Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 135

1.

Genetic Testing for Diagnosis of Hypertrophic Cardiomyopathy Mimics: Yield and Clinical Significance.

Hoss S, Habib M, Silver J, Care M, Chan RH, Hanneman K, Morel CF, Iwanochko RM, Gollob MH, Rakowski H, Adler A.

Circ Genom Precis Med. 2020 Mar 9. doi: 10.1161/CIRCGEN.119.002748. [Epub ahead of print]

PMID:
32150461
2.

An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.

Adler A, Novelli V, Amin AS, Abiusi E, Care M, Nannenberg EA, Feilotter H, Amenta S, Mazza D, Bikker H, Sturm AC, Garcia J, Ackerman MJ, Hershberger RE, Perez MV, Zareba W, Ware JS, Wilde AAM, Gollob MH.

Circulation. 2020 Feb 11;141(6):418-428. doi: 10.1161/CIRCULATIONAHA.119.043132. Epub 2020 Jan 27.

3.

An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.

Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ.

Circulation. 2020 Feb 11;141(6):429-439. doi: 10.1161/CIRCULATIONAHA.119.043114. Epub 2020 Jan 16.

PMID:
31941373
4.

Gene discovery: From biological plausibility to genetic evidence supporting disease causation.

Gollob MH.

Heart Rhythm. 2019 Nov;16(11):1707-1709. doi: 10.1016/j.hrthm.2019.07.030. Epub 2019 Jul 29. No abstract available.

PMID:
31369872
5.

Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

6.

Response by Wilde and Gollob to Letter Regarding Article, "Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome".

Wilde AAM, Gollob MH.

Circulation. 2019 Apr 2;139(14):1760-1761. doi: 10.1161/CIRCULATIONAHA.119.039065. No abstract available.

PMID:
30933625
7.

Phospholamban cardiomyopathy: a Canadian perspective on a unique population.

Cheung CC, Healey JS, Hamilton R, Spears D, Gollob MH, Mellor G, Steinberg C, Sanatani S, Laksman ZW, Krahn AD.

Neth Heart J. 2019 Apr;27(4):208-213. doi: 10.1007/s12471-019-1247-0.

8.

Brugada syndrome: Let's talk about sex.

Jons C, Gollob MH.

Heart Rhythm. 2018 Oct;15(10):1466-1467. doi: 10.1016/j.hrthm.2018.07.004. Epub 2018 Jul 4. No abstract available.

PMID:
29981479
9.

Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome.

Hosseini SM, Kim R, Udupa S, Costain G, Jobling R, Liston E, Jamal SM, Szybowska M, Morel CF, Bowdin S, Garcia J, Care M, Sturm AC, Novelli V, Ackerman MJ, Ware JS, Hershberger RE, Wilde AAM, Gollob MH; National Institutes of Health Clinical Genome Resource Consortium.

Circulation. 2018 Sep 18;138(12):1195-1205. doi: 10.1161/CIRCULATIONAHA.118.035070.

10.

Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease.

Liu J, Bayer JD, Aschar-Sobbi R, Wauchop M, Spears D, Gollob M, Vigmond EJ, Tsushima R, Backx PH, Chauhan VS.

PLoS One. 2018 May 23;13(5):e0197273. doi: 10.1371/journal.pone.0197273. eCollection 2018.

11.

The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome.

Hu D, Li Y, Zhang J, Pfeiffer R, Gollob MH, Healey J, Harrell DT, Makita N, Abe H, Sun Y, Guo J, Zhang L, Yan G, Mah D, Walsh EP, Leopold HB, Giustetto C, Gaita F, Zienciuk-Krajka A, Mazzanti A, Priori SG, Antzelevitch C, Barajas-Martinez H.

JACC Clin Electrophysiol. 2017 Jul;3(7):727-743. doi: 10.1016/j.jacep.2016.11.013. Epub 2017 Feb 1.

12.

T-Wave Morphology Analysis in Congenital Long QT Syndrome Discriminates Patients From Healthy Individuals.

Porta-Sánchez A, Spillane DR, Harris L, Xue J, Dorsey P, Care M, Chauhan V, Gollob MH, Spears DA.

