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Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation.

Fernandes VC, Golubeva VA, Di Pietro G, Shields C, Amankwah K, Nepomuceno TC, de Gregoriis G, Abreu RBV, Harro C, Gomes TT, Silva RF, Suarez-Kurtz G, Couch F, Iversen ES, Monteiro ANA, Carvalho MA.

J Biol Chem. 2019 Feb 14. pii: jbc.RA118.005274. doi: 10.1074/jbc.RA118.005274. [Epub ahead of print]


A Case of Tracheomalacia in Chronic Obstructive Pulmonary Disease: What Went Wrong?

Pais C, Silva RC, Gomes T, Carvalho S.

Eur J Case Rep Intern Med. 2018 Jul 26;5(7):000906. doi: 10.12890/2018_000906. eCollection 2018.


Microencapsulation of tiger nut milk by lyophilization: Morphological characteristics, shelf life and microbiological stability.

da Costa Neto JJG, Gomes TLM, Justo TF, Pereira KS, Amaral PFF, Rocha Leão MHM, Fontes Sant'Ana GC.

Food Chem. 2019 Jun 30;284:133-139. doi: 10.1016/j.foodchem.2019.01.110. Epub 2019 Jan 24.


An integrative biological effects assessment of a mine discharge into a Norwegian fjord using field transplanted mussels.

Brooks SJ, Escudero-Oñate C, Gomes T, Ferrando-Climent L.

Sci Total Environ. 2018 Dec 10;644:1056-1069. doi: 10.1016/j.scitotenv.2018.07.058. Epub 2018 Jul 11.


Evaluation of the fentanyl patch-for-patch program in Ontario, Canada.

Tadrous M, Greaves S, Martins D, Nadeem K, Singh S, Mamdani MM, Juurlink DN, Gomes T.

Int J Drug Policy. 2019 Feb 8;66:82-86. doi: 10.1016/j.drugpo.2019.01.025. [Epub ahead of print]


Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.

Miragaia RJ, Gomes T, Chomka A, Jardine L, Riedel A, Hegazy AN, Whibley N, Tucci A, Chen X, Lindeman I, Emerton G, Krausgruber T, Shields J, Haniffa M, Powrie F, Teichmann SA.

Immunity. 2019 Feb 19;50(2):493-504.e7. doi: 10.1016/j.immuni.2019.01.001. Epub 2019 Feb 5.


Multiple Approaches to Address Potential Risk Factors of Chagas Disease Transmission in Northeastern Brazil.

Daflon-Teixeira NF, Coutinho C, Gomes TF, Toma HK, Duarte R, Bóia MN, Carvalho-Costa FA, Almeida CE, Lima MM.

Am J Trop Med Hyg. 2019 Feb;100(2):296-302. doi: 10.4269/ajtmh.18-0480.


Microneedling on the external female genitalia's flaccidity in patients with Ehlers-Danlos: Case report.

Gomes T, Baqueiro P, Oliveira C, Alves R, Lordelo P.

J Cosmet Dermatol. 2019 Feb 7. doi: 10.1111/jocd.12867. [Epub ahead of print]


An eye on hepatitis C: a review.

Bertrand RHC, Bertrand ALX, Gomes TM, Ferreira ASP.

Arq Bras Oftalmol. 2019 Mar-Apr;82(2):161-167. doi: 10.5935/0004-2749.20190027. Epub 2019 Jan 24.


"Like being put on an ice floe and shoved away": A qualitative study of the impacts of opioid-related policy changes on people who take opioids.

Antoniou T, Ala-Leppilampi K, Shearer D, Parsons JA, Tadrous M, Gomes T.

Int J Drug Policy. 2019 Jan 24;66:15-22. doi: 10.1016/j.drugpo.2019.01.015. [Epub ahead of print]


Low vitamin D at ICU admission is associated with cancer, infections, acute respiratory insufficiency, and liver failure.

Gomes TL, Fernandes RC, Vieira LL, Schincaglia RM, Mota JF, Nóbrega MS, Pichard C, Pimentel GD.

Nutrition. 2019 Apr;60:235-240. doi: 10.1016/j.nut.2018.10.018. Epub 2018 Oct 24.


Muscle function loss is associated with anxiety in patients with gastrointestinal cancer.

Soares JDP, Gomes TLN, Siqueira JM, Oliveira ICL, Mota JF, Laviano A, Pimentel GD.

Clin Nutr ESPEN. 2019 Feb;29:149-153. doi: 10.1016/j.clnesp.2018.11.003. Epub 2018 Nov 22.


Sublethal psychotropic pharmaceutical effects on the model organism Danio rerio: Oxidative stress and metal dishomeostasis.

