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Items: 44

1.

Microglia in Health and Disease: A Unique Immune Cell Population.

Michelucci A, Mittelbronn M, Gomez-Nicola D.

Front Immunol. 2018 Aug 15;9:1779. doi: 10.3389/fimmu.2018.01779. eCollection 2018. No abstract available.

2.

PD-1 deficiency is not sufficient to induce myeloid mobilization to the brain or alter the inflammatory profile during chronic neurodegeneration.

Obst J, Mancuso R, Simon E, Gomez-Nicola D.

Brain Behav Immun. 2018 Oct;73:708-716. doi: 10.1016/j.bbi.2018.08.006. Epub 2018 Aug 4.

3.

Microglial Dynamics During Human Brain Development.

Menassa DA, Gomez-Nicola D.

Front Immunol. 2018 May 24;9:1014. doi: 10.3389/fimmu.2018.01014. eCollection 2018. Review.

4.

Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age.

Núñez JA, Goring A, Javaheri B, Razi H, Gomez-Nicola D, Pitsillides AA, Thurner PJ, Gomez-Nicola D, Schneider P, Clarkin CE.

Eur Cell Mater. 2018 May 23;35:281-299. doi: 10.22203/eCM.v035a20.

5.

The Evolving Dialogue of Microglia and Neurons in Alzheimer's Disease: Microglia as Necessary Transducers of Pathology.

Simon E, Obst J, Gomez-Nicola D.

Neuroscience. 2018 Feb 8. pii: S0306-4522(18)30089-7. doi: 10.1016/j.neuroscience.2018.01.059. [Epub ahead of print] Review.

6.

Neuroinflammation: Microglia and T Cells Get Ready to Tango.

Schetters STT, Gomez-Nicola D, Garcia-Vallejo JJ, Van Kooyk Y.

Front Immunol. 2018 Jan 25;8:1905. doi: 10.3389/fimmu.2017.01905. eCollection 2017.

7.

Development and maintenance of the brain's immune toolkit: Microglia and non-parenchymal brain macrophages.

Lopez-Atalaya JP, Askew KE, Sierra A, Gomez-Nicola D.

Dev Neurobiol. 2018 Jun;78(6):561-579. doi: 10.1002/dneu.22545. Epub 2017 Oct 24. Review.

8.

The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity.

Obst J, Simon E, Mancuso R, Gomez-Nicola D.

Front Aging Neurosci. 2017 Jun 23;9:207. doi: 10.3389/fnagi.2017.00207. eCollection 2017. Review.

9.

STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy.

Dahal LN, Dou L, Hussain K, Liu R, Earley A, Cox KL, Murinello S, Tracy I, Forconi F, Steele AJ, Duriez PJ, Gomez-Nicola D, Teeling JL, Glennie MJ, Cragg MS, Beers SA.

Cancer Res. 2017 Jul 1;77(13):3619-3631. doi: 10.1158/0008-5472.CAN-16-2784. Epub 2017 May 16.

10.

A story of birth and death: Insights into the formation and dynamics of the microglial population.

Askew K, Gomez-Nicola D.

Brain Behav Immun. 2018 Mar;69:9-17. doi: 10.1016/j.bbi.2017.03.009. Epub 2017 Mar 21. Review.

11.

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.

Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J; FReJA, Oliver PL, Gomez-Nicola D, Isaacs AM.

Hum Mol Genet. 2017 Mar 1;26(5):873-887. doi: 10.1093/hmg/ddx003.

12.

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain.

Askew K, Li K, Olmos-Alonso A, Garcia-Moreno F, Liang Y, Richardson P, Tipton T, Chapman MA, Riecken K, Beccari S, Sierra A, Molnár Z, Cragg MS, Garaschuk O, Perry VH, Gomez-Nicola D.

Cell Rep. 2017 Jan 10;18(2):391-405. doi: 10.1016/j.celrep.2016.12.041.

13.

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.

Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco MD, Matute C, Maletic-Savatic M, Encinas JM, Sierra A.

PLoS Biol. 2016 Sep 20;14(9):e1002554. doi: 10.1371/journal.pbio.1002554. eCollection 2016 Sep.

14.

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.

Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco MD, Matute C, Maletic-Savatic M, Encinas JM, Sierra A.

PLoS Biol. 2016 Jun 30;14(6):e1002508. doi: 10.1371/journal.pbio.1002508. eCollection 2016 Jun.

