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Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma.

Lilis I, Ntaliarda G, Papaleonidopoulos V, Giotopoulou GA, Oplopoiou M, Marazioti A, Spella M, Marwitz S, Goldmann T, Bravou V, Giopanou I, Stathopoulos GT.

Oncoimmunology. 2019 Apr 11;8(7):1593802. doi: 10.1080/2162402X.2019.1593802. eCollection 2019.


DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A.

Cell. 2018 Aug 23;174(5):1325-1326. doi: 10.1016/j.cell.2018.08.015. No abstract available.


Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease.

Heinbockel L, Marwitz S, Schromm AB, Watz H, Kugler C, Ammerpohl O, Schnepf K, Rabe KF, Droemann D, Goldmann T.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 26;13:2255-2259. doi: 10.2147/COPD.S161958. eCollection 2018.


Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5.

Heinbockel L, Weindl G, Martinez-de-Tejada G, Correa W, Sanchez-Gomez S, Bárcena-Varela S, Goldmann T, Garidel P, Gutsmann T, Brandenburg K.

Front Immunol. 2018 Jul 26;9:1704. doi: 10.3389/fimmu.2018.01704. eCollection 2018. Review.


Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers.

Kordowski F, Kolarova J, Schafmayer C, Buch S, Goldmann T, Marwitz S, Kugler C, Scheufele S, Gassling V, Németh CG, Brosch M, Hampe J, Lucius R, Röder C, Kalthoff H, Siebert R, Ammerpohl O, Reiss K.

BMC Cancer. 2018 Aug 6;18(1):796. doi: 10.1186/s12885-018-4701-2.


Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis.

Goldmann T, Zissel G, Watz H, Drömann D, Reck M, Kugler C, Rabe KF, Marwitz S.

Respir Res. 2018 Jul 24;19(1):138. doi: 10.1186/s12931-018-0841-9.


Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues.

Marwitz S, Heinbockel L, Scheufele S, Kugler C, Reck M, Rabe KF, Perner S, Goldmann T, Ammerpohl O.

Int J Cancer. 2018 Dec 15;143(12):3061-3070. doi: 10.1002/ijc.31641. Epub 2018 Oct 16.


IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma.

Vreka M, Lilis I, Papageorgopoulou M, Giotopoulou GA, Lianou M, Giopanou I, Kanellakis NI, Spella M, Agalioti T, Armenis V, Goldmann T, Marwitz S, Yull FE, Blackwell TS, Pasparakis M, Marazioti A, Stathopoulos GT.

Cancer Res. 2018 Jun 1;78(11):2939-2951. doi: 10.1158/0008-5472.CAN-17-1944. Epub 2018 Mar 27.


Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils.

Pedersen F, Waschki B, Marwitz S, Goldmann T, Kirsten A, Malmgren A, Rabe KF, Uddin M, Watz H.

Eur Respir J. 2018 Apr 12;51(4). pii: 1700970. doi: 10.1183/13993003.00970-2017. Print 2018 Apr. No abstract available.


Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.

Blank T, Goldmann T, Koch M, Amann L, Schön C, Bonin M, Pang S, Prinz M, Burnet M, Wagner JE, Biel M, Michalakis S.

Front Immunol. 2018 Jan 5;8:1930. doi: 10.3389/fimmu.2017.01930. eCollection 2017.


Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation.

Kuhlmann N, Heinbockel L, Correa W, Gutsmann T, Goldmann T, Englisch U, Brandenburg K.

Eur J Pharm Sci. 2018 Mar 30;115:240-247. doi: 10.1016/j.ejps.2018.01.022. Epub 2018 Jan 12.


Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung.

Tamò L, Simillion C, Hibaoui Y, Feki A, Gugger M, Prasse A, Jäger B, Goldmann T, Geiser T, Gazdhar A.

Stem Cell Rev. 2018 Jun;14(3):412-424. doi: 10.1007/s12015-017-9790-9.


Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.

Marwitz S, Heinbockel L, Scheufele S, Nitschkowski D, Kugler C, Perner S, Reck M, Ammerpohl O, Goldmann T.

