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Mass cytometry reveals species-specific differences and a new level of complexity for immune cells in the prostate.

Fox JJ, Navarro HI, Hashimoto T, Garcia AJ, Goldstein AS.

Am J Clin Exp Urol. 2019 Aug 15;7(4):281-296. eCollection 2019.


Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate.

Crowell PD, Fox JJ, Hashimoto T, Diaz JA, Navarro HI, Henry GH, Feldmar BA, Lowe MG, Garcia AJ, Wu YE, Sajed DP, Strand DW, Goldstein AS.

Cell Rep. 2019 Aug 6;28(6):1499-1510.e6. doi: 10.1016/j.celrep.2019.07.007.


Improving the Osteogenicity of PCL Fiber Substrates by Surface-Immobilization of Bone Morphogenic Protein-2.

Gadalla D, Goldstein AS.

Ann Biomed Eng. 2019 May 21. doi: 10.1007/s10439-019-02286-1. [Epub ahead of print]


Assessing the Effects of Ripasudil, a Novel Rho Kinase Inhibitor, on Human Corneal Endothelial Cell Health.

Goldstein AS, Aldrich BT, Skeie JM, Schmidt GA, Reed CR, Zimmerman MB, Greiner MA.

J Ocul Pharmacol Ther. 2018 Oct 12. doi: 10.1089/jop.2018.0063. [Epub ahead of print]


CD38 is methylated in prostate cancer and regulates extracellular NAD.

Mottahedeh J, Haffner MC, Grogan TR, Hashimoto T, Crowell PD, Beltran H, Sboner A, Bareja R, Esopi D, Isaacs WB, Yegnasubramanian S, Rettig MB, Elashoff DA, Platz EA, De Marzo AM, Teitell MA, Goldstein AS.

Cancer Metab. 2018 Sep 21;6:13. doi: 10.1186/s40170-018-0186-3. eCollection 2018.


HoxB13 mediates AR-V7 activity in prostate cancer.

Navarro HI, Goldstein AS.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6528-6529. doi: 10.1073/pnas.1808196115. Epub 2018 Jun 11. No abstract available.


Proteomic analysis of corneal endothelial cell-descemet membrane tissues reveals influence of insulin dependence and disease severity in type 2 diabetes mellitus.

Skeie JM, Aldrich BT, Goldstein AS, Schmidt GA, Reed CR, Greiner MA.

PLoS One. 2018 Mar 12;13(3):e0192287. doi: 10.1371/journal.pone.0192287. eCollection 2018.


Corrigendum to "Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV" [J Hepatol 68 (2018) 33-41].

Karampatou A, Han X, Kondili LA, Taliani G, Ciancio A, Morisco F, Critelli RM, Baraldi E, Bernabucci V, Troshina G, Guarino M, Tagliavini S, D'Ambrosio F, Bristot L, Turco L, Rosato S, Vella S, Trenti T, Neri I, La Marca A, Manthena S, Goldstein AS, Bruno S, Bao Y, Gonzalez YS, Villa E; PITER framework investigators.

J Hepatol. 2018 Apr;68(4):867. doi: 10.1016/j.jhep.2018.01.004. Epub 2018 Feb 1. No abstract available.


Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors.

Chen Y, Zhu JY, Hong KH, Mikles DC, Georg GI, Goldstein AS, Amory JK, Sch├Ânbrunn E.

ACS Chem Biol. 2018 Mar 16;13(3):582-590. doi: 10.1021/acschembio.7b00685. Epub 2018 Jan 3.


Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity.

Haenisch M, Treuting PM, Brabb T, Goldstein AS, Berkseth K, Amory JK, Paik J.

Obes Res Clin Pract. 2018 Jan - Feb;12(1):93-101. doi: 10.1016/j.orcp.2017.08.003. Epub 2017 Sep 12.


Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV.

Karampatou A, Han X, Kondili LA, Taliani G, Ciancio A, Morisco F, Critelli RM, Baraldi E, Bernabucci V, Troshina G, Guarino M, Tagliavini S, D'Ambrosio F, Bristot L, Turco L, Rosato S, Vella S, Trenti T, Neri I, La Marca A, Manthena S, Goldstein AS, Bruno S, Bao Y, Gonzalez YS, Villa E; PITER framework investigators; PITER Investigators.

J Hepatol. 2017 Sep 5. pii: S0168-8278(17)32259-6. doi: 10.1016/j.jhep.2017.08.019. [Epub ahead of print] Erratum in: J Hepatol. 2018 Jan 20;:.


Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer.

Crowell PD, Goldstein AS.

Mol Cell Oncol. 2017 Jan 13;4(2):e1279723. doi: 10.1080/23723556.2017.1279723. eCollection 2017.


Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.

Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS.

Cell Rep. 2016 Dec 6;17(10):2596-2606. doi: 10.1016/j.celrep.2016.11.010.


Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.

Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466. Epub 2016 Sep 30.


Cell layer-electrospun mesh composites for coronary artery bypass grafts.

Erndt-Marino JD, Becerra-Bayona S, McMahon RE, Goldstein AS, Hahn MS.

J Biomed Mater Res A. 2016 Sep;104(9):2200-9. doi: 10.1002/jbm.a.35753. Epub 2016 May 4.


Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells.

Thayer PS, Verbridge SS, Dahlgren LA, Kakar S, Guelcher SA, Goldstein AS.

J Biomed Mater Res A. 2016 Aug;104(8):1894-901. doi: 10.1002/jbm.a.35716. Epub 2016 Apr 1.


Tissue Recombination Models for the Study of Epithelial Cancer.

Zong Y, Goldstein AS, Witte ON.

Cold Spring Harb Protoc. 2015 Dec 2;2015(12):pdb.top069880. doi: 10.1101/pdb.top069880.


The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis.

Lawson DA, Werb Z, Zong Y, Goldstein AS.

Cold Spring Harb Protoc. 2015 Dec 2;2015(12):pdb.prot078071. doi: 10.1101/pdb.prot078071.


Dissociated Prostate Regeneration under the Renal Capsule.

Zong Y, Goldstein AS, Witte ON.

Cold Spring Harb Protoc. 2015 Nov 2;2015(11):991-4. doi: 10.1101/pdb.prot078063.


Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models.

Zong Y, Goldstein AS, Witte ON.

Cold Spring Harb Protoc. 2015 Nov 2;2015(11):988-90. doi: 10.1101/pdb.prot078055.


Motivating Action and Maintaining Change: The Time-Varying Role of Homework Following a Brief Couples' Intervention.

Hawrilenko M, Eubanks Fleming CJ, Goldstein AS, Cordova JV.

J Marital Fam Ther. 2016 Jul;42(3):396-408. doi: 10.1111/jmft.12142. Epub 2015 Oct 12.


The many ways to make a luminal cell and a prostate cancer cell.

Strand DW, Goldstein AS.

Endocr Relat Cancer. 2015 Dec;22(6):T187-97. doi: 10.1530/ERC-15-0195. Epub 2015 Aug 25. Review.


Static and cyclic mechanical loading of mesenchymal stem cells on elastomeric, electrospun polyurethane meshes.

Cardwell RD, Kluge JA, Thayer PS, Guelcher SA, Dahlgren LA, Kaplan DL, Goldstein AS.

J Biomech Eng. 2015 Jul;137(7). doi: 10.1115/1.4030404. Epub 2015 Jun 3.


Electrospun meshes possessing region-wise differences in fiber orientation, diameter, chemistry and mechanical properties for engineering bone-ligament-bone tissues.

Samavedi S, Vaidya P, Gaddam P, Whittington AR, Goldstein AS.

Biotechnol Bioeng. 2014 Dec;111(12):2549-59. doi: 10.1002/bit.25299. Epub 2014 Sep 26.


Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice.

Paik J, Haenisch M, Muller CH, Goldstein AS, Arnold S, Isoherranen N, Brabb T, Treuting PM, Amory JK.

J Biol Chem. 2014 May 23;289(21):15104-17. doi: 10.1074/jbc.M113.540211. Epub 2014 Apr 7.


Inflammation promotes prostate differentiation.

Liu X, Goldstein AS.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1666-7. doi: 10.1073/pnas.1323181111. Epub 2014 Jan 23. No abstract available.


A symbiotic relationship between epithelial and stromal stem cells.

Goldstein AS.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20356-7. doi: 10.1073/pnas.1320032110. Epub 2013 Nov 27. No abstract available.


Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.

Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20111-6. doi: 10.1073/pnas.1320565110. Epub 2013 Nov 26.


Cellularized cylindrical fiber/hydrogel composites for ligament tissue engineering.

Thayer PS, Dimling AF, Plessl DS, Hahn MR, Guelcher SA, Dahlgren LA, Goldstein AS.

Biomacromolecules. 2014 Jan 13;15(1):75-83. doi: 10.1021/bm4013056. Epub 2013 Dec 5.


Does the microenvironment influence the cell types of origin for prostate cancer?

Goldstein AS, Witte ON.

Genes Dev. 2013 Jul 15;27(14):1539-44. doi: 10.1101/gad.222380.113.


The molecular basis for ethnic variation and histological subtype differences in prostate cancer.

Zong Y, Goldstein AS, Huang J.

