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Inflammasomes: Their Role in Normal and Complicated Pregnancies.

Gomez-Lopez N, Motomura K, Miller D, Garcia-Flores V, Galaz J, Romero R.

J Immunol. 2019 Dec 1;203(11):2757-2769. doi: 10.4049/jimmunol.1900901. Review.


Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study.

Romero R, Gomez-Lopez N, Winters AD, Jung E, Shaman M, Bieda J, Panaitescu B, Pacora P, Erez O, Greenberg JM, Ahmad MM, Hsu CD, Theis KR.

J Perinat Med. 2019 Nov 26;47(9):915-931. doi: 10.1515/jpm-2019-0297.


Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions.

Rattila S, Dunk CEE, Im M, Grichenko O, Zhou Y, Yanez-Mo M, Blois SM, Yamada KM, Erez O, Gomez-Lopez N, Lye SJ, Hinz B, Romero R, Cohen M, Dveksler G.

Cells. 2019 Oct 31;8(11). pii: E1369. doi: 10.3390/cells8111369.


Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy.

Yan Y, Gomez-Lopez N, Basij M, Shahvari AV, Vadillo-Ortega F, Hernandez-Andrade E, Hassan SS, Romero R, MehrMohammadi M.

Biomed Opt Express. 2019 Aug 19;10(9):4643-4655. doi: 10.1364/BOE.10.004643. eCollection 2019 Sep 1.


The origin of amniotic fluid monocytes/macrophages in women with intra-amniotic inflammation or infection.

Gomez-Lopez N, Romero R, Leng Y, Xu Y, Slutsky R, Levenson D, Pacora P, Jung E, Panaitescu B, Hsu CD.

J Perinat Med. 2019 Oct 25;47(8):822-840. doi: 10.1515/jpm-2019-0262.


Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth.

Gomez-Lopez N, Romero R, Xu Y, Miller D, Arenas-Hernandez M, Garcia-Flores V, Panaitescu B, Galaz J, Hsu CD, Para R, Berry SM.

J Immunol. 2019 Oct 1;203(7):1793-1807. doi: 10.4049/jimmunol.1900621. Epub 2019 Sep 6.


Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.

Gomez-Lopez N, Romero R, Tarca AL, Miller D, Panaitescu B, Schwenkel G, Gudicha DW, Hassan SS, Pacora P, Jung E, Hsu CD.

Am J Reprod Immunol. 2019 Dec;82(6):e13184. doi: 10.1111/aji.13184. Epub 2019 Sep 20.


Cellular immune responses in amniotic fluid of women with preterm labor and intra-amniotic infection or intra-amniotic inflammation.

Gomez-Lopez N, Romero R, Galaz J, Xu Y, Panaitescu B, Slutsky R, Motomura K, Gill N, Para R, Pacora P, Jung E, Hsu CD.

Am J Reprod Immunol. 2019 Nov;82(5):e13171. doi: 10.1111/aji.13171. Epub 2019 Sep 3.


Does the endometrial cavity have a molecular microbial signature?

Winters AD, Romero R, Gervasi MT, Gomez-Lopez N, Tran MR, Garcia-Flores V, Pacora P, Jung E, Hassan SS, Hsu CD, Theis KR.

Sci Rep. 2019 Jul 9;9(1):9905. doi: 10.1038/s41598-019-46173-0.


Reducing maternal mortality: can elabela help in this fight?

Hassan SS, Gomez-Lopez N.

Lancet. 2019 Jul 6;394(10192):8-9. doi: 10.1016/S0140-6736(19)30543-4. Epub 2019 Jul 4. No abstract available.


Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor.

Slutsky R, Romero R, Xu Y, Galaz J, Miller D, Done B, Tarca AL, Gregor S, Hassan SS, Leng Y, Gomez-Lopez N.

J Immunol Res. 2019 May 23;2019:3128010. doi: 10.1155/2019/3128010. eCollection 2019.


The prediction of early preeclampsia: Results from a longitudinal proteomics study.

Tarca AL, Romero R, Benshalom-Tirosh N, Than NG, Gudicha DW, Done B, Pacora P, Chaiworapongsa T, Panaitescu B, Tirosh D, Gomez-Lopez N, Draghici S, Hassan SS, Erez O.

PLoS One. 2019 Jun 4;14(6):e0217273. doi: 10.1371/journal.pone.0217273. eCollection 2019.


QUEST MRI assessment of fetal brain oxidative stress in utero.

Berkowitz BA, Romero R, Podolsky RH, Lins-Childers KM, Shen Y, Rosales T, Wadghiri YZ, Hoang DM, Arenas-Hernandez M, Garcia-Flores V, Schwenkel G, Panaitescu B, Gomez-Lopez N.

