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Glial cells in schizophrenia: a unified hypothesis.

Dietz AG, Goldman SA, Nedergaard M.

Lancet Psychiatry. 2019 Nov 5. pii: S2215-0366(19)30302-5. doi: 10.1016/S2215-0366(19)30302-5. [Epub ahead of print] Review.


Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.

Nobuta H, Yang N, Ng YH, Marro SG, Sabeur K, Chavali M, Stockley JH, Killilea DW, Walter PB, Zhao C, Huie P Jr, Goldman SA, Kriegstein AR, Franklin RJM, Rowitch DH, Wernig M.

Cell Stem Cell. 2019 Oct 3;25(4):531-541.e6. doi: 10.1016/j.stem.2019.09.003.


Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.

Wang M, Qin C, Luo X, Wang J, Wang X, Xie M, Hu J, Cao J, Hu T, Goldman SA, Nedergaard M, Wang W.

Theranostics. 2019 Jun 9;9(15):4474-4493. doi: 10.7150/thno.31942. eCollection 2019.


Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Liu Z, Osipovitch M, Benraiss A, Huynh NPT, Foti R, Bates J, Chandler-Militello D, Findling RL, Tesar PJ, Nedergaard M, Windrem MS, Goldman SA.

Cell Rep. 2019 Jun 25;27(13):3832-3843.e6. doi: 10.1016/j.celrep.2019.05.088.


Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease.

Mariani JN, Zou L, Goldman SA.

Methods Mol Biol. 2019;1936:311-331. doi: 10.1007/978-1-4939-9072-6_18. Review.


Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.

Osipovitch M, Asenjo Martinez A, Mariani JN, Cornwell A, Dhaliwal S, Zou L, Chandler-Militello D, Wang S, Li X, Benraiss SJ, Agate R, Lampp A, Benraiss A, Windrem MS, Goldman SA.

Cell Stem Cell. 2019 Jan 3;24(1):107-122.e7. doi: 10.1016/j.stem.2018.11.010. Epub 2018 Dec 13.


The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards?

Barker RA, Carpenter MK, Forbes S, Goldman SA, Jamieson C, Murry CE, Takahashi J, Weir G.

Stem Cell Reports. 2018 May 8;10(5):1429-1431. doi: 10.1016/j.stemcr.2018.04.010. Review.


Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys.

Goldman SA.

Nat Med. 2018 Apr 10;24(4):388-390. doi: 10.1038/nm.4531. No abstract available.


Neurogenetics of Pelizaeus-Merzbacher disease.

Osório MJ, Goldman SA.

Handb Clin Neurol. 2018;148:701-722. doi: 10.1016/B978-0-444-64076-5.00045-4. Review.


Patience pays in spinal repair.

Goldman SA.

J Clin Invest. 2017 Sep 1;127(9):3284-3286. doi: 10.1172/JCI96650. Epub 2017 Aug 21.


Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Windrem MS, Osipovitch M, Liu Z, Bates J, Chandler-Militello D, Zou L, Munir J, Schanz S, McCoy K, Miller RH, Wang S, Nedergaard M, Findling RL, Tesar PJ, Goldman SA.

Cell Stem Cell. 2017 Aug 3;21(2):195-208.e6. doi: 10.1016/j.stem.2017.06.012. Epub 2017 Jul 20.


Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.

Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R.

Trends Neurosci. 2017 Jul;40(7):422-437. doi: 10.1016/j.tins.2017.05.002. Epub 2017 May 31. Review.


Progenitor cell-based treatment of glial disease.

Goldman SA.

Prog Brain Res. 2017;231:165-189. doi: 10.1016/bs.pbr.2017.02.010. Epub 2017 Apr 13.


Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.

Nevin ZS, Factor DC, Karl RT, Douvaras P, Laukka J, Windrem MS, Goldman SA, Fossati V, Hobson GM, Tesar PJ.

Am J Hum Genet. 2017 Apr 6;100(4):617-634. doi: 10.1016/j.ajhg.2017.03.005. Epub 2017 Mar 30.


SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.

Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Aalling N, Wang S, Benraiss A, Lou N, Goldman SA, Nedergaard M.

