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Revisiting Replication-Induced Transcription in Escherichia coli.

Golding I.

Bioessays. 2020 Jan;42(1):e1900193. doi: 10.1002/bies.201900193. Epub 2019 Nov 21. No abstract available.


Measuring transcription at a single gene copy reveals hidden drivers of bacterial individuality.

Wang M, Zhang J, Xu H, Golding I.

Nat Microbiol. 2019 Dec;4(12):2118-2127. doi: 10.1038/s41564-019-0553-z. Epub 2019 Sep 16.


Cofilin-Mediated Actin Stress Response Is Maladaptive in Heat-Stressed Embryos.

Figard L, Zheng L, Biel N, Xue Z, Seede H, Coleman S, Golding I, Sokac AM.

Cell Rep. 2019 Mar 26;26(13):3493-3501.e4. doi: 10.1016/j.celrep.2019.02.092.


Infection by bacteriophage lambda: an evolving paradigm for cellular individuality.

Golding I.

Curr Opin Microbiol. 2018 Jun;43:9-13. doi: 10.1016/j.mib.2017.09.014. Epub 2017 Nov 3. Review.


The transcription fidelity factor GreA impedes DNA break repair.

Sivaramakrishnan P, Sepúlveda LA, Halliday JA, Liu J, Núñez MAB, Golding I, Rosenberg SM, Herman C.

Nature. 2017 Oct 12;550(7675):214-218. doi: 10.1038/nature23907. Epub 2017 Oct 4.


Stochastic Kinetics of Nascent RNA.

Xu H, Skinner SO, Sokac AM, Golding I.

Phys Rev Lett. 2016 Sep 16;117(12). pii: 128101. Epub 2016 Sep 13.


Single-Cell Studies of Phage λ: Hidden Treasures Under Occam's Rug.

Golding I.

Annu Rev Virol. 2016 Sep 29;3(1):453-472. Epub 2016 Jul 22. Review.


Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir.

Figard L, Wang M, Zheng L, Golding I, Sokac AM.

Dev Cell. 2016 May 9;37(3):267-78. doi: 10.1016/j.devcel.2016.04.010.


Measurement of gene regulation in individual cells reveals rapid switching between promoter states.

Sepúlveda LA, Xu H, Zhang J, Wang M, Golding I.

Science. 2016 Mar 11;351(6278):1218-22. doi: 10.1126/science.aad0635. Epub 2016 Mar 10.


Single-cell analysis of transcription kinetics across the cell cycle.

Skinner SO, Xu H, Nagarkar-Jaiswal S, Freire PR, Zwaka TP, Golding I.

Elife. 2016 Jan 29;5:e12175. doi: 10.7554/eLife.12175.


The spliceosome is a therapeutic vulnerability in MYC-driven cancer.

Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF.

Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2.


Corrigendum: Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization.

Skinner SO, Sepúlveda LA, Xu H, Golding I.

Nat Protoc. 2015 Sep;10(9):1457. doi: 10.1038/nprot0915-1457c. Epub 2015 Aug 27. No abstract available.


DksA involvement in transcription fidelity buffers stochastic epigenetic change.

Satory D, Gordon AJ, Wang M, Halliday JA, Golding I, Herman C.

Nucleic Acids Res. 2015 Dec 2;43(21):10190-9. doi: 10.1093/nar/gkv839. Epub 2015 Aug 24.


Combining protein and mRNA quantification to decipher transcriptional regulation.

Xu H, Sepúlveda LA, Figard L, Sokac AM, Golding I.

Nat Methods. 2015 Aug;12(8):739-42. doi: 10.1038/nmeth.3446. Epub 2015 Jun 22.


RNA biochemistry. Determination of in vivo target search kinetics of regulatory noncoding RNA.

Fei J, Singh D, Zhang Q, Park S, Balasubramanian D, Golding I, Vanderpool CK, Ha T.

Science. 2015 Mar 20;347(6228):1371-4. doi: 10.1126/science.1258849.


Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.

Gordon AJ, Satory D, Wang M, Halliday JA, Golding I, Herman C.

Nucleic Acids Res. 2014 Oct 29;42(19):12015-26. doi: 10.1093/nar/gku912. Epub 2014 Oct 7.


