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Items: 1 to 50 of 65

1.

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity.

Malfacini D, Patt J, Annala S, Harpsøe K, Eryilmaz F, Reher R, Crüsemann M, Hanke W, Zhang H, Tietze D, Gloriam DE, Bräuner-Osborne H, Strømgaard K, König GM, Inoue A, Gomeza J, Kostenis E.

J Biol Chem. 2019 Apr 12;294(15):5747-5758. doi: 10.1074/jbc.RA118.007250. Epub 2019 Feb 11.

2.

Inactivation of the Mouse L-Proline Transporter PROT Alters Glutamatergic Synapse Biochemistry and Perturbs Behaviors Required to Respond to Environmental Changes.

Schulz D, Morschel J, Schuster S, Eulenburg V, Gomeza J.

Front Mol Neurosci. 2018 Aug 20;11:279. doi: 10.3389/fnmol.2018.00279. eCollection 2018.

3.

Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.

Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E.

Cell Chem Biol. 2018 Jun 21;25(6):775-786.e5. doi: 10.1016/j.chembiol.2018.03.012. Epub 2018 Apr 26.

PMID:
29706593
4.

Lack of beta-arrestin signaling in the absence of active G proteins.

Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E.

Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3.

5.

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.

Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt NK, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E.

Mol Pharmacol. 2017 May;91(5):518-532. doi: 10.1124/mol.116.107904. Epub 2017 Mar 2. Erratum in: Mol Pharmacol. 2017 Jul;92 (1):100.

PMID:
28254957
6.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

7.

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.

Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J.

J Biol Chem. 2016 Jan 8;291(2):705-18. doi: 10.1074/jbc.M115.683953. Epub 2015 Nov 30.

8.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

9.

Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.

Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, Blättermann S, Akkari R, Schrage R, Schröder R, Schulz D, Vermeiren C, Zimmermann K, Kehraus S, Drewke C, Pfeifer A, König GM, Mohr K, Gillard M, Müller CE, Lu QR, Gomeza J, Kostenis E.

Sci Signal. 2013 Oct 22;6(298):ra93. doi: 10.1126/scisignal.2004350.

10.

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter.

Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G, Gether U.

Nat Commun. 2013;4:1580. doi: 10.1038/ncomms2568. Erratum in: Nat Commun. 2013;4:2589.

11.

Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.

Schröder R, Schmidt J, Blättermann S, Peters L, Janssen N, Grundmann M, Seemann W, Kaufel D, Merten N, Drewke C, Gomeza J, Milligan G, Mohr K, Kostenis E.

Nat Protoc. 2011 Oct 20;6(11):1748-60. doi: 10.1038/nprot.2011.386.

PMID:
22015845
12.

Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.

Schmidt J, Liebscher K, Merten N, Grundmann M, Mielenz M, Sauerwein H, Christiansen E, Due-Hansen ME, Ulven T, Ullrich S, Gomeza J, Drewke C, Kostenis E.

J Biol Chem. 2011 Apr 8;286(14):11890-4. doi: 10.1074/jbc.C110.200477. Epub 2011 Feb 21.

13.

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

Schröder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, Müller A, Blättermann S, Mohr-Andrä M, Zahn S, Wenzel J, Smith NJ, Gomeza J, Drewke C, Milligan G, Mohr K, Kostenis E.

Nat Biotechnol. 2010 Sep;28(9):943-9. doi: 10.1038/nbt.1671. Epub 2010 Aug 15.

PMID:
20711173
14.

Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice.

Eulenburg V, Retiounskaia M, Papadopoulos T, Gomeza J, Betz H.

Glia. 2010 Jul;58(9):1066-73. doi: 10.1002/glia.20987.

PMID:
20468048
15.

Development of synaptic inhibition in glycine transporter 2 deficient mice.

Latal AT, Kremer T, Gomeza J, Eulenburg V, Hülsmann S.

Mol Cell Neurosci. 2010 Aug;44(4):342-52. doi: 10.1016/j.mcn.2010.04.005. Epub 2010 May 4.

PMID:
20447457
16.

Neurotransmitter transporters expressed in glial cells as regulators of synapse function.

Eulenburg V, Gomeza J.

Brain Res Rev. 2010 May;63(1-2):103-12. doi: 10.1016/j.brainresrev.2010.01.003. Epub 2010 Jan 26. Review.

PMID:
20097227
17.

The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.

Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E.

J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14.

18.

Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia.

Eulenburg V, Becker K, Gomeza J, Schmitt B, Becker CM, Betz H.

Biochem Biophys Res Commun. 2006 Sep 22;348(2):400-5. Epub 2006 Jul 26.

PMID:
16884688
19.

Lessons from the knocked-out glycine transporters.

Gomeza J, Armsen W, Betz H, Eulenburg V.

Handb Exp Pharmacol. 2006;(175):457-83. Review.

PMID:
16722246
20.

Glycine transporters: essential regulators of synaptic transmission.

Betz H, Gomeza J, Armsen W, Scholze P, Eulenburg V.

Biochem Soc Trans. 2006 Feb;34(Pt 1):55-8. Review.

PMID:
16417482
21.

Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors.

Goutagny R, Comte JC, Salvert D, Gomeza J, Yamada M, Wess J, Luppi PH, Fort P.

Neuropsychobiology. 2005;52(3):140-6. Epub 2005 Aug 17.

PMID:
16110248
22.

Glycine transporters: essential regulators of neurotransmission.

Eulenburg V, Armsen W, Betz H, Gomeza J.

Trends Biochem Sci. 2005 Jun;30(6):325-33. Review.

PMID:
15950877
23.

M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity.

Seeger T, Fedorova I, Zheng F, Miyakawa T, Koustova E, Gomeza J, Basile AS, Alzheimer C, Wess J.

