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Items: 14


Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels.

Finol-Urdaneta RK, McArthur JR, Goldschen-Ohm MP, Gaudet R, Tikhonov DB, Zhorov BS, French RJ.

J Gen Physiol. 2019 Feb 4;151(2):186-199. doi: 10.1085/jgp.201812278. Epub 2018 Dec 26.


SnapShot: Channel Gating Mechanisms.

Goldschen-Ohm MP, Chanda B.

Cell. 2017 Jul 27;170(3):594-594.e1. doi: 10.1016/j.cell.2017.07.019.


The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation.

Zhao Y, Goldschen-Ohm MP, Morais-Cabral JH, Chanda B, Robertson GA.

J Gen Physiol. 2017 Feb;149(2):249-260. doi: 10.1085/jgp.201611701. Epub 2017 Jan 25.


Observing Single-Molecule Dynamics at Millimolar Concentrations.

Goldschen-Ohm MP, White DS, Klenchin VA, Chanda B, Goldsmith RH.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2399-2402. doi: 10.1002/anie.201612050. Epub 2017 Jan 24.


Structure and dynamics underlying elementary ligand binding events in human pacemaking channels.

Goldschen-Ohm MP, Klenchin VA, White DS, Cowgill JB, Cui Q, Goldsmith RH, Chanda B.

Elife. 2016 Nov 18;5. pii: e20797. doi: 10.7554/eLife.20797.


How to open a proton pore-more than S4?

Goldschen-Ohm MP, Chanda B.

Nat Struct Mol Biol. 2015 Apr;22(4):277-8. doi: 10.1038/nsmb.2997.


A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAA receptors.

Goldschen-Ohm MP, Haroldson A, Jones MV, Pearce RA.

J Gen Physiol. 2014 Jul;144(1):27-39. doi: 10.1085/jgp.201411183.


Probing gating mechanisms of sodium channels using pore blockers.

Goldschen-Ohm MP, Chanda B.

Handb Exp Pharmacol. 2014;221:183-201. doi: 10.1007/978-3-642-41588-3_9. Review.


Evolutionarily conserved intracellular gate of voltage-dependent sodium channels.

Oelstrom K, Goldschen-Ohm MP, Holmgren M, Chanda B.

Nat Commun. 2014 Mar 12;5:3420. doi: 10.1038/ncomms4420.


Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.

Capes DL, Goldschen-Ohm MP, Arcisio-Miranda M, Bezanilla F, Chanda B.

J Gen Physiol. 2013 Aug;142(2):101-12. doi: 10.1085/jgp.201310998. Epub 2013 Jul 15.


Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel.

Goldschen-Ohm MP, Capes DL, Oelstrom KM, Chanda B.

Nat Commun. 2013;4:1350. doi: 10.1038/ncomms2356.


Three arginines in the GABAA receptor binding pocket have distinct roles in the formation and stability of agonist- versus antagonist-bound complexes.

Goldschen-Ohm MP, Wagner DA, Jones MV.

Mol Pharmacol. 2011 Oct;80(4):647-56. doi: 10.1124/mol.111.072033. Epub 2011 Jul 15.


An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.

Goldschen-Ohm MP, Wagner DA, Petrou S, Jones MV.

Mol Pharmacol. 2010 Jan;77(1):35-45. doi: 10.1124/mol.109.058289. Epub 2009 Oct 21.


Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor.

Wagner DA, Goldschen-Ohm MP, Hales TG, Jones MV.

J Neurosci. 2005 Nov 9;25(45):10462-8.

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