15.

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.

Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco Md, Matute C, Maletic-Savatic M, Encinas JM, Sierra A.

PLoS Biol. 2016 May 26;14(5):e1002466. doi: 10.1371/journal.pbio.1002466. eCollection 2016 May. Erratum in: PLoS Biol. 2016 Jun;14(6):e1002508. PLoS Biol. 2016 Sep;14(9):e1002554.

16.

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves.

Martínez-Muriana A, Mancuso R, Francos-Quijorna I, Olmos-Alonso A, Osta R, Perry VH, Navarro X, Gomez-Nicola D, López-Vales R.

Sci Rep. 2016 May 13;6:25663. doi: 10.1038/srep25663.

17.

Long-term in vivo single-cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb.

Liang Y, Li K, Riecken K, Maslyukov A, Gomez-Nicola D, Kovalchuk Y, Fehse B, Garaschuk O.

Cell Res. 2016 Jul;26(7):805-21. doi: 10.1038/cr.2016.55. Epub 2016 May 13.

18.

The use of human neurons for novel drug discovery in dementia research.

Vargas-Caballero M, Willaime-Morawek S, Gomez-Nicola D, Perry VH, Bulters D, Mudher A.

Expert Opin Drug Discov. 2016;11(4):355-67. doi: 10.1517/17460441.2016.1154528. Epub 2016 Mar 1. Review.

PMID:
26878555
19.

Dark microglia: A new phenotype predominantly associated with pathological states.

Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ.

Glia. 2016 May;64(5):826-39. doi: 10.1002/glia.22966. Epub 2016 Feb 5.

20.

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.

Olmos-Alonso A, Schetters ST, Sri S, Askew K, Mancuso R, Vargas-Caballero M, Holscher C, Perry VH, Gomez-Nicola D.

Brain. 2016 Mar;139(Pt 3):891-907. doi: 10.1093/brain/awv379. Epub 2016 Jan 8.

21.

Microglia regulate hippocampal neurogenesis during chronic neurodegeneration.

De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D, Perry VH, Gomez-Nicola D.

Brain Behav Immun. 2016 Jul;55:179-190. doi: 10.1016/j.bbi.2015.11.001. Epub 2015 Nov 2.

22.

The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.

Zaru R, Matthews SP, Edgar AJ, Prescott AR, Gomez-Nicola D, Hanauer A, Watts C.

J Immunol. 2015 Nov 1;195(9):4264-72. doi: 10.4049/jimmunol.1501520. Epub 2015 Sep 23.

23.

Analysis of Microglial Proliferation in Alzheimer's Disease.

Gomez-Nicola D, Perry VH.

Methods Mol Biol. 2016;1303:185-93. doi: 10.1007/978-1-4939-2627-5_10.

PMID:
26235067
24.

Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease.

Gomez-Nicola D, Boche D.

Alzheimers Res Ther. 2015 Apr 22;7(1):42. doi: 10.1186/s13195-015-0126-1. eCollection 2015.

25.

Multicolor RGB Marking Allows Morphometric and Functional Analysis of Hippocampal Granule Neurons at the Single-Cell Level.

Gomez-Nicola D, Riecken K, Perry VH, Fehse B.

Hum Gene Ther. 2015 Jun;26(6):332-3. doi: 10.1089/hum.2015.010. Epub 2015 Apr 20.

26.

In-vivo RGB marking and multicolour single-cell tracking in the adult brain.

Gomez-Nicola D, Riecken K, Fehse B, Perry VH.

Sci Rep. 2014 Dec 22;4:7520. doi: 10.1038/srep07520.

27.

How can we exploit the brain's ability to repair itself?

Miller V, Gomez-Nicola D.

Expert Rev Neurother. 2014 Dec;14(12):1345-8. doi: 10.1586/14737175.2014.985659.

PMID:
25427149
28.

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration.

Gomez-Nicola D, Suzzi S, Vargas-Caballero M, Fransen NL, Al-Malki H, Cebrian-Silla A, Garcia-Verdugo JM, Riecken K, Fehse B, Perry VH.

Brain. 2014 Aug;137(Pt 8):2312-28. doi: 10.1093/brain/awu155. Epub 2014 Jun 18.

29.

Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity.

Gomez-Nicola D, Perry VH.

Neuroscientist. 2015 Apr;21(2):169-84. doi: 10.1177/1073858414530512. Epub 2014 Apr 10. Review.

