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Items: 1 to 50 of 77

1.

Remembering to remember: T cell memory maintenance and plasticity.

Omilusik KD, Goldrath AW.

Curr Opin Immunol. 2019 Jun 3;58:89-97. doi: 10.1016/j.coi.2019.04.009. [Epub ahead of print] Review.

PMID:
31170601
2.

T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells.

Stone SL, Peel JN, Scharer CD, Risley CA, Chisolm DA, Schultz MD, Yu B, Ballesteros-Tato A, Wojciechowski W, Mousseau B, Misra RS, Hanidu A, Jiang H, Qi Z, Boss JM, Randall TD, Brodeur SR, Goldrath AW, Weinmann AS, Rosenberg AF, Lund FE.

Immunity. 2019 May 21;50(5):1172-1187.e7. doi: 10.1016/j.immuni.2019.04.004. Epub 2019 May 7.

PMID:
31076359
3.

Origins of CD4+ circulating and tissue-resident memory T-cells.

Nguyen QP, Deng TZ, Witherden DA, Goldrath AW.

Immunology. 2019 May;157(1):3-12. doi: 10.1111/imm.13059. Review.

PMID:
30897205
4.

The Transcription Factor Zfx Regulates Peripheral T Cell Self-Renewal and Proliferation.

Smith-Raska MR, Arenzana TL, D'Cruz LM, Khodadadi-Jamayran A, Tsirigos A, Goldrath AW, Reizis B.

Front Immunol. 2018 Jul 4;9:1482. doi: 10.3389/fimmu.2018.01482. eCollection 2018.

5.

The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.

Wang D, Diao H, Getzler AJ, Rogal W, Frederick MA, Milner J, Yu B, Crotty S, Goldrath AW, Pipkin ME.

Immunity. 2018 Apr 17;48(4):659-674.e6. doi: 10.1016/j.immuni.2018.03.028.

6.

Transcriptional programming of tissue-resident memory CD8+ T cells.

Milner JJ, Goldrath AW.

Curr Opin Immunol. 2018 Apr;51:162-169. doi: 10.1016/j.coi.2018.03.017. Epub 2018 Apr 2. Review.

7.

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells.

Omilusik KD, Nadjsombati MS, Shaw LA, Yu B, Milner JJ, Goldrath AW.

J Exp Med. 2018 Mar 5;215(3):773-783. doi: 10.1084/jem.20171584. Epub 2018 Feb 12.

8.

Erratum: Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW.

Nature. 2018 Feb 15;554(7692):392. doi: 10.1038/nature25445. Epub 2018 Jan 10.

PMID:
29320476
9.

The origins of memory T cells.

Omilusik KD, Goldrath AW.

Nature. 2017 Dec 21;552(7685):337-339. doi: 10.1038/d41586-017-08280-8. No abstract available.

PMID:
29293221
10.

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.

Delpoux A, Michelini RH, Verma S, Lai CY, Omilusik KD, Utzschneider DT, Redwood AJ, Goldrath AW, Benedict CA, Hedrick SM.

J Exp Med. 2018 Feb 5;215(2):575-594. doi: 10.1084/jem.20170697. Epub 2017 Dec 27.

11.

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW.

Nature. 2017 Dec 14;552(7684):253-257. doi: 10.1038/nature24993. Epub 2017 Dec 6. Erratum in: Nature. 2018 Jan 10;:.

12.

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.

Palazon A, Tyrakis PA, Macias D, Veliça P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS.

Cancer Cell. 2017 Nov 13;32(5):669-683.e5. doi: 10.1016/j.ccell.2017.10.003.

13.

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT.

J Clin Invest. 2017 Oct 2;127(10):3609-3623. doi: 10.1172/JCI90895. Epub 2017 Aug 28.

14.

Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW.

Nat Immunol. 2017 May 18;18(6):705. doi: 10.1038/ni0617-705b. No abstract available.

PMID:
28518161
15.

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity.

Phan AT, Goldrath AW, Glass CK.

Immunity. 2017 May 16;46(5):714-729. doi: 10.1016/j.immuni.2017.04.016. Review.

16.

Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW.

Nat Immunol. 2017 May;18(5):573-582. doi: 10.1038/ni.3706. Epub 2017 Mar 13. Erratum in: Nat Immunol. 2017 May 18;18(6):705.

17.

Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing.

Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW.

Nat Immunol. 2017 Apr;18(4):422-432. doi: 10.1038/ni.3688. Epub 2017 Feb 20.

18.

Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection.

