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Items: 20

1.

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.

Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR.

J Mol Cell Cardiol. 2019 May;130:96-106. doi: 10.1016/j.yjmcc.2019.03.018. Epub 2019 Mar 27.

2.

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.

Batiste SM, Blackwell DJ, Kim K, Kryshtal DO, Gomez-Hurtado N, Rebbeck RT, Cornea RL, Johnston JN, Knollmann BC.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4810-4815. doi: 10.1073/pnas.1816685116. Epub 2019 Feb 21.

3.

Fibroblast growth factor-23 promotes rhythm alterations and contractile dysfunction in adult ventricular cardiomyocytes.

Navarro-García JA, Delgado C, Fernández-Velasco M, Val-Blasco A, Rodríguez-Sánchez E, Aceves-Ripoll J, Gómez-Hurtado N, Bada-Bosch T, Mérida-Herrero E, Hernández E, Praga M, Salguero R, Solís J, Arribas F, Delgado JF, Bueno H, Kuro-O M, Ruilope LM, Ruiz-Hurtado G.

Nephrol Dial Transplant. 2019 Nov 1;34(11):1864-1875. doi: 10.1093/ndt/gfy392.

PMID:
30629224
4.

Calcitriol, the Bioactive Metabolite of Vitamin D, Increases Ventricular K+ Currents in Isolated Mouse Cardiomyocytes.

Tamayo M, Martin-Nunes L, Val-Blasco A, Piedras MJ, Larriba MJ, Gómez-Hurtado N, Fernández-Velasco M, Delgado C.

Front Physiol. 2018 Aug 24;9:1186. doi: 10.3389/fphys.2018.01186. eCollection 2018.

5.

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Parikh SS, Blackwell DJ, Gomez-Hurtado N, Frisk M, Wang L, Kim K, Dahl CP, Fiane A, Tønnessen T, Kryshtal DO, Louch WE, Knollmann BC.

Circ Res. 2017 Dec 8;121(12):1323-1330. doi: 10.1161/CIRCRESAHA.117.311920. Epub 2017 Oct 2.

6.

Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR.

J Am Coll Cardiol. 2017 Jul 4;70(1):115-117. doi: 10.1016/j.jacc.2017.04.055. No abstract available.

7.

Modelling human calmodulinopathies with induced pluripotent stem cells: progress and challenges.

Gomez-Hurtado N, Blackwell DJ, Knollmann BC.

Cardiovasc Res. 2017 Apr 1;113(5):437-439. doi: 10.1093/cvr/cvx041. No abstract available.

8.

Beneficial effects of leptin treatment in a setting of cardiac dysfunction induced by transverse aortic constriction in mouse.

Gómez-Hurtado N, Domínguez-Rodríguez A, Mateo P, Fernández-Velasco M, Val-Blasco A, Aizpún R, Sabourin J, Gómez AM, Benitah JP, Delgado C.

J Physiol. 2017 Jul 1;595(13):4227-4243. doi: 10.1113/JP274030. Epub 2017 May 23.

9.

Role of NOD1 in Heart Failure Progression via Regulation of Ca2+ Handling.

Val-Blasco A, Piedras MJGM, Ruiz-Hurtado G, Suarez N, Prieto P, Gonzalez-Ramos S, Gómez-Hurtado N, Delgado C, Pereira L, Benito G, Zaragoza C, Domenech N, Crespo-Leiro MG, Vasquez-Echeverri D, Nuñez G, Lopez-Collazo E, Boscá L, Fernández-Velasco M.

J Am Coll Cardiol. 2017 Jan 31;69(4):423-433. doi: 10.1016/j.jacc.2016.10.073.

10.

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC.

Circ Arrhythm Electrophysiol. 2016 Aug;9(8). pii: e004161. doi: 10.1161/CIRCEP.116.004161.

11.

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.