JACC Clin Electrophysiol. 2017 Apr;3(4):374-381. doi: 10.1016/j.jacep.2016.10.013. Epub 2016 Dec 21.

13.

Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability.

Bianchi B, Ozhathil LC, Medeiros-Domingo A, Gollob MH, Abriel H.

Front Physiol. 2018 Mar 8;9:177. doi: 10.3389/fphys.2018.00177. eCollection 2018.

14.

Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?

Roberts JD, Krahn AD, Ackerman MJ, Rohatgi RK, Moss AJ, Nazer B, Tadros R, Gerull B, Sanatani S, Wijeyeratne YD, Baruteau AE, Muir AR, Pang B, Cadrin-Tourigny J, Talajic M, Rivard L, Tester DJ, Liu T, Whitman IR, Wojciak J, Conacher S, Gula LJ, Leong-Sit P, Manlucu J, Green MS, Hamilton R, Healey JS, Lopes CM, Behr ER, Wilde AA, Gollob MH, Scheinman MM.

Circ Arrhythm Electrophysiol. 2017 Aug;10(8). pii: e005282. doi: 10.1161/CIRCEP.117.005282.

PMID:
28794082
15.

Safety of Outpatient Initiation of Disopyramide for Obstructive Hypertrophic Cardiomyopathy Patients.

Adler A, Fourey D, Weissler-Snir A, Hindieh W, Chan RH, Gollob MH, Rakowski H.

J Am Heart Assoc. 2017 May 26;6(6). pii: e005152. doi: 10.1161/JAHA.116.005152.

16.

Prevalence and Clinical Implication of Double Mutations in Hypertrophic Cardiomyopathy: Revisiting the Gene-Dose Effect.

Fourey D, Care M, Siminovitch KA, Weissler-Snir A, Hindieh W, Chan RH, Gollob MH, Rakowski H, Adler A.

Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e001685. doi: 10.1161/CIRCGENETICS.116.001685. Erratum in: Circ Cardiovasc Genet. 2017 Aug;10(4):e000038.

PMID:
28420666
17.

Bundle Branch Re-Entrant Ventricular Tachycardia: Novel Genetic Mechanisms in a Life-Threatening Arrhythmia.

Roberts JD, Gollob MH, Young C, Connors SP, Gray C, Wilton SB, Green MS, Zhu DW, Hodgkinson KA, Poon A, Li Q, Orr N, Tang AS, Klein GJ, Wojciak J, Campagna J, Olgin JE, Badhwar N, Vedantham V, Marcus GM, Kwok PY, Deo RC, Scheinman MM.

JACC Clin Electrophysiol. 2017 Mar;3(3):276-288. doi: 10.1016/j.jacep.2016.09.019. Epub 2016 Dec 21.

18.

Evaluation of Prolonged QT Interval: Structural Heart Disease Mimicking Long QT Syndrome.

Weissler-Snir A, Gollob MH, Chauhan V, Care M, Spears DA.

Pacing Clin Electrophysiol. 2017 Apr;40(4):417-424. doi: 10.1111/pace.13040. Epub 2017 Mar 16.

PMID:
28155223
19.

Editorial commentary: Genetic testing in the absence of phenotype: When genetic testing may cause harm.

Gollob MH.

Trends Cardiovasc Med. 2017 Apr;27(3):214-215. doi: 10.1016/j.tcm.2016.10.001. Epub 2016 Oct 11. No abstract available.

PMID:
27780684
20.

Toward Translation of Genomic Discovery to Clinical Efficacy in Atrial Fibrillation.

Gollob MH.

J Am Coll Cardiol. 2016 Oct 25;68(17):1895-1897. doi: 10.1016/j.jacc.2016.08.022. No abstract available.

21.

Usefulness of 14-Day Holter for Detection of Nonsustained Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy.

Weissler-Snir A, Chan RH, Adler A, Care M, Chauhan V, Gollob MH, Ziv-Baran T, Fourey D, Hindieh W, Rakowski H, Spears DA.

Am J Cardiol. 2016 Oct 15;118(8):1258-1263. doi: 10.1016/j.amjcard.2016.07.043. Epub 2016 Jul 29.

