zheng TS, Gommerman J, Hess H, Gottenberg JE, Mackay F, Donzé O, Schneider P.

J Biol Chem. 2016 Sep 16;291(38):19826-34. doi: 10.1074/jbc.M116.725929. Epub 2016 Jul 22.


The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.

Ramachandran S, Haddad D, Li C, Le MX, Ling AK, So CC, Nepal RM, Gommerman JL, Yu K, Ketela T, Moffat J, Martin A.

Cell Rep. 2016 May 17;15(7):1554-1565. doi: 10.1016/j.celrep.2016.04.041. Epub 2016 May 5.


Meningeal Tertiary Lymphoid Tissues and Multiple Sclerosis: A Gathering Place for Diverse Types of Immune Cells during CNS Autoimmunity.

Pikor NB, Prat A, Bar-Or A, Gommerman JL.

Front Immunol. 2016 Jan 13;6:657. doi: 10.3389/fimmu.2015.00657. eCollection 2015. Review.


Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis.

Li R, Rezk A, Healy LM, Muirhead G, Prat A, Gommerman JL, Bar-Or A; MSSRF Canadian B cells in MS Team.

Front Immunol. 2016 Jan 8;6:626. doi: 10.3389/fimmu.2015.00626. eCollection 2015. Review.


B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation.

Michel L, Touil H, Pikor NB, Gommerman JL, Prat A, Bar-Or A.

Front Immunol. 2015 Dec 24;6:636. doi: 10.3389/fimmu.2015.00636. eCollection 2015. Review.


Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.

Pikor NB, Astarita JL, Summers-Deluca L, Galicia G, Qu J, Ward LA, Armstrong S, Dominguez CX, Malhotra D, Heiden B, Kay R, Castanov V, Touil H, Boon L, O'Connor P, Bar-Or A, Prat A, Ramaglia V, Ludwin S, Turley SJ, Gommerman JL.

Immunity. 2015 Dec 15;43(6):1160-73. doi: 10.1016/j.immuni.2015.11.010.


Hematopoietic LTβR deficiency results in skewed T cell cytokine profiles during a mucosal viral infection.

Sun T, Rojas OL, Li C, Philpott DJ, Gommerman JL.

J Leukoc Biol. 2016 Jul;100(1):103-10. doi: 10.1189/jlb.4MAB0715-294R. Epub 2015 Dec 10.


Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy.

Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore CS, Michel L, Althekair F, Rajasekharan S, Gommerman JL, Prat A, Fillatreau S, Bar-Or A; Canadian B cells in MS Team.

Sci Transl Med. 2015 Oct 21;7(310):310ra166. doi: 10.1126/scitranslmed.aab4176.


A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology.

Ng D, Maître B, Cummings D, Lin A, Ward LA, Rahbar R, Mossman KL, Ohashi PS, Gommerman JL.

J Immunol. 2015 Nov 15;195(10):4650-9. doi: 10.4049/jimmunol.1501053. Epub 2015 Oct 12.


Asthma, type 1 and type 2 diabetes mellitus, and inflammatory bowel disease amongst South Asian immigrants to Canada and their children: a population-based cohort study.

Benchimol EI, Manuel DG, To T, Mack DR, Nguyen GC, Gommerman JL, Croitoru K, Mojaverian N, Wang X, Quach P, Guttmann A.

PLoS One. 2015 Apr 7;10(4):e0123599. doi: 10.1371/journal.pone.0123599. eCollection 2015.


Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.

Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA.

J Virol. 2015 May;89(9):4748-59. doi: 10.1128/JVI.02976-14. Epub 2015 Feb 11.


Re-thinking the functions of IgA(+) plasma cells.

Gommerman JL, Rojas OL, Fritz JH.

Gut Microbes. 2014;5(5):652-62. doi: 10.4161/19490976.2014.969977. Review.


HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.

