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Items: 45


TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation.

Toki S, Goleniewska K, Zhang J, Zhou W, Newcomb DC, Zhou B, Kita H, Boyd KL, Peebles RS Jr.

Allergy. 2020 Jan 23. doi: 10.1111/all.14196. [Epub ahead of print]


IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development.

Stier MT, Mitra R, Nyhoff LE, Goleniewska K, Zhang J, Puccetti MV, Casanova HC, Seegmiller AC, Newcomb DC, Kendall PL, Eischen CM, Peebles RS Jr.

J Immunol. 2019 Sep 15;203(6):1457-1467. doi: 10.4049/jimmunol.1900408. Epub 2019 Aug 7.


Human IgE mAbs define variability in commercial Aspergillus extract allergen composition.

Wurth MA, Hadadianpour A, Horvath DJ, Daniel J, Bogdan O, Goleniewska K, Pomés A, Hamilton RG, Peebles RS Jr, Smith SA.

JCI Insight. 2018 Oct 18;3(20). pii: 123387. doi: 10.1172/jci.insight.123387.


Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.

Fuseini H, Yung JA, Cephus JY, Zhang J, Goleniewska K, Polosukhin VV, Peebles RS Jr, Newcomb DC.

J Immunol. 2018 Oct 1;201(7):1843-1854. doi: 10.4049/jimmunol.1800293. Epub 2018 Aug 20.


The PGI2 Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells.

Zhou W, Zhang J, Toki S, Goleniewska K, Johnson MO, Bloodworth MH, Newcomb DC, Peebles RS Jr.

J Immunol. 2018 Oct 1;201(7):1936-1945. doi: 10.4049/jimmunol.1700605. Epub 2018 Aug 20.


Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.

Bloodworth MH, Rusznak M, Pfister CC, Zhang J, Bastarache L, Calvillo SA, Chappell JD, Boyd KL, Toki S, Newcomb DC, Stier MT, Zhou W, Goleniewska K, Moore ML, Hartert TV, Niswender KD, Peebles RS Jr.

J Allergy Clin Immunol. 2018 Aug;142(2):683-687.e12. doi: 10.1016/j.jaci.2018.01.053. Epub 2018 Apr 17. No abstract available.


Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model.

Toki S, Zhou W, Goleniewska K, Reiss S, Dulek DE, Newcomb DC, Lawson WE, Peebles RS Jr.

Prostaglandins Other Lipid Mediat. 2018 May;136:33-43. doi: 10.1016/j.prostaglandins.2018.04.001. Epub 2018 Apr 13.


Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo.

Toki S, Goleniewska K, Reiss S, Zhang J, Bloodworth MH, Stier MT, Zhou W, Newcomb DC, Ware LB, Stanwood GD, Galli A, Boyd KL, Niswender KD, Peebles RS Jr.

J Allergy Clin Immunol. 2018 Nov;142(5):1515-1528.e8. doi: 10.1016/j.jaci.2017.11.043. Epub 2018 Jan 10.


IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.

Stier MT, Zhang J, Goleniewska K, Cephus JY, Rusznak M, Wu L, Van Kaer L, Zhou B, Newcomb DC, Peebles RS Jr.

J Exp Med. 2018 Jan 2;215(1):263-281. doi: 10.1084/jem.20170449. Epub 2017 Dec 8.


Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation.

Cephus JY, Stier MT, Fuseini H, Yung JA, Toki S, Bloodworth MH, Zhou W, Goleniewska K, Zhang J, Garon SL, Hamilton RG, Poloshukin VV, Boyd KL, Peebles RS Jr, Newcomb DC.

Cell Rep. 2017 Nov 28;21(9):2487-2499. doi: 10.1016/j.celrep.2017.10.110.


STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection.

Stier MT, Goleniewska K, Cephus JY, Newcomb DC, Sherrill TP, Boyd KL, Bloodworth MH, Moore ML, Chen K, Kolls JK, Peebles RS Jr.

