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Items: 1 to 50 of 243

1.

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.

Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB.

J Biol Chem. 2018 Jul 20;293(29):11341-11357. doi: 10.1074/jbc.RA117.000441. Epub 2018 Jun 1.

PMID:
29858247
2.

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB.

Stem Cell Reports. 2018 Mar 13;10(3):1046-1058. doi: 10.1016/j.stemcr.2018.01.031. Epub 2018 Mar 1.

3.

High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells.

D'Antonio M, Woodruff G, Nathanson JL, D'Antonio-Chronowska A, Arias A, Matsui H, Williams R, Herrera C, Reyna SM, Yeo GW, Goldstein LSB, Panopoulos AD, Frazer KA.

Stem Cell Reports. 2017 Apr 11;8(4):1101-1111. doi: 10.1016/j.stemcr.2017.03.011.

4.

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.

Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA.

Stem Cell Reports. 2017 Apr 11;8(4):1086-1100. doi: 10.1016/j.stemcr.2017.03.012.

5.

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.

Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein LS.

Cell Rep. 2016 Oct 11;17(3):759-773. doi: 10.1016/j.celrep.2016.09.034.

6.

Mechanical Ventilation Antioxidant Trial.

Howe KP, Clochesy JM, Goldstein LS, Owen H.

Am J Crit Care. 2015 Sep;24(5):440-5. doi: 10.4037/ajcc2015335.

7.

Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.

Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland SD, Goldstein LS.

Cell Stem Cell. 2015 Apr 2;16(4):373-85. doi: 10.1016/j.stem.2015.02.004. Epub 2015 Mar 12.

8.

Cellular functions of the amyloid precursor protein from development to dementia.

van der Kant R, Goldstein LS.

Dev Cell. 2015 Feb 23;32(4):502-15. doi: 10.1016/j.devcel.2015.01.022. Review. Erratum in: Dev Cell. 2015 Apr 20:33(2):240.

9.

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.

Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C.

PLoS One. 2015 Feb 24;10(2):e0118379. doi: 10.1371/journal.pone.0118379. eCollection 2015.

10.

Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology.

Goldstein LS, Reyna S, Woodruff G.

Neurotherapeutics. 2015 Jan;12(1):121-5. doi: 10.1007/s13311-014-0326-6. Review.

11.

Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis.

Neumann S, Campbell GE, Szpankowski L, Goldstein LS, Encalada SE.

J Vis Exp. 2014 Oct 30;(92):e52029. doi: 10.3791/52029.

12.

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.

Niederst ED, Reyna SM, Goldstein LS.

Mol Biol Cell. 2015 Jan 15;26(2):205-17. doi: 10.1091/mbc.E14-06-1049. Epub 2014 Nov 12.

13.

Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers.

Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH.

JAMA Neurol. 2014 Dec;71(12):1481-9. doi: 10.1001/jamaneurol.2014.2482.

14.

Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury.

Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LS, Tuszynski MH.

Neuron. 2014 Aug 20;83(4):789-96. doi: 10.1016/j.neuron.2014.07.014. Epub 2014 Aug 7.

15.

Culture-Sensitive Question Order Effects of Self-Rated Health Between Older Hispanic and Non-Hispanic Adults in the United States.

Lee S, Schwarz N, Goldstein LS.

J Aging Health. 2014 Aug;26(5):860-883. Epub 2014 May 8.

PMID:
24812265
16.

Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration.

Encalada SE, Goldstein LS.

Annu Rev Biophys. 2014;43:141-69. doi: 10.1146/annurev-biophys-051013-022746. Review.

PMID:
24702007
17.

UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.

Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS.

J Neurosci. 2014 Feb 26;34(9):3320-39. doi: 10.1523/JNEUROSCI.1503-13.2014.

18.

Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function.

Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LS, Falzone TL.

J Cell Sci. 2014 Apr 1;127(Pt 7):1537-49. doi: 10.1242/jcs.140780. Epub 2014 Feb 12.

19.

The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.

Woodruff G, Young JE, Martinez FJ, Buen F, Gore A, Kinaga J, Li Z, Yuan SH, Zhang K, Goldstein LS.

Cell Rep. 2013 Nov 27;5(4):974-85. doi: 10.1016/j.celrep.2013.10.018. Epub 2013 Nov 14.

20.

Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.

Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS.

J Biol Chem. 2013 Dec 6;288(49):35222-36. doi: 10.1074/jbc.M113.513705. Epub 2013 Oct 21.

21.

The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila.

Duncan JE, Lytle NK, Zuniga A, Goldstein LS.

PLoS One. 2013 Jun 26;8(6):e68324. doi: 10.1371/journal.pone.0068324. Print 2013.

22.

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.

Gunawardena S, Yang G, Goldstein LS.

Hum Mol Genet. 2013 Oct 1;22(19):3828-43. doi: 10.1093/hmg/ddt237. Epub 2013 May 24.

23.

Position statement on the provision and procurement of human eggs for stem cell research.

Haimes E, Skene L, Ballantyne AJ, Caulfield T, Goldstein LS, Hyun I, Kimmelman J, Robert JS, Roxland BE, Scott CT, Solbakk JH, Sugarman J, Taylor PL, Testa G; ISSCR.

Cell Stem Cell. 2013 Mar 7;12(3):285-91. doi: 10.1016/j.stem.2013.02.002.

24.

Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver.

Ordonez MP, Goldstein LS.