30.

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease.

Gómez-Nicola D, Schetters ST, Perry VH.

Glia. 2014 Jul;62(7):1041-52. doi: 10.1002/glia.22660. Epub 2014 Mar 19.

31.

The role of inflammatory mediators in immune-to-brain communication during health and disease.

Gomez-Nicola D, Teeling J, Guaza C, Godbout JP, Taub DD.

Mediators Inflamm. 2013;2013:429231. doi: 10.1155/2013/429231. Epub 2013 Sep 10. No abstract available.

32.

Regulation of microglial proliferation during chronic neurodegeneration.

Gómez-Nicola D, Fransen NL, Suzzi S, Perry VH.

J Neurosci. 2013 Feb 6;33(6):2481-93. doi: 10.1523/JNEUROSCI.4440-12.2013.

33.

Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells.

Burgos E, Gómez-Nicola D, Pascual D, Martín MI, Nieto-Sampedro M, Goicoechea C.

Eur J Pharmacol. 2012 May 5;682(1-3):62-72. doi: 10.1016/j.ejphar.2012.02.008. Epub 2012 Feb 21.

PMID:
22374260
34.

Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.

Nieto-Sampedro M, Valle-Argos B, Gómez-Nicola D, Fernández-Mayoralas A, Nieto-Díaz M.

Clin Med Insights Oncol. 2011;5:265-314. doi: 10.4137/CMO.S7685. Epub 2011 Sep 21.

35.

Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells.

Gómez-Nicola D, Valle-Argos B, Pallas-Bazarra N, Nieto-Sampedro M.

Mol Biol Cell. 2011 Jun 15;22(12):1960-70. doi: 10.1091/mbc.E11-01-0053. Epub 2011 Apr 20.

36.

Neurostatin blocks glioma cell cycle progression by inhibiting EGFR activation.

Valle-Argos B, Gómez-Nicola D, Nieto-Sampedro M.

Mol Cell Neurosci. 2011 Jan;46(1):89-100. doi: 10.1016/j.mcn.2010.08.009. Epub 2010 Aug 27.

PMID:
20801220
37.

CCR7 is expressed in astrocytes and upregulated after an inflammatory injury.

Gomez-Nicola D, Pallas-Bazarra N, Valle-Argos B, Nieto-Sampedro M.

J Neuroimmunol. 2010 Oct 8;227(1-2):87-92. doi: 10.1016/j.jneuroim.2010.06.018. Epub 2010 Jul 16.

PMID:
20638137
38.

Glioma growth inhibition by neurostatin and O-But GD1b.

Valle-Argos B, Gómez-Nicola D, Nieto-Sampedro M.

Neuro Oncol. 2010 Nov;12(11):1135-46. doi: 10.1093/neuonc/noq073. Epub 2010 Jul 8.

39.

Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth.

Valle-Argos B, Gómez-Nicola D, Nieto-Sampedro M.

Eur J Med Chem. 2010 May;45(5):2034-43. doi: 10.1016/j.ejmech.2010.01.015. Epub 2010 Jan 28.

PMID:
20153569
40.

Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice.

Gomez-Nicola D, Spagnolo A, Guaza C, Nieto-Sampedro M.

Exp Neurol. 2010 Apr;222(2):235-42. doi: 10.1016/j.expneurol.2009.12.034. Epub 2010 Jan 11.

PMID:
20070942
41.

Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release.

Gomez-Nicola D, Valle-Argos B, Nieto-Sampedro M.

Glia. 2010 Feb;58(3):264-76. doi: 10.1002/glia.20920.

PMID:
19610094
42.

Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltration.

Gómez-Nicola D, Valle-Argos B, Suardíaz M, Taylor JS, Nieto-Sampedro M.

J Neurochem. 2008 Dec;107(6):1741-52. doi: 10.1111/j.1471-4159.2008.05746.x. Epub 2008 Nov 7.

43.

Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury.

Gómez-Nicola D, Valle-Argos B, Pita-Thomas DW, Nieto-Sampedro M.

Glia. 2008 Apr;56(5):494-505. doi: 10.1002/glia.20628.

PMID:
18240307
44.

Regulation by GD3 of the proinflammatory response of microglia mediated by interleukin-15.

Gómez-Nicola D, Doncel-Pérez E, Nieto-Sampedro M.

J Neurosci Res. 2006 Apr;83(5):754-62.

PMID:
16477650

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