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Items: 1 to 50 of 291

1.

Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production.

Itcho K, Oki K, Gomez-Sanchez CE, Gomez-Sanchez EP, Ohno H, Kobuke K, Nagano G, Yoshii Y, Baba R, Hattori N, Yoneda M.

Hypertension. 2020 Feb;75(2):492-499. doi: 10.1161/HYPERTENSIONAHA.119.14062. Epub 2019 Dec 23.

PMID:
31865789
2.

Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation.

Taylor MJ, Ullenbruch MR, Frucci EC, Rege J, Ansorge MS, Gomez-Sanchez CE, Begum S, Laufer E, Breault DT, Rainey WE.

J Clin Invest. 2020 Jan 2;130(1):83-93. doi: 10.1172/JCI127429.

3.

Mineralocorticoid Receptor Signaling Contributes to Normal Muscle Repair After Acute Injury.

Hauck JS, Howard ZM, Lowe J, Rastogi N, Pico MG, Swager SA, Petrosino JM, Gomez-Sanchez CE, Gomez-Sanchez EP, Accornero F, Rafael-Fortney JA.

Front Physiol. 2019 Oct 25;10:1324. doi: 10.3389/fphys.2019.01324. eCollection 2019.

4.

Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling.

El Zein RM, Soria AH, Golib Dzib JF, Rickard AJ, Fernandes-Rosa FL, Samson-Couterie B, Giscos-Douriez I, Rocha A, Poglitsch M, Gomez-Sanchez CE, Amar L, Ghyselinck NB, Benecke A, Zennaro MC, Boulkroun S.

Sci Rep. 2019 Oct 11;9(1):14677. doi: 10.1038/s41598-019-50988-2.

5.

Primary Aldosteronism: KCNJ5 Mutations and Adrenocortical Cell Growth.

Yang Y, Gomez-Sanchez CE, Jaquin D, Aristizabal Prada ET, Meyer LS, Knösel T, Schneider H, Beuschlein F, Reincke M, Williams TA.

Hypertension. 2019 Oct;74(4):809-816. doi: 10.1161/HYPERTENSIONAHA.119.13476. Epub 2019 Aug 26.

PMID:
31446799
6.

DLK1/PREF1 marks a novel cell population in the human adrenal cortex.

Hadjidemetriou I, Mariniello K, Ruiz-Babot G, Pittaway J, Mancini A, Mariannis D, Gomez-Sanchez CE, Parvanta L, Drake WM, Chung TT, Abdel-Aziz TE, DiMarco A, Palazzo FF, Wierman ME, Kiseljak-Vassiliades K, King PJ, Guasti L.

J Steroid Biochem Mol Biol. 2019 Oct;193:105422. doi: 10.1016/j.jsbmb.2019.105422. Epub 2019 Jun 29.

7.

Measurement of 11-dehydrocorticosterone in mice, rats and songbirds: Effects of age, sex and stress.

Hamden JE, Salehzadeh M, Jalabert C, O'Leary TP, Snyder JS, Gomez-Sanchez CE, Soma KK.

Gen Comp Endocrinol. 2019 Sep 15;281:173-182. doi: 10.1016/j.ygcen.2019.05.018. Epub 2019 May 27.

PMID:
31145891
8.

18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status.

Tezuka Y, Yamazaki Y, Kitada M, Morimoto R, Kudo M, Seiji K, Takase K, Kawasaki Y, Mitsuzuka K, Ito A, Nishikawa J, Asai N, Nakamura Y, Gomez-Sanchez CE, Ito S, Dezawa M, Sasano H, Satoh F.

Hypertension. 2019 Jun;73(6):1283-1290. doi: 10.1161/HYPERTENSIONAHA.118.12064.

PMID:
31006333
9.

Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice.

Oakley RH, Cruz-Topete D, He B, Foley JF, Myers PH, Xu X, Gomez-Sanchez CE, Chambon P, Willis MS, Cidlowski JA.

