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Items: 1 to 50 of 158

1.

New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery.

Ng MY, Zhang H, Weil A, Singh V, Jamiolkowski R, Baradaran-Heravi A, Roberge M, Jacobson A, Friesen W, Welch E, Goldman YE, Cooperman BS.

ACS Med Chem Lett. 2018 Nov 21;9(12):1285-1291. doi: 10.1021/acsmedchemlett.8b00472. eCollection 2018 Dec 13.

PMID:
30613341
2.

Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke.

Woody MS, Greenberg MJ, Barua B, Winkelmann DA, Goldman YE, Ostap EM.

Nat Commun. 2018 Sep 21;9(1):3838. doi: 10.1038/s41467-018-06193-2.

3.

E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form.

Johansen JS, Kavaliauskas D, Pfeil SH, Blaise M, Cooperman BS, Goldman YE, Thirup SS, Knudsen CR.

Nucleic Acids Res. 2018 Sep 19;46(16):8641-8650. doi: 10.1093/nar/gky697.

4.

Structural dynamics of translation elongation factor Tu during aa-tRNA delivery to the ribosome.

Kavaliauskas D, Chen C, Liu W, Cooperman BS, Goldman YE, Knudsen CR.

Nucleic Acids Res. 2018 Sep 19;46(16):8651-8661. doi: 10.1093/nar/gky651.

5.

Translocation kinetics and structural dynamics of ribosomes are modulated by the conformational plasticity of downstream pseudoknots.

Wu B, Zhang H, Sun R, Peng S, Cooperman BS, Goldman YE, Chen C.

Nucleic Acids Res. 2018 Oct 12;46(18):9736-9748. doi: 10.1093/nar/gky636.

6.

Electro-optic deflectors deliver advantages over acousto-optical deflectors in a high resolution, ultra-fast force-clamp optical trap.

Woody MS, Capitanio M, Ostap EM, Goldman YE.

Opt Express. 2018 Apr 30;26(9):11181-11193. doi: 10.1364/OE.26.011181.

7.

The Antiparallel Dimerization of Myosin X Imparts Bundle Selectivity for Processive Motility.

Caporizzo MA, Fishman CE, Sato O, Jamiolkowski RM, Ikebe M, Goldman YE.

Biophys J. 2018 Mar 27;114(6):1400-1410. doi: 10.1016/j.bpj.2018.01.038.

8.

tRNA Fluctuations Observed on Stalled Ribosomes Are Suppressed during Ongoing Protein Synthesis.

Jamiolkowski RM, Chen C, Cooperman BS, Goldman YE.

Biophys J. 2017 Dec 5;113(11):2326-2335. doi: 10.1016/j.bpj.2017.08.052.

9.

Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk.

Lippert LG, Dadosh T, Hadden JA, Karnawat V, Diroll BT, Murray CB, Holzbaur ELF, Schulten K, Reck-Peterson SL, Goldman YE.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4564-E4573. doi: 10.1073/pnas.1620149114. Epub 2017 May 22.

10.

Deconvolution of Camera Instrument Response Functions.

Lewis JH, Jamiolkowski RM, Woody MS, Ostap EM, Goldman YE.

Biophys J. 2017 Mar 28;112(6):1214-1220. doi: 10.1016/j.bpj.2017.02.014.

11.

Single molecule optical measurements of orientation and rotations of biological macromolecules.

Shroder DY, Lippert LG, Goldman YE.

Methods Appl Fluoresc. 2016 Nov 22;4(4):042004. doi: 10.1088/2050-6120/4/4/042004.

12.

Measuring Molecular Forces Using Calibrated Optical Tweezers in Living Cells.

Hendricks AG, Goldman YE.

Methods Mol Biol. 2017;1486:537-552. doi: 10.1007/978-1-4939-6421-5_21.

13.

Interferometric Scattering Microscopy for the Study of Molecular Motors.

Andrecka J, Takagi Y, Mickolajczyk KJ, Lippert LG, Sellers JR, Hancock WO, Goldman YE, Kukura P.

Methods Enzymol. 2016;581:517-539. doi: 10.1016/bs.mie.2016.08.016. Epub 2016 Oct 10.

14.

MEMLET: An Easy-to-Use Tool for Data Fitting and Model Comparison Using Maximum-Likelihood Estimation.

Woody MS, Lewis JH, Greenberg MJ, Goldman YE, Ostap EM.

Biophys J. 2016 Jul 26;111(2):273-282. doi: 10.1016/j.bpj.2016.06.019.

15.

Elongation factor G initiates translocation through a power stroke.

Chen C, Cui X, Beausang JF, Zhang H, Farrell I, Cooperman BS, Goldman YE.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7515-20. doi: 10.1073/pnas.1602668113. Epub 2016 Jun 16.

16.

