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An Autocrine Proliferation Repressor Regulates Dictyostelium discoideum Proliferation and Chemorepulsion Using the G Protein-Coupled Receptor GrlH.

Tang Y, Wu Y, Herlihy SE, Brito-Aleman FJ, Ting JH, Janetopoulos C, Gomer RH.

MBio. 2018 Feb 13;9(1). pii: e02443-17. doi: 10.1128/mBio.02443-17.


Protease activated-receptor 2 is necessary for neutrophil chemorepulsion induced by trypsin, tryptase, or dipeptidyl peptidase IV.

White MJV, Chinea LE, Pilling D, Gomer RH.

J Leukoc Biol. 2018 Jan;103(1):119-128. doi: 10.1002/JLB.3A0717-308R. Epub 2017 Dec 11.


Dietary NaCl affects bleomycin-induced lung fibrosis in mice.

Chen W, Pilling D, Gomer RH.

Exp Lung Res. 2017 Nov - Dec;43(9-10):395-406. doi: 10.1080/01902148.2017.1385110. Epub 2017 Dec 8.


Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model.

Karhadkar TR, Pilling D, Cox N, Gomer RH.

Sci Rep. 2017 Nov 8;7(1):15069. doi: 10.1038/s41598-017-15198-8.


Identification of compounds that decrease numbers of Mycobacteria in human macrophages in the presence of serum amyloid P.

Xiang W, Cox N, Gomer RH.

J Leukoc Biol. 2017 Sep;102(3):857-869. doi: 10.1189/jlb.1A0317-118RR. Epub 2017 Aug 2.


Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands.

Pilling D, Galvis-Carvajal E, Karhadkar TR, Cox N, Gomer RH.

BMC Immunol. 2017 Jun 15;18(1):30. doi: 10.1186/s12865-017-0214-z.


Extracellular polyphosphate signals through Ras and Akt to prime Dictyostelium discoideum cells for development.

Suess PM, Watson J, Chen W, Gomer RH.

J Cell Sci. 2017 Jul 15;130(14):2394-2404. doi: 10.1242/jcs.203372. Epub 2017 Jun 5.


Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV.

Herlihy SE, Tang Y, Phillips JE, Gomer RH.

Protein Sci. 2017 Mar;26(3):578-585. doi: 10.1002/pro.3107. Epub 2017 Feb 15.


A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases.

Phillips JE, Gomer RH.

Ann Transl Med. 2016 Oct;4(Suppl 1):S20. No abstract available.


Evoking picomolar binding in RNA by a single phosphorodithioate linkage.

Abeydeera ND, Egli M, Cox N, Mercier K, Conde JN, Pallan PS, Mizurini DM, Sierant M, Hibti FE, Hassell T, Wang T, Liu FW, Liu HM, Martinez C, Sood AK, Lybrand TP, Frydman C, Monteiro RQ, Gomer RH, Nawrot B, Yang X.

Nucleic Acids Res. 2016 Sep 30;44(17):8052-64. doi: 10.1093/nar/gkw725. Epub 2016 Aug 26.


Extracellular Polyphosphate Inhibits Proliferation in an Autocrine Negative Feedback Loop in Dictyostelium discoideum.

Suess PM, Gomer RH.

J Biol Chem. 2016 Sep 16;291(38):20260-9. doi: 10.1074/jbc.M116.737825. Epub 2016 Aug 12.


Peritoneal Dialysis Fluid and Some of Its Components Potentiate Fibrocyte Differentiation.

Herlihy SE, Starke HE, Lopez-Anton M, Cox N, Keyhanian K, Fraser DJ, Gomer RH.

Perit Dial Int. 2016 Jul-Aug;36(4):367-73. doi: 10.3747/pdi.2014.00284. Epub 2015 Oct 22.


Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.

White MJ, Gomer RH.

PLoS One. 2015 Sep 25;10(9):e0138748. doi: 10.1371/journal.pone.0138748. eCollection 2015.


TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation.

Pilling D, Vakil V, Cox N, Gomer RH.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11929-34. doi: 10.1073/pnas.1507387112. Epub 2015 Sep 8.