A nutrient-tunable bistable switch controls motility in Salmonella enterica serovar Typhimurium.

Koirala S, Mears P, Sim M, Golding I, Chemla YR, Aldridge PD, Rao CV.

mBio. 2014 Aug 26;5(5):e01611-14. doi: 10.1128/mBio.01611-14.


Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda.

Bednarz M, Halliday JA, Herman C, Golding I.

PLoS One. 2014 Jun 25;9(6):e100876. doi: 10.1371/journal.pone.0100876. eCollection 2014.


Escherichia coli swimming is robust against variations in flagellar number.

Mears PJ, Koirala S, Rao CV, Golding I, Chemla YR.

Elife. 2014 Feb 11;3:e01916. doi: 10.7554/eLife.01916.


The plasma membrane flattens out to fuel cell-surface growth during Drosophila cellularization.

Figard L, Xu H, Garcia HG, Golding I, Sokac AM.

Dev Cell. 2013 Dec 23;27(6):648-55. doi: 10.1016/j.devcel.2013.11.006. Epub 2013 Dec 5.


Genetic determinants and cellular constraints in noisy gene expression.

Sanchez A, Golding I.

Science. 2013 Dec 6;342(6163):1188-93. doi: 10.1126/science.1242975. Review.


The maternal-to-zygotic transition targets actin to promote robustness during morphogenesis.

Zheng L, Sepúlveda LA, Lua RC, Lichtarge O, Golding I, Sokac AM.

PLoS Genet. 2013 Nov;9(11):e1003901. doi: 10.1371/journal.pgen.1003901. Epub 2013 Nov 7.


Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization.

Skinner SO, Sepúlveda LA, Xu H, Golding I.

Nat Protoc. 2013 Jun;8(6):1100-13. doi: 10.1038/nprot.2013.066. Epub 2013 May 16. Erratum in: Nat Protoc. 2015 Sep;10(9):1457.


Visualizing Escherichia coli sub-cellular structure using sparse deconvolution Spatial Light Interference Tomography.

Mir M, Babacan SD, Bednarz M, Do MN, Golding I, Popescu G.

PLoS One. 2012;7(6):e39816. doi: 10.1371/journal.pone.0039816. Epub 2012 Jun 28.


Chemotactic adaptation kinetics of individual Escherichia coli cells.

Min TL, Mears PJ, Golding I, Chemla YR.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9869-74. doi: 10.1073/pnas.1120218109. Epub 2012 Jun 7.


A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.

Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF.

Science. 2012 Jan 20;335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8.


Following cell-fate in E. coli after infection by phage lambda.

Zeng L, Golding I.

J Vis Exp. 2011 Oct 14;(56):e3363. doi: 10.3791/3363.


Two-photon 3D FIONA of individual quantum dots in an aqueous environment.

Zhang R, Rothenberg E, Fruhwirth G, Simonson PD, Ye F, Golding I, Ng T, Lopes W, Selvin PR.

Nano Lett. 2011 Oct 12;11(10):4074-8. doi: 10.1021/nl201225r. Epub 2011 Sep 13.


Optical measurement of cycle-dependent cell growth.

Mir M, Wang Z, Shen Z, Bednarz M, Bashir R, Golding I, Prasanth SG, Popescu G.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13124-9. doi: 10.1073/pnas.1100506108. Epub 2011 Jul 25.


Single-virus tracking reveals a spatial receptor-dependent search mechanism.

Rothenberg E, Sepúlveda LA, Skinner SO, Zeng L, Selvin PR, Golding I.

Biophys J. 2011 Jun 22;100(12):2875-82. doi: 10.1016/j.bpj.2011.05.014.


Decision making in living cells: lessons from a simple system.

Golding I.

Annu Rev Biophys. 2011;40:63-80. doi: 10.1146/annurev-biophys-042910-155227. Review.


General properties of transcriptional time series in Escherichia coli.

So LH, Ghosh A, Zong C, Sepúlveda LA, Segev R, Golding I.

Nat Genet. 2011 Jun;43(6):554-60. doi: 10.1038/ng.821. Epub 2011 May 1.


Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene.

