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Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution.

Golparian D, Harris SR, Sánchez-Busó L, Hoffmann S, Shafer WM, Bentley SD, Jensen JS, Unemo M.

BMC Genomics. 2020 Feb 3;21(1):116. doi: 10.1186/s12864-020-6511-6.


In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae.

Foerster S, Drusano G, Golparian D, Neely M, Piddock LJV, Alirol E, Unemo M.

J Antimicrob Chemother. 2019 Dec 1;74(12):3521-3529. doi: 10.1093/jac/dkz376.


Genetic variation regulates the activation and specificity of Restriction-Modification systems in Neisseria gonorrhoeae.

Sánchez-Busó L, Golparian D, Parkhill J, Unemo M, Harris SR.

Sci Rep. 2019 Oct 11;9(1):14685. doi: 10.1038/s41598-019-51102-2.


The impact of antimicrobials on gonococcal evolution.

Sánchez-Busó L, Golparian D, Corander J, Grad YH, Ohnishi M, Flemming R, Parkhill J, Bentley SD, Unemo M, Harris SR.

Nat Microbiol. 2019 Nov;4(11):1941-1950. doi: 10.1038/s41564-019-0501-y. Epub 2019 Jul 29.


Now Is the Time to Implement Whole Genome Sequencing in the Global Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae?

Golparian D, Unemo M.

EClinicalMedicine. 2019 Feb 18;7:11-12. doi: 10.1016/j.eclinm.2019.02.002. eCollection 2019 Jan. No abstract available.


Prediction of Minimum Inhibitory Concentrations of Antimicrobials for Neisseria gonorrhoeae Using Whole-Genome Sequencing.

Eyre DW, Golparian D, Unemo M.

Methods Mol Biol. 2019;1997:59-76. doi: 10.1007/978-1-4939-9496-0_4.


Antimicrobial Resistance in Neisseria gonorrhoeae and Treatment of Gonorrhea.

Unemo M, Golparian D, Eyre DW.

Methods Mol Biol. 2019;1997:37-58. doi: 10.1007/978-1-4939-9496-0_3.


Antimicrobial susceptibility of Neisseria gonorrhoeae isolates and treatment of gonorrhoea patients in Ternopil and Dnipropetrovsk regions of Ukraine, 2013-2018.

Boiko I, Golparian D, Krynytska I, Bezkorovaina H, Frankenberg A, Onuchyna M, Jacobsson S, Unemo M.

APMIS. 2019 Jul;127(7):503-509. doi: 10.1111/apm.12948. Epub 2019 May 21.


Genome-based epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates with decreased susceptibility and resistance to extended-spectrum cephalosporins in Argentina in 2011-16.

Gianecini RA, Golparian D, Zittermann S, Litvik A, Gonzalez S, Oviedo C, Melano RG, Unemo M, Galarza P; Gonococcal Antimicrobial Susceptibility Surveillance Programme-Argentina (GASSP-AR) Working Group .

J Antimicrob Chemother. 2019 Jun 1;74(6):1551-1559. doi: 10.1093/jac/dkz054.


Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer.

Golparian D, Donà V, Sánchez-Busó L, Foerster S, Harris S, Endimiani A, Low N, Unemo M.

Sci Rep. 2018 Dec 4;8(1):17596. doi: 10.1038/s41598-018-35750-4.


Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.

Golparian D, Rose L, Lynam A, Mohamed A, Bercot B, Ohnishi M, Crowley B, Unemo M.

Euro Surveill. 2018 Nov;23(47). doi: 10.2807/1560-7917.ES.2018.23.47.1800617.


WHO laboratory validation of Xpert® CT/NG and Xpert® TV on the GeneXpert system verifies high performances.

Jacobsson S, Boiko I, Golparian D, Blondeel K, Kiarie J, Toskin I, Peeling RW, Unemo M.

APMIS. 2018 Dec;126(12):907-912. doi: 10.1111/apm.12902.


Aptima Trichomonas vaginalis assay elucidates significant underdiagnosis of trichomoniasis among women in Brazil according to an observational study.

Bruni MP, Freitas da Silveira M, Stauffert D, Bicca GLO, Caetano Dos Santos C, da Rosa Farias NA, Golparian D, Unemo M.

Sex Transm Infect. 2019 Mar;95(2):129-132. doi: 10.1136/sextrans-2018-053635. Epub 2018 Aug 28.


Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.

Eyre DW, Sanderson ND, Lord E, Regisford-Reimmer N, Chau K, Barker L, Morgan M, Newnham R, Golparian D, Unemo M, Crook DW, Peto TE, Hughes G, Cole MJ, Fifer H, Edwards A, Andersson MI.