Neuroimage. 2019 Oct 15;200:601-606. doi: 10.1016/j.neuroimage.2019.05.069. Epub 2019 May 31.


Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.

Gomez-Lopez N, Romero R, Panaitescu B, Miller D, Zou C, Gudicha DW, Tarca AL, Para R, Pacora P, Hassan SS, Hsu CD.

J Matern Fetal Neonatal Med. 2019 May 6:1-11. doi: 10.1080/14767058.2019.1610740. [Epub ahead of print]


Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes.

Para R, Romero R, Miller D, Panaitescu B, Varrey A, Chaiworapongsa T, Hassan SS, Hsu CD, Gomez-Lopez N.

J Matern Fetal Neonatal Med. 2019 Apr 18:1-16. doi: 10.1080/14767058.2019.1597047. [Epub ahead of print]


Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone.

Arenas-Hernandez M, Romero R, Xu Y, Panaitescu B, Garcia-Flores V, Miller D, Ahn H, Done B, Hassan SS, Hsu CD, Tarca AL, Sanchez-Torres C, Gomez-Lopez N.

J Immunol. 2019 May 1;202(9):2585-2608. doi: 10.4049/jimmunol.1801350. Epub 2019 Mar 27.


Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics.

Theis KR, Romero R, Winters AD, Greenberg JM, Gomez-Lopez N, Alhousseini A, Bieda J, Maymon E, Pacora P, Fettweis JM, Buck GA, Jefferson KK, Strauss JF 3rd, Erez O, Hassan SS.

Am J Obstet Gynecol. 2019 Mar;220(3):267.e1-267.e39. doi: 10.1016/j.ajog.2018.10.018.


Are B cells altered in the decidua of women with preterm or term labor?

Leng Y, Romero R, Xu Y, Galaz J, Slutsky R, Arenas-Hernandez M, Garcia-Flores V, Motomura K, Hassan SS, Reboldi A, Gomez-Lopez N.

Am J Reprod Immunol. 2019 May;81(5):e13102. doi: 10.1111/aji.13102. Epub 2019 Mar 29.


The immunophenotype of decidual macrophages in acute atherosis.

Gill N, Leng Y, Romero R, Xu Y, Panaitescu B, Miller D, Arif A, Mumuni S, Qureshi F, Hsu CD, Hassan SS, Staff AC, Gomez-Lopez N.

Am J Reprod Immunol. 2019 Apr;81(4):e13098. doi: 10.1111/aji.13098. Epub 2019 Mar 4.


Targeted expression profiling by RNA-Seq improves detection of cellular dynamics during pregnancy and identifies a role for T cells in term parturition.

Tarca AL, Romero R, Xu Z, Gomez-Lopez N, Erez O, Hsu CD, Hassan SS, Carey VJ.

Sci Rep. 2019 Jan 29;9(1):848. doi: 10.1038/s41598-018-36649-w.


Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes†.

Gomez-Lopez N, Romero R, Garcia-Flores V, Leng Y, Miller D, Hassan SS, Hsu CD, Panaitescu B.

Biol Reprod. 2019 May 1;100(5):1306-1318. doi: 10.1093/biolre/ioy264.


Intra-amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome†.

Faro J, Romero R, Schwenkel G, Garcia-Flores V, Arenas-Hernandez M, Leng Y, Xu Y, Miller D, Hassan SS, Gomez-Lopez N.

Biol Reprod. 2019 May 1;100(5):1290-1305. doi: 10.1093/biolre/ioy261.


Innate Lymphoid Cells in the Maternal and Fetal Compartments.

Miller D, Motomura K, Garcia-Flores V, Romero R, Gomez-Lopez N.

Front Immunol. 2018 Oct 26;9:2396. doi: 10.3389/fimmu.2018.02396. eCollection 2018. Review.


Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation.

Gomez-Lopez N, Romero R, Maymon E, Kusanovic JP, Panaitescu B, Miller D, Pacora P, Tarca AL, Motomura K, Erez O, Jung E, Hassan SS, Hsu CD.

J Perinat Med. 2019 Apr 24;47(3):276-287. doi: 10.1515/jpm-2018-0271.


Clinical Chorioamnionitis at Term: New Insights into the Etiology, Microbiology, and the Fetal, Maternal and Amniotic Cavity Inflammatory Responses.

Romero R, Gomez-Lopez N, Kusanovic JP, Pacora P, Panaitescu B, Erez O, Yoon BH.

Nogyogyaszati Szuleszeti Tovabbkepzo Szemle. 2018 Jun;20(3):103-112.


Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation.

Gomez-Lopez N, Romero R, Panaitescu B, Leng Y, Xu Y, Tarca AL, Faro J, Pacora P, Hassan SS, Hsu CD.