Role of the neutrophil chemorepellent soluble dipeptidyl peptidase IV in decreasing inflammation in a murine model of arthritis.

Herlihy SE, Brown ML, Pilling D, Weeks BR, Myers LK, Gomer RH.

Arthritis Rheumatol. 2015 Oct;67(10):2634-8. doi: 10.1002/art.39250.


Galectin-3 Binding Protein Secreted by Breast Cancer Cells Inhibits Monocyte-Derived Fibrocyte Differentiation.

White MJ, Roife D, Gomer RH.

J Immunol. 2015 Aug 15;195(4):1858-67. doi: 10.4049/jimmunol.1500365. Epub 2015 Jul 1.


DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.

Cox N, Pilling D, Gomer RH.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8385-90. doi: 10.1073/pnas.1500956112. Epub 2015 Jun 23.


The long pentraxin PTX3 promotes fibrocyte differentiation.

Pilling D, Cox N, Vakil V, Verbeek JS, Gomer RH.

PLoS One. 2015 Mar 16;10(3):e0119709. doi: 10.1371/journal.pone.0119709. eCollection 2015.


Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis.

Pilling D, Zheng Z, Vakil V, Gomer RH.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18291-6. doi: 10.1073/pnas.1417426112. Epub 2014 Dec 8.


A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.

White MJ, Galvis-Carvajal E, Gomer RH.

J Immunol. 2015 Jan 1;194(1):142-50. doi: 10.4049/jimmunol.1401777. Epub 2014 Nov 26.


Distinct Fcγ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.

Cox N, Pilling D, Gomer RH.

J Immunol. 2014 Aug 15;193(4):1701-8. doi: 10.4049/jimmunol.1400281. Epub 2014 Jul 14.


Secondary ion mass spectrometry imaging of Dictyostelium discoideum aggregation streams.

DeBord JD, Smith DF, Anderton CR, Heeren RM, Paša-Tolić L, Gomer RH, Fernandez-Lima FA.

PLoS One. 2014 Jun 9;9(6):e99319. doi: 10.1371/journal.pone.0099319. eCollection 2014.


Serum amyloid P: a systemic regulator of the innate immune response.

Cox N, Pilling D, Gomer RH.

J Leukoc Biol. 2014 Nov;96(5):739-43. doi: 10.1189/jlb.1MR0114-068R. Epub 2014 May 7. Review.


Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI.

Pilling D, Crawford JR, Verbeek JS, Gomer RH.

J Leukoc Biol. 2014 Aug;96(2):275-82. doi: 10.1189/jlb.3AB0913-490RR. Epub 2014 Apr 21.


Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.

Pilling D, Gomer RH.

PLoS One. 2014 Apr 2;9(4):e93730. doi: 10.1371/journal.pone.0093730. eCollection 2014.


A retinoblastoma orthologue is required for the sensing of a chalone in Dictyostelium discoideum.

Bakthavatsalam D, White MJ, Herlihy SE, Phillips JE, Gomer RH.

Eukaryot Cell. 2014 Mar;13(3):376-82. doi: 10.1128/EC.00306-13. Epub 2014 Jan 3.


New approaches to modulating idiopathic pulmonary fibrosis.

Gomer RH.

Curr Allergy Asthma Rep. 2013 Dec;13(6):607-12. Review.


Trypsin potentiates human fibrocyte differentiation.

White MJ, Glenn M, Gomer RH.

PLoS One. 2013 Aug 7;8(8):e70795. doi: 10.1371/journal.pone.0070795. eCollection 2013.


Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.

Herlihy SE, Pilling D, Maharjan AS, Gomer RH.

J Immunol. 2013 Jun 15;190(12):6468-77. doi: 10.4049/jimmunol.1202583. Epub 2013 May 15.


A Dictyostelium secreted factor requires a PTEN-like phosphatase to slow proliferation and induce chemorepulsion.

Herlihy SE, Tang Y, Gomer RH.

PLoS One. 2013;8(3):e59365. doi: 10.1371/journal.pone.0059365. Epub 2013 Mar 12.


Serum amyloid P inhibits granulocyte adhesion.