J Neurosci. 2017 Apr 26;37(17):4493-4507. doi: 10.1523/JNEUROSCI.3199-16.2017. Epub 2017 Mar 23.


Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.

Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA.

Stem Cells. 2017 Feb;35(2):311-315. doi: 10.1002/stem.2530. Epub 2016 Nov 23. Review.


3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.

Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV.

Nat Med. 2016 Sep;22(9):1050-5. doi: 10.1038/nm.4154. Epub 2016 Aug 22.


Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.

Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung JU.

Cell Stem Cell. 2016 Nov 3;19(5):663-671. doi: 10.1016/j.stem.2016.07.019. Epub 2016 Aug 11.


Causality Assessment in Premarketing Drug Clinical Trials: Regulatory Evolution in the USA and Ongoing Concerns.

Goldman SA.

Drug Saf. 2016 Oct;39(10):895-901. doi: 10.1007/s40264-016-0442-9.


Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Richard Lu Q.

Dev Cell. 2016 Jun 20;37(6):582. doi: 10.1016/j.devcel.2016.06.004. No abstract available.


Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.

Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA.

Nat Commun. 2016 Jun 7;7:11758. doi: 10.1038/ncomms11758.


Glial progenitor cell-based treatment of the childhood leukodystrophies.

Osorio MJ, Goldman SA.

Exp Neurol. 2016 Sep;283(Pt B):476-88. doi: 10.1016/j.expneurol.2016.05.010. Epub 2016 May 8. Review.



Nedergaard M, Goldman SA.

Sci Am. 2016 Mar;314(3):44-9. No abstract available.


Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, Parry L, Goldman SA, Clevers H, Lu QR.

Nat Commun. 2016 Mar 9;7:10883. doi: 10.1038/ncomms10883.


Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Lu QR.

Dev Cell. 2016 Feb 8;36(3):316-30. doi: 10.1016/j.devcel.2016.01.002.


Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking.

Goldman SA.

Cell Stem Cell. 2016 Feb 4;18(2):174-88. doi: 10.1016/j.stem.2016.01.012. Review.


Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.

Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1074-9. doi: 10.1073/pnas.1520398113. Epub 2016 Jan 11.


How to make an oligodendrocyte.

Goldman SA, Kuypers NJ.

Development. 2015 Dec 1;142(23):3983-95. doi: 10.1242/dev.126409. Review.


PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo.

Auvergne R, Wu C, Connell A, Au S, Cornwell A, Osipovitch M, Benraiss A, Dangelmajer S, Guerrero-Cazares H, Quinones-Hinojosa A, Goldman SA.

Oncogene. 2016 Jul 21;35(29):3817-28. doi: 10.1038/onc.2015.452. Epub 2015 Nov 30.


Implications of the discovery of brain lymphatic pathways.

Iliff JJ, Goldman SA, Nedergaard M.

Lancet Neurol. 2015 Oct;14(10):977-9. doi: 10.1016/S1474-4422(15)00221-5. No abstract available.


A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.

Ribeiro Xavier AL, Kress BT, Goldman SA, Lacerda de Menezes JR, Nedergaard M.

J Neurosci. 2015 Aug 26;35(34):11848-61. doi: 10.1523/JNEUROSCI.1217-15.2015.


Modeling cognition and disease using human glial chimeric mice.

Goldman SA, Nedergaard M, Windrem MS.

Glia. 2015 Aug;63(8):1483-93. doi: 10.1002/glia.22862. Epub 2015 May 24. Review.


Glia Disease and Repair-Remyelination.

Franklin RJ, Goldman SA.

Cold Spring Harb Perspect Biol. 2015 May 18;7(7):a020594. doi: 10.1101/cshperspect.a020594. Review.


Disease specific therapies in leukodystrophies and leukoencephalopathies.

Helman G, Van Haren K, Bonkowsky JL, Bernard G, Pizzino A, Braverman N, Suhr D, Patterson MC, Ali Fatemi S, Leonard J, van der Knaap MS, Back SA, Damiani S, Goldman SA, Takanohashi A, Petryniak M, Rowitch D, Messing A, Wrabetz L, Schiffmann R, Eichler F, Escolar ML, Vanderver A; GLIA Consortium.