NeutrAvidin Functionalization of CdSe/CdS Quantum Nanorods and Quantification of Biotin Binding Sites using Biotin-4-Fluorescein Fluorescence Quenching.

Lippert LG, Hallock JT, Dadosh T, Diroll BT, Murray CB, Goldman YE.

Bioconjug Chem. 2016 Mar 16;27(3):562-8. doi: 10.1021/acs.bioconjchem.5b00577. Epub 2016 Jan 14.

17.

EF-Tu dynamics during pre-translocation complex formation: EF-Tu·GDP exits the ribosome via two different pathways.

Liu W, Chen C, Kavaliauskas D, Knudsen CR, Goldman YE, Cooperman BS.

Nucleic Acids Res. 2015 Oct 30;43(19):9519-28. doi: 10.1093/nar/gkv856. Epub 2015 Sep 3.

18.

Labeled EF-Tus for rapid kinetic studies of pretranslocation complex formation.

Liu W, Kavaliauskas D, Schrader JM, Poruri K, Birkedal V, Goldman E, Jakubowski H, Mandecki W, Uhlenbeck OC, Knudsen CR, Goldman YE, Cooperman BS.

ACS Chem Biol. 2014 Oct 17;9(10):2421-31. doi: 10.1021/cb500409y. Epub 2014 Aug 22.

19.

Reconstituting the motility of isolated intracellular cargoes.

Hendricks AG, Goldman YE, Holzbaur EL.

Methods Enzymol. 2014;540:249-62. doi: 10.1016/B978-0-12-397924-7.00014-5.

PMID:
24630111
20.

Remembrance of Hugh E. Huxley, a founder of our field.

Pollard TD, Goldman YE.

Cytoskeleton (Hoboken). 2013 Sep;70(9):471-5. doi: 10.1002/cm.21141.

PMID:
24106169
21.

Quantifying elongation rhythm during full-length protein synthesis.

Rosenblum G, Chen C, Kaur J, Cui X, Zhang H, Asahara H, Chong S, Smilansky Z, Goldman YE, Cooperman BS.

J Am Chem Soc. 2013 Jul 31;135(30):11322-9. doi: 10.1021/ja405205c. Epub 2013 Jul 16.

22.

Local cytoskeletal and organelle interactions impact molecular-motor- driven early endosomal trafficking.

Zajac AL, Goldman YE, Holzbaur EL, Ostap EM.

Curr Biol. 2013 Jul 8;23(13):1173-80. doi: 10.1016/j.cub.2013.05.015. Epub 2013 Jun 13.

23.

Tb(3+)-tRNA for LRET studies of protein synthesis.

Alonso D, Liu W, Rosenblum G, Mani T, Goldman YE, Cooperman BS.

Bioconjug Chem. 2013 Jul 17;24(7):1186-90. doi: 10.1021/bc400062d. Epub 2013 Jun 17.

24.

Dynamics of translation by single ribosomes through mRNA secondary structures.

Chen C, Zhang H, Broitman SL, Reiche M, Farrell I, Cooperman BS, Goldman YE.

Nat Struct Mol Biol. 2013 May;20(5):582-8. doi: 10.1038/nsmb.2544. Epub 2013 Mar 31.

25.

Tilting and wobble of myosin V by high-speed single-molecule polarized fluorescence microscopy.

Beausang JF, Shroder DY, Nelson PC, Goldman YE.

Biophys J. 2013 Mar 19;104(6):1263-73. doi: 10.1016/j.bpj.2013.01.057. Epub 2013 Mar 19.

26.

Orienting actin filaments for directional motility of processive myosin motors.

Yuan J, Pillarisetti A, Goldman YE, Bau HH.

Nano Lett. 2013 Jan 9;13(1):79-84. doi: 10.1021/nl303500k. Epub 2012 Dec 19.

PMID:
23240631
27.

Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors.

Hendricks AG, Holzbaur EL, Goldman YE.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18447-52. doi: 10.1073/pnas.1215462109. Epub 2012 Oct 22.

28.

Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules.

Dawicki-McKenna JM, Goldman YE, Ostap EM.

PLoS One. 2012;7(8):e43662. doi: 10.1371/journal.pone.0043662. Epub 2012 Aug 20.

29.

Myosin IC generates power over a range of loads via a new tension-sensing mechanism.

Greenberg MJ, Lin T, Goldman YE, Shuman H, Ostap EM.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2433-40. doi: 10.1073/pnas.1207811109. Epub 2012 Aug 20.

30.

Nanoscale topography mediates the adhesion of F-actin.

Caporizzo MA, Sun Y, Goldman YE, Composto RJ.

Langmuir. 2012 Aug 21;28(33):12216-24. doi: 10.1021/la302250x. Epub 2012 Aug 13.

PMID:
22839968
31.

Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections.