Semin Liver Dis. 2012 Nov;32(4):298-306. doi: 10.1055/s-0032-1329898. Epub 2013 Feb 8. Review.

PMID:
23397530
25.

A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.

Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH.

Cell Stem Cell. 2013 Mar 7;12(3):316-28. doi: 10.1016/j.stem.2012.12.011. Epub 2013 Jan 17.

26.

Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein.

Weaver C, Leidel C, Szpankowski L, Farley NM, Shubeita GT, Goldstein LS.

Traffic. 2013 Mar;14(3):295-308. doi: 10.1111/tra.12037. Epub 2013 Jan 20.

27.

ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.

Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, Frazer KA, Jamieson CH.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1041-6. doi: 10.1073/pnas.1213021110. Epub 2012 Dec 28.

28.

New frontiers in human cell biology and medicine: can pluripotent stem cells deliver?

Goldstein LS.

J Cell Biol. 2012 Nov 12;199(4):577-81. doi: 10.1083/jcb.201209118.

29.

An October call to arms: we are research!

Goldstein LS.

Mol Biol Cell. 2012 Sep;23(17):3279-80. doi: 10.1091/mbc.E12-01-0064.

30.

Alzheimer's disease in a dish: promises and challenges of human stem cell models.

Young JE, Goldstein LS.

Hum Mol Genet. 2012 Oct 15;21(R1):R82-9. Epub 2012 Aug 2. Review.

31.

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.

Rodrigues EM, Weissmiller AM, Goldstein LS.

Hum Mol Genet. 2012 Nov 1;21(21):4587-601. doi: 10.1093/hmg/dds297. Epub 2012 Jul 27.

32.

Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles.

Szpankowski L, Encalada SE, Goldstein LS.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8582-7. doi: 10.1073/pnas.1120510109. Epub 2012 May 11.

33.

Axonal transport and neurodegenerative disease: can we see the elephant?

Goldstein LS.

Prog Neurobiol. 2012 Dec;99(3):186-90. doi: 10.1016/j.pneurobio.2012.03.006. Epub 2012 Apr 1. Review.

34.

Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.

Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS.

Hum Mol Genet. 2012 Jun 15;21(12):2651-62. doi: 10.1093/hmg/dds090. Epub 2012 Mar 21.

35.

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila.

Reis GF, Yang G, Szpankowski L, Weaver C, Shah SB, Robinson JT, Hays TS, Danuser G, Goldstein LS.

Mol Biol Cell. 2012 May;23(9):1700-14. doi: 10.1091/mbc.E11-11-0938. Epub 2012 Mar 7.

36.

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS.

Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.

37.

Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.

Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein LS.

PLoS One. 2012;7(1):e29755. doi: 10.1371/journal.pone.0029755. Epub 2012 Jan 17.

38.

In the trenches: lessons for scientists from California's Proposition 71 campaign.

Goldstein LS.

Mol Biol Cell. 2011 Nov;22(21):3943-4. doi: 10.1091/mbc.E11-05-0473.

39.

Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds.

DeQuach JA, Yuan SH, Goldstein LS, Christman KL.

Tissue Eng Part A. 2011 Nov;17(21-22):2583-92. doi: 10.1089/ten.TEA.2010.0724. Epub 2011 Oct 17.

40.

A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila.

Henthorn KS, Roux MS, Herrera C, Goldstein LS.

Mol Biol Cell. 2011 Nov;22(21):4038-46. doi: 10.1091/mbc.E10-07-0572. Epub 2011 Aug 31.

41.

Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges.

Israel MA, Goldstein LS.

Genome Med. 2011 Jul 27;3(7):49. doi: 10.1186/gm265.

42.

Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells.

Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT.

PLoS One. 2011 Mar 2;6(3):e17540. doi: 10.1371/journal.pone.0017540.

43.

Somatic coding mutations in human induced pluripotent stem cells.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K.

Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805.

44.

Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles.

Encalada SE, Szpankowski L, Xia CH, Goldstein LS.

Cell. 2011 Feb 18;144(4):551-65. doi: 10.1016/j.cell.2011.01.021.

45.

Investigating synapse formation and function using human pluripotent stem cell-derived neurons.

Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage FH, Ellisman MH, Ghosh A.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3005-10. doi: 10.1073/pnas.1007753108. Epub 2011 Jan 28.

46.

Unconventional allies: interdisciplinary approaches to science policy and funding.

Goldstein LS.

Trends Cell Biol. 2010 Dec;20(12):695-8. doi: 10.1016/j.tcb.2010.09.008. Epub 2010 Nov 4.

PMID:
21106464
47.

Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.

Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein LS.

Hum Mol Genet. 2010 Nov 15;19(22):4399-408. doi: 10.1093/hmg/ddq363. Epub 2010 Sep 3.

48.

Patients beware: commercialized stem cell treatments on the web.

Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL.

Cell Stem Cell. 2010 Jul 2;7(1):43-9. doi: 10.1016/j.stem.2010.06.001. Epub 2010 Jun 17.

49.

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.

Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL.

Genes Dev. 2010 Jun 1;24(11):1106-18. doi: 10.1101/gad.1903310.

50.

Sunday driver interacts with two distinct classes of axonal organelles.

Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS, Cavalli V.

J Biol Chem. 2009 Dec 11;284(50):34628-39. doi: 10.1074/jbc.M109.035022. Epub 2009 Sep 29.

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