J Immunol. 2017 Jul 15;199(2):510-519. doi: 10.4049/jimmunol.1601984. Epub 2017 Jun 2.


Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.

Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS Jr.

J Immunol. 2016 Sep 1;197(5):1577-86. doi: 10.4049/jimmunol.1501063. Epub 2016 Jul 25.


Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin.

Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, Quitalig M, Hotard AL, Moore ML, Hartert TV, Zhou B, McKenzie AN, Peebles RS Jr.

J Allergy Clin Immunol. 2016 Sep;138(3):814-824.e11. doi: 10.1016/j.jaci.2016.01.050. Epub 2016 Apr 9.


The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation.

Toki S, Goleniewska K, Reiss S, Zhou W, Newcomb DC, Bloodworth MH, Stier MT, Boyd KL, Polosukhin VV, Subramaniam S, Peebles RS Jr.

Thorax. 2016 Jul;71(7):633-45. doi: 10.1136/thoraxjnl-2015-207728. Epub 2016 Apr 12.


STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection.

Bloodworth MH, Newcomb DC, Dulek DE, Stier MT, Cephus JY, Zhang J, Goleniewska K, Kolls JK, Peebles RS Jr.

Infect Immun. 2016 Apr 22;84(5):1548-1555. doi: 10.1128/IAI.00646-15. Print 2016 May.


Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor.

Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS Jr, Komalavilas P.

Am J Respir Cell Mol Biol. 2016 Aug;55(2):225-33. doi: 10.1165/rcmb.2015-0139OC.


Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.

Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS Jr.

J Allergy Clin Immunol. 2015 Oct;136(4):1025-34.e11. doi: 10.1016/j.jaci.2015.05.046. Epub 2015 Aug 1.


Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS Jr.

J Allergy Clin Immunol. 2014 Sep;134(3):698-705.e5. doi: 10.1016/j.jaci.2014.06.004. Epub 2014 Jul 18.


Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner.

Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS Jr.

Infect Immun. 2014 Sep;82(9):3723-39. doi: 10.1128/IAI.00035-14. Epub 2014 Jun 23.


PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells.

Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS Jr.

J Leukoc Biol. 2013 Jul;94(1):77-88. doi: 10.1189/jlb.1112559. Epub 2013 Apr 26.


Deficiency of gp91phox inhibits allergic airway inflammation.

Sevin CM, Newcomb DC, Toki S, Han W, Sherrill TP, Boswell MG, Zhu Z, Collins RD, Boyd KL, Goleniewska K, Huckabee MM, Blackwell TS, Peebles RS Jr.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):396-402. doi: 10.1165/rcmb.2012-0442OC.


IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation.

Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, Harintho MT, Lukacs NW, Kolls JK, Peebles RS Jr.

Thorax. 2013 Aug;68(8):717-23. doi: 10.1136/thoraxjnl-2012-202404. Epub 2013 Feb 19.


IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia.

Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, Brody SL, Kolls JK, Adler KB, Peebles RS Jr.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):711-6. doi: 10.1165/rcmb.2013-0017OC.


Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis.

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS Jr.

PLoS One. 2012;7(5):e33518. doi: 10.1371/journal.pone.0033518. Epub 2012 May 10.


IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner.

Newcomb DC, Boswell MG, Huckabee MM, Goleniewska K, Dulek DE, Reiss S, Lukacs NW, Kolls JK, Peebles RS Jr.

J Immunol. 2012 Feb 1;188(3):1027-35. doi: 10.4049/jimmunol.1102216. Epub 2011 Dec 30.


PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS Jr.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L615-22. doi: 10.1152/ajplung.00224.2010. Epub 2011 Jul 15.


Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice.

Stokes KL, Chi MH, Sakamoto K, Newcomb DC, Currier MG, Huckabee MM, Lee S, Goleniewska K, Pretto C, Williams JV, Hotard A, Sherrill TP, Peebles RS Jr, Moore ML.

J Virol. 2011 Jun;85(12):5782-93. doi: 10.1128/JVI.01693-10. Epub 2011 Apr 6.


Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production.

Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Hershey GK, Kolls JK, Peebles RS Jr.

J Allergy Clin Immunol. 2011 Apr;127(4):1006-13.e1-4. doi: 10.1016/j.jaci.2010.11.043. Epub 2011 Jan 13.


Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.

Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS Jr, Blackwell TS.

Am J Respir Crit Care Med. 2010 Nov 15;182(10):1273-81. doi: 10.1164/rccm.201001-0001OC. Epub 2010 Jul 1.


STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS Jr.

J Immunol. 2009 Aug 1;183(3):2016-26. doi: 10.4049/jimmunol.0803167. Epub 2009 Jul 8.


Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice.

Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS Jr, Biaggioni I, Feoktistov I.

Am J Respir Cell Mol Biol. 2010 May;42(5):564-71. doi: 10.1165/rcmb.2008-0391OC. Epub 2009 Jun 25.


Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation.

Yin H, Liu W, Goleniewska K, Porter NA, Morrow JD, Peebles RS Jr.

Free Radic Biol Med. 2009 Sep 1;47(5):622-8. doi: 10.1016/j.freeradbiomed.2009.05.033. Epub 2009 Jun 6.


A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production.

Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS Jr.

J Immunol. 2009 May 1;182(9):5317-21. doi: 10.4049/jimmunol.0803868.


A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction.

Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE Jr, Goleniewska K, Williams JV, Collins PL, Peebles RS Jr.

J Virol. 2009 May;83(9):4185-94. doi: 10.1128/JVI.01853-08. Epub 2009 Feb 11.


Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.

Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS Jr.

J Immunol. 2008 Oct 15;181(8):5360-7.


Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection.

Moore ML, Chi MH, Goleniewska K, Durbin JE, Peebles RS Jr.

Viral Immunol. 2008 Sep;21(3):327-39. doi: 10.1089/vim.2008.0003.


Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity.

Moore ML, Chi MH, Zhou W, Goleniewska K, O'Neal JF, Higginbotham JN, Peebles RS Jr.

J Immunol. 2007 Mar 1;178(5):2651-4.


Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells.

Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS Jr.

J Immunol. 2007 Jan 15;178(2):702-10.


Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells.

Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS Jr.

J Leukoc Biol. 2007 Mar;81(3):809-17. Epub 2006 Nov 29.


IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse.

Zhou W, Hashimoto K, Moore ML, Elias JA, Zhu Z, Durbin J, Colasurdo G, Rutigliano JA, Chiappetta CL, Goleniewska K, O'Neal JF, Graham BS, Peebles RS Jr.

Microbes Infect. 2006 Nov-Dec;8(14-15):2880-9. Epub 2006 Oct 24.


Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent.

Peebles RS Jr, Hashimoto K, Sheller JR, Moore ML, Morrow JD, Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham BS, Zhou W.

J Immunol. 2005 Dec 15;175(12):8253-9.


Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels.

Hashimoto K, Durbin JE, Zhou W, Collins RD, Ho SB, Kolls JK, Dubin PJ, Sheller JR, Goleniewska K, O'Neal JF, Olson SJ, Mitchell D, Graham BS, Peebles RS Jr.

J Allergy Clin Immunol. 2005 Sep;116(3):550-7.


Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms.

Hashimoto K, Sheller JR, Morrow JD, Collins RD, Goleniewska K, O'Neal J, Zhou W, Ji S, Mitchell DB, Graham BS, Peebles RS Jr.

J Immunol. 2005 Jan 1;174(1):525-32.


Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness.

Hashimoto K, Graham BS, Geraci MW, FitzGerald GA, Egan K, Zhou W, Goleniewska K, O'Neal JF, Morrow JD, Durbin RK, Wright PF, Collins RD, Suzutani T, Peebles RS Jr.

J Virol. 2004 Oct;78(19):10303-9.


Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5.

Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF, Peebles RS Jr.

Am J Respir Crit Care Med. 2004 Aug 1;170(3):306-12. Epub 2004 May 6.


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