Maharjan AS, Roife D, Brazill D, Gomer RH.

Fibrogenesis Tissue Repair. 2013 Jan 17;6(1):2. doi: 10.1186/1755-1536-6-2.


NaCl potentiates human fibrocyte differentiation.

Cox N, Pilling D, Gomer RH.

PLoS One. 2012;7(9):e45674. doi: 10.1371/journal.pone.0045674. Epub 2012 Sep 18.


Differentiation of circulating monocytes into fibroblast-like cells.

Pilling D, Gomer RH.

Methods Mol Biol. 2012;904:191-206. doi: 10.1007/978-1-61779-943-3_16.


A secreted protein is an endogenous chemorepellant in Dictyostelium discoideum.

Phillips JE, Gomer RH.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10990-5. doi: 10.1073/pnas.1206350109. Epub 2012 Jun 18.


FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.

Crawford JR, Pilling D, Gomer RH.

J Leukoc Biol. 2012 Oct;92(4):699-711. doi: 10.1189/jlb.0112033. Epub 2012 Apr 9.


Alternative origins of stroma in normal organs and disease.

Kolonin MG, Evans KW, Mani SA, Gomer RH.

Stem Cell Res. 2012 Mar;8(2):312-23. doi: 10.1016/j.scr.2011.11.005. Epub 2011 Dec 8. Review.


Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology.

Crawford JR, Bjorklund NL, Taglialatela G, Gomer RH.

Neurochem Res. 2012 Apr;37(4):795-801. doi: 10.1007/s11064-011-0674-0. Epub 2011 Dec 29.


High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.

Maharjan AS, Pilling D, Gomer RH.

PLoS One. 2011;6(10):e26078. doi: 10.1371/journal.pone.0026078. Epub 2011 Oct 11.


The putative bZIP transcription factor BzpN slows proliferation and functions in the regulation of cell density by autocrine signals in Dictyostelium.

Phillips JE, Huang E, Shaulsky G, Gomer RH.

PLoS One. 2011;6(7):e21765. doi: 10.1371/journal.pone.0021765. Epub 2011 Jul 7.


Cell density sensing and size determination.

Gomer RH, Jang W, Brazill D.

Dev Growth Differ. 2011 May;53(4):482-94. doi: 10.1111/j.1440-169X.2010.01248.x. Epub 2011 Apr 27. Review.


Pirfenidone treatment of idiopathic pulmonary fibrosis.

Gan Y, Herzog EL, Gomer RH.

Ther Clin Risk Manag. 2011 Feb 8;7:39-47. doi: 10.2147/TCRM.S12209.


Initial cell type choice in Dictyostelium.

Jang W, Gomer RH.

Eukaryot Cell. 2011 Feb;10(2):150-5. doi: 10.1128/EC.00219-10. Epub 2010 Dec 10. Review.


Toll-like receptor 2 agonists inhibit human fibrocyte differentiation.

Maharjan AS, Pilling D, Gomer RH.

Fibrogenesis Tissue Repair. 2010 Nov 24;3:23. doi: 10.1186/1755-1536-3-23.


Improved serum-free culture conditions for spleen-derived murine fibrocytes.

Crawford JR, Pilling D, Gomer RH.

J Immunol Methods. 2010 Dec 15;363(1):9-20. doi: 10.1016/j.jim.2010.09.025. Epub 2010 Oct 1.


The ROCO kinase QkgA is necessary for proliferation inhibition by autocrine signals in Dictyostelium discoideum.

Phillips JE, Gomer RH.

Eukaryot Cell. 2010 Oct;9(10):1557-65. doi: 10.1128/EC.00121-10. Epub 2010 Aug 13.


Investigational approaches to therapies for idiopathic pulmonary fibrosis.

Gomer RH, Lupher ML Jr.

Expert Opin Investig Drugs. 2010 Jun;19(6):737-45. doi: 10.1517/13543784.2010.484018. Review.


The secreted proteome profile of developing Dictyostelium discoideum cells.

Bakthavatsalam D, Gomer RH.

Proteomics. 2010 Jul;10(13):2556-9. doi: 10.1002/pmic.200900516.

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