Am J Reprod Immunol. 2018 Nov;80(5):e13049. doi: 10.1111/aji.13049. Epub 2018 Sep 18.


Human β-defensin-1: A natural antimicrobial peptide present in amniotic fluid that is increased in spontaneous preterm labor with intra-amniotic infection.

Varrey A, Romero R, Panaitescu B, Miller D, Chaiworapongsa T, Patwardhan M, Faro J, Pacora P, Hassan SS, Hsu CD, Gomez-Lopez N.

Am J Reprod Immunol. 2018 Oct;80(4):e13031. doi: 10.1111/aji.13031. Epub 2018 Aug 12.


Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4.

Garcia-Flores V, Romero R, Miller D, Xu Y, Done B, Veerapaneni C, Leng Y, Arenas-Hernandez M, Khan N, Panaitescu B, Hassan SS, Alvarez-Salas LM, Gomez-Lopez N.

Front Immunol. 2018 Jun 18;9:1291. doi: 10.3389/fimmu.2018.01291. eCollection 2018.


ELABELA plasma concentrations are increased in women with late-onset preeclampsia.

Panaitescu B, Romero R, Gomez-Lopez N, Pacora P, Erez O, Vadillo-Ortega F, Yeo L, Hassan SS, Hsu CD.

J Matern Fetal Neonatal Med. 2020 Jan;33(1):5-15. doi: 10.1080/14767058.2018.1484089. Epub 2018 Jul 22.


Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors.

Fitzgerald W, Gomez-Lopez N, Erez O, Romero R, Margolis L.

Am J Reprod Immunol. 2018 Jul;80(1):e12860. doi: 10.1111/aji.12860. Epub 2018 May 4.


Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.

Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC.

Sci Transl Med. 2018 Apr 25;10(438). pii: eaan2263. doi: 10.1126/scitranslmed.aan2263.


The immunophenotype of amniotic fluid leukocytes in normal and complicated pregnancies.

Gomez-Lopez N, Romero R, Xu Y, Miller D, Leng Y, Panaitescu B, Silva P, Faro J, Alhousseini A, Gill N, Hassan SS, Hsu CD.

Am J Reprod Immunol. 2018 Apr;79(4):e12827. doi: 10.1111/aji.12827. Epub 2018 Mar 3.


Innate lymphoid cells at the human maternal-fetal interface in spontaneous preterm labor.

Xu Y, Romero R, Miller D, Silva P, Panaitescu B, Theis KR, Arif A, Hassan SS, Gomez-Lopez N.

Am J Reprod Immunol. 2018 Jun;79(6):e12820. doi: 10.1111/aji.12820. Epub 2018 Feb 19.


CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses.

Miller D, Romero R, Unkel R, Xu Y, Vadillo-Ortega F, Hassan SS, Gomez-Lopez N.

J Leukoc Biol. 2018 Apr;103(4):761-775. doi: 10.1002/JLB.5A0717-291RRR. Epub 2018 Feb 1.


Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term.

Arenas-Hernandez M, Gomez-Lopez N, Garcia-Flores V, Rangel-Escareño C, Alvarez-Salas LM, Martinez-Acuña N, Vazquez-Perez JA, Vega-Sanchez R.

Genes Immun. 2019 Jan;20(1):56-68. doi: 10.1038/s41435-017-0010-z. Epub 2018 Jan 24.


Novel expression of CD11b in epithelial ovarian cancer: Potential therapeutic target.

Saed GM, Fletcher NM, Diamond MP, Morris RT, Gomez-Lopez N, Memaj I.

Gynecol Oncol. 2018 Mar;148(3):567-575. doi: 10.1016/j.ygyno.2017.12.018. Epub 2018 Jan 10.


In vivo evidence of inflammasome activation during spontaneous labor at term.

Panaitescu B, Romero R, Gomez-Lopez N, Xu Y, Leng Y, Maymon E, Pacora P, Erez O, Yeo L, Hassan SS, Hsu CD.

J Matern Fetal Neonatal Med. 2019 Jun;32(12):1978-1991. doi: 10.1080/14767058.2017.1422714. Epub 2018 Jan 17.


Spontaneous preterm birth: advances toward the discovery of genetic predisposition.

Strauss JF 3rd, Romero R, Gomez-Lopez N, Haymond-Thornburg H, Modi BP, Teves ME, Pearson LN, York TP, Schenkein HA.

Am J Obstet Gynecol. 2018 Mar;218(3):294-314.e2. doi: 10.1016/j.ajog.2017.12.009. Epub 2017 Dec 14. Review.


Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM).

Modi BP, Teves ME, Pearson LN, Parikh HI, Haymond-Thornburg H, Tucker JL, Chaemsaithong P, Gomez-Lopez N, York TP, Romero R, Strauss JF 3rd.