Sci Signal. 2019 Apr 16;12(577). pii: eaau9685. doi: 10.1126/scisignal.aau9685.

PMID:
30992401
10.

Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity.

Hayashi T, Zhang Z, Al-Eyd G, Sasaki A, Yasuda M, Oyama M, Gomez-Sanchez CE, Asakura H, Seki T, Mukai K, Nishimoto K.

J Steroid Biochem Mol Biol. 2019 Jul;191:105361. doi: 10.1016/j.jsbmb.2019.04.010. Epub 2019 Apr 8.

PMID:
30974191
11.

Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.

Nanba K, Omata K, Gomez-Sanchez CE, Stratakis CA, Demidowich AP, Suzuki M, Thompson LDR, Cohen DL, Luther JM, Gellert L, Vaidya A, Barletta JA, Else T, Giordano TJ, Tomlins SA, Rainey WE.

Hypertension. 2019 Apr;73(4):885-892. doi: 10.1161/HYPERTENSIONAHA.118.12070.

PMID:
30739536
12.

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.

Basham KJ, Rodriguez S, Turcu AF, Lerario AM, Logan CY, Rysztak MR, Gomez-Sanchez CE, Breault DT, Koo BK, Clevers H, Nusse R, Val P, Hammer GD.

Genes Dev. 2019 Feb 1;33(3-4):209-220. doi: 10.1101/gad.317412.118. Epub 2019 Jan 28.

13.

Visualizing Adrenal Steroids in Primary Aldosteronism.

Gomez-Sanchez CE, Williams TA.

Hypertension. 2018 Dec;72(6):1269-1271. doi: 10.1161/HYPERTENSIONAHA.118.11369. No abstract available.

14.

Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma.

Yamazaki Y, Omata K, Tezuka Y, Ono Y, Morimoto R, Adachi Y, Ise K, Nakamura Y, Gomez-Sanchez CE, Shibahara Y, Kitamoto T, Nishikawa T, Ito S, Satoh F, Sasano H.

Hypertension. 2018 Sep;72(3):632-640. doi: 10.1161/HYPERTENSIONAHA.118.10907.

15.

Immunohistopathology and Steroid Profiles Associated With Biochemical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism.

Meyer LS, Wang X, Sušnik E, Burrello J, Burrello A, Castellano I, Eisenhofer G, Fallo F, Kline GA, Knösel T, Kocjan T, Lenders JWM, Mulatero P, Naruse M, Nishikawa T, Peitzsch M, Rump LC, Beuschlein F, Hahner S, Gomez-Sanchez CE, Reincke M, Williams TA.

Hypertension. 2018 Sep;72(3):650-657. doi: 10.1161/HYPERTENSIONAHA.118.11465.

16.

Mineralocorticoid Receptor Antagonists in Muscular Dystrophy Mice During Aging and Exercise.

Lowe J, Kadakia FK, Zins JG, Haupt M, Peczkowski KK, Rastogi N, Floyd KT, Gomez-Sanchez EP, Gomez-Sanchez CE, Elnakish MT, Rafael-Fortney JA, Janssen PML.

J Neuromuscul Dis. 2018;5(3):295-306. doi: 10.3233/JND-180323.

17.

The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications.

Seccia TM, Caroccia B, Gomez-Sanchez EP, Gomez-Sanchez CE, Rossi GP.

Endocr Rev. 2018 Dec 1;39(6):1029-1056. doi: 10.1210/er.2018-00060. Review.

18.

Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma.

Kobuke K, Oki K, Gomez-Sanchez CE, Ohno H, Itcho K, Yoshii Y, Yoneda M, Hattori N.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):965-971. doi: 10.1210/jc.2017-01996.

PMID:
29294065
19.

Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.