Schroeder HW 3rd, Hendricks AG, Ikeda K, Shuman H, Rodionov V, Ikebe M, Goldman YE, Holzbaur EL.

Biophys J. 2012 Jul 3;103(1):48-58. doi: 10.1016/j.bpj.2012.05.037.

32.

Structural changes in isometrically contracting insect flight muscle trapped following a mechanical perturbation.

Wu S, Liu J, Reedy MC, Perz-Edwards RJ, Tregear RT, Winkler H, Franzini-Armstrong C, Sasaki H, Lucaveche C, Goldman YE, Reedy MK, Taylor KA.

PLoS One. 2012;7(6):e39422. doi: 10.1371/journal.pone.0039422. Epub 2012 Jun 25.

33.

Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration.

Liu J, Zhao Y, Sun Y, He B, Yang C, Svitkina T, Goldman YE, Guo W.

Curr Biol. 2012 Aug 21;22(16):1510-5. doi: 10.1016/j.cub.2012.05.055. Epub 2012 Jun 28.

34.

Andrew Fielding Huxley (1917-2012).

Goldman YE, Franzini-Armstrong C, Armstrong CM.

Nature. 2012 Jun 27;486(7404):474. doi: 10.1038/486474a. No abstract available.

PMID:
22739307
35.

FRET-based identification of mRNAs undergoing translation.

Stevens B, Chen C, Farrell I, Zhang H, Kaur J, Broitman SL, Smilansky Z, Cooperman BS, Goldman YE.

PLoS One. 2012;7(5):e38344. doi: 10.1371/journal.pone.0038344. Epub 2012 May 31.

36.

The polarized total internal reflection fluorescence microscopy (polTIRFM) processive motility assay for myosin V.

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):716-8. doi: 10.1101/pdb.prot069393.

37.

Construction of flow chambers for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays.

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):712-5. doi: 10.1101/pdb.prot069385.

38.

The acquisition and analysis of polarized total internal reflection fluorescence microscopy (polTIRFM) data.

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):722-5. doi: 10.1101/pdb.prot069419.

39.

The polarized total internal reflection fluorescence microscopy (polTIRFM) twirling filament assay.

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):719-21. doi: 10.1101/pdb.prot069401.

40.

Preparation of filamentous actin for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays.

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 May 1;2012(5). pii: pdb.prot069377. doi: 10.1101/pdb.prot069377.

41.

Fluorescent labeling of myosin V for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays.

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 May 1;2012(5). pii: pdb.prot069369. doi: 10.1101/pdb.prot069369.

42.

Fluorescent labeling of calmodulin with bifunctional rhodamine.

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 May 1;2012(5). pii: pdb.prot069351. doi: 10.1101/pdb.prot069351.

43.

Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy (polTIRFM).

Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE.

Cold Spring Harb Protoc. 2012 May 1;2012(5). pii: pdb.top069344. doi: 10.1101/pdb.top069344.

44.

Kinetic schemes for post-synchronized single molecule dynamics.

Chen C, Greenberg MJ, Laakso JM, Ostap EM, Goldman YE, Shuman H.

Biophys J. 2012 Mar 21;102(6):L23-5. doi: 10.1016/j.bpj.2012.01.054. Epub 2012 Mar 20.

45.

Dynein tethers and stabilizes dynamic microtubule plus ends.

Hendricks AG, Lazarus JE, Perlson E, Gardner MK, Odde DJ, Goldman YE, Holzbaur EL.

Curr Biol. 2012 Apr 10;22(7):632-7. doi: 10.1016/j.cub.2012.02.023. Epub 2012 Mar 22.

46.

Real-time assay for testing components of protein synthesis.

Rosenblum G, Chen C, Kaur J, Cui X, Goldman YE, Cooperman BS.

Nucleic Acids Res. 2012 Jul;40(12):e88. doi: 10.1093/nar/gks232. Epub 2012 Mar 14.

47.

The azimuthal path of myosin V and its dependence on lever-arm length.

Lewis JH, Beausang JF, Sweeney HL, Goldman YE.

J Gen Physiol. 2012 Feb;139(2):101-20. doi: 10.1085/jgp.201110715.

48.

Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis.

Chen C, Stevens B, Kaur J, Smilansky Z, Cooperman BS, Goldman YE.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16980-5. doi: 10.1073/pnas.1106999108. Epub 2011 Oct 3.

49.

The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis.

Liu H, Chen C, Zhang H, Kaur J, Goldman YE, Cooperman BS.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16223-8. doi: 10.1073/pnas.1103820108. Epub 2011 Sep 19.

50.

Lever-arm mechanics of processive myosins.

Sun Y, Goldman YE.

Biophys J. 2011 Jul 6;101(1):1-11. doi: 10.1016/j.bpj.2011.05.026. Review. No abstract available.

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