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Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule.

Sun Q, Wu Y, Jonusaite S, Pleinis JM, Humphreys JM, He H, Schellinger JN, Akella R, Stenesen D, Krämer H, Goldsmith EJ, Rodan AR.

J Am Soc Nephrol. 2018 May;29(5):1449-1461. doi: 10.1681/ASN.2017101091. Epub 2018 Mar 30.


How activating mutations affect MEK1 regulation and function.

Jindal GA, Goyal Y, Humphreys JM, Yeung E, Tian K, Patterson VL, He H, Burdine RD, Goldsmith EJ, Shvartsman SY.

J Biol Chem. 2017 Nov 17;292(46):18814-18820. doi: 10.1074/jbc.C117.806067. Epub 2017 Oct 10.


Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening.

Piala AT, Akella R, Potts MB, Dudics-Giagnocavo SA, He H, Wei S, White MA, Posner BA, Goldsmith EJ.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7. doi: 10.1016/j.bmcl.2016.07.016. Epub 2016 Jul 6.


Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.

Taylor CA 4th, Juang YC, Earnest S, Sengupta S, Goldsmith EJ, Cobb MH.

Biochemistry. 2015 Aug 18;54(32):5063-71. doi: 10.1021/acs.biochem.5b00593. Epub 2015 Aug 3.


MAP kinase modules: the excursion model and the steps that count.

Piala AT, Humphreys JM, Goldsmith EJ.

Biophys J. 2014 Nov 4;107(9):2006-15. doi: 10.1016/j.bpj.2014.09.024. Review.


Chloride sensing by WNK1 involves inhibition of autophosphorylation.

Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ.

Sci Signal. 2014 May 6;7(324):ra41. doi: 10.1126/scisignal.2005050.


Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade.

Humphreys JM, Piala AT, Akella R, He H, Goldsmith EJ.

J Biol Chem. 2013 Aug 9;288(32):23322-30. doi: 10.1074/jbc.M113.462101. Epub 2013 Jun 6.


Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain.

Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ.

J Mol Biol. 2013 Apr 26;425(8):1245-52. doi: 10.1016/j.jmb.2013.01.031. Epub 2013 Jan 30.


Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL.

Cell. 2012 May 11;149(4):753-67. doi: 10.1016/j.cell.2012.04.017.


Three-dimensional docking in the MAPK p38α.

Goldsmith EJ.

Sci Signal. 2011 Dec 20;4(204):pe47. doi: 10.1126/scisignal.2002697. Review.


Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression.

Ahn YH, Yang Y, Gibbons DL, Creighton CJ, Yang F, Wistuba II, Lin W, Thilaganathan N, Alvarez CA, Roybal J, Goldsmith EJ, Tournier C, Kurie JM.

Mol Cell Biol. 2011 Nov;31(21):4270-85. doi: 10.1128/MCB.05562-11. Epub 2011 Sep 6.


Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford DM, Angulo-Barturen I, Ferrer SB, Jiménez-Díaz MB, Gamo FJ, Goldsmith EJ, Charman WN, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA.

J Med Chem. 2011 Aug 11;54(15):5540-61. doi: 10.1021/jm200592f. Epub 2011 Jul 14.


The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution.

Akella R, Min X, Wu Q, Gardner KH, Goldsmith EJ.

Structure. 2010 Dec 8;18(12):1571-8. doi: 10.1016/j.str.2010.09.015.


Structural studies of MAP Kinase cascade components.

Goldsmith EJ, Min X, He H, Zhou T.

Methods Mol Biol. 2010;661:223-37. doi: 10.1007/978-1-60761-795-2_13.


Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.

Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E.

J Biol Chem. 2010 Oct 22;285(43):33054-64. doi: 10.1074/jbc.M110.162081. Epub 2010 Aug 11.


Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.

Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA.

J Biol Chem. 2010 Aug 13;285(33):25708-19. doi: 10.1074/jbc.M110.121137. Epub 2010 Jun 8.


Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.

Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist NA, Goldsmith EJ, Rathod PK, Phillips MA.

J Biol Chem. 2009 Sep 25;284(39):26999-7009. doi: 10.1074/jbc.M109.028589. Epub 2009 Jul 28.


Crystal structure of domain-swapped STE20 OSR1 kinase domain.

Lee SJ, Cobb MH, Goldsmith EJ.

Protein Sci. 2009 Feb;18(2):304-13. doi: 10.1002/pro.27.


The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.

Min X, Akella R, He H, Humphreys JM, Tsutakawa SE, Lee SJ, Tainer JA, Cobb MH, Goldsmith EJ.

Structure. 2009 Jan 14;17(1):96-104. doi: 10.1016/j.str.2008.11.007.


