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Items: 1 to 50 of 57

1.

Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

Hemmings HC Jr, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA.

Trends Pharmacol Sci. 2019 Jul;40(7):464-481. doi: 10.1016/j.tips.2019.05.001. Epub 2019 May 27. Review.

PMID:
31147199
2.

NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells.

Tchieu J, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L.

Nat Biotechnol. 2019 Mar;37(3):267-275. doi: 10.1038/s41587-019-0035-0. Epub 2019 Feb 25.

3.

Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency.

Joyce RL, Beyer NP, Vasilopoulos G, Woll KA, Hall AC, Eckenhoff RG, Barman DN, Warren JD, Tibbs GR, Goldstein PA.

Biochem Pharmacol. 2019 May;163:493-508. doi: 10.1016/j.bcp.2019.02.013. Epub 2019 Feb 13.

PMID:
30768926
4.

The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment.

Safavynia SA, Goldstein PA.

Front Psychiatry. 2019 Jan 17;9:752. doi: 10.3389/fpsyt.2018.00752. eCollection 2018. Review.

5.

Optimizing Patient Access During an Emergency While Using Intraoperative Computed Tomography.

Bustillo MA, Lien CA, Mack PF, Kopman DJ, Safavynia SA, Rubin L, Stein D, Hartl R, Stieg PE, Hernandez RN, Goldstein PA.

World Neurosurg. 2019 Jan;121:274-278.e1. doi: 10.1016/j.wneu.2018.09.134. Epub 2018 Sep 26.

PMID:
30266700
6.

Neuromonitoring in the ambulatory anesthesia setting: a pro-con discussion.

Grosland JO, Todd MM, Goldstein PA.

Curr Opin Anaesthesiol. 2018 Dec;31(6):667-672. doi: 10.1097/ACO.0000000000000654. Review.

PMID:
30124541
7.

A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Acetaminophen on Hospital Length of Stay in Obese Individuals Undergoing Sleeve Gastrectomy.

Cooke FE, Samuels JD, Pomp A, Gadalla F, Wu X, Afaneh C, Dakin GF, Goldstein PA.

Obes Surg. 2018 Oct;28(10):2998-3006. doi: 10.1007/s11695-018-3316-7.

PMID:
29948869
8.

HCN and K2P Channels in Anesthetic Mechanisms Research.

Riegelhaupt PM, Tibbs GR, Goldstein PA.

Methods Enzymol. 2018;602:391-416. doi: 10.1016/bs.mie.2018.01.015. Epub 2018 Mar 2. Review.

PMID:
29588040
9.

Nonhuman Primates in Anesthesia Research: Have We Reached the End of the Road?

Goldstein PA.

Anesth Analg. 2018 Jun;126(6):2129-2134. doi: 10.1213/ANE.0000000000002655. Review. No abstract available.

PMID:
29210787
10.
11.

Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy; cause and effect?

Aromolaran KA, Goldstein PA.

Mol Pain. 2017 Jan-Dec;13:1744806917714693. doi: 10.1177/1744806917714693.

12.

Relevance of Clinical Relevance.

Riegelhaupt PM, Hemmings HC Jr, Goldstein PA.

Anesthesiology. 2016 Oct;125(4):821-2. doi: 10.1097/ALN.0000000000001257. No abstract available.

PMID:
27649439
13.

Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?

Tibbs GR, Posson DJ, Goldstein PA.

Trends Pharmacol Sci. 2016 Jul;37(7):522-542. doi: 10.1016/j.tips.2016.05.002. Epub 2016 May 24. Review.

PMID:
27233519
14.

Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability.

Inan M, Zhao M, Manuszak M, Karakaya C, Rajadhyaksha AM, Pickel VM, Schwartz TH, Goldstein PA, Manfredi G.

Neurobiol Dis. 2016 Sep;93:35-46. doi: 10.1016/j.nbd.2016.04.004. Epub 2016 Apr 20.

