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Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin.

Xin HW, Ambe CM, Miller TC, Chen JQ, Wiegand GW, Anderson AJ, Ray S, Mullinax JE, Hari DM, Koizumi T, Godbout JD, Goldsmith PK, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.

J Cancer. 2016 Jun 6;7(9):1142-51. doi: 10.7150/jca.10047. eCollection 2016.


Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.

Flanders KC, Heger CD, Conway C, Tang B, Sato M, Dengler SL, Goldsmith PK, Hewitt SM, Wakefield LM.

J Histochem Cytochem. 2014 Dec;62(12):846-63. doi: 10.1369/0022155414550163. Epub 2014 Aug 20.


Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands.

Kedei N, Chen JQ, Herrmann MA, Telek A, Goldsmith PK, Petersen ME, Keck GE, Blumberg PM.

J Med Chem. 2014 Jun 26;57(12):5356-69. doi: 10.1021/jm500417b. Epub 2014 Jun 6.


Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer.

Chen JQ, Lee JH, Herrmann MA, Park KS, Heldman MR, Goldsmith PK, Wang Y, Giaccone G.

Mol Cancer Ther. 2013 Nov;12(11):2601-13. doi: 10.1158/1535-7163.MCT-13-0074. Epub 2013 Aug 26.


Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.

Chen JQ, Heldman MR, Herrmann MA, Kedei N, Woo W, Blumberg PM, Goldsmith PK.

Anal Biochem. 2013 Nov 1;442(1):97-103. doi: 10.1016/j.ab.2013.07.022. Epub 2013 Jul 26.


Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae.

Boeckmann L, Takahashi Y, Au WC, Mishra PK, Choy JS, Dawson AR, Szeto MY, Waybright TJ, Heger C, McAndrew C, Goldsmith PK, Veenstra TD, Baker RE, Basrai MA.

Mol Biol Cell. 2013 Jun;24(12):2034-44. doi: 10.1091/mbc.E12-12-0893. Epub 2013 May 1.


Label-retaining liver cancer cells are relatively resistant to sorafenib.

Xin HW, Ambe CM, Hari DM, Wiegand GW, Miller TC, Chen JQ, Anderson AJ, Ray S, Mullinax JE, Koizumi T, Langan RC, Burka D, Herrmann MA, Goldsmith PK, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.

Gut. 2013 Dec;62(12):1777-86. doi: 10.1136/gutjnl-2012-303261. Epub 2013 Feb 14.


Gr-1+CD11b+ cells are responsible for tumor promoting effect of TGF-β in breast cancer progression.

Li Z, Pang Y, Gara SK, Achyut BR, Heger C, Goldsmith PK, Lonning S, Yang L.

Int J Cancer. 2012 Dec 1;131(11):2584-95. doi: 10.1002/ijc.27572. Epub 2012 May 8.


LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.

Ward Y, Lake R, Yin JJ, Heger CD, Raffeld M, Goldsmith PK, Merino M, Kelly K.

Cancer Res. 2011 Dec 1;71(23):7301-11. doi: 10.1158/0008-5472.CAN-11-2381. Epub 2011 Oct 6.


The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.

Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, Blumberg PM.

Biochem Pharmacol. 2011 Jun 1;81(11):1296-308. doi: 10.1016/j.bcp.2011.03.018. Epub 2011 Mar 30.


TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.

Jelinek I, Leonard JN, Price GE, Brown KN, Meyer-Manlapat A, Goldsmith PK, Wang Y, Venzon D, Epstein SL, Segal DM.

J Immunol. 2011 Feb 15;186(4):2422-9. doi: 10.4049/jimmunol.1002845. Epub 2011 Jan 17.


Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients.

Wei BR, Hoover SB, Ross MM, Zhou W, Meani F, Edwards JB, Spehalski EI, Risinger JI, Alvord WG, Quiñones OA, Belluco C, Martella L, Campagnutta E, Ravaggi A, Dai RM, Goldsmith PK, Woolard KD, Pecorelli S, Liotta LA, Petricoin EF, Simpson RM.

PLoS One. 2009 Oct 30;4(10):e7670. doi: 10.1371/journal.pone.0007670.


The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation.

Garcia GL, Rericha EC, Heger CD, Goldsmith PK, Parent CA.

Mol Biol Cell. 2009 Jul;20(14):3295-304. doi: 10.1091/mbc.E09-03-0223. Epub 2009 May 28.


Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines.

Lorenzi PL, Llamas J, Gunsior M, Ozbun L, Reinhold WC, Varma S, Ji H, Kim H, Hutchinson AA, Kohn EC, Goldsmith PK, Birrer MJ, Weinstein JN.

Mol Cancer Ther. 2008 Oct;7(10):3123-8. doi: 10.1158/1535-7163.MCT-08-0589.


Multiplexing siRNAs to compress RNAi-based screen size in human cells.

Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, Gunsior M, Weinstein JN, Goldsmith PK, Lader E, Huppi K, Caplen NJ.

Nucleic Acids Res. 2007;35(8):e57. Epub 2007 Mar 28.


Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca(2+) receptor.

Hu J, Reyes-Cruz G, Goldsmith PK, Gantt NM, Miller JL, Spiegel AM.

J Bone Miner Res. 2007 Apr;22(4):601-8.


Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.

Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN.

Mol Cancer Ther. 2006 Nov;5(11):2613-23. Epub 2006 Nov 6.


Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants.

Reyes-Cruz G, Hu J, Goldsmith PK, Steinbach PJ, Spiegel AM.

J Biol Chem. 2001 Aug 24;276(34):32145-51. Epub 2001 Jun 8.


The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds.

Hu J, Reyes-Cruz G, Goldsmith PK, Spiegel AM.

J Biol Chem. 2001 Mar 9;276(10):6901-4. Epub 2001 Jan 19.


Expression of the calcium-sensing receptor in gastrinomas.

Goebel SU, Peghini PL, Goldsmith PK, Spiegel AM, Gibril F, Raffeld M, Jensen RT, Serrano J.

J Clin Endocrinol Metab. 2000 Nov;85(11):4131-7.


Stable overexpression of MEN1 suppresses tumorigenicity of RAS.

Kim YS, Burns AL, Goldsmith PK, Heppner C, Park SY, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

Oncogene. 1999 Oct 21;18(43):5936-42.


Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.

Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree J, Erdos MR, Collins FS, Chandrasekharappa SC.

Recent Prog Horm Res. 1999;54:397-438; discussion 438-9. Review.


The gene for multiple endocrine neoplasia type 1: recent findings.

Marx SJ, Agarwal SK, Heppner C, Kim YS, Kester MB, Goldsmith PK, Skarulis MC, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree JS, Collins FS, Chandrasekharappa SC.

Bone. 1999 Jul;25(1):119-22. Review.


A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor.

Zhao XM, Hauache O, Goldsmith PK, Collins R, Spiegel AM.

FEBS Lett. 1999 Apr 1;448(1):180-4.


Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor.

Goldsmith PK, Fan GF, Ray K, Shiloach J, McPhie P, Rogers KV, Spiegel AM.

J Biol Chem. 1999 Apr 16;274(16):11303-9.


Identification and localization of G protein subunits in human spermatozoa.

Merlet F, Weinstein LS, Goldsmith PK, Rarick T, Hall JL, Bisson JP, de Mazancourt P.

Mol Hum Reprod. 1999 Jan;5(1):38-45.


Menin, the product of the MEN1 gene, is a nuclear protein.

Guru SC, Goldsmith PK, Burns AL, Marx SJ, Spiegel AM, Collins FS, Chandrasekharappa SC.

Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1630-4.


N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface.

Fan G, Goldsmith PK, Collins R, Dunn CK, Krapcho KJ, Rogers KV, Spiegel AM.

Endocrinology. 1997 May;138(5):1916-22.


Functional characterization of five V2 vasopressin receptor gene mutations.

Wenkert D, Schoneberg T, Merendino JJ Jr, Rodriguez Pena MS, Vinitsky R, Goldsmith PK, Wess J, Spiegel AM.

Mol Cell Endocrinol. 1996 Nov 29;124(1-2):43-50.


Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line.

Pines M, Fukayama S, Costas K, Meurer E, Goldsmith PK, Xu X, Muallem S, Behar V, Chorev M, Rosenblatt M, Tashjian AH Jr, Suva LJ.

Bone. 1996 Apr;18(4):381-9.


Site-related differences in G-protein alpha subunit expression during adipogenesis in vitro: possible key role for Gq/11 alpha in the control of preadipocyte differentiation.

Denis-Henriot D, Lacasa D, Goldsmith PK, De Mazancourt P, Giudicelli Y.

Biochem Biophys Res Commun. 1996 Mar 18;220(2):443-8.


The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.

Xu N, Coso O, Mahadevan D, De Blasi A, Goldsmith PK, Simonds WF, Gutkind JS.

Cell Mol Neurobiol. 1996 Feb;16(1):51-9.


Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding.

Unson CG, Cypess AM, Wu CR, Goldsmith PK, Merrifield RB, Sakmar TP.

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):310-5.


Expression of G protein alpha-subunits in bovine parathyroid.

Varrault A, Pena MS, Goldsmith PK, Mithal A, Brown EM, Spiegel AM.

Endocrinology. 1995 Oct;136(10):4390-6.


Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone.

Abou-Samra AB, Goldsmith PK, Xie LY, Jüppner H, Spiegel AM, Segre GV.

Endocrinology. 1994 Dec;135(6):2588-94.


Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3.

de Mazancourt P, Goldsmith PK, Weinstein LS.

Biochem J. 1994 Oct 15;303 ( Pt 2):369-75.


Smooth muscle myosin is composed of homodimeric heavy chains.

Kelley CA, Sellers JR, Goldsmith PK, Adelstein RS.

J Biol Chem. 1992 Feb 5;267(4):2127-30.


Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.

LaMorte VJ, Goldsmith PK, Spiegel AM, Meinkoth JL, Feramisco JR.

J Biol Chem. 1992 Jan 15;267(2):691-4.


Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.

Fargin A, Yamamoto K, Cotecchia S, Goldsmith PK, Spiegel AM, Lapetina EG, Caron MG, Lefkowitz RJ.

Cell Signal. 1991;3(6):547-57.


Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.

Spiegel AM, Simonds WF, Jones TL, Goldsmith PK, Unson CG.

Biochem Soc Symp. 1990;56:61-9. Review.


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