Gomes TB, Fernandes Sales Junior S, Saint'Pierre TD, Correia FV, Hauser-Davis RA, Saggioro EM.

Ecotoxicol Environ Saf. 2019 Apr 30;171:781-789. doi: 10.1016/j.ecoenv.2019.01.041. Epub 2019 Jan 17.


The Burden of Opioid-Related Mortality in the United States.

Gomes T, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN.

JAMA Netw Open. 2018 Jun 1;1(2):e180217. doi: 10.1001/jamanetworkopen.2018.0217.


Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.

Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA.

Cell. 2019 Feb 7;176(4):882-896.e18. doi: 10.1016/j.cell.2018.11.044. Epub 2019 Jan 10.


Effects of Copper Oxide Nanoparticles on Tissue Accumulation and Antioxidant Enzymes of Galleria mellonella L.

Sezer Tuncsoy B, Tuncsoy M, Gomes T, Sousa V, Teixeira MR, Bebianno MJ, Ozalp P.

Bull Environ Contam Toxicol. 2019 Jan 2. doi: 10.1007/s00128-018-2529-8. [Epub ahead of print]


Can waist circumference provide a new "third" dimension to BMI when predicting percentage body fat in children? Insights using allometric modelling.

Nevill AM, Bryant E, Wilkinson K, Gomes TN, Chaves R, Pereira S, Katzmarzyk PT, Maia J, Duncan MJ.

Pediatr Obes. 2018 Dec 27:e12491. doi: 10.1111/ijpo.12491. [Epub ahead of print]


XEN® implant and trabeculectomy medium-term quality of life assessment and comparison of results.

Basílio AL, Moura-Coelho N, Passos I, Cardoso MS, Domingues I, Reina M, Flores R, Gomes T.

Int J Ophthalmol. 2018 Dec 18;11(12):1941-1944. doi: 10.18240/ijo.2018.12.11. eCollection 2018.


The Influence of Acanthamoeba-Legionella Interaction in the Virulence of Two Different Legionella Species.

Gomes TS, Gjiknuri J, Magnet A, Vaccaro L, Ollero D, Izquierdo F, Fenoy S, Hurtado C, Del Águila C.

Front Microbiol. 2018 Dec 5;9:2962. doi: 10.3389/fmicb.2018.02962. eCollection 2018.


A simulation environment for polymeric nanoparticles based on multi-agent systems.

Zamberlan AO, Kurtz GC, Gomes TL, Bordini RH, Fagan SB.

J Mol Model. 2018 Dec 18;25(1):5. doi: 10.1007/s00894-018-3889-z.


Distribution of the pilS gene in Escherichia coli pathovars, its transfer ability and influence in the typical enteropathogenic E. coli adherence phenotype.

Garcia BG, Castro FS, Vieira MAM, Girão DM, Uenishi LT, Cergole-Novella MC, Dos Santos LF, Piazza RMF, Hernandes RT, Gomes TAT.

Int J Med Microbiol. 2019 Jan;309(1):66-72. doi: 10.1016/j.ijmm.2018.12.001. Epub 2018 Dec 11.


Why are children different in their moderate-to-vigorous physical activity levels? A multilevel analysis.

Pereira S, Reyes A, Moura-Dos-Santos MA, Santos C, Gomes TN, Tani G, Vasconcelos O, Barreira TV, Katzmarzyk PT, Maia J.

J Pediatr (Rio J). 2018 Dec 11. pii: S0021-7557(18)30656-9. doi: 10.1016/j.jped.2018.10.013. [Epub ahead of print]


Analysis of Trends in Insulin Utilization and Spending Across Canada From 2010 to 2015.

Xu Y, Gomes T, Mamdani MM, Juurlink DN, Cadarette SM, Tadrous M.

Can J Diabetes. 2018 Aug 16. pii: S1499-2671(18)30200-4. doi: 10.1016/j.jcjd.2018.08.190. [Epub ahead of print]


Management challenges for best practices of the Kangaroo Method in the Neonatal ICU.

Silva LJD, Leite JL, Silva TPD, Silva ÍR, Mourão PP, Gomes TM.

Rev Bras Enferm. 2018;71(suppl 6):2783-2791. doi: 10.1590/0034-7167-2018-0428. English, Portuguese.

Free Article

Draft Whole-Genome Sequences of 10 Atypical Enteropathogenic Escherichia coli Strains Isolated in Brazil.

Santos FF, Richardson EJ, Bryant JA, Yamamoto D, Elias WP, Gomes TAT, Henderson IR.