Boczek NJ, Gomez-Hurtado N, Ye D, Calvert ML, Tester DJ, Kryshtal D, Hwang HS, Johnson CN, Chazin WJ, Loporcaro CG, Shah M, Papez AL, Lau YR, Kanter R, Knollmann BC, Ackerman MJ.

Circ Cardiovasc Genet. 2016 Apr;9(2):136-146. doi: 10.1161/CIRCGENETICS.115.001323. Epub 2016 Mar 11.

12.

Essential Role of Calmodulin in RyR Inhibition by Dantrolene.

Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR.

Mol Pharmacol. 2015 Jul;88(1):57-63. doi: 10.1124/mol.115.097691. Epub 2015 Apr 28.

13.

NOD1, a new player in cardiac function and calcium handling.

Delgado C, Ruiz-Hurtado G, Gómez-Hurtado N, González-Ramos S, Rueda A, Benito G, Prieto P, Zaragoza C, Delicado EG, Pérez-Sen R, Miras-Portugal MT, Núñez G, Boscá L, Fernández-Velasco M.

Cardiovasc Res. 2015 Jun 1;106(3):375-86. doi: 10.1093/cvr/cvv118. Epub 2015 Mar 30.

PMID:
25824149
14.

Impaired calcium-calmodulin-dependent inactivation of Cav1.2 contributes to loss of sarcoplasmic reticulum calcium release refractoriness in mice lacking calsequestrin 2.

Kryshtal DO, Gryshchenko O, Gomez-Hurtado N, Knollmann BC.

J Mol Cell Cardiol. 2015 May;82:75-83. doi: 10.1016/j.yjmcc.2015.02.027. Epub 2015 Mar 7.

15.

Calcium in atrial fibrillation - pulling the trigger or not?

Gomez-Hurtado N, Knollmann BC.

J Clin Invest. 2014 Nov;124(11):4684-6. doi: 10.1172/JCI77986. Epub 2014 Oct 20.

16.

Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin.

Guzmán-Ruiz R, Gómez-Hurtado N, Gil-Ortega M, Somoza B, González MC, Aránguez I, Martín-Ramos M, González-Martín C, Delgado C, Fernández-Alfonso M, Ruiz-Gayo M.

Front Endocrinol (Lausanne). 2013 Nov 15;4:175. doi: 10.3389/fendo.2013.00175. eCollection 2013.

17.

Prolonged leptin treatment increases transient outward K⁺ current via upregulation of Kv4.2 and Kv4.3 channel subunits in adult rat ventricular myocytes.

Gómez-Hurtado N, Fernández-Velasco M, Fernández-Alfonso MS, Boscá L, Delgado C.

Pflugers Arch. 2014 May;466(5):903-14. doi: 10.1007/s00424-013-1348-3. Epub 2013 Sep 18.

PMID:
24046152
18.

DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.

Martín R, Miana M, Jurado-López R, Martínez-Martínez E, Gómez-Hurtado N, Delgado C, Bartolomé MV, San Román JA, Cordova C, Lahera V, Nieto ML, Cachofeiro V.

PLoS One. 2012;7(7):e41545. doi: 10.1371/journal.pone.0041545. Epub 2012 Jul 23.

19.

Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.

Ruiz-Hurtado G, Gómez-Hurtado N, Fernández-Velasco M, Calderón E, Smani T, Ordoñez A, Cachofeiro V, Boscá L, Díez J, Gómez AM, Delgado C.

Cardiovasc Res. 2012 Oct 1;96(1):81-9. doi: 10.1093/cvr/cvs234. Epub 2012 Jul 11.

PMID:
22787135
20.

Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes.

Smani T, Calderón-Sanchez E, Gómez-Hurtado N, Fernández-Velasco M, Cachofeiro V, Lahera V, Ordoñez A, Delgado C.

Cardiovasc Res. 2010 Aug 1;87(3):459-66. doi: 10.1093/cvr/cvq063. Epub 2010 Feb 26.

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