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Connective tissue growth factor is correlated with peritoneal lymphangiogenesis.

Kinashi H, Toda N, Sun T, Nguyen TQ, Suzuki Y, Katsuno T, Yokoi H, Aten J, Mizuno M, Maruyama S, Yanagita M, Goldschmeding R, Ito Y.

Sci Rep. 2019 Aug 21;9(1):12175. doi: 10.1038/s41598-019-48699-9.


Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools.

Knoppert SN, Valentijn FA, Nguyen TQ, Goldschmeding R, Falke LL.

Front Pharmacol. 2019 Jul 12;10:770. doi: 10.3389/fphar.2019.00770. eCollection 2019. Review.


Epigenetically quantified immune cells in salivary glands of Sjögren's syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology.

Blokland SLM, van Vliet-Moret FM, Hillen MR, Pandit A, Goldschmeding R, Kruize AA, Bouma G, van Maurik A, Olek S, Hoffmueller U, van Roon JAG, Radstake TRDJ.

Rheumatology (Oxford). 2019 Jul 19. pii: kez268. doi: 10.1093/rheumatology/kez268. [Epub ahead of print]


Importance of Genetic Diagnostics in Adult-Onset Focal Segmental Glomerulosclerosis.

Snoek R, Nguyen TQ, van der Zwaag B, van Zuilen AD, Kruis HME, van Gils-Verrij LA, Goldschmeding R, Knoers NVAM, Rookmaaker MB, van Eerde AM.

Nephron. 2019;142(4):351-358. doi: 10.1159/000499937. Epub 2019 May 16.


Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways.

Patel S, Tang J, Overstreet JM, Anorga S, Lian F, Arnouk A, Goldschmeding R, Higgins PJ, Samarakoon R.

FASEB J. 2019 Sep;33(9):9797-9810. doi: 10.1096/fj.201802489RR. Epub 2019 May 16.


Connective Tissue Growth Factor Is Related to All-cause Mortality in Hemodialysis Patients and Is Lowered by On-line Hemodiafiltration: Results from the Convective Transport Study.

den Hoedt CH, van Gelder MK, Grooteman MP, Nubé MJ, Blankestijn PJ, Goldschmeding R, Kok RJ, Bots ML, van den Dorpel MA, Gerritsen KGF.

Toxins (Basel). 2019 May 13;11(5). pii: E268. doi: 10.3390/toxins11050268.


A multicenter application of the 2018 Banff Classification for BK polyomavirus-associated nephropathy in renal transplantation.

Bouatou Y, Nguyen TQ, Roelofs JJTH, Bemelman FJ, Michielsen L, Goldschmeding R, Kers J, Florquin S.

Transplantation. 2019 Mar 21. doi: 10.1097/TP.0000000000002712. [Epub ahead of print]


Inflammatory and Fibrotic Mediators in Renal Diseases.

Rayego-Mateos S, Goldschmeding R, Ruiz-Ortega M.

Mediators Inflamm. 2019 Feb 10;2019:7025251. doi: 10.1155/2019/7025251. eCollection 2019. No abstract available.


Histological characteristics of Acute Tubular Injury during Delayed Graft Function predict renal function after renal transplantation.

Pieters TT, Falke LL, Nguyen TQ, Verhaar MC, Florquin S, Bemelman FJ, Kers J, Vanhove T, Kuypers D, Goldschmeding R, Rookmaaker MB.

Physiol Rep. 2019 Mar;7(5):e14000. doi: 10.14814/phy2.14000.


Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage.

Rayego-Mateos S, Rodrigues-Diez R, Morgado-Pascual JL, Valentijn F, Valdivielso JM, Goldschmeding R, Ruiz-Ortega M.

Mediators Inflamm. 2018 Dec 23;2018:8739473. doi: 10.1155/2018/8739473. eCollection 2018. Review.


[Hereditary kidney disease in adolescents and adults].