Clin Epigenetics. 2017 Nov 28;9:123. doi: 10.1186/s13148-017-0423-6. eCollection 2017.


Signalling mechanisms in PAF-induced intestinal failure.

Lautenschläger I, Wong YL, Sarau J, Goldmann T, Zitta K, Albrecht M, Frerichs I, Weiler N, Uhlig S.

Sci Rep. 2017 Oct 17;7(1):13382. doi: 10.1038/s41598-017-13850-x.


Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema.

Eggers LF, Müller J, Marella C, Scholz V, Watz H, Kugler C, Rabe KF, Goldmann T, Schwudke D.

Sci Rep. 2017 Sep 11;7(1):11087. doi: 10.1038/s41598-017-11339-1.


P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata CK, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Lazarowski ER, Blackburn MR, Idzko M.

Front Immunol. 2017 Aug 22;8:1028. doi: 10.3389/fimmu.2017.01028. eCollection 2017.


Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells.

Kaufhold I, Osbahr S, Shima K, Marwitz S, Rohmann K, Drömann D, Goldmann T, Dalhoff K, Rupp J.

Microbes Infect. 2017 Nov;19(11):560-566. doi: 10.1016/j.micinf.2017.07.002. Epub 2017 Aug 10.


Meat allergy associated with galactosyl-α-(1,3)-galactose (α-Gal)-Closing diagnostic gaps by anti-α-Gal IgE immune profiling.

Jappe U, Minge S, Kreft B, Ludwig A, Przybilla B, Walker A, Varga R, Seidel P, Biedermann T, Anemüller W, Kromminga A, Ruëff F, Merk H, Wagner N, Treudler R, Worm M, Waldmann I, Saloga J, Becker WM, Goldmann T, Platts-Mills TA, Homann A.

Allergy. 2018 Jan;73(1):93-105. doi: 10.1111/all.13238. Epub 2017 Aug 15.


Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits.

Bárcena-Varela S, Martínez-de-Tejada G, Martin L, Schuerholz T, Gil-Royo AG, Fukuoka S, Goldmann T, Droemann D, Correa W, Gutsmann T, Brandenburg K, Heinbockel L.

Exp Mol Med. 2017 Jun 16;49(6):e345. doi: 10.1038/emm.2017.75.


Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma.

Watz H, Uddin M, Pedersen F, Kirsten A, Goldmann T, Stellmacher F, Groth E, Larsson B, Böttcher G, Malmgren A, Kraan M, Rabe KF.

Pulm Pharmacol Ther. 2017 Aug;45:121-123. doi: 10.1016/j.pupt.2017.05.012. Epub 2017 May 23. No abstract available.


Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression.

Marwitz S, Scheufele S, Perner S, Reck M, Ammerpohl O, Goldmann T.

Clin Epigenetics. 2017 May 11;9:51. doi: 10.1186/s13148-017-0354-2. eCollection 2017.


The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata K, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Blackburn MR, Idzko M.

Oncotarget. 2017 May 30;8(22):35962-35972. doi: 10.18632/oncotarget.16414.


Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation.

Wolf Y, Shemer A, Polonsky M, Gross M, Mildner A, Yona S, David E, Kim KW, Goldmann T, Amit I, Heikenwalder M, Nedospasov S, Prinz M, Friedman N, Jung S.

J Exp Med. 2017 Apr 3;214(4):905-917. doi: 10.1084/jem.20160499. Epub 2017 Mar 22.


PilY1 Promotes Legionella pneumophila Infection of Human Lung Tissue Explants and Contributes to Bacterial Adhesion, Host Cell Invasion, and Twitching Motility.

Hoppe J, Ünal CM, Thiem S, Grimpe L, Goldmann T, Gaßler N, Richter M, Shevchuk O, Steinert M.

Front Cell Infect Microbiol. 2017 Mar 7;7:63. doi: 10.3389/fcimb.2017.00063. eCollection 2017.


DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A.

Cell. 2016 Nov 17;167(5):1264-1280.e18. doi: 10.1016/j.cell.2016.09.054. Epub 2016 Oct 27. Erratum in: Cell. 2018 Aug 23;174(5):1325-1326.


Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis.

Schnerch J, Prasse A, Vlachakis D, Schuchardt KL, Pechkovsky DV, Goldmann T, Gaede KI, Müller-Quernheim J, Zissel G.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):749-757.


Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.

Meuwissen ME, Schot R, Buta S, Oudesluijs G, Tinschert S, Speer SD, Li Z, van Unen L, Heijsman D, Goldmann T, Lequin MH, Kros JM, Stam W, Hermann M, Willemsen R, Brouwer RW, Van IJcken WF, Martin-Fernandez M, de Coo I, Dudink J, de Vries FA, Bertoli Avella A, Prinz M, Crow YJ, Verheijen FW, Pellegrini S, Bogunovic D, Mancini GM.

J Exp Med. 2016 Jun 27;213(7):1163-74. doi: 10.1084/jem.20151529. Epub 2016 Jun 20.


Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

Marwitz S, Depner S, Dvornikov D, Merkle R, Szczygieł M, Müller-Decker K, Lucarelli P, Wäsch M, Mairbäurl H, Rabe KF, Kugler C, Vollmer E, Reck M, Scheufele S, Kröger M, Ammerpohl O, Siebert R, Goldmann T, Klingmüller U.

Cancer Res. 2016 Jul 1;76(13):3785-801. doi: 10.1158/0008-5472.CAN-15-1326. Epub 2016 May 17.


Origin, fate and dynamics of macrophages at central nervous system interfaces.

Goldmann T, Wieghofer P, Jordão MJ, Prutek F, Hagemeyer N, Frenzel K, Amann L, Staszewski O, Kierdorf K, Krueger M, Locatelli G, Hochgerner H, Zeiser R, Epelman S, Geissmann F, Priller J, Rossi FM, Bechmann I, Kerschensteiner M, Linnarsson S, Jung S, Prinz M.

Nat Immunol. 2016 Jul;17(7):797-805. doi: 10.1038/ni.3423. Epub 2016 May 2.


Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.

Kolter J, Feuerstein R, Spoeri E, Gharun K, Elling R, Trieu-Cuot P, Goldmann T, Waskow C, Chen ZJ, Kirschning CJ, Deshmukh SD, Henneke P.

J Immunol. 2016 Mar 15;196(6):2733-41. doi: 10.4049/jimmunol.1501014. Epub 2016 Feb 12.


Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells.

Ganbat D, Seehase S, Richter E, Vollmer E, Reiling N, Fellenberg K, Gaede KI, Kugler C, Goldmann T.

BMC Pulm Med. 2016 Jan 23;16:19. doi: 10.1186/s12890-016-0185-5.


Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: a large scale study of 1465 non-small cell lung cancer cases.

Kriegsmann M, Muley T, Harms A, Tavernar L, Goldmann T, Dienemann H, Herpel E, Warth A.

Diagn Pathol. 2015 Dec 8;10:210. doi: 10.1186/s13000-015-0441-7.


PD-L1 copy number gain in nonsmall-cell lung cancer defines a new subset of patients for anti PD-L1 therapy.

Goldmann T, Kugler C, Reinmuth N, Vollmer E, Reck M.

Ann Oncol. 2016 Jan;27(1):206-7. doi: 10.1093/annonc/mdv510. Epub 2015 Oct 20. No abstract available.


Budesonide Inhibits Intracellular Infection with Non-Typeable Haemophilus influenzae Despite Its Anti-Inflammatory Effects in Respiratory Cells and Human Lung Tissue: A Role for p38 MAP Kinase.

Wagner C, Goldmann T, Rohmann K, Rupp J, Marwitz S, Rotta Detto Loria J, Limmer S, Zabel P, Dalhoff K, Drömann D.

Respiration. 2015;90(5):416-25. doi: 10.1159/000439226. Epub 2015 Oct 10.


Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.

Ejlerskov P, Hultberg JG, Wang J, Carlsson R, Ambjørn M, Kuss M, Liu Y, Porcu G, Kolkova K, Friis Rundsten C, Ruscher K, Pakkenberg B, Goldmann T, Loreth D, Prinz M, Rubinsztein DC, Issazadeh-Navikas S.

