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Peptidoglycan Recognition Protein 4 Suppresses Early Inflammatory Responses to Bordetella pertussis and Contributes to Sphingosine-1-Phosphate Receptor Agonist-Mediated Disease Attenuation.

Skerry C, Goldman WE, Carbonetti NH.

Infect Immun. 2019 Jan 24;87(2). pii: e00601-18. doi: 10.1128/IAI.00601-18. Print 2019 Feb.


Recent admixture between species of the fungal pathogen Histoplasma.

Maxwell CS, Sepulveda VE, Turissini DA, Goldman WE, Matute DR.

Evol Lett. 2018 Jun 22;2(3):210-220. doi: 10.1002/evl3.59. eCollection 2018 Jun.


Genome Sequences Reveal Cryptic Speciation in the Human Pathogen Histoplasma capsulatum.

Sepúlveda VE, Márquez R, Turissini DA, Goldman WE, Matute DR.

MBio. 2017 Dec 5;8(6). pii: e01339-17. doi: 10.1128/mBio.01339-17.


Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.

Wong CO, Gregory S, Hu H, Chao Y, Sepúlveda VE, He Y, Li-Kroeger D, Goldman WE, Bellen HJ, Venkatachalam K.

Cell Host Microbe. 2017 Jun 14;21(6):719-730.e6. doi: 10.1016/j.chom.2017.05.002. Epub 2017 Jun 1.


SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans.

Paik D, Monahan A, Caffrey DR, Elling R, Goldman WE, Silverman N.

J Immunol. 2017 Jul 1;199(1):263-270. doi: 10.4049/jimmunol.1600409. Epub 2017 May 24.


Environmental cues and symbiont microbe-associated molecular patterns function in concert to drive the daily remodelling of the crypt-cell brush border of the Euprymna scolopes light organ.

Heath-Heckman EA, Foster J, Apicella MA, Goldman WE, McFall-Ngai M.

Cell Microbiol. 2016 Nov;18(11):1642-1652. doi: 10.1111/cmi.12602. Epub 2016 May 3.


Pneumonic Plague: The Darker Side of Yersinia pestis.

Pechous RD, Sivaraman V, Stasulli NM, Goldman WE.

Trends Microbiol. 2016 Mar;24(3):190-197. doi: 10.1016/j.tim.2015.11.008. Epub 2015 Dec 14. Review.


Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague.

Stasulli NM, Eichelberger KR, Price PA, Pechous RD, Montgomery SA, Parker JS, Goldman WE.

MBio. 2015 Oct 13;6(5):e01530-15. doi: 10.1128/mBio.01530-15.


Structural and functional features of a developmentally regulated lipopolysaccharide-binding protein.

Krasity BC, Troll JV, Lehnert EM, Hackett KT, Dillard JP, Apicella MA, Goldman WE, Weiss JP, McFall-Ngai MJ.

MBio. 2015 Oct 13;6(5):e01193-15. doi: 10.1128/mBio.01193-15.


The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia.

Muñoz JF, Gauthier GM, Desjardins CA, Gallo JE, Holder J, Sullivan TD, Marty AJ, Carmen JC, Chen Z, Ding L, Gujja S, Magrini V, Misas E, Mitreva M, Priest M, Saif S, Whiston EA, Young S, Zeng Q, Goldman WE, Mardis ER, Taylor JW, McEwen JG, Clay OK, Klein BS, Cuomo CA.

PLoS Genet. 2015 Oct 6;11(10):e1005493. doi: 10.1371/journal.pgen.1005493. eCollection 2015 Oct.


Illuminating Targets of Bacterial Secretion.

Pechous RD, Goldman WE.

PLoS Pathog. 2015 Aug 6;11(8):e1004981. doi: 10.1371/journal.ppat.1004981. eCollection 2015 Aug. Review. No abstract available.


Small heat-shock proteins, IbpAB, protect non-pathogenic Escherichia coli from killing by macrophage-derived reactive oxygen species.

Goeser L, Fan TJ, Tchaptchet S, Stasulli N, Goldman WE, Sartor RB, Hansen JJ.

PLoS One. 2015 Mar 23;10(3):e0120249. doi: 10.1371/journal.pone.0120249. eCollection 2015.


Yersinia pestis activates both IL-1β and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague.

Sivaraman V, Pechous RD, Stasulli NM, Eichelberger KR, Miao EA, Goldman WE.

PLoS Pathog. 2015 Mar 17;11(3):e1004688. doi: 10.1371/journal.ppat.1004688. eCollection 2015 Mar. Erratum in: PLoS Pathog. 2015 May;11(5):e1004921.


In vivo transcriptional profiling of Yersinia pestis reveals a novel bacterial mediator of pulmonary inflammation.

Pechous RD, Broberg CA, Stasulli NM, Miller VL, Goldman WE.

MBio. 2015 Feb 17;6(1):e02302-14. doi: 10.1128/mBio.02302-14.


Comparison of phylogenetically distinct Histoplasma strains reveals evolutionarily divergent virulence strategies.

Sepúlveda VE, Williams CL, Goldman WE.