Euro Surveill. 2018 Jul;23(27). doi: 10.2807/1560-7917.ES.2018.23.27.1800323.


Antimicrobial resistance and molecular epidemiology using whole-genome sequencing of Neisseria gonorrhoeae in Ireland, 2014-2016: focus on extended-spectrum cephalosporins and azithromycin.

Ryan L, Golparian D, Fennelly N, Rose L, Walsh P, Lawlor B, Mac Aogáin M, Unemo M, Crowley B.

Eur J Clin Microbiol Infect Dis. 2018 Sep;37(9):1661-1672. doi: 10.1007/s10096-018-3296-5. Epub 2018 Jun 7.


In vitro activity of the novel triazaacenaphthylene gepotidacin (GSK2140944) against MDR Neisseria gonorrhoeae.

Jacobsson S, Golparian D, Scangarella-Oman N, Unemo M.

J Antimicrob Chemother. 2018 Aug 1;73(8):2072-2077. doi: 10.1093/jac/dky162.


Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey.

Harris SR, Cole MJ, Spiteri G, Sánchez-Busó L, Golparian D, Jacobsson S, Goater R, Abudahab K, Yeats CA, Bercot B, Borrego MJ, Crowley B, Stefanelli P, Tripodo F, Abad R, Aanensen DM, Unemo M; Euro-GASP study group.

Lancet Infect Dis. 2018 Jul;18(7):758-768. doi: 10.1016/S1473-3099(18)30225-1. Epub 2018 May 15.


Macrolide and fluoroquinolone resistance in Mycoplasma genitalium in two Swedish counties, 2011-2015.

Hadad R, Golparian D, Lagos AC, Ljungberg J, Nilsson P, Jensen JS, Fredlund H, Unemo M.

APMIS. 2018 Feb;126(2):123-127. doi: 10.1111/apm.12792. Epub 2017 Dec 13.


In vitro activity and time-kill curve analysis of sitafloxacin against a global panel of antimicrobial-resistant and multidrug-resistant Neisseria gonorrhoeae isolates.

Jönsson A, Foerster S, Golparian D, Hamasuna R, Jacobsson S, Lindberg M, Jensen JS, Ohnishi M, Unemo M.

APMIS. 2018 Jan;126(1):29-37. doi: 10.1111/apm.12777. Epub 2017 Nov 20.


Clinical and analytical evaluation of the new Aptima Mycoplasma genitalium assay, with data on M. genitalium prevalence and antimicrobial resistance in M. genitalium in Denmark, Norway and Sweden in 2016.

Unemo M, Salado-Rasmussen K, Hansen M, Olsen AO, Falk M, Golparian D, Aasterød M, Ringlander J, Nilsson CS, Sundqvist M, Schønning K, Moi H, Westh H, Jensen JS.

Clin Microbiol Infect. 2018 May;24(5):533-539. doi: 10.1016/j.cmi.2017.09.006. Epub 2017 Sep 18.


In Vitro Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae.

Jacobsson S, Paukner S, Golparian D, Jensen JS, Unemo M.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01497-17. doi: 10.1128/AAC.01497-17. Print 2017 Nov.


Recent advances in the development and use of molecular tests to predict antimicrobial resistance in Neisseria gonorrhoeae.

Donà V, Low N, Golparian D, Unemo M.

Expert Rev Mol Diagn. 2017 Sep;17(9):845-859. doi: 10.1080/14737159.2017.1360137. Epub 2017 Aug 3. Review.


Trichomonas vaginalis is Rare Among Women in Iceland.

Hilmarsdottir I, Sigmundsdottir E, Eiriksdottir A, Golparian D, Unemo M.

Acta Derm Venereol. 2017 Nov 15;97(10):1258-1260. doi: 10.2340/00015555-2747. No abstract available.


Trichomonas vaginalis is very rare among women with vaginal discharge in Podlaskie province, Poland.

Serwin AB, Bulhak-Koziol V, Sokolowska M, Golparian D, Unemo M.

APMIS. 2017 Sep;125(9):840-843. doi: 10.1111/apm.12713. Epub 2017 Jun 14.


Prevalence of macrolide and fluoroquinolone resistance-mediating mutations in Mycoplasma genitalium in five cities in Russia and Estonia.

Shipitsyna E, Rumyantseva T, Golparian D, Khayrullina G, Lagos AC, Edelstein I, Joers K, Jensen JS, Savicheva A, Rudneva N, Sukhanova L, Kozlov R, Guschin A, Unemo M.

