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Items: 42


Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival.

Zhang D, Golubkov VS, Han W, Correa RG, Zhou Y, Lee S, Strongin AY, Dong PD.

Dev Biol. 2014 Nov 1;395(1):96-110. doi: 10.1016/j.ydbio.2014.08.025. Epub 2014 Aug 29.


Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis.

Golubkov VS, Prigozhina NL, Zhang Y, Stoletov K, Lewis JD, Schwartz PE, Hoffman RM, Strongin AY.

J Biol Chem. 2014 Aug 29;289(35):24238-49. doi: 10.1074/jbc.M114.574459. Epub 2014 Jul 8.


Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.

Golubkov VS, Strongin AY.

Cell Commun Signal. 2014 Mar 11;12:15. doi: 10.1186/1478-811X-12-15.


A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.

Shiryaev SA, Remacle AG, Golubkov VS, Ingvarsen S, Porse A, Behrendt N, Cieplak P, Strongin AY.

Oncogenesis. 2013 Dec 2;2:e80. doi: 10.1038/oncsis.2013.44.


Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface.

Shiryaev SA, Remacle AG, Chernov AV, Golubkov VS, Motamedchaboki K, Muranaka N, Dambacher CM, Capek P, Kukreja M, Kozlov IA, Perucho M, Cieplak P, Strongin AY.

J Biol Chem. 2013 Nov 29;288(48):34956-67. doi: 10.1074/jbc.M113.516153. Epub 2013 Oct 21.


Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.

Remacle AG, Shiryaev SA, Golubkov VS, Freskos JN, Brown MA, Karwa AS, Naik AD, Howard CP, Sympson CJ, Strongin AY.

J Biol Chem. 2013 Jul 12;288(28):20568-80. doi: 10.1074/jbc.M113.471508. Epub 2013 Jun 3.


High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.

Shiryaev SA, Chernov AV, Golubkov VS, Thomsen ER, Chudin E, Chee MS, Kozlov IA, Strongin AY, Cieplak P.

PLoS One. 2013;8(1):e54290. doi: 10.1371/journal.pone.0054290. Epub 2013 Jan 15.


Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7).

Golubkov VS, Strongin AY.

J Biol Chem. 2012 Dec 7;287(50):42009-18. doi: 10.1074/jbc.M112.371153. Epub 2012 Oct 24.


Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.

Liu H, Shiryaev SA, Chernov AV, Kim Y, Shubayev I, Remacle AG, Baranovskaya S, Golubkov VS, Strongin AY, Shubayev VI.

J Neuroinflammation. 2012 Jun 7;9:119. doi: 10.1186/1742-2094-9-119.


The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.

Kim Y, Remacle AG, Chernov AV, Liu H, Shubayev I, Lai C, Dolkas J, Shiryaev SA, Golubkov VS, Mizisin AP, Strongin AY, Shubayev VI.

PLoS One. 2012;7(3):e33664. doi: 10.1371/journal.pone.0033664. Epub 2012 Mar 16.


Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth.

Remacle AG, Golubkov VS, Shiryaev SA, Dahl R, Stebbins JL, Chernov AV, Cheltsov AV, Pellecchia M, Strongin AY.

Cancer Res. 2012 May 1;72(9):2339-49. doi: 10.1158/0008-5472.CAN-11-4149. Epub 2012 Mar 9.


Wild-type amyloid beta 1-40 peptide induces vascular smooth muscle cell death independently from matrix metalloprotease activity.

Blaise R, Mateo V, Rouxel C, Zaccarini F, Glorian M, Béréziat G, Golubkov VS, Limon I.

Aging Cell. 2012 Jun;11(3):384-93. doi: 10.1111/j.1474-9726.2012.00797.x. Epub 2012 Feb 22.


Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.

Golubkov VS, Chernov AV, Strongin AY.

J Biol Chem. 2011 Sep 30;286(39):34215-23. doi: 10.1074/jbc.M111.264036. Epub 2011 Aug 8.


Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.

Golubkov VS, Aleshin AE, Strongin AY.

J Biol Chem. 2011 Jun 10;286(23):20970-6. doi: 10.1074/jbc.M111.237669. Epub 2011 Apr 25.


The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.

Golubkov VS, Chekanov AV, Cieplak P, Aleshin AE, Chernov AV, Zhu W, Radichev IA, Zhang D, Dong PD, Strongin AY.

J Biol Chem. 2010 Nov 12;285(46):35740-9. doi: 10.1074/jbc.M110.165159. Epub 2010 Sep 13.


Mass spectrometry of murine leukemia virus core proteins.

Medvedkin V, Moore R, Falick AM, Conner J, Omelchenko T, Young M, Anderson WF, Golubkov VS, Rozenberg-Adler Y.

J Virol Methods. 2010 Nov;169(2):290-5. doi: 10.1016/j.jviromet.2010.07.028. Epub 2010 Aug 4.


Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.

Golubkov VS, Cieplak P, Chekanov AV, Ratnikov BI, Aleshin AE, Golubkova NV, Postnova TI, Radichev IA, Rozanov DV, Zhu W, Motamedchaboki K, Strongin AY.

J Biol Chem. 2010 Sep 3;285(36):27726-36. doi: 10.1074/jbc.M110.135442. Epub 2010 Jul 6.


A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.

Gawlik K, Remacle AG, Shiryaev SA, Golubkov VS, Ouyang M, Wang Y, Strongin AY.

PLoS One. 2010 Jun 24;5(6):e11305. doi: 10.1371/journal.pone.0011305.


Microarray-based transcriptional and epigenetic profiling of matrix metalloproteinases, collagens, and related genes in cancer.