Mol Genet Metab. 2015 Apr;114(4):527-36. doi: 10.1016/j.ymgme.2015.01.014. Epub 2015 Feb 7.


A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia.

Windrem MS, Schanz SJ, Morrow C, Munir J, Chandler-Militello D, Wang S, Goldman SA.

J Neurosci. 2014 Nov 26;34(48):16153-61. doi: 10.1523/JNEUROSCI.1510-14.2014.


Human glial chimeric mice reveal astrocytic dependence of JC virus infection.

Kondo Y, Windrem MS, Zou L, Chandler-Militello D, Schanz SJ, Auvergne RM, Betstadt SJ, Harrington AR, Johnson M, Kazarov A, Gorelik L, Goldman SA.

J Clin Invest. 2014 Dec;124(12):5323-36. doi: 10.1172/JCI76629. Epub 2014 Nov 17.


Identification of novel tumor-associated cell surface sialoglycoproteins in human glioblastoma tumors using quantitative proteomics.

Autelitano F, Loyaux D, Roudières S, Déon C, Guette F, Fabre P, Ping Q, Wang S, Auvergne R, Badarinarayana V, Smith M, Guillemot JC, Goldman SA, Natesan S, Ferrara P, August P.

PLoS One. 2014 Oct 31;9(10):e110316. doi: 10.1371/journal.pone.0110316. eCollection 2014.


Fine-tuning the central nervous system: microglial modelling of cells and synapses.

Xavier AL, Menezes JR, Goldman SA, Nedergaard M.

Philos Trans R Soc Lond B Biol Sci. 2014 Oct 19;369(1654):20130593. doi: 10.1098/rstb.2013.0593. Review.


Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

Fox IJ, Daley GQ, Goldman SA, Huard J, Kamp TJ, Trucco M.

Science. 2014 Aug 22;345(6199):1247391. doi: 10.1126/science.1247391. Review.


So many progenitors, so little myelin.

Goldman SA, Osorio J.

Nat Neurosci. 2014 Apr;17(4):483-5. doi: 10.1038/nn.3685. No abstract available.


Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Benraiss A, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA.

Cell Stem Cell. 2013 Jun 6;12(6):787-99. doi: 10.1016/j.stem.2013.04.014.


Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.

Auvergne RM, Sim FJ, Wang S, Chandler-Militello D, Burch J, Al Fanek Y, Davis D, Benraiss A, Walter K, Achanta P, Johnson M, Quinones-Hinojosa A, Natesan S, Ford HL, Goldman SA.

Cell Rep. 2013 Jun 27;3(6):2127-41. doi: 10.1016/j.celrep.2013.04.035. Epub 2013 May 30. Erratum in: Cell Rep. 2013 Jul 25;4(2):402.


White matter from fibroblasts.

Goldman SA.

Nat Biotechnol. 2013 May;31(5):412-3. doi: 10.1038/nbt.2570. No abstract available.


An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV.

J Neurosci. 2013 Apr 3;33(14):6181-90. doi: 10.1523/JNEUROSCI.4491-12.2013.


Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.

Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M.

Cell Stem Cell. 2013 Mar 7;12(3):342-53. doi: 10.1016/j.stem.2012.12.015.


Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.

Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, Maherali N, Studer L, Hochedlinger K, Windrem M, Goldman SA.

Cell Stem Cell. 2013 Feb 7;12(2):252-64. doi: 10.1016/j.stem.2012.12.002.


Testosterone modulation of angiogenesis and neurogenesis in the adult songbird brain.

Chen Z, Ye R, Goldman SA.

Neuroscience. 2013 Jun 3;239:139-48. doi: 10.1016/j.neuroscience.2012.12.043. Epub 2013 Jan 3. Review.


Glial progenitor cell-based treatment and modeling of neurological disease.

Goldman SA, Nedergaard M, Windrem MS.

Science. 2012 Oct 26;338(6106):491-5. doi: 10.1126/science.1218071. Review.


A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M.

Sci Transl Med. 2012 Aug 15;4(147):147ra111. doi: 10.1126/scitranslmed.3003748.

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