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A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy.

Kumar R, de Vijver MV, Tortora G, Ciardiello F, Goldkorn T, Miller WH Jr, Norton L.

Cancer Res. 2019 Sep 1;79(17):4315-4323. doi: 10.1158/0008-5472.CAN-19-0989. Epub 2019 Jun 18. Review.


Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.

Bratt JM, Chang KY, Rabowsky M, Franzi LM, Ott SP, Filosto S, Goldkorn T, Arif M, Last JA, Kenyon NJ, Zeki AA.

J Immunol. 2018 Jun 1;200(11):3840-3856. doi: 10.4049/jimmunol.1601317. Epub 2018 Apr 27.


Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium.

Chung S, Vu S, Filosto S, Goldkorn T.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):738-48. doi: 10.1165/rcmb.2014-0122OC.


Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells.

Filosto S, Baston DS, Chung S, Becker CR, Goldkorn T.

Mol Cancer Ther. 2013 Aug;12(8):1579-90. doi: 10.1158/1535-7163.MCT-12-1029. Epub 2013 May 17.


Lung cancer and lung injury: the dual role of ceramide.

Goldkorn T, Chung S, Filosto S.

Handb Exp Pharmacol. 2013;(216):93-113. doi: 10.1007/978-3-7091-1511-4_5. Review.


Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.

Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, Pinkerton KE.

Eur Respir J. 2013 Aug;42(2):350-61. doi: 10.1183/09031936.00042512. Epub 2012 Nov 22.


Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.

Gills JJ, Zhang C, Abu-Asab MS, Castillo SS, Marceau C, LoPiccolo J, Kozikowski AP, Tsokos M, Goldkorn T, Dennis PA.

Cell Death Dis. 2012 Jul 5;3:e340. doi: 10.1038/cddis.2012.72.


Cigarette smoke induces aberrant EGF receptor activation that mediates lung cancer development and resistance to tyrosine kinase inhibitors.

Filosto S, Becker CR, Goldkorn T.

Mol Cancer Ther. 2012 Apr;11(4):795-804. doi: 10.1158/1535-7163.MCT-11-0698. Epub 2012 Feb 1.


Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines.

Filosto S, Ashfaq M, Chung S, Fry W, Goldkorn T.

J Biol Chem. 2012 Jan 2;287(1):514-22. doi: 10.1074/jbc.M111.315481. Epub 2011 Nov 10.


EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization.

Filosto S, Khan EM, Tognon E, Becker C, Ashfaq M, Ravid T, Goldkorn T.

PLoS One. 2011;6(8):e23240. doi: 10.1371/journal.pone.0023240. Epub 2011 Aug 10.


Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research.

Zeki AA, Kenyon NJ, Goldkorn T.

Drug Metab Lett. 2011 Jan;5(1):40-4. Review.


Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke.

Goldkorn T, Filosto S.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):259-68. doi: 10.1165/rcmb.2010-0220RT. Epub 2010 Jun 4. Review.


Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.

Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N, Last J, Pinkerton K, Tuder R, Goldkorn T.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):350-60. doi: 10.1165/rcmb.2009-0422OC. Epub 2010 May 6.


Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B).

Filosto S, Fry W, Knowlton AA, Goldkorn T.

J Biol Chem. 2010 Apr 2;285(14):10213-22. doi: 10.1074/jbc.M109.069963. Epub 2010 Jan 27.


Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells.

Valacchi G, Davis PA, Khan EM, Lanir R, Maioli E, Pecorelli A, Cross CE, Goldkorn T.

Int J Biochem Cell Biol. 2011 Jul;43(7):1065-70. doi: 10.1016/j.biocel.2009.05.014. Epub 2009 Jun 2.


Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death.

Levy M, Khan E, Careaga M, Goldkorn T.

Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L125-33. doi: 10.1152/ajplung.00031.2009. Epub 2009 Apr 24.


Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis.

Raychaudhuri S, Willgohs E, Nguyen TN, Khan EM, Goldkorn T.

Biophys J. 2008 Oct;95(8):3559-62. doi: 10.1529/biophysj.108.135483. Epub 2008 Jul 18.


Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking.

Khan EM, Lanir R, Danielson AR, Goldkorn T.

FASEB J. 2008 Mar;22(3):910-7. Epub 2007 Oct 30.


Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells.

Castillo SS, Levy M, Thaikoottathil JV, Goldkorn T.

Exp Cell Res. 2007 Jul 15;313(12):2680-6. Epub 2007 Apr 6.


Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis.

Castillo SS, Levy M, Wang C, Thaikoottathil JV, Khan E, Goldkorn T.

Exp Cell Res. 2007 Feb 15;313(4):816-23. Epub 2006 Dec 15.


nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis.

Levy M, Castillo SS, Goldkorn T.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):900-5. Epub 2006 Apr 19.


Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking.

Khan EM, Heidinger JM, Levy M, Lisanti MP, Ravid T, Goldkorn T.

J Biol Chem. 2006 May 19;281(20):14486-93. Epub 2006 Jan 3.


Laser induces apoptosis and ceramide production in human retinal pigment epithelial cells.

Barak A, Goldkorn T, Morse LS.

Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2587-91.


Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt.