Chernov AV, Baranovskaya S, Golubkov VS, Wakeman DR, Snyder EY, Williams R, Strongin AY.

J Biol Chem. 2010 Jun 18;285(25):19647-59. doi: 10.1074/jbc.M109.088153. Epub 2010 Apr 19.


Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.

Remacle AG, Gawlik K, Golubkov VS, Cadwell GW, Liddington RC, Cieplak P, Millis SZ, Desjardins R, Routhier S, Yuan XW, Neugebauer WA, Day R, Strongin AY.

Int J Biochem Cell Biol. 2010 Jun;42(6):987-95. doi: 10.1016/j.biocel.2010.02.013. Epub 2010 Mar 1.


Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.

Sounni NE, Rozanov DV, Remacle AG, Golubkov VS, Noel A, Strongin AY.

Int J Cancer. 2010 Mar 1;126(5):1067-78. doi: 10.1002/ijc.24690. Erratum in: Int J Cancer. 2010 Apr 15;126(8):2002.


Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.

Rozanov DV, Savinov AY, Golubkov VS, Rozanova OL, Postnova TI, Sergienko EA, Vasile S, Aleshin AE, Rega MF, Pellecchia M, Strongin AY.

Mol Cancer Ther. 2009 Jun;8(6):1515-25. doi: 10.1158/1535-7163.MCT-09-0202. Epub 2009 Jun 9.


Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells.

Radichev IA, Remacle AG, Sounni NE, Shiryaev SA, Rozanov DV, Zhu W, Golubkova NV, Postnova TI, Golubkov VS, Strongin AY.

Biochem J. 2009 Apr 28;420(1):37-47. doi: 10.1042/BJ20090082.


Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.

Rozanov DV, Savinov AY, Williams R, Liu K, Golubkov VS, Krajewski S, Strongin AY.

Cancer Res. 2008 Jun 1;68(11):4086-96. doi: 10.1158/0008-5472.CAN-07-6458.


Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation.

Wen Y, Golubkov VS, Strongin AY, Jiang W, Reed JC.

J Biol Chem. 2008 Feb 1;283(5):2793-803. Epub 2007 Nov 21.


Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.

Golubkov VS, Chekanov AV, Shiryaev SA, Aleshin AE, Ratnikov BI, Gawlik K, Radichev I, Motamedchaboki K, Smith JW, Strongin AY.

J Biol Chem. 2007 Dec 14;282(50):36283-91. Epub 2007 Oct 15.


Proteolysis-driven oncogenesis.

Golubkov VS, Strongin AY.

Cell Cycle. 2007 Jan 15;6(2):147-50. Epub 2007 Jan 12. Review.


Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells.

Golubkov VS, Chekanov AV, Savinov AY, Rozanov DV, Golubkova NV, Strongin AY.

Cancer Res. 2006 Nov 1;66(21):10460-5.


O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).

Remacle AG, Chekanov AV, Golubkov VS, Savinov AY, Rozanov DV, Strongin AY.

J Biol Chem. 2006 Jun 23;281(25):16897-905. Epub 2006 Apr 20.


Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.

Savinov AY, Remacle AG, Golubkov VS, Krajewska M, Kennedy S, Duffy MJ, Rozanov DV, Krajewski S, Strongin AY.

Cancer Res. 2006 Mar 1;66(5):2716-24.


Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency.

Chekanov AV, Remacle AG, Golubkov VS, Akatov VS, Sikora S, Savinov AY, Fugere M, Day R, Rozanov DV, Strongin AY.

Arch Biochem Biophys. 2006 Feb 1;446(1):52-9. Epub 2005 Dec 7.


The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP).

Remacle AG, Rozanov DV, Baciu PC, Chekanov AV, Golubkov VS, Strongin AY.

J Cell Sci. 2005 Nov 1;118(Pt 21):4975-84. Epub 2005 Oct 11.


Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.

Savinov AY, Rozanov DV, Golubkov VS, Wong FS, Strongin AY.

J Biol Chem. 2005 Jul 29;280(30):27755-8. Epub 2005 Jun 8.


Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.

Golubkov VS, Boyd S, Savinov AY, Chekanov AV, Osterman AL, Remacle A, Rozanov DV, Doxsey SJ, Strongin AY.

J Biol Chem. 2005 Jul 1;280(26):25079-86. Epub 2005 May 4.


Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin.

Li W, Savinov AY, Rozanov DV, Golubkov VS, Hedayat H, Postnova TI, Golubkova NV, Linli Y, Krajewski S, Strongin AY.

Cancer Res. 2004 Dec 1;64(23):8657-65.


Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system.

Rozanov DV, Savinov AY, Golubkov VS, Postnova TI, Remacle A, Tomlinson S, Strongin AY.

J Biol Chem. 2004 Nov 5;279(45):46551-7. Epub 2004 Sep 14.


[Primary culture of epithelial secretory cells from venom gland of the common adder Vipera berus].

Golubkov VS, Lezhnev EI, Bezgina EN, Moshkov DA.

Tsitologiia. 2001;43(5):453-61. Russian.


[Secretion of venom from the common viper (Vipera berus) under in vitro conditions].

Golubkov VS, Lezhnev EI.

Dokl Akad Nauk. 1999 Dec;369(6):833-5. Russian. No abstract available.


[The cultivation of fragments of the parotid venom-secreting gland in the common adder (Vipera berus)].

Golubkov VS, Lavrovskaia VP, Lezhnev EI, Savel'eva LN, Moshkov DA.

Tsitologiia. 1997;39(7):537-40. Russian.


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