MBio. 2014 Jul 1;5(4):e01376-14. doi: 10.1128/mBio.01376-14.


Shaping the microenvironment: evidence for the influence of a host galaxin on symbiont acquisition and maintenance in the squid-Vibrio symbiosis.

Heath-Heckman EA, Gillette AA, Augustin R, Gillette MX, Goldman WE, McFall-Ngai MJ.

Environ Microbiol. 2014 Dec;16(12):3669-82. doi: 10.1111/1462-2920.12496. Epub 2014 Jun 3.


Posttranscriptional regulation of the Yersinia pestis cyclic AMP receptor protein Crp and impact on virulence.

Lathem WW, Schroeder JA, Bellows LE, Ritzert JT, Koo JT, Price PA, Caulfield AJ, Goldman WE.

MBio. 2014 Feb 11;5(1):e01038-13. doi: 10.1128/mBio.01038-13.


Early host cell targets of Yersinia pestis during primary pneumonic plague.

Pechous RD, Sivaraman V, Price PA, Stasulli NM, Goldman WE.

PLoS Pathog. 2013;9(10):e1003679. doi: 10.1371/journal.ppat.1003679. Epub 2013 Oct 3.


Bacterial bioluminescence regulates expression of a host cryptochrome gene in the squid-Vibrio symbiosis.

Heath-Heckman EA, Peyer SM, Whistler CA, Apicella MA, Goldman WE, McFall-Ngai MJ.

MBio. 2013 Apr 2;4(2). pii: e00167-13. doi: 10.1128/mBio.00167-13.


Expression of Paracoccidioides brasiliensis AMY1 in a Histoplasma capsulatum amy1 mutant, relates an α-(1,4)-amylase to cell wall α-(1,3)-glucan synthesis.

Camacho E, Sepulveda VE, Goldman WE, San-Blas G, Niño-Vega GA.

PLoS One. 2012;7(11):e50201. doi: 10.1371/journal.pone.0050201. Epub 2012 Nov 20.


Modulation of symbiont lipid A signaling by host alkaline phosphatases in the squid-vibrio symbiosis.

Rader BA, Kremer N, Apicella MA, Goldman WE, McFall-Ngai MJ.

MBio. 2012 May 1;3(3). pii: e00093-12. doi: 10.1128/mBio.00093-12. Print 2012.


Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation.

Price PA, Jin J, Goldman WE.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3083-8. doi: 10.1073/pnas.1112729109. Epub 2012 Feb 1.


Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis.

Bobrov AG, Kirillina O, Ryjenkov DA, Waters CM, Price PA, Fetherston JD, Mack D, Goldman WE, Gomelsky M, Perry RD.

Mol Microbiol. 2011 Jan;79(2):533-51. doi: 10.1111/j.1365-2958.2010.07470.x. Epub 2010 Dec 3.


The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background.

Weening EH, Cathelyn JS, Kaufman G, Lawrenz MB, Price P, Goldman WE, Miller VL.

Infect Immun. 2011 Feb;79(2):644-52. doi: 10.1128/IAI.00981-10. Epub 2010 Nov 29.


Generation of IL-23 producing dendritic cells (DCs) by airborne fungi regulates fungal pathogenicity via the induction of T(H)-17 responses.

Chamilos G, Ganguly D, Lande R, Gregorio J, Meller S, Goldman WE, Gilliet M, Kontoyiannis DP.

PLoS One. 2010 Sep 23;5(9):e12955. doi: 10.1371/journal.pone.0012955.


Taming the symbiont for coexistence: a host PGRP neutralizes a bacterial symbiont toxin.

Troll JV, Bent EH, Pacquette N, Wier AM, Goldman WE, Silverman N, McFall-Ngai MJ.

Environ Microbiol. 2010 Aug;12(8):2190-203. doi: 10.1111/j.1462-2920.2009.02121.x. Epub 2009 Dec 27.


Molecular basis for peptidoglycan recognition by a bactericidal lectin.

Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7722-7. doi: 10.1073/pnas.0909449107. Epub 2010 Apr 9.


Peptidoglycan induces loss of a nuclear peptidoglycan recognition protein during host tissue development in a beneficial animal-bacterial symbiosis.

Troll JV, Adin DM, Wier AM, Paquette N, Silverman N, Goldman WE, Stadermann FJ, Stabb EV, McFall-Ngai MJ.

Cell Microbiol. 2009 Jul;11(7):1114-27. doi: 10.1111/j.1462-5822.2009.01315.x. Epub 2009 Mar 12.


NMR structure of a fungal virulence factor reveals structural homology with mammalian saposin B.

Beck MR, Dekoster GT, Cistola DP, Goldman WE.

Mol Microbiol. 2009 Apr;72(2):344-53. doi: 10.1111/j.1365-2958.2009.06647.x. Epub 2009 Mar 3.


Mutations in ampG and lytic transglycosylase genes affect the net release of peptidoglycan monomers from Vibrio fischeri.

Adin DM, Engle JT, Goldman WE, McFall-Ngai MJ, Stabb EV.

J Bacteriol. 2009 Apr;191(7):2012-22. doi: 10.1128/JB.01547-08. Epub 2008 Dec 12.


