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Items: 36


Structural and mechanistic insights into regulation of the retromer coat by TBC1d5.

Jia D, Zhang JS, Li F, Wang J, Deng Z, White MA, Osborne DG, Phillips-Krawczak C, Gomez TS, Li H, Singla A, Burstein E, Billadeau DD, Rosen MK.

Nat Commun. 2016 Nov 9;7:13305. doi: 10.1038/ncomms13305.


Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.

Deng ZH, Gomez TS, Osborne DG, Phillips-Krawczak CA, Zhang JS, Billadeau DD.

J Cell Sci. 2015 Jan 15;128(2):373-84. doi: 10.1242/jcs.161513. Epub 2014 Nov 27.


COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Sluis Bv, Billadeau DD, Burstein E.

Mol Biol Cell. 2015 Jan 1;26(1):91-103. doi: 10.1091/mbc.E14-06-1073. Epub 2014 Oct 29.


Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, Dani A, Billadeau DD, Swat W.

PLoS One. 2014 Jun 2;9(6):e98606. doi: 10.1371/journal.pone.0098606. eCollection 2014.


Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.

Zhang JS, Herreros-Villanueva M, Koenig A, Deng Z, de Narvajas AA, Gomez TS, Meng X, Bujanda L, Ellenrieder V, Li XK, Kaufmann SH, Billadeau DD.

Cell Death Dis. 2014 Mar 27;5:e1142. doi: 10.1038/cddis.2014.102. Erratum in: Cell Death Dis. 2014 Aug;5:e1365. Herreros-Vilanueva, M [corrected to Herreros-Villanueva, M].


Epigenetic regulation of autophagy by the methyltransferase G9a.

Artal-Martinez de Narvajas A, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujanda L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD.

Mol Cell Biol. 2013 Oct;33(20):3983-93. doi: 10.1128/MCB.00813-13. Epub 2013 Aug 5.


SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells.

Herreros-Villanueva M, Zhang JS, Koenig A, Abel EV, Smyrk TC, Bamlet WR, de Narvajas AA, Gomez TS, Simeone DM, Bujanda L, Billadeau DD.

Oncogenesis. 2013 Aug 5;2:e61. doi: 10.1038/oncsis.2013.23.


Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.

Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR.

Cell. 2013 Feb 28;152(5):1051-64. doi: 10.1016/j.cell.2013.01.051.


WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function.

Piotrowski JT, Gomez TS, Schoon RA, Mangalam AK, Billadeau DD.

Mol Cell Biol. 2013 Mar;33(5):958-73. doi: 10.1128/MCB.01288-12. Epub 2012 Dec 28.


Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Gomez TS, Gorman JA, de Narvajas AA, Koenig AO, Billadeau DD.

Mol Biol Cell. 2012 Aug;23(16):3215-28. doi: 10.1091/mbc.E12-02-0101. Epub 2012 Jun 20.


Rab GTPase regulation of retromer-mediated cargo export during endosome maturation.

Liu TT, Gomez TS, Sackey BK, Billadeau DD, Burd CG.

Mol Biol Cell. 2012 Jul;23(13):2505-15. doi: 10.1091/mbc.E11-11-0915. Epub 2012 May 16.


The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.

Gorman JA, Babich A, Dick CJ, Schoon RA, Koenig A, Gomez TS, Burkhardt JK, Billadeau DD.

J Immunol. 2012 Jun 15;188(12):6135-44. doi: 10.4049/jimmunol.1103487. Epub 2012 May 9.


Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.

Jia D, Gomez TS, Billadeau DD, Rosen MK.

Mol Biol Cell. 2012 Jun;23(12):2352-61. doi: 10.1091/mbc.E11-12-1059. Epub 2012 Apr 18.


Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex.

Colón-Franco JM, Gomez TS, Billadeau DD.

J Cell Sci. 2011 Sep 15;124(Pt 18):3118-26. doi: 10.1242/jcs.083725. Epub 2011 Aug 24.


Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells.

Dehring DA, Clarke F, Ricart BG, Huang Y, Gomez TS, Williamson EK, Hammer DA, Billadeau DD, Argon Y, Burkhardt JK.

J Immunol. 2011 Apr 15;186(8):4805-18. doi: 10.4049/jimmunol.1003102. Epub 2011 Mar 11.


Structure and control of the actin regulatory WAVE complex.

Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK.

Nature. 2010 Nov 25;468(7323):533-8. doi: 10.1038/nature09623.


WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.

Jia D, Gomez TS, Metlagel Z, Umetani J, Otwinowski Z, Rosen MK, Billadeau DD.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10442-7. doi: 10.1073/pnas.0913293107. Epub 2010 May 24.