Natural language query in the biochemistry and molecular biology domains based on cognition search™.

Goldsmith EJ, Mendiratta S, Akella R, Dahlgren K.

Summit Transl Bioinform. 2009 Mar 1;2009:32-7.


Unique MAP Kinase binding sites.

Akella R, Moon TM, Goldsmith EJ.

Biochim Biophys Acta. 2008 Jan;1784(1):48-55. Epub 2007 Nov 19. Review.


Substrate and docking interactions in serine/threonine protein kinases.

Goldsmith EJ, Akella R, Min X, Zhou T, Humphreys JM.

Chem Rev. 2007 Nov;107(11):5065-81. Epub 2007 Oct 19. Review. No abstract available.


Mutations in ERK2 binding sites affect nuclear entry.

Yazicioglu MN, Goad DL, Ranganathan A, Whitehurst AW, Goldsmith EJ, Cobb MH.

J Biol Chem. 2007 Sep 28;282(39):28759-67. Epub 2007 Jul 26.


Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.

Lee J, Michael AJ, Martynowski D, Goldsmith EJ, Phillips MA.

J Biol Chem. 2007 Sep 14;282(37):27115-25. Epub 2007 Jul 11.


X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity.

Shah R, Akella R, Goldsmith EJ, Phillips MA.

Biochemistry. 2007 Mar 13;46(10):2831-41. Epub 2007 Feb 17.


Characterization of mitogen-activated protein kinase (MAPK) dimers.

Wilsbacher JL, Juang YC, Khokhlatchev AV, Gallagher E, Binns D, Goldsmith EJ, Cobb MH.

Biochemistry. 2006 Nov 7;45(44):13175-82.


Crystallization of MAP kinases.

Lee SJ, Zhou T, Goldsmith EJ.

Methods. 2006 Nov;40(3):224-33. Review.


Docking interactions induce exposure of activation loop in the MAP kinase ERK2.

Zhou T, Sun L, Humphreys J, Goldsmith EJ.

Structure. 2006 Jun;14(6):1011-9.


Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.

Zhou TJ, Sun LG, Gao Y, Goldsmith EJ.

Acta Biochim Biophys Sin (Shanghai). 2006 Jun;38(6):385-92.


Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K.

Science. 2006 May 26;312(5777):1211-4.


Determinants that control the specific interactions between TAB1 and p38alpha.

Zhou H, Zheng M, Chen J, Xie C, Kolatkar AR, Zarubin T, Ye Z, Akella R, Lin S, Goldsmith EJ, Han J.

Mol Cell Biol. 2006 May;26(10):3824-34.


Properties of WNK1 and implications for other family members.

Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26653-8. Epub 2005 May 9.


WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.

Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH.

Cell Res. 2005 Jan;15(1):6-10. Review.


Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase.

Jackson LK, Baldwin J, Akella R, Goldsmith EJ, Phillips MA.

Biochemistry. 2004 Oct 19;43(41):12990-9.


Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.

Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ.

Structure. 2004 Oct;12(10):1891-900.


WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.

Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH.

Mol Cell. 2004 Sep 10;15(5):741-51.


Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry.

Lee T, Hoofnagle AN, Kabuyama Y, Stroud J, Min X, Goldsmith EJ, Chen L, Resing KA, Ahn NG.

Mol Cell. 2004 Apr 9;14(1):43-55.


Structure of MAPKs.

Goldsmith EJ, Cobb MH, Chang CI.

Methods Mol Biol. 2004;250:127-44. No abstract available.


Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.

Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH.

J Biol Chem. 2002 Dec 13;277(50):48456-62. Epub 2002 Oct 8.


Another twist in helix C and a missing pocket.

Goldsmith EJ, Chang CI.

Structure. 2002 Jul;10(7):888-9.


Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution.

Coleman DE, Rao GS, Goldsmith EJ, Cook PF, Harris BG.

Biochemistry. 2002 Jun 4;41(22):6928-38.


Serpins and other covalent protease inhibitors.

Ye S, Goldsmith EJ.

Curr Opin Struct Biol. 2001 Dec;11(6):740-5. Review.


The structure of a Michaelis serpin-protease complex.

Ye S, Cech AL, Belmares R, Bergstrom RC, Tong Y, Corey DR, Kanost MR, Goldsmith EJ.

Nat Struct Biol. 2001 Nov;8(11):979-83.


Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange.

Hoofnagle AN, Resing KA, Goldsmith EJ, Ahn NG.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):956-61.


Altering the reaction specificity of eukaryotic ornithine decarboxylase.

Jackson LK, Brooks HB, Osterman AL, Goldsmith EJ, Phillips MA.

Biochemistry. 2000 Sep 19;39(37):11247-57.


WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.

Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2000 Jun 2;275(22):16795-801.

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