PLoS One. 2017 Apr 13;12(4):e0175763. doi: 10.1371/journal.pone.0175763. eCollection 2017.


The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization.

Unemo M, Golparian D, Sánchez-Busó L, Grad Y, Jacobsson S, Ohnishi M, Lahra MM, Limnios A, Sikora AE, Wi T, Harris SR.

J Antimicrob Chemother. 2016 Nov;71(11):3096-3108. Epub 2016 Jul 17.


WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014.

Jacobsson S, Golparian D, Cole M, Spiteri G, Martin I, Bergheim T, Borrego MJ, Crowley B, Crucitti T, Van Dam AP, Hoffmann S, Jeverica S, Kohl P, Mlynarczyk-Bonikowska B, Pakarna G, Stary A, Stefanelli P, Pavlik P, Tzelepi E, Abad R, Harris SR, Unemo M.

J Antimicrob Chemother. 2016 Nov;71(11):3109-3116. Epub 2016 Jul 17.


Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea.

Fifer H, Natarajan U, Jones L, Alexander S, Hughes G, Golparian D, Unemo M.

N Engl J Med. 2016 Jun 23;374(25):2504-6. doi: 10.1056/NEJMc1512757. No abstract available.


Genetic Resistance Determinants, In Vitro Time-Kill Curve Analysis and Pharmacodynamic Functions for the Novel Topoisomerase II Inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae.

Foerster S, Golparian D, Jacobsson S, Hathaway LJ, Low N, Shafer WM, Althaus CL, Unemo M.

Front Microbiol. 2015 Dec 10;6:1377. doi: 10.3389/fmicb.2015.01377. eCollection 2015.


Analytical specificity and sensitivity of the novel dual-target GeneProof Neisseria gonorrhoeae PCR kit for detection of N. gonorrhoeae.

Golparian D, Hellmark B, Unemo M.

APMIS. 2015 Nov;123(11):955-8. doi: 10.1111/apm.12440. Epub 2015 Sep 2.


Evaluation of the new AmpliSens multiplex real-time PCR assay for simultaneous detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis.

Rumyantseva T, Golparian D, Nilsson CS, Johansson E, Falk M, Fredlund H, Van Dam A, Guschin A, Unemo M.

APMIS. 2015 Oct;123(10):879-86. doi: 10.1111/apm.12430. Epub 2015 Aug 24.


Will Genome Analysis Elucidate Evolution, Global Transmission and Virulence of Neisseria Meningitidis Lineages?

Golparian D, Unemo M.

EBioMedicine. 2015 Feb 9;2(3):186-7. doi: 10.1016/j.ebiom.2015.02.001. eCollection 2015 Mar. No abstract available.


Antimicrobial susceptibility/resistance and NG-MAST characterisation of Neisseria gonorrhoeae in Belarus, Eastern Europe, 2010-2013.

Lebedzeu F, Golparian D, Titov L, Pankratava N, Glazkova S, Shimanskaya I, Charniakova N, Lukyanau A, Domeika M, Unemo M.

BMC Infect Dis. 2015 Jan 31;15:29. doi: 10.1186/s12879-015-0755-9.


First antimicrobial resistance data and genetic characteristics of Neisseria gonorrhoeae isolates from Estonia, 2009-2013.

Golparian D, Brilene T, Laaring Y, Viktorova E, Johansson E, Domeika M, Unemo M.

New Microbes New Infect. 2014 Sep;2(5):150-3. doi: 10.1002/nmi2.57. Epub 2014 Aug 3.


In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains.

Jacobsson S, Golparian D, Phan LT, Ohnishi M, Fredlund H, Or YS, Unemo M.

J Antimicrob Chemother. 2015 Jan;70(1):173-7. doi: 10.1093/jac/dku344. Epub 2014 Sep 1.


Characterisation of blaTEM genes and types of β-lactamase plasmids in Neisseria gonorrhoeae - the prevalent and conserved blaTEM-135 has not recently evolved and existed in the Toronto plasmid from the origin.

Muhammad I, Golparian D, Dillon JA, Johansson A, Ohnishi M, Sethi S, Chen SC, Nakayama S, Sundqvist M, Bala M, Unemo M.

BMC Infect Dis. 2014 Aug 22;14:454. doi: 10.1186/1471-2334-14-454.


Trichomonas vaginalis infections are rare among young patients attending an STI clinic in Sweden.

Pellrud H, Golparian D, Nilsson CS, Falk M, Fredlund H, Unemo M.