Zong C, So LH, Sepúlveda LA, Skinner SO, Golding I.

Mol Syst Biol. 2010 Nov 30;6:440. doi: 10.1038/msb.2010.96.


FliZ induces a kinetic switch in flagellar gene expression.

Saini S, Koirala S, Floess E, Mears PJ, Chemla YR, Golding I, Aldridge C, Aldridge PD, Rao CV.

J Bacteriol. 2010 Dec;192(24):6477-81. doi: 10.1128/JB.00751-10. Epub 2010 Oct 8.


Decision making at a subcellular level determines the outcome of bacteriophage infection.

Zeng L, Skinner SO, Zong C, Sippy J, Feiss M, Golding I.

Cell. 2010 May 14;141(4):682-91. doi: 10.1016/j.cell.2010.03.034.


Lambda-prophage induction modeled as a cooperative failure mode of lytic repression.

Chia N, Golding I, Goldenfeld N.

Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Sep;80(3 Pt 1):030901. Epub 2009 Sep 1.


High-resolution, long-term characterization of bacterial motility using optical tweezers.

Min TL, Mears PJ, Chubiz LM, Rao CV, Golding I, Chemla YR.

Nat Methods. 2009 Nov;6(11):831-5. doi: 10.1038/nmeth.1380. Epub 2009 Oct 4.


Quantitative transcription factor binding kinetics at the single-molecule level.

Wang Y, Guo L, Golding I, Cox EC, Ong NP.

Biophys J. 2009 Jan;96(2):609-20. doi: 10.1016/j.bpj.2008.09.040.


Chapter 8: Spatiotemporal dynamics in bacterial cells: real-time studies with single-event resolution.

Golding I, Cox EC.

Methods Cell Biol. 2008;89:223-51. doi: 10.1016/S0091-679X(08)00608-0.


Protein synthesis molecule by molecule.

Golding I, Cox EC.

Genome Biol. 2006;7(6):221. Review.


Eukaryotic transcription: what does it mean for a gene to be 'on'?

Golding I, Cox EC.

Curr Biol. 2006 May 23;16(10):R371-3.


Physical nature of bacterial cytoplasm.

Golding I, Cox EC.

Phys Rev Lett. 2006 Mar 10;96(9):098102. Epub 2006 Mar 10.


Real-time kinetics of gene activity in individual bacteria.

Golding I, Paulsson J, Zawilski SM, Cox EC.

Cell. 2005 Dec 16;123(6):1025-36.


Single-molecule studies of repressor-DNA interactions show long-range interactions.

Wang YM, Tegenfeldt JO, Reisner W, Riehn R, Guan XJ, Guo L, Golding I, Cox EC, Sturm J, Austin RH.

Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9796-801. Epub 2005 Jun 30.


Population fitness and the regulation of Escherichia coli genes by bacterial viruses.

Chen Y, Golding I, Sawai S, Guo L, Cox EC.

PLoS Biol. 2005 Jul;3(7):e229. Epub 2005 Jun 21.


RNA dynamics in live Escherichia coli cells.

Golding I, Cox EC.

Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11310-5. Epub 2004 Jul 26.


Autoimmunity as an immune defense against degenerative processes: a primary mathematical model illustrating the bright side of autoimmunity.

Nevo U, Golding I, Neumann AU, Schwartz M, Akselrod S.

J Theor Biol. 2004 Apr 21;227(4):583-92.


Prospective observational cohort study of time saved by prehospital thrombolysis for ST elevation myocardial infarction delivered by paramedics.

Pedley DK, Bissett K, Connolly EM, Goodman CG, Golding I, Pringle TH, McNeill GP, Pringle SD, Jones MC.

BMJ. 2003 Jul 5;327(7405):22-6.


Autoimmunity as a special case of immunity: removing threats from within.

Nevo U, Kipnis J, Golding I, Shaked I, Neumann A, Akselrod S, Schwartz M.

Trends Mol Med. 2003 Mar;9(3):88-93.


Morphological characterization of in vitro neuronal networks.

Shefi O, Golding I, Segev R, Ben-Jacob E, Ayali A.

Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Aug;66(2 Pt 1):021905. Epub 2002 Aug 14.


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