PMID:
27567133
22.

Response to Letter Regarding Article, "Outcome of Apparently Unexplained Cardiac Arrest: Results From Investigation and Follow-Up of the Prospective Cardiac Arrest Survivors With Preserved Ejection Fraction Registry".

Herman AR, Cheung C, Gerull B, Simpson CS, Birnie DH, Klein GJ, Champagne J, Healey JS, Gibbs K, Talajic M, Gardner M, Bennett MT, Steinberg C, Janzen M, Gollob MH, Angaran P, Yee R, Leather R, Chakrabarti S, Sanatani S, Chauhan VS, Krahn AD.

Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e004012. doi: 10.1161/CIRCEP.116.004012. No abstract available.

PMID:
27069091
23.

A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.

Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DYR, Gollob MH.

Nat Commun. 2016 Apr 12;7:11303. doi: 10.1038/ncomms11303.

24.

Rapid Device-Detected Nonsustained Ventricular Tachycardia in the Risk Stratification of Hypertrophic Cardiomyopathy.

Viswanathan K, Suszko AM, DAS M, Jackson N, Gollob M, Cameron D, Spears D, Woo A, Rakowski H, Khurana M, Chauhan VS.

Pacing Clin Electrophysiol. 2016 Jul;39(7):642-51. doi: 10.1111/pace.12861. Epub 2016 May 4.

PMID:
27027856
25.

Outcome of Apparently Unexplained Cardiac Arrest: Results From Investigation and Follow-Up of the Prospective Cardiac Arrest Survivors With Preserved Ejection Fraction Registry.

Herman AR, Cheung C, Gerull B, Simpson CS, Birnie DH, Klein GJ, Champagne J, Healey JS, Gibbs K, Talajic M, Gardner M, Bennett MT, Steinberg C, Janzen M, Gollob MH, Angaran P, Yee R, Leather R, Chakrabarti S, Sanatani S, Chauhan VS, Krahn AD.

Circ Arrhythm Electrophysiol. 2016 Jan;9(1):e003619. doi: 10.1161/CIRCEP.115.003619.

PMID:
26783233
26.

Primary prevention of idiopathic ventricular fibrillation: Not for the faint of heart.

Adler A, Gollob MH.

Heart Rhythm. 2016 Apr;13(4):913-4. doi: 10.1016/j.hrthm.2015.12.043. Epub 2015 Dec 29. No abstract available.

PMID:
26744096
27.

Patient Outcomes From a Specialized Inherited Arrhythmia Clinic.

Adler A, Sadek MM, Chan AY, Dell E, Rutberg J, Davis D, Green MS, Spears DA, Gollob MH.

Circ Arrhythm Electrophysiol. 2016 Jan;9(1):e003440. doi: 10.1161/CIRCEP.115.003440.

PMID:
26743238
28.

Genetics of inherited primary arrhythmia disorders.

Spears DA, Gollob MH.

Appl Clin Genet. 2015 Sep 18;8:215-33. doi: 10.2147/TACG.S55762. eCollection 2015. Review.

29.

Epsilon wave uncovered by exercise test in a patient with desmoplakin-positive arrhythmogenic right ventricular cardiomyopathy.

Adler A, Perrin MJ, Spears D, Gollob MH.

Can J Cardiol. 2015 Jun;31(6):819.e1-2. doi: 10.1016/j.cjca.2015.01.025. Epub 2015 Jan 29.

PMID:
25936878
30.

Go protein subunit Goα and the secretory process of the natriuretic peptide hormones ANF and BNP.

Roeske C, Martinuk A, Choudhry A, Hendy GN, Gollob M, Li Q, Georgalis T, de Bold AJ.

J Mol Endocrinol. 2015 Jun;54(3):277-88. doi: 10.1530/JME-15-0081. Epub 2015 Apr 27.

PMID:
25917834
31.

A prospective randomized evaluation of a pharmacogenomic approach to antiplatelet therapy among patients with ST-elevation myocardial infarction: the RAPID STEMI study.