Acta Derm Venereol. 2015 Mar;95(3):343-4. doi: 10.2340/00015555-1946. No abstract available.


Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report.

van Dam AP, van Ogtrop ML, Golparian D, Mehrtens J, de Vries HJ, Unemo M.

Sex Transm Infect. 2014 Nov;90(7):513-4. doi: 10.1136/sextrans-2014-051552. Epub 2014 Aug 11.


Four treatment failures of pharyngeal gonorrhoea with ceftriaxone (500 mg) or cefotaxime (500 mg), Sweden, 2013 and 2014.

Golparian D, Ohlsson A, Janson H, Lidbrink P, Richtner T, Ekelund O, Fredlund H, Unemo M.

Euro Surveill. 2014 Jul 31;19(30). pii: 20862. Erratum in: Euro Surveill. 2014;19(32):pii/20874.


High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea.

Jacobsson S, Golparian D, Alm RA, Huband M, Mueller J, Jensen JS, Ohnishi M, Unemo M.

Antimicrob Agents Chemother. 2014 Sep;58(9):5585-8. doi: 10.1128/AAC.03090-14. Epub 2014 Jun 30.


Importance of multidrug efflux pumps in the antimicrobial resistance property of clinical multidrug-resistant isolates of Neisseria gonorrhoeae.

Golparian D, Shafer WM, Ohnishi M, Unemo M.

Antimicrob Agents Chemother. 2014 Jun;58(6):3556-9. doi: 10.1128/AAC.00038-14. Epub 2014 Apr 14.


Challenges with gonorrhea in the era of multi-drug and extensively drug resistance - are we on the right track?

Unemo M, Golparian D, Shafer WM.

Expert Rev Anti Infect Ther. 2014 Jun;12(6):653-6. doi: 10.1586/14787210.2014.906902. Epub 2014 Apr 4.


High in vitro activity of a novel dual bacterial topoisomerase inhibitor of the ATPase activities of GyrB and ParE (VT12-008911) against Neisseria gonorrhoeae isolates with various high-level antimicrobial resistance and multidrug resistance.

Jeverica S, Golparian D, Hanzelka B, Fowlie AJ, Matičič M, Unemo M.

J Antimicrob Chemother. 2014 Jul;69(7):1866-72. doi: 10.1093/jac/dku073. Epub 2014 Mar 20.


Phenotypic and molecular characterization of Neisseria gonorrhoeae isolates from Slovenia, 2006-12: rise and fall of the multidrug-resistant NG-MAST genogroup 1407 clone?

Jeverica S, Golparian D, Matičič M, Potočnik M, Mlakar B, Unemo M.

J Antimicrob Chemother. 2014 Jun;69(6):1517-25. doi: 10.1093/jac/dku026. Epub 2014 Feb 16.


Antimicrobial susceptibility/resistance and genetic characteristics of Neisseria gonorrhoeae isolates from Poland, 2010-2012.

Mlynarczyk-Bonikowska B, Serwin AB, Golparian D, Walter de Walthoffen S, Majewski S, Koper M, Malejczyk M, Domeika M, Unemo M.

BMC Infect Dis. 2014 Feb 6;14:65. doi: 10.1186/1471-2334-14-65.


First three Neisseria gonorrhoeae isolates with high-level resistance to azithromycin in Sweden: a threat to currently available dual-antimicrobial regimens for treatment of gonorrhea?

Unemo M, Golparian D, Hellmark B.

Antimicrob Agents Chemother. 2014;58(1):624-5. doi: 10.1128/AAC.02093-13. Epub 2013 Nov 4. No abstract available.


Analytical evaluation of GeneXpert CT/NG, the first genetic point-of-care assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis.

Tabrizi SN, Unemo M, Golparian D, Twin J, Limnios AE, Lahra M, Guy R; TTANGO Investigators.

J Clin Microbiol. 2013 Jun;51(6):1945-7. doi: 10.1128/JCM.00806-13. Epub 2013 Apr 3.


Whole-genome sequences of Chlamydia trachomatis directly from clinical samples without culture.

Seth-Smith HM, Harris SR, Skilton RJ, Radebe FM, Golparian D, Shipitsyna E, Duy PT, Scott P, Cutcliffe LT, O'Neill C, Parmar S, Pitt R, Baker S, Ison CA, Marsh P, Jalal H, Lewis DA, Unemo M, Clarke IN, Parkhill J, Thomson NR.

Genome Res. 2013 May;23(5):855-66. doi: 10.1101/gr.150037.112. Epub 2013 Mar 22.

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