Cell. 2015 Oct 8;163(2):324-39. doi: 10.1016/j.cell.2015.08.069.


Fine-tuning of type I IFN-signaling in microglia--implications for homeostasis, CNS autoimmunity and interferonopathies.

Goldmann T, Blank T, Prinz M.

Curr Opin Neurobiol. 2016 Feb;36:38-42. doi: 10.1016/j.conb.2015.09.003. Epub 2015 Sep 20. Review.


Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides.

Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller KH, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K.

Sci Rep. 2015 Sep 22;5:14292. doi: 10.1038/srep14292.


Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients.

Pedersen F, Marwitz S, Holz O, Kirsten A, Bahmer T, Waschki B, Magnussen H, Rabe KF, Goldmann T, Uddin M, Watz H.

Respir Med. 2015 Oct;109(10):1360-2. doi: 10.1016/j.rmed.2015.08.008. Epub 2015 Aug 22.


Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?

Watermann I, Schmitt B, Stellmacher F, Müller J, Gaber R, Kugler Ch, Reinmuth N, Huber RM, Thomas M, Zabel P, Rabe KF, Jonigk D, Warth A, Vollmer E, Reck M, Goldmann T.

Diagn Pathol. 2015 Jul 28;10:130. doi: 10.1186/s13000-015-0362-5.


Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mier W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G.

PLoS One. 2015 Jul 21;10(7):e0133291. doi: 10.1371/journal.pone.0133291. eCollection 2015.


Correction: Hydroxyethyl Starch (HES 130/0.4) Impairs Intestinal Barrier Integrity and Metabolic Function: Findings from a Mouse Model of the Isolated Perfused Small Intestine.

Wong YL, Lautenschläger I, Dombrowsky H, Zitta K, Bein B, Krause T, Goldmann T, Frerichs I, Steinfath M, Weiler N, Albrecht M.

PLoS One. 2015 Apr 23;10(4):e0127136. doi: 10.1371/journal.pone.0127136. eCollection 2015.


USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M.

EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20.


Hydroxyethyl starch (HES 130/0.4) impairs intestinal barrier integrity and metabolic function: findings from a mouse model of the isolated perfused small intestine.

Wong YL, Lautenschläger I, Dombrowsky H, Zitta K, Bein B, Krause T, Goldmann T, Frerichs I, Steinfath M, Weiler N, Albrecht M.

PLoS One. 2015 Mar 23;10(3):e0121497. doi: 10.1371/journal.pone.0121497. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127136.


Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis.

Lautenschläger I, Frerichs I, Dombrowsky H, Sarau J, Goldmann T, Zitta K, Albrecht M, Weiler N, Uhlig S.

PLoS One. 2015 Mar 20;10(3):e0120802. doi: 10.1371/journal.pone.0120802. eCollection 2015.


Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases.

Zehethofer N, Bermbach S, Hagner S, Garn H, Müller J, Goldmann T, Lindner B, Schwudke D, König P.

Chromatographia. 2015;78(5-6):403-413. Epub 2014 Nov 7.


Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20.


Multi-analyte profiling of inflammatory mediators in COPD sputum--the effects of processing.

Pedersen F, Holz O, Lauer G, Quintini G, Kiwull-Schöne H, Kirsten AM, Magnussen H, Rabe KF, Goldmann T, Watz H.

Cytokine. 2015 Feb;71(2):401-4. doi: 10.1016/j.cyto.2014.10.008. Epub 2014 Nov 15.


Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging.

Kallenberg K, Goldmann T, Menke J, Strik H, Bock HC, Mohr A, Buhk JH, Frahm J, Dechent P, Knauth M.

Folia Neuropathol. 2014;52(3):226-33.


Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC.

Gaber R, Watermann I, Kugler C, Reinmuth N, Huber RM, Schnabel PA, Vollmer E, Reck M, Goldmann T.

Diagn Pathol. 2014 Sep 17;9:165. doi: 10.1186/s13000-014-0165-0.

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