Medina EA, Afsari RR, Ravid T, Castillo SS, Erickson KL, Goldkorn T.

Endocrinology. 2005 Jun;146(6):2726-35. Epub 2005 Mar 3.


Life and death decisions: ceramide generation and EGF receptor trafficking are modulated by oxidative stress.

Goldkorn T, Ravid T, Khan EM.

Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):119-28. Review.


c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes.

Ravid T, Heidinger JM, Gee P, Khan EM, Goldkorn T.

J Biol Chem. 2004 Aug 27;279(35):37153-62. Epub 2004 Jun 21.


Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells.

Ravid T, Tsaba A, Gee P, Rasooly R, Medina EA, Goldkorn T.

Am J Physiol Lung Cell Mol Physiol. 2003 Jun;284(6):L1082-92. Epub 2003 Feb 7.


Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation.

Ravid T, Sweeney C, Gee P, Carraway KL 3rd, Goldkorn T.

J Biol Chem. 2002 Aug 23;277(34):31214-9. Epub 2002 Jun 12.


Cellular actions of Al at low (1.25 microM) concentrations in primary oligodendrocyte culture.

Golub MS, Zhang W, Keen CL, Goldkorn T.

Brain Res. 2002 Jun 21;941(1-2):82-90.


Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione.

Lavrentiadou SN, Chan C, Kawcak T, Ravid T, Tsaba A, van der Vliet A, Rasooly R, Goldkorn T.

Am J Respir Cell Mol Biol. 2001 Dec;25(6):676-84.


Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating Protein (TRAP).

Balaban N, Goldkorn T, Gov Y, Hirshberg M, Koyfman N, Matthews HR, Nhan RT, Singh B, Uziel O.

J Biol Chem. 2001 Jan 26;276(4):2658-67. Erratum in: J Biol Chem 2001 Apr 13;276(15):12476. J Biol Chem 2001 Jun 8;276(23):20803.


Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells.

Barak A, Morse LS, Goldkorn T.

Invest Ophthalmol Vis Sci. 2001 Jan;42(1):247-54.


Ceramide path in human lung cell death.

Chan C, Goldkorn T.

Am J Respir Cell Mol Biol. 2000 Apr;22(4):460-8.


Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels.

Blank M, Krause I, Goldkorn T, Praprotnik S, Livneh A, Langevitz P, Kaganovsky E, Morgenstern S, Cohen S, Barak V, Eldor A, Weksler B, Shoenfeld Y.

Arthritis Rheum. 1999 Jul;42(7):1421-32.


Peroxynitrite induces covalent dimerization of epidermal growth factor receptors in A431 epidermoid carcinoma cells.

van der Vliet A, Hristova M, Cross CE, Eiserich JP, Goldkorn T.

J Biol Chem. 1998 Nov 27;273(48):31860-6.


EGF-Receptor phosphorylation and signaling are targeted by H2O2 redox stress.

Goldkorn T, Balaban N, Matsukuma K, Chea V, Gould R, Last J, Chan C, Chavez C.

Am J Respir Cell Mol Biol. 1998 Nov;19(5):786-98.


H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells.

Goldkorn T, Balaban N, Shannon M, Chea V, Matsukuma K, Gilchrist D, Wang H, Chan C.

J Cell Sci. 1998 Nov;111 ( Pt 21):3209-20.


Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus.

Balaban N, Goldkorn T, Nhan RT, Dang LB, Scott S, Ridgley RM, Rasooly A, Wright SC, Larrick JW, Rasooly R, Carlson JR.

Science. 1998 Apr 17;280(5362):438-40.


EGF receptor phosphorylation is affected by ionizing radiation.

Goldkorn T, Balaban N, Shannon M, Matsukuma K.

Biochim Biophys Acta. 1997 Oct 11;1358(3):289-99.


The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation.

Balaban N, Moni J, Shannon M, Dang L, Murphy E, Goldkorn T.

Biochim Biophys Acta. 1996 Nov 8;1314(1-2):147-56.


Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action.

Goldkorn T, Dressler KA, Muindi J, Radin NS, Mendelsohn J, Menaldino D, Liotta D, Kolesnick RN.

J Biol Chem. 1991 Aug 25;266(24):16092-7.


Functional molecular weight of the lac carrier protein from Escherichia coli as studied by radiation inactivation analysis.

Goldkorn T, Rimon G, Kempner ES, Kaback HR.

Proc Natl Acad Sci U S A. 1984 Feb;81(4):1021-5.


The lac carrier protein from Escherichia coli.

Kaback HR, Carrasco N, Foster D, Garcia ML, Goldkorn T, Patel L, Viitanen P.

Soc Gen Physiol Ser. 1984;38:323-30. No abstract available.


Topology of the lac carrier protein in the membrane of Escherichia coli.

Goldkorn T, Rimon G, Kaback HR.

Proc Natl Acad Sci U S A. 1983 Jun;80(11):3322-6.


Preparation, characterization, and properties of monoclonal antibodies against the lac carrier protein from Escherichia coli.

Carrasco N, Tahara SM, Patel L, Goldkorn T, Kaback HR.

Proc Natl Acad Sci U S A. 1982 Nov;79(22):6894-8.


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