Sci China Life Sci. 2013 Sep;56(9):780-7. doi: 10.1007/s11427-013-4522-0. Epub 2013 Jul 13. Review.


Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior.

Samavedi S, Whittington AR, Goldstein AS.

Acta Biomater. 2013 Sep;9(9):8037-45. doi: 10.1016/j.actbio.2013.06.014. Epub 2013 Jun 19. Review.


Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.

Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S.

Stem Cells. 2013 Apr;31(4):808-22. doi: 10.1002/stem.1337.


Adaptation or selection--mechanisms of castration-resistant prostate cancer.

Zong Y, Goldstein AS.

Nat Rev Urol. 2013 Feb;10(2):90-8. doi: 10.1038/nrurol.2012.237. Epub 2012 Dec 18. Review.


Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells.

Stoyanova TI, Goldstein AS.

Asian J Androl. 2013 Jan;15(1):83-4. doi: 10.1038/aja.2012.133. Epub 2012 Dec 3. No abstract available.


A plethora of progenitors in the post-natal prostate.

Goldstein AS, Witte ON.

EMBO Rep. 2012 Dec;13(12):1036-7. doi: 10.1038/embor.2012.169. Epub 2012 Nov 9. No abstract available.


Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via ╬▓-catenin signaling.

Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON.

Genes Dev. 2012 Oct 15;26(20):2271-85. doi: 10.1101/gad.196451.112.


Electrospun fibre diameter, not alignment, affects mesenchymal stem cell differentiation into the tendon/ligament lineage.

Cardwell RD, Dahlgren LA, Goldstein AS.

J Tissue Eng Regen Med. 2014 Dec;8(12):937-45. doi: 10.1002/term.1589. Epub 2012 Oct 5.


Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells.

Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H.

PLoS One. 2012;7(8):e42564. doi: 10.1371/journal.pone.0042564. Epub 2012 Aug 3.


Response of bone marrow stromal cells to graded co-electrospun scaffolds and its implications for engineering the ligament-bone interface.

Samavedi S, Guelcher SA, Goldstein AS, Whittington AR.

Biomaterials. 2012 Nov;33(31):7727-35. doi: 10.1016/j.biomaterials.2012.07.008. Epub 2012 Jul 25.


p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation.

Miller JP, Yeh N, Hofstetter CP, Keskin D, Goldstein AS, Koff A.

J Biol Chem. 2012 Jun 8;287(24):19775-85. doi: 10.1074/jbc.M112.361972. Epub 2012 Apr 17.


Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.

Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1643-8. doi: 10.1073/pnas.1120985109. Epub 2012 Jan 17.


Degradable segmented polyurethane elastomers for bone tissue engineering: effect of polycaprolactone content.

Kavlock KD, Whang K, Guelcher SA, Goldstein AS.

J Biomater Sci Polym Ed. 2013;24(1):77-93. doi: 10.1163/156856212X624985. Epub 2012 May 11.


The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.

Moreb JS, Ucar D, Han S, Amory JK, Goldstein AS, Ostmark B, Chang LJ.

Chem Biol Interact. 2012 Jan 5;195(1):52-60. doi: 10.1016/j.cbi.2011.10.007. Epub 2011 Nov 3.


Do neuroendocrine cells come up large in small cell lung cancer?

Goldstein AS, Huang J.

Cell Cycle. 2011 Nov 1;10(21):3627. doi: 10.4161/cc.10.21.17688. Epub 2011 Nov 1. No abstract available.


Effect of pulse frequency on the osteogenic differentiation of mesenchymal stem cells in a pulsatile perfusion bioreactor.

Kavlock KD, Goldstein AS.

J Biomech Eng. 2011 Sep;133(9):091005. doi: 10.1115/1.4004919.


In vitro evaluation of osteoblastic differentiation on amorphous calcium phosphate-decorated poly(lactic-co-glycolic acid) scaffolds.

Popp JR, Laflin KE, Love BJ, Goldstein AS.

J Tissue Eng Regen Med. 2011 Nov;5(10):780-9. doi: 10.1002/term.376. Epub 2010 Dec 29.


Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament-bone interface.

Samavedi S, Olsen Horton C, Guelcher SA, Goldstein AS, Whittington AR.

Acta Biomater. 2011 Dec;7(12):4131-8. doi: 10.1016/j.actbio.2011.07.008. Epub 2011 Jul 14.


Nerve growth factor-immobilized electrically conducting fibrous scaffolds for potential use in neural engineering applications.

Lee JY, Bashur CA, Milroy CA, Forciniti L, Goldstein AS, Schmidt CE.

IEEE Trans Nanobioscience. 2012 Mar;11(1):15-21. doi: 10.1109/TNB.2011.2159621. Epub 2011 Jun 27.

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