Phan AT, Doedens AL, Palazon A, Tyrakis PA, Cheung KP, Johnson RS, Goldrath AW.

Immunity. 2016 Nov 15;45(5):1024-1037. doi: 10.1016/j.immuni.2016.10.017. Epub 2016 Nov 8.

19.

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS.

Nature. 2016 Dec 8;540(7632):236-241. doi: 10.1038/nature20165. Epub 2016 Oct 26.

20.

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Clever D, Roychoudhuri R, Constantinides MG, Askenase MH, Sukumar M, Klebanoff CA, Eil RL, Hickman HD, Yu Z, Pan JH, Palmer DC, Phan AT, Goulding J, Gattinoni L, Goldrath AW, Belkaid Y, Restifo NP.

Cell. 2016 Aug 25;166(5):1117-1131.e14. doi: 10.1016/j.cell.2016.07.032.

21.

Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance.

Doedens AL, Rubinstein MP, Gross ET, Best JA, Craig DH, Baker MK, Cole DJ, Bui JD, Goldrath AW.

Cancer Immunol Res. 2016 Sep 2;4(9):799-811. doi: 10.1158/2326-6066.CIR-15-0178. Epub 2016 Aug 2.

22.

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.

Shaw LA, Bélanger S, Omilusik KD, Cho S, Scott-Browne JP, Nance JP, Goulding J, Lasorella A, Lu LF, Crotty S, Goldrath AW.

Nat Immunol. 2016 Jul;17(7):834-43. doi: 10.1038/ni.3461. Epub 2016 May 23.

23.

Id2 regulates hyporesponsive invariant natural killer T cells.

Stradner MH, Cheung KP, Lasorella A, Goldrath AW, D'Cruz LM.

Immunol Cell Biol. 2016 Aug;94(7):640-5. doi: 10.1038/icb.2016.19. Epub 2016 Feb 16.

24.

Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling.

Chea S, Schmutz S, Berthault C, Perchet T, Petit M, Burlen-Defranoux O, Goldrath AW, Rodewald HR, Cumano A, Golub R.

Cell Rep. 2016 Feb 16;14(6):1500-1516. doi: 10.1016/j.celrep.2016.01.015. Epub 2016 Jan 28.

25.

B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel.

Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A.

Blood. 2016 Mar 10;127(10):1276-86. doi: 10.1182/blood-2014-10-606988. Epub 2016 Jan 14.

26.

IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy.

Su EW, Moore CJ, Suriano S, Johnson CB, Songalia N, Patterson A, Neitzke DJ, Andrijauskaite K, Garrett-Mayer E, Mehrotra S, Paulos CM, Doedens AL, Goldrath AW, Li Z, Cole DJ, Rubinstein MP.

Sci Transl Med. 2015 Oct 28;7(311):311ra170. doi: 10.1126/scitranslmed.aac8155.

27.

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.

Omilusik KD, Best JA, Yu B, Goossens S, Weidemann A, Nguyen JV, Seuntjens E, Stryjewska A, Zweier C, Roychoudhuri R, Gattinoni L, Bird LM, Higashi Y, Kondoh H, Huylebroeck D, Haigh J, Goldrath AW.

J Exp Med. 2015 Nov 16;212(12):2027-39. doi: 10.1084/jem.20150194. Epub 2015 Oct 26.

28.

Hypoxia-inducible factors regulate T cell metabolism and function.

Phan AT, Goldrath AW.

Mol Immunol. 2015 Dec;68(2 Pt C):527-35. doi: 10.1016/j.molimm.2015.08.004. Epub 2015 Aug 19. Review.

29.

ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.

Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Lin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick SM.

Immunity. 2015 Feb 17;42(2):239-251. doi: 10.1016/j.immuni.2015.01.017.

30.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Farhang Ghahremani M, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Canté-Barrett K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JP, Soulier J, Van Vlierberghe P, Haigh JJ.

Nat Commun. 2015 Jan 7;6:5794. doi: 10.1038/ncomms6794.

31.

The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.

Fulton RB, Hamilton SE, Xing Y, Best JA, Goldrath AW, Hogquist KA, Jameson SC.

Nat Immunol. 2015 Jan;16(1):107-17. doi: 10.1038/ni.3043. Epub 2014 Nov 24.

32.

Molecular regulation of effector and memory T cell differentiation.

Chang JT, Wherry EJ, Goldrath AW.

Nat Immunol. 2014 Dec;15(12):1104-15. doi: 10.1038/ni.3031. Review.

33.