Microbiol Resour Announc. 2018 Dec 6;7(22). pii: e01432-18. doi: 10.1128/MRA.01432-18. eCollection 2018 Dec.


Modeling the interactions among phythopatogens and phyllosphere microorganisms for the biological disease control of Olea europaea L.

Baptista P, Bulai IM, Gomes T, Venturino E.

Math Biosci. 2019 Feb;308:42-58. doi: 10.1016/j.mbs.2018.12.002. Epub 2018 Dec 4.


A multilevel analysis of individual- and school-level correlates of physical fitness in children.

Santos C, Reyes AC, André Moura Dos Santos M, Pereira S, Gomes TN, Tani G, Vasconcelos O, Chaves RN, Garganta R, Barreira TV, Katzmarzyk PT, Maia J.

Ann Hum Biol. 2018 Dec 4:1-25. doi: 10.1080/03014460.2018.1549684. [Epub ahead of print]


Do Diagnostic and Procedure Codes Within Population-Based, Administrative Datasets Accurately Identify Patients with Rectal Cancer?

Musselman RP, Gomes T, Rothwell DM, Auer RC, Moloo H, Boushey RP, van Walraven C.

J Gastrointest Surg. 2019 Feb;23(2):367-376. doi: 10.1007/s11605-018-4043-z. Epub 2018 Dec 3.


Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study.

Watt JA, Gomes T, Bronskill SE, Huang A, Austin PC, Ho JM, Straus SE.

CMAJ. 2018 Nov 26;190(47):E1376-E1383. doi: 10.1503/cmaj.180551.


Zoonotic potential of atypical enteropathogenic Escherichia coli (aEPEC) isolated from puppies with diarrhoea in Brazil.

Arais LR, Barbosa AV, Andrade JRC, Gomes TAT, Asensi MD, Aires CAM, Cerqueira AMF.

Vet Microbiol. 2018 Dec;227:45-51. doi: 10.1016/j.vetmic.2018.10.023. Epub 2018 Oct 30.


Potential benefits of near critical and supercritical pre-treatment of lignocellulosic biomass towards anaerobic digestion.

Rosero-Henao JC, Bueno BE, de Souza R, Ribeiro R, Lopes de Oliveira A, Gomide CA, Gomes TM, Tommaso G.

Waste Manag Res. 2019 Jan;37(1):74-82. doi: 10.1177/0734242X18806998. Epub 2018 Nov 9.


Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy.

Dos Santos TC, Gomes TM, Pinto BAS, Camara AL, Paes AMA.

Front Pharmacol. 2018 Oct 18;9:1192. doi: 10.3389/fphar.2018.01192. eCollection 2018. Review.


Regional variation in healthcare spending and mortality among senior high-cost healthcare users in Ontario, Canada: a retrospective matched cohort study.

Muratov S, Lee J, Holbrook A, Costa A, Paterson JM, Guertin JR, Mbuagbaw L, Gomes T, Khuu W, Tarride JE.

BMC Geriatr. 2018 Nov 1;18(1):262. doi: 10.1186/s12877-018-0952-7.


Gene expression variability across cells and species shapes innate immunity.

Hagai T, Chen X, Miragaia RJ, Rostom R, Gomes T, Kunowska N, Henriksson J, Park JE, Proserpio V, Donati G, Bossini-Castillo L, Vieira Braga FA, Naamati G, Fletcher J, Stephenson E, Vegh P, Trynka G, Kondova I, Dennis M, Haniffa M, Nourmohammad A, Lässig M, Teichmann SA.

Nature. 2018 Nov;563(7730):197-202. doi: 10.1038/s41586-018-0657-2. Epub 2018 Oct 24.


Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.

Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park JE, Natarajan K, Meyer KB, Miao Z, McKenzie ANJ, Mahata B, Teichmann SA.

Genome Med. 2018 Oct 24;10(1):76. doi: 10.1186/s13073-018-0589-3.


RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing.

Nojima T, Rebelo K, Gomes T, Grosso AR, Proudfoot NJ, Carmo-Fonseca M.

Mol Cell. 2018 Oct 18;72(2):369-379.e4. doi: 10.1016/j.molcel.2018.09.004.


Insertional anatomy of peroneal brevis and longus tendon - A cadaveric study.

Gomes MDR, Pinto AP, Fabián AA, Gomes TJM, Navarro A, Oliva XM.

Foot Ankle Surg. 2018 Jul 23. pii: S1268-7731(18)30169-3. doi: 10.1016/j.fas.2018.07.005. [Epub ahead of print]


Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.

Chan JL, Wu S, Geis AL, Chan GV, Gomes TAM, Beck SE, Wu X, Fan H, Tam AJ, Chung L, Ding H, Wang H, Pardoll DM, Housseau F, Sears CL.