Heinze B, Fuss CT, Mulatero P, Beuschlein F, Reincke M, Mustafa M, Schirbel A, Deutschbein T, Williams TA, Rhayem Y, Quinkler M, Rayes N, Monticone S, Wild V, Gomez-Sanchez CE, Reis AC, Petersenn S, Wester HJ, Kropf S, Fassnacht M, Lang K, Herrmann K, Buck AK, Bluemel C, Hahner S.

Hypertension. 2018 Feb;71(2):317-325. doi: 10.1161/HYPERTENSIONAHA.117.09975. Epub 2017 Dec 26.

20.

Disordered CYP11B2 Expression in Primary Aldosteronism.

Gomez-Sanchez CE, Kuppusamy M, Reincke M, Williams TA.

Horm Metab Res. 2017 Dec;49(12):957-962. doi: 10.1055/s-0043-122238. Epub 2017 Dec 4. Review.

PMID:
29202495
21.

Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma.

Kobuke K, Oki K, Gomez-Sanchez CE, Gomez-Sanchez EP, Ohno H, Itcho K, Yoshii Y, Yoneda M, Hattori N.

Hypertension. 2018 Jan;71(1):125-133. doi: 10.1161/HYPERTENSIONAHA.117.10205. Epub 2017 Nov 6.

22.

Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology.

Aragao-Santiago L, Gomez-Sanchez CE, Mulatero P, Spyroglou A, Reincke M, Williams TA.

Endocrinology. 2017 Dec 1;158(12):4129-4138. doi: 10.1210/en.2017-00637.

23.

Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells.

Seccia TM, Caroccia B, Gomez-Sanchez EP, Vanderriele PE, Gomez-Sanchez CE, Rossi GP.

Hypertension. 2017 Nov;70(5):867-874. doi: 10.1161/HYPERTENSIONAHA.117.09991. Epub 2017 Sep 25. Review. No abstract available.

24.

DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18-hydroxycortisol: is there clinical utility of these steroids?

Lenders JWM, Williams TA, Reincke M, Gomez-Sanchez CE.

Eur J Endocrinol. 2018 Jan;178(1):R1-R9. doi: 10.1530/EJE-17-0563. Epub 2017 Sep 13. Review.

25.

Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia.

Kometani M, Yoneda T, Demura M, Koide H, Nishimoto K, Mukai K, Gomez-Sanchez CE, Akagi T, Yokota T, Horike SI, Karashima S, Miyamori I, Yamagishi M, Takeda Y.

Sci Rep. 2017 Sep 11;7(1):11205. doi: 10.1038/s41598-017-11435-2.

26.

Development of monoclonal antibodies against the human 3β-hydroxysteroid dehydrogenase/isomerase isozymes.

Gomez-Sanchez CE, Lewis M, Nanba K, Rainey WE, Kuppusamy M, Gomez-Sanchez EP.

Steroids. 2017 Nov;127:56-61. doi: 10.1016/j.steroids.2017.08.011. Epub 2017 Aug 31.

27.

Rapid Screening of Primary Aldosteronism by a Novel Chemiluminescent Immunoassay.

Morimoto R, Ono Y, Tezuka Y, Kudo M, Yamamoto S, Arai T, Gomez-Sanchez CE, Sasano H, Ito S, Satoh F.

Hypertension. 2017 Aug;70(2):334-341. doi: 10.1161/HYPERTENSIONAHA.117.09078. Epub 2017 Jun 26.

28.

Of Mice and Man and the Regulation of Aldosterone Secretion.

Gomez-Sanchez CE, Kuppusamy M, Gomez-Sanchez EP.

Hypertension. 2017 Aug;70(2):240-242. doi: 10.1161/HYPERTENSIONAHA.117.09013. Epub 2017 Jun 19. No abstract available.

29.

Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort.

Williams TA, Lenders JWM, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L, Quinkler M, Deinum J, Beuschlein F, Kitamoto KK, Pham U, Morimoto R, Umakoshi H, Prejbisz A, Kocjan T, Naruse M, Stowasser M, Nishikawa T, Young WF Jr, Gomez-Sanchez CE, Funder JW, Reincke M; Primary Aldosteronism Surgery Outcome (PASO) investigators.