J Neurosci. 2004 Nov 10;24(45):10117-27.

24.

The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1.

Ohno K, Koroll M, El Far O, Scholze P, Gomeza J, Betz H.

Mol Cell Neurosci. 2004 Aug;26(4):518-29.

PMID:
15276154
25.

Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors.

Fisher JT, Vincent SG, Gomeza J, Yamada M, Wess J.

FASEB J. 2004 Apr;18(6):711-3. Epub 2004 Feb 20.

PMID:
14977875
26.

Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.

Gomeza J, Ohno K, Hülsmann S, Armsen W, Eulenburg V, Richter DW, Laube B, Betz H.

Neuron. 2003 Nov 13;40(4):797-806.

27.

Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.

Gomeza J, Hülsmann S, Ohno K, Eulenburg V, Szöke K, Richter D, Betz H.

Neuron. 2003 Nov 13;40(4):785-96. Erratum in: Neuron. 2004 Feb 19;41(4):675.

28.

Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises.

Gomeza J, Ohno K, Betz H.

Curr Opin Drug Discov Devel. 2003 Sep;6(5):675-82. Review.

PMID:
14579517
29.

M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system.

Wess J, Duttaroy A, Zhang W, Gomeza J, Cui Y, Miyakawa T, Bymaster FP, McKinzie L, Felder CC, Lamping KG, Faraci FM, Deng C, Yamada M.

Receptors Channels. 2003;9(4):279-90. Review.

PMID:
12893539
30.

Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice.

Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG.

Mol Psychiatry. 2003 Jul;8(7):673-9.

PMID:
12874603
31.

Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.

Bymaster FP, Carter PA, Yamada M, Gomeza J, Wess J, Hamilton SE, Nathanson NM, McKinzie DL, Felder CC.

Eur J Neurosci. 2003 Apr;17(7):1403-10.

PMID:
12713643
32.

Use of knockout mice reveals involvement of M2-muscarinic receptors in control of the kinetics of acetylcholine release.

Slutsky I, Wess J, Gomeza J, Dudel J, Parnas I, Parnas H.

J Neurophysiol. 2003 Apr;89(4):1954-67.

33.

Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice.

Jagoda EM, Kiesewetter DO, Shimoji K, Ravasi L, Yamada M, Gomeza J, Wess J, Eckelman WC.

Neuropharmacology. 2003 Apr;44(5):653-61.

PMID:
12668051
34.

Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review.

Wess J, Duttaroy A, Gomeza J, Zhang W, Yamada M, Felder CC, Bernardini N, Reeh PW.

Life Sci. 2003 Mar 28;72(18-19):2047-54.

PMID:
12628455
35.
36.

Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice.

Duttaroy A, Gomeza J, Gan JW, Siddiqui N, Basile AS, Harman WD, Smith PL, Felder CC, Levey AI, Wess J.

Mol Pharmacol. 2002 Nov;62(5):1084-93.

PMID:
12391271
37.
38.

Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception.

Bernardini N, Roza C, Sauer SK, Gomeza J, Wess J, Reeh PW.

J Neurosci. 2002 Jun 15;22(12):RC229. Epub 2002 Jun 3.

39.

M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices.

Berkeley JL, Gomeza J, Wess J, Hamilton SE, Nathanson NM, Levey AI.

Mol Cell Neurosci. 2001 Nov;18(5):512-24.

PMID:
11922142
40.

Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.

Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J.

J Neurosci. 2002 Mar 1;22(5):1709-17.

41.

Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice.

Zhou H, Meyer A, Starke K, Gomeza J, Wess J, Trendelenburg AU.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Feb;365(2):112-22. Epub 2001 Dec 18.

PMID:
11819029
42.

Elucidating the role of muscarinic receptors in psychosis.

Felder CC, Porter AC, Skillman TL, Zhang L, Bymaster FP, Nathanson NM, Hamilton SE, Gomeza J, Wess J, McKinzie DL.

Life Sci. 2001 Apr 27;68(22-23):2605-13.

PMID:
11392633
43.

Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons.

Shapiro MS, Gomeza J, Hamilton SE, Hille B, Loose MD, Nathanson NM, Roche JP, Wess J.

Life Sci. 2001 Apr 27;68(22-23):2481-7.

PMID:
11392616
44.

Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice.

Bymaster FP, Carter PA, Zhang L, Falcone JF, Stengel PW, Cohen ML, Shannon HE, Gomeza J, Wess J, Felder CC.

Life Sci. 2001 Apr 27;68(22-23):2473-9.

PMID:
11392615
45.

Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice.

Gomeza J, Zhang L, Kostenis E, Felder CC, Bymaster FP, Brodkin J, Shannon H, Xia B, Duttaroy A, Deng CX, Wess J.

Life Sci. 2001 Apr 27;68(22-23):2457-66.

PMID:
11392613
46.

Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes.

Horiuchi M, Nicke A, Gomeza J, Aschrafi A, Schmalzing G, Betz H.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1448-53. Epub 2001 Feb 6.

47.

M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro.

Stengel PW, Gomeza J, Wess J, Cohen ML.

J Pharmacol Exp Ther. 2000 Mar;292(3):877-85.

PMID:
10688600
48.

Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice.

Shapiro MS, Loose MD, Hamilton SE, Nathanson NM, Gomeza J, Wess J, Hille B.

Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10899-904.

49.

Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.

Gomeza J, Zhang L, Kostenis E, Felder C, Bymaster F, Brodkin J, Shannon H, Xia B, Deng C, Wess J.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10483-8.

50.

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.

Gomeza J, Shannon H, Kostenis E, Felder C, Zhang L, Brodkin J, Grinberg A, Sheng H, Wess J.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1692-7.

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