Dendooven A, Van Craenenbroeck AH, Nguyen TQ, Goldschmeding R, Loeys B, Helbert M.

Ned Tijdschr Geneeskd. 2018 May 25;162. pii: D2427. Dutch.


The aging lung: tissue telomere shortening in health and disease.

Everaerts S, Lammertyn EJ, Martens DS, De Sadeleer LJ, Maes K, van Batenburg AA, Goldschmeding R, van Moorsel CHM, Dupont LJ, Wuyts WA, Vos R, Gayan-Ramirez G, Kaminski N, Hogg JC, Janssens W, Verleden GM, Nawrot TS, Verleden SE, McDonough JE, Vanaudenaerde BM.

Respir Res. 2018 May 11;19(1):95. doi: 10.1186/s12931-018-0794-z.


Connective tissue growth factor (CTGF) from basics to clinics.

Ramazani Y, Knops N, Elmonem MA, Nguyen TQ, Arcolino FO, van den Heuvel L, Levtchenko E, Kuypers D, Goldschmeding R.

Matrix Biol. 2018 Aug;68-69:44-66. doi: 10.1016/j.matbio.2018.03.007. Epub 2018 Mar 21. Review.


Cell Type-Specific Quantification of Telomere Length and DNA Double-strand Breaks in Individual Lung Cells by Fluorescence In Situ Hybridization and Fluorescent Immunohistochemistry.

van Batenburg AA, Kazemier KM, Peeters T, van Oosterhout MFM, van der Vis JJ, Grutters JC, Goldschmeding R, van Moorsel CHM.

J Histochem Cytochem. 2018 Jul;66(7):485-495. doi: 10.1369/0022155418761351. Epub 2018 Mar 12.


Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype.

Anorga S, Overstreet JM, Falke LL, Tang J, Goldschmeding RG, Higgins PJ, Samarakoon R.

FASEB J. 2018 May;32(5):2644-2657. doi: 10.1096/fj.201700722R. Epub 2018 Jan 3.


Short telomere length in IPF lung associates with fibrotic lesions and predicts survival.

Snetselaar R, van Batenburg AA, van Oosterhout MFM, Kazemier KM, Roothaan SM, Peeters T, van der Vis JJ, Goldschmeding R, Grutters JC, van Moorsel CHM.

PLoS One. 2017 Dec 27;12(12):e0189467. doi: 10.1371/journal.pone.0189467. eCollection 2017.


Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

van Koppen A, Verschuren L, van den Hoek AM, Verheij J, Morrison MC, Li K, Nagabukuro H, Costessi A, Caspers MPM, van den Broek TJ, Sagartz J, Kluft C, Beysen C, Emson C, van Gool AJ, Goldschmeding R, Stoop R, Bobeldijk-Pastorova I, Turner SM, Hanauer G, Hanemaaijer R.

Cell Mol Gastroenterol Hepatol. 2017 Oct 14;5(1):83-98.e10. doi: 10.1016/j.jcmgh.2017.10.001. eCollection 2018.


Cellular senescence in the aging and diseased kidney.

Valentijn FA, Falke LL, Nguyen TQ, Goldschmeding R.

J Cell Commun Signal. 2018 Mar;12(1):69-82. doi: 10.1007/s12079-017-0434-2. Epub 2017 Dec 19. Review.


Predicting Outcome in Patients with Anti-GBM Glomerulonephritis.

van Daalen EE, Jennette JC, McAdoo SP, Pusey CD, Alba MA, Poulton CJ, Wolterbeek R, Nguyen TQ, Goldschmeding R, Alchi B, Griffiths M, de Zoysa JR, Vincent B, Bruijn JA, Bajema IM.

Clin J Am Soc Nephrol. 2018 Jan 6;13(1):63-72. doi: 10.2215/CJN.04290417. Epub 2017 Nov 21.


Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation.