HIF transcription factors, inflammation, and immunity.

Palazon A, Goldrath AW, Nizet V, Johnson RS.

Immunity. 2014 Oct 16;41(4):518-28. doi: 10.1016/j.immuni.2014.09.008. Review.

34.

E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.

D'Cruz LM, Stradner MH, Yang CY, Goldrath AW.

J Immunol. 2014 Mar 1;192(5):2227-36. doi: 10.4049/jimmunol.1302904. Epub 2014 Jan 27.

35.

G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.

Rubinstein MP, Salem ML, Doedens AL, Moore CJ, Chiuzan C, Rivell GL, Cole DJ, Goldrath AW.

J Hematol Oncol. 2013 Oct 1;6:75. doi: 10.1186/1756-8722-6-75.

36.

HIF isoforms in the skin differentially regulate systemic arterial pressure.

Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17570-5. doi: 10.1073/pnas.1306942110. Epub 2013 Oct 7.

37.

Remembering one's ID/E-ntity: E/ID protein regulation of T cell memory.

Omilusik KD, Shaw LA, Goldrath AW.

Curr Opin Immunol. 2013 Oct;25(5):660-6. doi: 10.1016/j.coi.2013.09.004. Epub 2013 Oct 1. Review.

38.

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.

Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson RS, Goldrath AW.

Nat Immunol. 2013 Nov;14(11):1173-82. doi: 10.1038/ni.2714. Epub 2013 Sep 29.

39.

IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells.

Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D.

J Exp Med. 2013 Aug 26;210(9):1823-37. doi: 10.1084/jem.20122332. Epub 2013 Aug 19.

40.

Differentiation of CD8 memory T cells depends on Foxo1.

Hess Michelini R, Doedens AL, Goldrath AW, Hedrick SM.

J Exp Med. 2013 Jun 3;210(6):1189-200. doi: 10.1084/jem.20130392. Epub 2013 May 27.

41.

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.

Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW; Immunological Genome Project Consortium.

Nat Immunol. 2013 Apr;14(4):404-12. doi: 10.1038/ni.2536. Epub 2013 Feb 10.

42.

Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells.

Knell J, Best JA, Lind NA, Yang E, D'Cruz LM, Goldrath AW.

J Immunol. 2013 Feb 15;190(4):1501-9. doi: 10.4049/jimmunol.1200750. Epub 2013 Jan 16.

43.

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development.

Li HS, Yang CY, Nallaparaju KC, Zhang H, Liu YJ, Goldrath AW, Watowich SS.

Blood. 2012 Nov 22;120(22):4363-73. doi: 10.1182/blood-2012-07-441311. Epub 2012 Oct 1.

44.

FOXO transcription factors throughout T cell biology.

Hedrick SM, Hess Michelini R, Doedens AL, Goldrath AW, Stone EL.

Nat Rev Immunol. 2012 Sep;12(9):649-61. doi: 10.1038/nri3278. Review.

45.

Molecular definition of the identity and activation of natural killer cells.

Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, Lanier LL; Immunological Genome Project Consortium.

Nat Immunol. 2012 Oct;13(10):1000-9. doi: 10.1038/ni.2395. Epub 2012 Aug 19.

46.

Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.

D'Cruz LM, Lind KC, Wu BB, Fujimoto JK, Goldrath AW.

Eur J Immunol. 2012 Aug;42(8):2031-41. doi: 10.1002/eji.201242497.

47.

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.

Yang CY, Best JA, Knell J, Yang E, Sheridan AD, Jesionek AK, Li HS, Rivera RR, Lind KC, D'Cruz LM, Watowich SS, Murre C, Goldrath AW.

Nat Immunol. 2011 Nov 6;12(12):1221-9. doi: 10.1038/ni.2158.

48.

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.

Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering TA, Angelosanto JM, Laidlaw BJ, Yang CY, Sathaliyawala T, Kubota M, Turner D, Diamond JM, Goldrath AW, Farber DL, Collman RG, Wherry EJ, Artis D.

Nat Immunol. 2011 Nov;12(11):1045-54. doi: 10.1031/ni.2131.

49.

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.

Elpek KG, Rubinstein MP, Bellemare-Pelletier A, Goldrath AW, Turley SJ.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21647-52. doi: 10.1073/pnas.1012128107. Epub 2010 Nov 22.

50.

Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression.

Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS.

Cancer Res. 2010 Oct 1;70(19):7465-75. doi: 10.1158/0008-5472.CAN-10-1439. Epub 2010 Sep 14.

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