So DY, Wells GA, McPherson R, Labinaz M, Le May MR, Glover C, Dick AJ, Froeschl M, Marquis JF, Gollob MH, Tran L, Bernick J, Hibbert B, Roberts JD.

Pharmacogenomics J. 2016 Feb;16(1):71-8. doi: 10.1038/tpj.2015.17. Epub 2015 Apr 7.

PMID:
25850030
32.

Whole exome sequencing identifies the TNNI3K gene as a cause of familial conduction system disease and congenital junctional ectopic tachycardia.

Xi Y, Honeywell C, Zhang D, Schwartzentruber J, Beaulieu CL, Tetreault M, Hartley T, Marton J, Vidal SM, Majewski J, Aravind L; Care4Rare Canada Consortium, Gollob M, Boycott KM, Gow RM.

Int J Cardiol. 2015 Apr 15;185:114-6. doi: 10.1016/j.ijcard.2015.03.130. Epub 2015 Mar 11. No abstract available.

33.

Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.

Roberts JD, Longoria J, Poon A, Gollob MH, Dewland TA, Kwok PY, Olgin JE, Deo RC, Marcus GM.

Circ Cardiovasc Genet. 2015 Feb;8(1):50-7. doi: 10.1161/CIRCGENETICS.114.000650. Epub 2014 Nov 18.

34.

A practical guide to early repolarization.

Adler A, Gollob MH.

Curr Opin Cardiol. 2015 Jan;30(1):8-16. doi: 10.1097/HCO.0000000000000126. Review.

PMID:
25389652
35.

Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.

Perrin MJ, Adler A, Green S, Al-Zoughool F, Doroshenko P, Orr N, Uppal S, Healey JS, Birnie D, Sanatani S, Gardner M, Champagne J, Simpson C, Ahmad K, van den Berg MP, Chauhan V, Backx PH, van Tintelen JP, Krahn AD, Gollob MH.

Circ Cardiovasc Genet. 2014 Dec;7(6):782-9. doi: 10.1161/CIRCGENETICS.114.000623. Epub 2014 Sep 11.

PMID:
25214526
36.

First report of a large duplication of the KCNQ1 gene in a patient with long QT syndrome.

Adler A, Uppal S, Orr N, Alzoughool F, Gollob MH.

Can J Cardiol. 2014 Oct;30(10):1249.e5-7. doi: 10.1016/j.cjca.2014.05.018. Epub 2014 Jun 2.

PMID:
25174857
37.

Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.

Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J, Gollob MH, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith JD, Psaty BM, Smith NL, Jukema JW, Chasman DI, Albert CM, Ebana Y, Furukawa T, Macfarlane PW, Harris TB, Darbar D, Dörr M, Holst AG, Svendsen JH, Hofman A, Uitterlinden AG, Gudnason V, Isobe M, Malik R, Dichgans M, Rosand J, Van Wagoner DR; METASTROKE Consortium; AFGen Consortium, Benjamin EJ, Milan DJ, Melander O, Heckbert SR, Ford I, Liu Y, Barnard J, Olesen MS, Stricker BH, Tanaka T, Kääb S, Ellinor PT.

Circulation. 2014 Oct 7;130(15):1225-35. doi: 10.1161/CIRCULATIONAHA.114.009892. Epub 2014 Aug 14.

38.

Atrial arrhythmias in the young: early onset atrial arrhythmias preceding a diagnosis of a primary muscular dystrophy.

Stoyanov N, Winterfield J, Varma N, Gollob MH.

Europace. 2014 Dec;16(12):1814-20. doi: 10.1093/europace/euu141. Epub 2014 Jun 17.

PMID:
24938630
39.

A contemporary review on the genetic basis of atrial fibrillation.

Roberts JD, Gollob MH.

Methodist Debakey Cardiovasc J. 2014 Jan-Mar;10(1):18-24. Review.

40.

Procainamide infusion in the evaluation of unexplained cardiac arrest: from the Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER).

Somani R, Krahn AD, Healey JS, Chauhan VS, Birnie DH, Champagne J, Sanatani S, Angaran P, Gow RM, Chakrabarti S, Gerull B, Yee R, Skanes AC, Gula LJ, Leong-Sit P, Klein GJ, Gollob MH, Talajic M, Gardner M, Simpson CS.