Rayego-Mateos S, Morgado-Pascual JL, Rodrigues-Diez RR, Rodrigues-Diez R, Falke LL, Mezzano S, Ortiz A, Egido J, Goldschmeding R, Ruiz-Ortega M.

J Pathol. 2018 Feb;244(2):227-241. doi: 10.1002/path.5007. Epub 2018 Jan 10.


Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.

Kok HM, van den Hoogen LL, van Roon JAG, Adriaansen EJM, Fritsch-Stork RDE, Nguyen TQ, Goldschmeding R, Radstake TRDJ, Bovenschen N.

Rheumatology (Oxford). 2017 Dec 1;56(12):2129-2134. doi: 10.1093/rheumatology/kex332.


The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle.

Morales MG, Acuña MJ, Cabrera D, Goldschmeding R, Brandan E.

J Cell Commun Signal. 2018 Mar;12(1):413-421. doi: 10.1007/s12079-017-0409-3. Epub 2017 Sep 8.


Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis.

Kinashi H, Falke LL, Nguyen TQ, Bovenschen N, Aten J, Leask A, Ito Y, Goldschmeding R.

Kidney Int. 2017 Oct;92(4):850-863. doi: 10.1016/j.kint.2017.03.029. Epub 2017 May 23.


Tamoxifen for induction of Cre-recombination may confound fibrosis studies in female mice.

Falke LL, Broekhuizen R, Huitema A, Maarseveen E, Nguyen TQ, Goldschmeding R.

J Cell Commun Signal. 2017 Jun;11(2):205-211. doi: 10.1007/s12079-017-0390-x. Epub 2017 May 11.


Tubulointerstitial expression and urinary excretion of connective tissue growth factor 3 months after renal transplantation predict interstitial fibrosis and tubular atrophy at 5 years in a retrospective cohort analysis.

Vanhove T, Kinashi H, Nguyen TQ, Metalidis C, Poesen K, Naesens M, Lerut E, Goldschmeding R, Kuypers DRJ.

Transpl Int. 2017 Jul;30(7):695-705. doi: 10.1111/tri.12960. Epub 2017 May 9.


Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies.

Sepehrkhouy S, Gho JMIH, van Es R, Harakalova M, de Jonge N, Dooijes D, van der Smagt JJ, Buijsrogge MP, Hauer RNW, Goldschmeding R, de Weger RA, Asselbergs FW, Vink A.

Heart Rhythm. 2017 Jul;14(7):1024-1032. doi: 10.1016/j.hrthm.2017.03.034. Epub 2017 Mar 30.


Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model.

Ellenbroek GHJM, van Hout GPJ, de Jager SCA, Timmers L, Vink A, Goldschmeding R, van der Kraak P, Pasterkamp G, Hoefer IE, Doevendans PA, Appelman Y.

J Cardiovasc Transl Res. 2017 Apr;10(2):221-232. doi: 10.1007/s12265-017-9743-3. Epub 2017 Mar 31.


Treatment of Renal Fibrosis-Turning Challenges into Opportunities.

Klinkhammer BM, Goldschmeding R, Floege J, Boor P.

Adv Chronic Kidney Dis. 2017 Mar;24(2):117-129. doi: 10.1053/j.ackd.2016.11.002. Review.


Gastrointestinal stromal tumour detection with somatostatin receptor imaging, 68Ga-HA-DOTATATE PET-CT.

Braat AJAT, Goldschmeding R, Brosens LAA, Vriens MR, de Keizer B.

Lancet Oncol. 2017 Mar;18(3):e185. doi: 10.1016/S1470-2045(17)30078-5. Epub 2017 Mar 2. No abstract available.


Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation.

Oosterhuis NR, Bongartz LG, Verhaar MC, Cheng C, Xu YJ, van Koppen A, Cramer MJ, Goldschmeding R, Gaillard CA, Doevendans PA, Braam B, Joles JA.