Hirbod T, Kong X, Kigozi G, Ndyanabo A, Serwadda D, Prodger JL, Tobian AA, Nalugoda F, Wawer MJ, Shahabi K, Rojas OL, Gommerman JL, Broliden K, Kaul R, Gray RH.

PLoS Pathog. 2014 Oct 2;10(10):e1004416. doi: 10.1371/journal.ppat.1004416. eCollection 2014 Oct. Erratum in: PLoS Pathog. 2014 Oct;10(10):e1004515.


An in vitro model of innate lymphoid cell function and differentiation.

Allan DS, Kirkham CL, Aguilar OA, Qu LC, Chen P, Fine JH, Serra P, Awong G, Gommerman JL, Zúñiga-Pflücker JC, Carlyle JR.

Mucosal Immunol. 2015 Mar;8(2):340-51. doi: 10.1038/mi.2014.71. Epub 2014 Aug 20.


A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected].

Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, Fillatreau S, Bar-Or A; CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity; MSSRF Canadian B cells in MS Team.

PLoS One. 2014 Aug 19;9(8):e105421. doi: 10.1371/journal.pone.0105421. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e109041.


The 14th International TNF Conference, Québec City, Canada - Des Progrės Récents aux Défis Futurs (Recent Advances toward Future Challenges).

Burkly L, Gommerman JL.

Cytokine Growth Factor Rev. 2014 Apr;25(2):77-81. doi: 10.1016/j.cytogfr.2014.03.002. Epub 2014 Mar 12.


The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.

Gommerman JL, Browning JL, Ware CF.

Cytokine Growth Factor Rev. 2014 Apr;25(2):139-45. doi: 10.1016/j.cytogfr.2014.02.002. Epub 2014 Mar 12. Review.


A TNF-α-CCL20-CCR6 axis regulates Nod1-induced B cell responses.

Paradis M, Mindt BC, Duerr CU, Rojas OL, Ng D, Boulianne B, McCarthy DD, Yu MD, Summers deLuca LE, Ward LA, Waldron JB, Philpott DJ, Gommerman JL, Fritz JH.

J Immunol. 2014 Mar 15;192(6):2787-99. doi: 10.4049/jimmunol.1203310. Epub 2014 Feb 17.


AID and caspase 8 shape the germinal center response through apoptosis.

Boulianne B, Rojas OL, Haddad D, Zaheen A, Kapelnikov A, Nguyen T, Li C, Hakem R, Gommerman JL, Martin A.

J Immunol. 2013 Dec 15;191(12):5840-7. doi: 10.4049/jimmunol.1301776. Epub 2013 Nov 15.


Plasmacytoid dendritic cells and autoimmune inflammation.

Galicia G, Gommerman JL.

Biol Chem. 2014 Mar;395(3):335-46. doi: 10.1515/hsz-2013-0213. Review.


AID-expressing germinal center B cells cluster normally within lymph node follicles in the absence of FDC-M1+ CD35+ follicular dendritic cells but dissipate prematurely.

Boulianne B, Le MX, Ward LA, Meng L, Haddad D, Li C, Martin A, Gommerman JL.

J Immunol. 2013 Nov 1;191(9):4521-30. doi: 10.4049/jimmunol.1300769. Epub 2013 Sep 25.


Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.

Satpathy AT, Briseño CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, Ouyang W, Murphy TL, Stappenbeck TS, Gommerman JL, Nussenzweig MC, Colonna M, Kopan R, Murphy KM.

Nat Immunol. 2013 Sep;14(9):937-48. doi: 10.1038/ni.2679. Epub 2013 Aug 4.


The Regulation of Immune Responses by DC Derived Type I IFN.

Ng D, Gommerman JL.

Front Immunol. 2013 Apr 22;4:94. doi: 10.3389/fimmu.2013.00094. eCollection 2013.


Secondary B cell receptor diversification is necessary for T cell mediated neuro-inflammation during experimental autoimmune encephalomyelitis.

Galicia G, Boulianne B, Pikor N, Martin A, Gommerman JL.