A FAM21-containing WASH complex regulates retromer-dependent sorting.

Gomez TS, Billadeau DD.

Dev Cell. 2009 Nov;17(5):699-711. doi: 10.1016/j.devcel.2009.09.009.


Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK.

J Immunol. 2009 Dec 1;183(11):7352-61. doi: 10.4049/jimmunol.0900973. Epub 2009 Nov 16.


Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.

Meng XW, Heldebrant MP, Flatten KS, Loegering DA, Dai H, Schneider PA, Gomez TS, Peterson KL, Trushin SA, Hess AD, Smith BD, Karp JE, Billadeau DD, Kaufmann SH.

J Biol Chem. 2010 Jan 8;285(2):888-902. doi: 10.1074/jbc.M109.057638. Epub 2009 Nov 3.


[Care for ulcers having diverse etiology prospective study on PermaFoam].

Cuervo FM, Soriano JV, López JR, Gómez TS.

Rev Enferm. 2009 Sep;32(9):21-6. Spanish.


Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity.

Arneson LN, Segovis CM, Gomez TS, Schoon RA, Dick CJ, Lou Z, Billadeau DD, Leibson PJ.

J Immunol. 2008 Nov 15;181(10):6995-7001.


T cell activation and the cytoskeleton: you can't have one without the other.

Gomez TS, Billadeau DD.

Adv Immunol. 2008;97:1-64. doi: 10.1016/S0065-2776(08)00001-1. Review.


Cutting edge: Rac GTPases sensitize activated T cells to die via Fas.

Ramaswamy M, Dumont C, Cruz AC, Muppidi JR, Gomez TS, Billadeau DD, Tybulewicz VL, Siegel RM.

J Immunol. 2007 Nov 15;179(10):6384-8.


Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.

Gomez TS, Kumar K, Medeiros RB, Shimizu Y, Leibson PJ, Billadeau DD.

Immunity. 2007 Feb;26(2):177-90.


Regulation of T-cell activation by the cytoskeleton.

Billadeau DD, Nolz JC, Gomez TS.

Nat Rev Immunol. 2007 Feb;7(2):131-43. Review.


Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation.

Miletic AV, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Gomez TS, Ota N, Kloeppel T, Kanagawa O, Tokunaga M, Billadeau DD, Swat W.

J Biol Chem. 2006 Dec 15;281(50):38257-65. Epub 2006 Oct 18.


HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.

Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK.

Immunity. 2006 Jun;24(6):741-52.


The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation.

Nolz JC, Gomez TS, Zhu P, Li S, Medeiros RB, Shimizu Y, Burkhardt JK, Freedman BD, Billadeau DD.

Curr Biol. 2006 Jan 10;16(1):24-34.


The Ezh2 methyltransferase complex: actin up in the cytosol.

Nolz JC, Gomez TS, Billadeau DD.

Trends Cell Biol. 2005 Oct;15(10):514-7. Epub 2005 Aug 26.


[LCT (lipocolloid technology) in lesions of venous etiology].

López JR, Bueno AM, Perejamo MA, Fornells MG, González RF, Gómez TS, Palmero AG, Sauvadet A.

Rev Enferm. 2005 Feb;28(2):52-6. Spanish.


Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse.

Gomez TS, Hamann MJ, McCarney S, Savoy DN, Lubking CM, Heldebrant MP, Labno CM, McKean DJ, McNiven MA, Burkhardt JK, Billadeau DD.

Nat Immunol. 2005 Mar;6(3):261-70. Epub 2005 Feb 6.


Low-proline environments impair growth, proline transport and in vivo survival of Staphylococcus aureus strain-specific putP mutants.

Schwan WR, Wetzel KJ, Gomez TS, Stiles MA, Beitlich BD, Grunwald S.

Microbiology. 2004 Apr;150(Pt 4):1055-1061. doi: 10.1099/mic.0.26710-0.


Differential regulation of TCR-mediated gene transcription by Vav family members.

Zakaria S, Gomez TS, Savoy DN, McAdam S, Turner M, Abraham RT, Billadeau DD.

J Exp Med. 2004 Feb 2;199(3):429-34.


Human immunodeficiency virus-induced apoptosis of human hepatocytes via CXCR4.

Vlahakis SR, Villasis-Keever A, Gomez TS, Bren GD, Paya CV.

J Infect Dis. 2003 Nov 15;188(10):1455-60. Epub 2003 Nov 18.


Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.

Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD.

J Clin Invest. 2003 May;111(10):1547-54.

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