Mol Genet Genomic Med. 2017 Nov;5(6):720-729. doi: 10.1002/mgg3.330. Epub 2017 Aug 23.


Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin?

Gomez-Lopez N, Romero R, Xu Y, Leng Y, Garcia-Flores V, Miller D, Jacques SM, Hassan SS, Faro J, Alsamsam A, Alhousseini A, Gomez-Roberts H, Panaitescu B, Yeo L, Maymon E.

Am J Obstet Gynecol. 2017 Dec;217(6):693.e1-693.e16. doi: 10.1016/j.ajog.2017.09.013. Epub 2017 Sep 28.


Fetal death: an extreme manifestation of maternal anti-fetal rejection.

Lannaman K, Romero R, Chaiworapongsa T, Kim YM, Korzeniewski SJ, Maymon E, Gomez-Lopez N, Panaitescu B, Hassan SS, Yeo L, Yoon BH, Jai Kim C, Erez O.

J Perinat Med. 2017 Oct 26;45(7):851-868. doi: 10.1515/jpm-2017-0073.


Preterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes.

Gomez-Lopez N, Romero R, Plazyo O, Schwenkel G, Garcia-Flores V, Unkel R, Xu Y, Leng Y, Hassan SS, Panaitescu B, Cha J, Dey SK.

Am J Obstet Gynecol. 2017 Nov;217(5):592.e1-592.e17. doi: 10.1016/j.ajog.2017.08.008. Epub 2017 Aug 25.


Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection.

Maymon E, Romero R, Bhatti G, Chaemsaithong P, Gomez-Lopez N, Panaitescu B, Chaiyasit N, Pacora P, Dong Z, Hassan SS, Erez O.

J Perinat Med. 2018 Feb 23;46(2):123-137. doi: 10.1515/jpm-2017-0042.


Amniotic fluid neutrophils can phagocytize bacteria: A mechanism for microbial killing in the amniotic cavity.

Gomez-Lopez N, Romero R, Garcia-Flores V, Xu Y, Leng Y, Alhousseini A, Hassan SS, Panaitescu B.

Am J Reprod Immunol. 2017 Oct;78(4). doi: 10.1111/aji.12723. Epub 2017 Jul 13.


The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery.

Tarca AL, Fitzgerald W, Chaemsaithong P, Xu Z, Hassan SS, Grivel JC, Gomez-Lopez N, Panaitescu B, Pacora P, Maymon E, Erez O, Margolis L, Romero R.

Am J Reprod Immunol. 2017 Sep;78(3). doi: 10.1111/aji.12686. Epub 2017 Jun 6.


In vivo activation of invariant natural killer T cells induces systemic and local alterations in T-cell subsets prior to preterm birth.

Gomez-Lopez N, Romero R, Arenas-Hernandez M, Schwenkel G, St Louis D, Hassan SS, Mial TN.

Clin Exp Immunol. 2017 Aug;189(2):211-225. doi: 10.1111/cei.12968. Epub 2017 May 10.


Rosiglitazone Regulates TLR4 and Rescues HO-1 and NRF2 Expression in Myometrial and Decidual Macrophages in Inflammation-Induced Preterm Birth.

Kadam L, Gomez-Lopez N, Mial TN, Kohan-Ghadr HR, Drewlo S.

Reprod Sci. 2017 Dec;24(12):1590-1599. doi: 10.1177/1933719117697128. Epub 2017 Mar 21.


Twenty-four percent of patients with clinical chorioamnionitis in preterm gestations have no evidence of either culture-proven intraamniotic infection or intraamniotic inflammation.

Oh KJ, Kim SM, Hong JS, Maymon E, Erez O, Panaitescu B, Gomez-Lopez N, Romero R, Yoon BH.

Am J Obstet Gynecol. 2017 Jun;216(6):604.e1-604.e11. doi: 10.1016/j.ajog.2017.02.035. Epub 2017 Feb 28.


Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term.

Gomez-Lopez N, Romero R, Xu Y, Garcia-Flores V, Leng Y, Panaitescu B, Miller D, Abrahams VM, Hassan SS.

Am J Reprod Immunol. 2017 May;77(5). doi: 10.1111/aji.12648. Epub 2017 Feb 24.


Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition.

El-Azzamy H, Balogh A, Romero R, Xu Y, LaJeunesse C, Plazyo O, Xu Z, Price TG, Dong Z, Tarca AL, Papp Z, Hassan SS, Chaiworapongsa T, Kim CJ, Gomez-Lopez N, Than NG.

J Pathol Transl Med. 2017 May;51(3):264-283. doi: 10.4132/jptm.2016.12.20. Epub 2017 Feb 22.

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