PMID:
27105708
15.

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease.

Steinbeck JA, Jaiswal MK, Calder EL, Kishinevsky S, Weishaupt A, Toyka KV, Goldstein PA, Studer L.

Cell Stem Cell. 2016 Jan 7;18(1):134-43. doi: 10.1016/j.stem.2015.10.002. Epub 2015 Nov 5.

16.

Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.

Heuermann RJ, Jaramillo TC, Ying SW, Suter BA, Lyman KA, Han Y, Lewis AS, Hampton TG, Shepherd GMG, Goldstein PA, Chetkovich DM.

Neurobiol Dis. 2016 Jan;85:81-92. doi: 10.1016/j.nbd.2015.10.005. Epub 2015 Oct 14.

17.

Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.

Calder EL, Tchieu J, Steinbeck JA, Tu E, Keros S, Ying SW, Jaiswal MK, Cornacchia D, Goldstein PA, Tabar V, Studer L.

J Neurosci. 2015 Aug 19;35(33):11462-81. doi: 10.1523/JNEUROSCI.3046-14.2015.

18.

HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore.

Goldstein PA.

Anesth Analg. 2015 Sep;121(3):594-6. doi: 10.1213/ANE.0000000000000871. No abstract available.

PMID:
26287292
19.

Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.

Jaiswal MK, Keros S, Zhao M, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA.

Front Cell Neurosci. 2015 Apr 9;9:127. doi: 10.3389/fncel.2015.00127. eCollection 2015.

20.

Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.

Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying SW, Goldstein PA, Kochs E, Haseneder R, Rammes G.

Anesthesiology. 2015 May;122(5):1047-59. doi: 10.1097/ALN.0000000000000635. Erratum in: Anesthesiology. 2017 Nov;127(5):905-910.

PMID:
25782754
21.

Images in anesthesiology: cranial settling: a cervical spine complication of rheumatoid arthritis.

Li J, Goldstein PA.

Anesthesiology. 2015 Sep;123(3):668. doi: 10.1097/ALN.0000000000000522. No abstract available.

PMID:
25415824
22.

Facilitating the initiation of the physician's professional identity: Cornell's urban semester program.

Goldstein PA, Storey-Johnson C, Beck S.

Perspect Med Educ. 2014 Dec;3(6):492-9. doi: 10.1007/s40037-014-0151-y.

23.

cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.

Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR.

PLoS One. 2014 Jul 1;9(7):e101236. doi: 10.1371/journal.pone.0101236. eCollection 2014.

24.

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.

Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L.

Cell Stem Cell. 2013 May 2;12(5):559-72. doi: 10.1016/j.stem.2013.04.008.

25.

HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.

Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC Jr, Andersen OS, Goldstein PA, Flood PD.

J Pharmacol Exp Ther. 2013 Jun;345(3):363-73. doi: 10.1124/jpet.113.203620. Epub 2013 Apr 2.

26.

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.

Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G, Ordovas-Montanes J, Jouanguy E, Plancoulaine S, Tu E, Elkabetz Y, Al-Muhsen S, Tardieu M, Schlaeger TM, Daley GQ, Abel L, Casanova JL, Studer L, Notarangelo LD.

Nature. 2012 Nov 29;491(7426):769-73. doi: 10.1038/nature11583. Epub 2012 Oct 28.

27.

Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.

Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA.

PLoS One. 2012;7(8):e42756. doi: 10.1371/journal.pone.0042756. Epub 2012 Aug 3.

28.

PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.

Ying SW, Tibbs GR, Picollo A, Abbas SY, Sanford RL, Accardi A, Hofmann F, Ludwig A, Goldstein PA.

J Neurosci. 2011 Jul 13;31(28):10412-23. doi: 10.1523/JNEUROSCI.0021-11.2011.

29.

All results count.

Naguib M, Goldstein PA.

Anesth Analg. 2009 Apr;108(4):1058-61. doi: 10.1213/ane.0b013e318196c7cc. No abstract available.