Lancet Diabetes Endocrinol. 2017 Sep;5(9):689-699. doi: 10.1016/S2213-8587(17)30135-3. Epub 2017 May 30.

30.

Interaction of the Mineralocorticoid Receptor With RACK1 and Its Role in Aldosterone Signaling.

Kuppusamy M, Gomez-Sanchez EP, Beloate LN, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez CE.

Endocrinology. 2017 Jul 1;158(7):2367-2375. doi: 10.1210/en.2017-00095.

31.

Gene expression effects of glucocorticoid and mineralocorticoid receptor agonists and antagonists on normal human skeletal muscle.

Chadwick JA, Hauck JS, Gomez-Sanchez CE, Gomez-Sanchez EP, Rafael-Fortney JA.

Physiol Genomics. 2017 Jun 1;49(6):277-286. doi: 10.1152/physiolgenomics.00128.2016. Epub 2017 Apr 21.

32.

Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin).

Teo AE, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ.

Hypertension. 2017 Jun;69(6):1207-1216. doi: 10.1161/HYPERTENSIONAHA.117.09156. Epub 2017 Apr 17.

33.

Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.

Fallo F, Castellano I, Gomez-Sanchez CE, Rhayem Y, Pilon C, Vicennati V, Santini D, Maffeis V, Fassina A, Mulatero P, Beuschlein F, Reincke M.

Endocrine. 2017 Dec;58(3):503-512. doi: 10.1007/s12020-017-1295-4. Epub 2017 Apr 12.

34.

Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism.

Yamazaki Y, Nakamura Y, Omata K, Ise K, Tezuka Y, Ono Y, Morimoto R, Nozawa Y, Gomez-Sanchez CE, Tomlins SA, Rainey WE, Ito S, Satoh F, Sasano H.

J Clin Endocrinol Metab. 2017 Apr 1;102(4):1182-1192. doi: 10.1210/jc.2016-2986.

35.

The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.

Wu VC, Wang SM, Chueh SJ, Yang SY, Huang KH, Lin YH, Wang JJ, Connolly R, Hu YH, Gomez-Sanchez CE, Peng KY, Wu KD.

Sci Rep. 2017 Jan 19;7:39121. doi: 10.1038/srep39121.

36.

Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.

Lowe J, Floyd KT, Rastogi N, Schultz EJ, Chadwick JA, Swager SA, Zins JG, Kadakia FK, Smart S, Gomez-Sanchez EP, Gomez-Sanchez CE, Raman SV, Janssen PM, Rafael-Fortney JA.

J Neuromuscul Dis. 2016;3(3):395-404.

37.

Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy.

Chadwick JA, Swager SA, Lowe J, Welc SS, Tidball JG, Gomez-Sanchez CE, Gomez-Sanchez EP, Rafael-Fortney JA.

Hum Mol Genet. 2016 Dec 1;25(23):5167-5177. doi: 10.1093/hmg/ddw331.

38.

Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3.

Gomez-Sanchez CE, Qi X, Gomez-Sanchez EP, Sasano H, Bohlen MO, Wisgerhof M.

Mol Cell Endocrinol. 2017 Jan 5;439:74-80. doi: 10.1016/j.mce.2016.10.025. Epub 2016 Oct 25.

39.

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.

Nishimoto K, Koga M, Seki T, Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE, Naruse M, Sakaguchi T, Morita S, Kosaka T, Oya M, Ogishima T, Yasuda M, Suematsu M, Kabe Y, Omura M, Nishikawa T, Mukai K.

Mol Cell Endocrinol. 2017 Feb 5;441:124-133. doi: 10.1016/j.mce.2016.10.014. Epub 2016 Oct 14. Review.

40.

Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells.

Louiset E, Duparc C, Lenglet S, Gomez-Sanchez CE, Lefebvre H.