Acta Physiol (Oxf). 2017 Jul;220(3):382-393. doi: 10.1111/apha.12829. Epub 2017 Feb 7.


Gremlin1 plays a key role in kidney development and renal fibrosis.

Church RH, Ali I, Tate M, Lavin D, Krishnakumar A, Kok HM, Hombrebueno JR, Dunne PD, Bingham V, Goldschmeding R, Martin F, Brazil DP.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F1141-F1157. doi: 10.1152/ajprenal.00344.2016. Epub 2017 Jan 18.


Kidney Fibrosis: Origins and Interventions.

Vanhove T, Goldschmeding R, Kuypers D.

Transplantation. 2017 Apr;101(4):713-726. doi: 10.1097/TP.0000000000001608. Review.


Pathology of aortic valve remodeling after continuous-flow left ventricular assist device support.

van Rijswijk JW, Vink A, Martina JR, Ramjankhan FZ, Goldschmeding R, de Jonge N, Kluin J.

J Heart Lung Transplant. 2017 Jan;36(1):113-116. doi: 10.1016/j.healun.2016.11.002. Epub 2016 Nov 10. No abstract available.


Age-dependent shifts in renal response to injury relate to altered BMP6/CTGF expression and signaling.

Falke LL, Kinashi H, Dendooven A, Broekhuizen R, Stoop R, Joles JA, Nguyen TQ, Goldschmeding R.

Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F926-F934. doi: 10.1152/ajprenal.00324.2016. Epub 2016 Aug 24.


CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy.

Falke LL, Leeuwis JW, Lyons KM, Mummery CL, Nguyen TQ, Goldschmeding R.

J Cell Commun Signal. 2017 Mar;11(1):39-48. doi: 10.1007/s12079-016-0358-2. Epub 2016 Oct 20.


Plasma CTGF is independently related to an increased risk of cardiovascular events and mortality in patients with atherosclerotic disease: the SMART study.

Gerritsen KG, Falke LL, van Vuuren SH, Leeuwis JW, Broekhuizen R, Nguyen TQ, de Borst GJ, Nathoe HM, Verhaar MC, Kok RJ, Goldschmeding R, Visseren FL; SMART Study Group.

Growth Factors. 2016 Aug;34(3-4):149-58. doi: 10.1080/08977194.2016.1210142.


Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis.

Gerritsen KG, Bovenschen N, Nguyen TQ, Sprengers D, Koeners MP, van Koppen AN, Joles JA, Goldschmeding R, Kok RJ.

J Cell Commun Signal. 2016 Dec;10(4):295-303. Epub 2016 Sep 19.


A potential role for CCN2/CTGF in aggressive colorectal cancer.

Ubink I, Verhaar ER, Kranenburg O, Goldschmeding R.

J Cell Commun Signal. 2016 Sep;10(3):223-227. Epub 2016 Sep 10.


Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair.

Samarakoon R, Rehfuss A, Khakoo NS, Falke LL, Dobberfuhl AD, Helo S, Overstreet JM, Goldschmeding R, Higgins PJ.

FASEB J. 2016 Oct;30(10):3308-3320. Epub 2016 Jun 21.


The morphological substrate for Renal Denervation: Nerve distribution patterns and parasympathetic nerves. A post-mortem histological study.

van Amsterdam WA, Blankestijn PJ, Goldschmeding R, Bleys RL.

Ann Anat. 2016 Mar;204:71-9. doi: 10.1016/j.aanat.2015.11.004. Epub 2015 Nov 23.


The Effects of Renal Denervation on Renal Hemodynamics and Renal Vasculature in a Porcine Model.

Verloop WL, Hubens LE, Spiering W, Doevendans PA, Goldschmeding R, Bleys RL, Voskuil M.

PLoS One. 2015 Nov 20;10(11):e0141609. doi: 10.1371/journal.pone.0141609. eCollection 2015.