PMID:
19299761
30.

The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem.

Jia F, Goldstein PA, Harrison NL.

J Pharmacol Exp Ther. 2009 Mar;328(3):1000-6. doi: 10.1124/jpet.108.146084. Epub 2008 Nov 25.

PMID:
19033556
31.

Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.

Ying SW, Werner DF, Homanics GE, Harrison NL, Goldstein PA.

Neuropharmacology. 2009 Feb;56(2):438-47. doi: 10.1016/j.neuropharm.2008.09.015. Epub 2008 Oct 9.

32.

Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).

Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW.

FASEB J. 2008 Oct;22(10):3648-60. doi: 10.1096/fj.08-110171. Epub 2008 Jul 4.

33.

Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus.

Jia F, Yue M, Chandra D, Keramidas A, Goldstein PA, Homanics GE, Harrison NL.

J Neurosci. 2008 Jan 2;28(1):106-15. doi: 10.1523/JNEUROSCI.3996-07.2008.

34.

Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.

Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL.

J Pharmacol Exp Ther. 2008 Mar;324(3):1127-35. Epub 2007 Dec 19.

PMID:
18094320
35.

Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons.

Ying SW, Jia F, Abbas SY, Hofmann F, Ludwig A, Goldstein PA.

J Neurosci. 2007 Aug 8;27(32):8719-32.

36.

Melatonin and anesthesia: a clinical perspective.

Naguib M, Gottumukkala V, Goldstein PA.

J Pineal Res. 2007 Jan;42(1):12-21. Review.

PMID:
17198534
38.

Supplemental oxygen and risk of surgical wound infection.

Pryor KO, Lien CA, Fahey TJ 3rd, Goldstein PA.

JAMA. 2006 Apr 12;295(14):1642; author reply 1642-3. No abstract available.

PMID:
16609081
39.

Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.

Ying SW, Abbas SY, Harrison NL, Goldstein PA.

Eur J Neurosci. 2006 Jan;23(2):465-80. Erratum in: Eur J Neurosci. 2006 Mar;23(5):1403.

PMID:
16420453
40.

An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.

Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA.

J Neurophysiol. 2005 Dec;94(6):4491-501. Epub 2005 Sep 14.

41.

Emerging molecular mechanisms of general anesthetic action.

Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL.

Trends Pharmacol Sci. 2005 Oct;26(10):503-10. Review.

PMID:
16126282
42.

Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.

Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA.

J Pharmacol Exp Ther. 2005 Nov;315(2):517-25. Epub 2005 Jul 20.

PMID:
16033909
44.

A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse.

Homanics GE, Elsen FP, Ying SW, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Goldstein PA, Kralic JE, Morrow AL, Harrison NL.

Genes Brain Behav. 2005 Feb;4(1):10-9.

45.

Propofol-block of SK channels in reticular thalamic neurons enhances GABAergic inhibition in relay neurons.

Ying SW, Goldstein PA.

J Neurophysiol. 2005 Apr;93(4):1935-48. Epub 2004 Nov 24.

46.
47.

Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit.

Goldstein PA, Elsen FP, Ying SW, Ferguson C, Homanics GE, Harrison NL.

J Neurophysiol. 2002 Dec;88(6):3208-17.

48.

Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury.

Okamoto M, Baba H, Goldstein PA, Higashi H, Shimoji K, Yoshimura M.

J Physiol. 2001 Apr 1;532(Pt 1):241-50.

49.

Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 2): effects on somatodendritic sites of GABAergic neurons.

Baba H, Goldstein PA, Okamoto M, Kohno T, Ataka T, Yoshimura M, Shimoji K.

Anesthesiology. 2000 Feb;92(2):485-92.

PMID:
10691236
50.

Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn.

Baba H, Kohno T, Okamoto M, Goldstein PA, Shimoji K, Yoshimura M.

J Physiol. 1998 Apr 1;508 ( Pt 1):83-93.

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