Heart Rhythm. 2014 Jun;11(6):1047-54. doi: 10.1016/j.hrthm.2014.03.022. Epub 2014 Mar 18.

PMID:
24657429
41.

Reply: Noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG.

Thorn SL, deKemp R, Dumouchel T, Klein R, Renaud JN, Wells RG, Gollob M, Beanlands RS, DaSilva JN.

J Nucl Med. 2014 May;55(5):866-7. doi: 10.2967/jnumed.114.138214. Epub 2014 Mar 20. No abstract available.

42.

Atrioventricular block as the initial manifestation of cardiac sarcoidosis in middle-aged adults.

Nery PB, Beanlands RS, Nair GM, Green M, Yang J, McArdle BA, Davis D, Ohira H, Gollob MH, Leung E, Healey JS, Birnie DH.

J Cardiovasc Electrophysiol. 2014 Aug;25(8):875-881. doi: 10.1111/jce.12401. Epub 2014 May 2.

PMID:
24602015
43.

Myocardial infarction in a teenager.

Sternick EB, de Almeida Araújo S, Rocha C, Gollob M.

Eur Heart J. 2014 Jun 14;35(23):1558. doi: 10.1093/eurheartj/ehu015. Epub 2014 Feb 3. No abstract available.

PMID:
24497343
44.

A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation.

Bartos DC, Giudicessi JR, Tester DJ, Ackerman MJ, Ohno S, Horie M, Gollob MH, Burgess DE, Delisle BP.

Heart Rhythm. 2014 Mar;11(3):459-68. doi: 10.1016/j.hrthm.2013.11.021. Epub 2013 Nov 21.

45.

Evolution of clinical diagnosis in patients presenting with unexplained cardiac arrest or syncope due to polymorphic ventricular tachycardia.

Vittoria Matassini M, Krahn AD, Gardner M, Champagne J, Sanatani S, Birnie DH, Gollob MH, Chauhan V, Simpson CS, Hamilton RM, Talajic M, Ahmad K, Gerull B, Chakrabarti S, Healey JS.

Heart Rhythm. 2014 Feb;11(2):274-81. doi: 10.1016/j.hrthm.2013.11.008. Epub 2013 Nov 14.

PMID:
24239842
46.

Evolution of a genetic diagnosis.

Laksman Z, Dulay D, Gollob MH, Skanes AC, Krahn AD.

Clin Genet. 2014 Dec;86(6):580-4. doi: 10.1111/cge.12320. Epub 2013 Dec 20.

PMID:
24237251
47.

Repeatable noninvasive measurement of mouse myocardial glucose uptake with 18F-FDG: evaluation of tracer kinetics in a type 1 diabetes model.

Thorn SL, deKemp RA, Dumouchel T, Klein R, Renaud JM, Wells RG, Gollob MH, Beanlands RS, DaSilva JN.

J Nucl Med. 2013 Sep;54(9):1637-44. doi: 10.2967/jnumed.112.110114. Epub 2013 Aug 12.

48.

Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model.

Thorn SL, Gollob MH, Harper ME, Beanlands RS, Dekemp RA, Dasilva JN.

EJNMMI Res. 2013 Jul 5;3(1):48. doi: 10.1186/2191-219X-3-48.

49.

Exercise testing in asymptomatic gene carriers exposes a latent electrical substrate of arrhythmogenic right ventricular cardiomyopathy.

Perrin MJ, Angaran P, Laksman Z, Zhang H, Porepa LF, Rutberg J, James C, Krahn AD, Judge DP, Calkins H, Gollob MH.

J Am Coll Cardiol. 2013 Nov 5;62(19):1772-9. doi: 10.1016/j.jacc.2013.04.084. Epub 2013 Jun 27.

50.

Early repolarization: a rare primary arrhythmic syndrome and common modifier of arrhythmic risk.

Roberts JD, Gollob MH.

J Cardiovasc Electrophysiol. 2013 Jul;24(7):837-43. doi: 10.1111/jce.12156. Epub 2013 Apr 30.

PMID:
23631702

Supplemental Content

Loading ...
Support Center