The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.

Gross R, Guzman CA, Sebaihia M, dos Santos VA, Pieper DH, Koebnik R, Lechner M, Bartels D, Buhrmester J, Choudhuri JV, Ebensen T, Gaigalat L, Herrmann S, Khachane AN, Larisch C, Link S, Linke B, Meyer F, Mormann S, Nakunst D, Rückert C, Schneiker-Bekel S, Schulze K, Vorhölter FJ, Yevsa T, Engle JT, Goldman WE, Pühler A, Göbel UB, Goesmann A, Blöcker H, Kaiser O, Martinez-Arias R.

BMC Genomics. 2008 Sep 30;9:449. doi: 10.1186/1471-2164-9-449.


Autophagic control of listeria through intracellular innate immune recognition in drosophila.

Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S.

Nat Immunol. 2008 Aug;9(8):908-16. doi: 10.1038/ni.1634. Epub 2008 Jul 6.


Structural features responsible for the biological stability of Histoplasma's virulence factor CBP.

Beck MR, DeKoster GT, Hambly DM, Gross ML, Cistola DP, Goldman WE.

Biochemistry. 2008 Apr 15;47(15):4427-38. doi: 10.1021/bi701495v. Epub 2008 Mar 25.


Fungal stealth technology.

Rappleye CA, Goldman WE.

Trends Immunol. 2008 Jan;29(1):18-24. Epub 2007 Nov 28. Review.


Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis.

Almeida AJ, Carmona JA, Cunha C, Carvalho A, Rappleye CA, Goldman WE, Hooykaas PJ, Leão C, Ludovico P, Rodrigues F.

Fungal Genet Biol. 2007 Dec;44(12):1387-98. Epub 2007 Apr 14.


A plasminogen-activating protease specifically controls the development of primary pneumonic plague.

Lathem WW, Price PA, Miller VL, Goldman WE.

Science. 2007 Jan 26;315(5811):509-13.


Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor.

Rappleye CA, Eissenberg LG, Goldman WE.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1366-70. Epub 2007 Jan 16.


An alpha-(1,4)-amylase is essential for alpha-(1,3)-glucan production and virulence in Histoplasma capsulatum.

Marion CL, Rappleye CA, Engle JT, Goldman WE.

Mol Microbiol. 2006 Nov;62(4):970-83. Epub 2006 Oct 13.


RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague.

Cathelyn JS, Crosby SD, Lathem WW, Goldman WE, Miller VL.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13514-9. Epub 2006 Aug 28.


Breaching the great wall: peptidoglycan and microbial interactions.

Cloud-Hansen KA, Peterson SB, Stabb EV, Goldman WE, McFall-Ngai MJ, Handelsman J.

Nat Rev Microbiol. 2006 Sep;4(9):710-6. Epub 2006 Aug 7. Review.


Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough.

Mielcarek N, Debrie AS, Raze D, Bertout J, Rouanet C, Younes AB, Creusy C, Engle J, Goldman WE, Locht C.

PLoS Pathog. 2006 Jul;2(7):e65.


Attenuated Bordetella pertussis: new live vaccines for intranasal immunisation.

Mielcarek N, Debrie AS, Raze D, Quatannens J, Engle J, Goldman WE, Locht C.

Vaccine. 2006 Apr 12;24 Suppl 2:S2-54-5.


PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan.

Kaneko T, Yano T, Aggarwal K, Lim JH, Ueda K, Oshima Y, Peach C, Erturk-Hasdemir D, Goldman WE, Oh BH, Kurata S, Silverman N.

Nat Immunol. 2006 Jul;7(7):715-23. Epub 2006 Jun 11.


Defining virulence genes in the dimorphic fungi.

Rappleye CA, Goldman WE.

Annu Rev Microbiol. 2006;60:281-303. Review.


Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins.

Lim JH, Kim MS, Kim HE, Yano T, Oshima Y, Aggarwal K, Goldman WE, Silverman N, Kurata S, Oh BH.

J Biol Chem. 2006 Mar 24;281(12):8286-95. Epub 2006 Jan 20.


Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs).

Swaminathan CP, Brown PH, Roychowdhury A, Wang Q, Guan R, Silverman N, Goldman WE, Boons GJ, Mariuzza RA.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):684-9. Epub 2006 Jan 9.


Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity.

Lathem WW, Crosby SD, Miller VL, Goldman WE.

Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17786-91. Epub 2005 Nov 23.


Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro.

Mellroth P, Karlsson J, Håkansson J, Schultz N, Goldman WE, Steiner H.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6455-60. Epub 2005 Apr 20.


Microbial factor-mediated development in a host-bacterial mutualism.

Koropatnick TA, Engle JT, Apicella MA, Stabb EV, Goldman WE, McFall-Ngai MJ.

Science. 2004 Nov 12;306(5699):1186-8.


Fosmid-based physical mapping of the Histoplasma capsulatum genome.

Magrini V, Warren WC, Wallis J, Goldman WE, Xu J, Mardis ER, McPherson JD.

Genome Res. 2004 Aug;14(8):1603-9.

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