Bioluminescent reporters to monitor killer cell-mediated delivery of granzymes inside target cells.

de Poot SA, van Erp EA, Meeldijk J, Broekhuizen R, Goldschmeding R, Olthof MC, Steeghs EM, Bovenschen N.

Blood. 2015 Dec 24;126(26):2893-5. doi: 10.1182/blood-2015-07-657841. Epub 2015 Nov 13. No abstract available.


Predominance of Nonatherosclerotic Internal Elastic Lamina Calcification in the Intracranial Internal Carotid Artery.

Vos A, Van Hecke W, Spliet WG, Goldschmeding R, Isgum I, Kockelkoren R, Bleys RL, Mali WP, de Jong PA, Vink A.

Stroke. 2016 Jan;47(1):221-3. doi: 10.1161/STROKEAHA.115.011196. Epub 2015 Oct 29.


CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload.

Fontes MS, Kessler EL, van Stuijvenberg L, Brans MA, Falke LL, Kok B, Leask A, van Rijen HV, Vos MA, Goldschmeding R, van Veen TA.

J Mol Cell Cardiol. 2015 Nov;88:82-90. doi: 10.1016/j.yjmcc.2015.09.015. Epub 2015 Sep 26.


The Dutch Transplantation in Vasculitis (DUTRAVAS) Study: Outcome of Renal Transplantation in Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis.

Göçeroğlu A, Rahmattulla C, Berden AE, Reinders ME, Wolterbeek R, Steenbergen EJ, Hilbrands LB, Noorlander I, Berger SP, Peutz-Kootstra CJ, Christiaans MH, van Dijk MC, de Joode AA, Goldschmeding R, van Zuilen AD, Harper L, Little MA, Hagen EC, Bruijn JA, Bajema IM.

Transplantation. 2016 Apr;100(4):916-24. doi: 10.1097/TP.0000000000000910.


Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction.

Gerritsen KG, Leeuwis JW, Koeners MP, Bakker SJ, van Oeveren W, Aten J, Tarnow L, Rossing P, Wetzels JF, Joles JA, Kok RJ, Goldschmeding R, Nguyen TQ.

J Diabetes Res. 2015;2015:539787. doi: 10.1155/2015/539787. Epub 2015 Jun 15.


A panel of novel biomarkers representing different disease pathways improves prediction of renal function decline in type 2 diabetes.

Pena MJ, Heinzel A, Heinze G, Alkhalaf A, Bakker SJ, Nguyen TQ, Goldschmeding R, Bilo HJ, Perco P, Mayer B, de Zeeuw D, Lambers Heerspink HJ.

PLoS One. 2015 May 14;10(5):e0120995. doi: 10.1371/journal.pone.0120995. eCollection 2015.


Release and pharmacokinetics of near-infrared labeled albumin from monodisperse poly(d,l-lactic-co-hydroxymethyl glycolic acid) microspheres after subcapsular renal injection.

Kazazi-Hyseni F, van Vuuren SH, van der Giezen DM, Pieters EH, Ramazani F, Rodriguez S, Veldhuis GJ, Goldschmeding R, van Nostrum CF, Hennink WE, Kok RJ.

Acta Biomater. 2015 Aug;22:141-54. doi: 10.1016/j.actbio.2015.04.030. Epub 2015 Apr 27.


Connective tissue growth factor and the cicatrization of cellular crescents in ANCA-associated glomerulonephritis.

Hilhorst M, Kok HM, Broekhuizen R, van Paassen P, van Breda Vriesman P, Goldschmeding R, Nguyen TQ, Cohen Tervaert JW; Limburg Renal Registry.

Nephrol Dial Transplant. 2015 Aug;30(8):1291-9. doi: 10.1093/ndt/gfv088. Epub 2015 Apr 26.


Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.

Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ.

J Pathol. 2015 Aug;236(4):421-32. doi: 10.1002/path.4538. Epub 2015 Apr 27.

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