Mol Cell Endocrinol. 2017 Feb 5;441:99-107. doi: 10.1016/j.mce.2016.10.008. Epub 2016 Oct 12.

41.

Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.

Yoshii Y, Oki K, Gomez-Sanchez CE, Ohno H, Itcho K, Kobuke K, Yoneda M.

Hypertension. 2016 Dec;68(6):1432-1437. Epub 2016 Oct 17.

42.

PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development.

Drelon C, Berthon A, Sahut-Barnola I, Mathieu M, Dumontet T, Rodriguez S, Batisse-Lignier M, Tabbal H, Tauveron I, Lefrançois-Martinez AM, Pointud JC, Gomez-Sanchez CE, Vainio S, Shan J, Sacco S, Schedl A, Stratakis CA, Martinez A, Val P.

Nat Commun. 2016 Sep 14;7:12751. doi: 10.1038/ncomms12751.

43.

Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism.

Tamura A, Nishimoto K, Seki T, Matsuzawa Y, Saito J, Omura M, Gomez-Sanchez CE, Makita K, Matsui S, Moriya N, Inoue A, Nagata M, Sasano H, Nakamura Y, Yamazaki Y, Kabe Y, Mukai K, Kosaka T, Oya M, Suematsu S, Nishikawa T.

Mol Cell Endocrinol. 2017 Feb 5;441:134-139. doi: 10.1016/j.mce.2016.07.031. Epub 2016 Aug 8.

44.

Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study.

Uchida T, Nishimoto K, Fukumura Y, Asahina M, Goto H, Kawano Y, Shimizu F, Tsujimura A, Seki T, Mukai K, Kabe Y, Suematsu M, Gomez-Sanchez CE, Yao T, Horie S, Watada H.

Endocr Pathol. 2017 Mar;28(1):27-35. doi: 10.1007/s12022-016-9441-8.

45.

YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter.

Oki K, Plonczynski MW, Gomez-Sanchez EP, Gomez-Sanchez CE.

Mol Cell Endocrinol. 2016 Oct 15;434:93-8. doi: 10.1016/j.mce.2016.06.022. Epub 2016 Jun 19.

46.

Temporal and spatial distribution of mast cells and steroidogenic enzymes in the human fetal adrenal.

Naccache A, Louiset E, Duparc C, Laquerrière A, Patrier S, Renouf S, Gomez-Sanchez CE, Mukai K, Lefebvre H, Castanet M.

Mol Cell Endocrinol. 2016 Oct 15;434:69-80. doi: 10.1016/j.mce.2016.06.015. Epub 2016 Jun 11.

PMID:
27302892
47.

Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma.

Kishimoto R, Oki K, Yoneda M, Gomez-Sanchez CE, Ohno H, Kobuke K, Itcho K, Kohno N.

Medicine (Baltimore). 2016 May;95(20):e3659. doi: 10.1097/MD.0000000000003659.

48.

Immunohistochemistry of the adrenal in primary aldosteronism.

Gomez-Sanchez CE, Gomez-Sanchez EP.

Curr Opin Endocrinol Diabetes Obes. 2016 Jun;23(3):242-8. doi: 10.1097/MED.0000000000000248. Review.

49.

Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production.

Hattangady NG, Karashima S, Yuan L, Ponce-Balbuena D, Jalife J, Gomez-Sanchez CE, Auchus RJ, Rainey WE, Else T.

J Mol Endocrinol. 2016 Jul;57(1):1-11. doi: 10.1530/JME-15-0324. Epub 2016 Apr 20.

50.

Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17.

Nakamura Y, Kitada M, Satoh F, Maekawa T, Morimoto R, Yamazaki Y, Ise K, Gomez-Sanchez CE, Ito S, Arai Y, Dezawa M, Sasano H.

Mol Cell Endocrinol. 2016 Feb 15;422:57-63. doi: 10.1016/j.mce.2015.11.014. Epub 2015 Nov 17.

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