Mucosal Immunol. 2019 Jan;12(1):164-177. doi: 10.1038/s41385-018-0085-5. Epub 2018 Oct 2.


Sub-lethal UV radiation during early life stages alters the behaviour, heart rate and oxidative stress parameters in zebrafish (Danio rerio).

Hurem S, Fraser TWK, Gomes T, Mayer I, Christensen T.

Ecotoxicol Environ Saf. 2018 Dec 30;166:359-365. doi: 10.1016/j.ecoenv.2018.09.082. Epub 2018 Oct 1.


Impact of timing of methadone initiation on perinatal outcomes following delivery among pregnant women on methadone maintenance therapy in Ontario.

Guan Q, Sproule BA, Vigod SN, Cadarette SM, Greaves S, Martins D, Gomes T.

Addiction. 2019 Feb;114(2):268-277. doi: 10.1111/add.14453. Epub 2018 Oct 30.


Interprovincial Variation of Psychotropic Prescriptions Dispensed to Older Canadian Adults.

Black CD, McCarthy L, Gomes T, Mamdani M, Juurlink D, Tadrous M.

Can Geriatr J. 2018 Sep 30;21(3):269-273. doi: 10.5770/cgj.21.307. eCollection 2018 Sep.


Trends in the utilisation of COPD therapeutic regimens before and after the introduction of LAMA/LABA combination products: A population-based study.

Parkin L, Khuu W, Stanbrook MB, Tadrous M, Martins D, Gomes T.

Respir Med. 2018 Oct;143:1-7. doi: 10.1016/j.rmed.2018.08.001. Epub 2018 Aug 14.


Opioid Use After ICU Admission Among Elderly Chronic Opioid Users in Ontario: A Population-Based Cohort Study.

Wang HT, Hill AD, Gomes T, Wijeysundera DN, Pinto R, Scales DC, Fowler R, Wunsch H.

Crit Care Med. 2018 Dec;46(12):1934-1942. doi: 10.1097/CCM.0000000000003401.


Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada.

Gomes T, Khuu W, Martins D, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN.

BMJ. 2018 Aug 29;362:k3207. doi: 10.1136/bmj.k3207.


Listeria monocytogenes impairs enzymes of the phosphotransfer network and alters antioxidant/oxidant status in cattle brain structures.

Jaguezeski AM, Baldissera MD, Rhoden LA, Gomes TMA, Mendes RE, Bottari NB, Morsch VM, Schetinger MRC, Stefani LM, Giongo JL, Vaucher RA, Da Silva AS.

Microb Pathog. 2018 Nov;124:284-290. doi: 10.1016/j.micpath.2018.08.044. Epub 2018 Aug 22.


Pregabalin and the Risk for Opioid-Related Death: A Nested Case-Control Study.

Gomes T, Greaves S, van den Brink W, Antoniou T, Mamdani MM, Paterson JM, Martins D, Juurlink DN.

Ann Intern Med. 2018 Nov 20;169(10):732-734. doi: 10.7326/M18-1136. Epub 2018 Aug 21. No abstract available.


Comparing the contribution of prescribed opioids to opioid-related hospitalizations across Canada: A multi-jurisdictional cross-sectional study.

Gomes T, Khuu W, Craiovan D, Martins D, Hunt J, Lee K, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN.

Drug Alcohol Depend. 2018 Oct 1;191:86-90. doi: 10.1016/j.drugalcdep.2018.06.028. Epub 2018 Jul 31.


The impact of biologics in surgical outcomes in ulcerative colitis.

Argollo MC, Kotze PG, Spinelli A, Gomes TNF, Danese S.

Best Pract Res Clin Gastroenterol. 2018 Feb - Apr;32-33:79-87. doi: 10.1016/j.bpg.2018.05.014. Epub 2018 Jun 8. Review.


Cognitive Stimulation of Elderly Individuals with Instrumental Virtual Reality-Based Activities of Daily Life: Pre-Post Treatment Study.

Gamito P, Oliveira J, Morais D, Coelho C, Santos N, Alves C, Galamba A, Soeiro M, Yerra M, French H, Talmers L, Gomes T, Brito R.

Cyberpsychol Behav Soc Netw. 2019 Jan;22(1):69-75. doi: 10.1089/cyber.2017.0679. Epub 2018 Jul 24.


Harm reduction strategies regarding the misuse of alcohol and other drugs: a review of the literature.

Gomes TB, Vecchia MD.

Cien Saude Colet. 2018 Jul;23(7):2327-2338. doi: 10.1590/1413-81232018237.21152016. Review. Portuguese, English.

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