PLoS One. 2013 Apr 22;8(4):e61478. doi: 10.1371/journal.pone.0061478. Print 2013.


A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner.

Galicia-Rosas G, Pikor N, Schwartz JA, Rojas O, Jian A, Summers-Deluca L, Ostrowski M, Nuesslein-Hildesheim B, Gommerman JL.

J Immunol. 2012 Oct 1;189(7):3700-6. Epub 2012 Aug 29.


Lymphotoxin-sensitive microenvironments in homeostasis and inflammation.

Boulianne B, Porfilio EA, Pikor N, Gommerman JL.

Front Immunol. 2012 Jul 31;3:243. doi: 10.3389/fimmu.2012.00243. eCollection 2012.


A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis.

Kim CJ, Nazli A, Rojas OL, Chege D, Alidina Z, Huibner S, Mujib S, Benko E, Kovacs C, Shin LY, Grin A, Kandel G, Loutfy M, Ostrowski M, Gommerman JL, Kaushic C, Kaul R.

Mucosal Immunol. 2012 Nov;5(6):670-80. doi: 10.1038/mi.2012.72. Epub 2012 Aug 1.


Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.

Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, Clayton K, Jones RB, Liu J, Lee EY, Benko E, Kovacs C, Gommerman J, Kaul R, Ostrowski MA.

PLoS One. 2012;7(7):e40146. doi: 10.1371/journal.pone.0040146. Epub 2012 Jul 5.


B cells in MS: Why, where and how?

Pikor N, Gommerman JL.

Mult Scler Relat Disord. 2012 Jul;1(3):123-30. doi: 10.1016/j.msard.2012.03.006. Epub 2012 Apr 7. Review.


Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.

Guerra FM, Gommerman JL, Corfe SA, Paige CJ, Rottapel R.

PLoS One. 2012;7(4):e35533. doi: 10.1371/journal.pone.0035533. Epub 2012 Apr 24.


Fine-tuning of dendritic cell biology by the TNF superfamily.

Summers deLuca L, Gommerman JL.

Nat Rev Immunol. 2012 Apr 10;12(5):339-51. doi: 10.1038/nri3193. Review.


Unusual timing of CD127 expression by mouse uterine natural killer cells.

Zhang J, Chen Z, Fritz JH, Rochman Y, Leonard WJ, Gommerman JL, Plumb AW, Abraham N, Croy BA.

J Leukoc Biol. 2012 Mar;91(3):417-26. doi: 10.1189/jlb.1011501. Epub 2012 Jan 6.


Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.

Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, Robertson SJ, Larijani M, Gosselin J, Ivanov II, Martin A, Casellas R, Philpott DJ, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, Gommerman JL.

Nature. 2011 Dec 11;481(7380):199-203. doi: 10.1038/nature10698.


Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells.

Dissanayake D, Hall H, Berg-Brown N, Elford AR, Hamilton SR, Murakami K, Deluca LS, Gommerman JL, Ohashi PS.

Nat Med. 2011 Nov 13;17(12):1663-7. doi: 10.1038/nm.2556.


Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B.

Immunity. 2011 Nov 23;35(5):780-91. doi: 10.1016/j.immuni.2011.08.013. Epub 2011 Oct 20.


LTβR and CD40: working together in dendritic cells to optimize immune responses.

Gommerman JL, Summers deLuca L.

Immunol Rev. 2011 Nov;244(1):85-98. doi: 10.1111/j.1600-065X.2011.01056.x. Review.


Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy.

McCarthy DD, Kujawa J, Wilson C, Papandile A, Poreci U, Porfilio EA, Ward L, Lawson MA, Macpherson AJ, McCoy KD, Pei Y, Novak L, Lee JY, Julian BA, Novak J, Ranger A, Gommerman JL, Browning JL.

J Clin Invest. 2011 Oct;121(10):3991-4002. doi: 10.1172/JCI45563. Epub 2011 Sep 1. Erratum in: J Clin Invest. 2012 Feb 1;122(2):778.

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