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Items: 1 to 50 of 315

1.

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.

Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang LZ, Wong AC, Noble MEM, Wedge SR, Cano C.

Eur J Med Chem. 2019 Sep 15;178:530-543. doi: 10.1016/j.ejmech.2019.05.057. Epub 2019 May 25.

PMID:
31212132
2.

Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity.

Lagassé HAD, Hengel H, Golding B, Sauna ZE.

AAPS J. 2019 May 6;21(4):62. doi: 10.1208/s12248-019-0336-8.

PMID:
31062128
3.

Photochemistry of 2-butenedial and 4-oxo-2-pentenal under atmospheric boundary layer conditions.

Newland MJ, Rea GJ, Thüner LP, Henderson AP, Golding BT, Rickard AR, Barnes I, Wenger J.

Phys Chem Chem Phys. 2019 Jan 21;21(3):1160-1171. doi: 10.1039/c8cp06437g. Epub 2019 Jan 8.

PMID:
30620029
4.

An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression.

Luu AK, Schott CR, Jones R, Poon AC, Golding B, Hamed R, Deheshi B, Mutsaers A, Wood GA, Viloria-Petit AM.

BMC Vet Res. 2018 Nov 26;14(1):365. doi: 10.1186/s12917-018-1651-5.

5.

Thrombospondin 1 and cathepsin D improve prostate cancer diagnosis by avoiding potentially unnecessary prostate biopsies.

Steuber T, Tennstedt P, Macagno A, Athanasiou A, Wittig A, Huber R, Golding B, Schiess R, Gillessen S.

BJU Int. 2019 May;123(5):826-833. doi: 10.1111/bju.14540. Epub 2018 Oct 11.

PMID:
30216634
6.

Parallel evolution of site-specific changes in divergent caribou lineages.

Horn RL, Marques AJD, Manseau M, Golding B, Klütsch CFC, Abraham K, Wilson PJ.

Ecol Evol. 2018 May 15;8(12):6053-6064. doi: 10.1002/ece3.4154. eCollection 2018 Jun.

7.

Hydrogen Sulfide: A Reagent for pH-Driven Bioinspired 1,2-Diol Mono-deoxygenation and Carbonyl Reduction in Water.

Barata-Vallejo S, Ferreri C, Golding BT, Chatgilialoglu C.

Org Lett. 2018 Jul 20;20(14):4290-4294. doi: 10.1021/acs.orglett.8b01713. Epub 2018 Jul 9.

PMID:
29985623
8.

Evaluating and Mitigating the Immunogenicity of Therapeutic Proteins.

Sauna ZE, Lagassé D, Pedras-Vasconcelos J, Golding B, Rosenberg AS.

Trends Biotechnol. 2018 Oct;36(10):1068-1084. doi: 10.1016/j.tibtech.2018.05.008. Epub 2018 Jun 13. Review.

PMID:
29908714
9.

The consequences of 'Brexit' for drug discovery and development, and the regulatory implications.

Golding BT, Waring MJ.

Expert Opin Drug Discov. 2018 Jul;13(7):583-585. doi: 10.1080/17460441.2018.1463215. Epub 2018 Apr 15. No abstract available.

PMID:
29634365
10.

Humanitarian nursing with Médecins Sans Frontières: Foregrounding the listening guide as a method for analysing oral history data.

Golding B, Hargreaves J.

J Adv Nurs. 2018 Apr 6. doi: 10.1111/jan.13585. [Epub ahead of print]

PMID:
29633306
11.

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.

Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C.

Org Biomol Chem. 2018 Mar 14;16(11):1843-1850. doi: 10.1039/c8ob00099a.

12.

The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC).

Golding B, Luu A, Jones R, Viloria-Petit AM.

Mol Cancer. 2018 Feb 19;17(1):52. doi: 10.1186/s12943-018-0810-4. Review.

13.

Cooperative hydrogen bonds form a pseudocycle stabilizing an isolated complex of isocyanic acid with urea.

Mullaney JC, Medcraft C, Tew DP, Lewis-Borrell L, Golding BT, Walker NR, Legon AC.

Phys Chem Chem Phys. 2017 Sep 20;19(36):25080-25085. doi: 10.1039/c7cp04315e.

PMID:
28880033
14.

Conversion of cis-2-carboxycyclohexylacetyl-CoA in the downstream pathway of anaerobic naphthalene degradation.

Weyrauch P, Zaytsev AV, Stephan S, Kocks L, Schmitz OJ, Golding BT, Meckenstock RU.

Environ Microbiol. 2017 Jul;19(7):2819-2830. doi: 10.1111/1462-2920.13806. Epub 2017 Jul 3.

PMID:
28574200
15.

The impact of Brexit on British science: Also Sprach Zunderland.

Golding BT.

Future Med Chem. 2017 Mar;9(3):271-273. doi: 10.4155/fmc-2016-0245. Epub 2017 Feb 8. No abstract available.

PMID:
28176537
16.

Modulating immunogenicity of factor IX by fusion to an immunoglobulin Fc domain: a study using a hemophilia B mouse model.

Levin D, Lagassé HA, Burch E, Strome S, Tan S, Jiang H, Sauna ZE, Golding B.

J Thromb Haemost. 2017 Apr;15(4):721-734. doi: 10.1111/jth.13649. Epub 2017 Mar 2.

17.

Association of immune globulin intravenous and thromboembolic adverse events.

Ovanesov MV, Menis MD, Scott DE, Forshee R, Anderson S, Bryan W, Golding B.

Am J Hematol. 2017 Apr;92(4):E44-E45. doi: 10.1002/ajh.24644. Epub 2017 Feb 13. No abstract available.

18.

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

Coxon CR, Anscombe E, Harnor SJ, Martin MP, Carbain B, Golding BT, Hardcastle IR, Harlow LK, Korolchuk S, Matheson CJ, Newell DR, Noble ME, Sivaprakasam M, Tudhope SJ, Turner DM, Wang LZ, Wedge SR, Wong C, Griffin RJ, Endicott JA, Cano C.

J Med Chem. 2017 Mar 9;60(5):1746-1767. doi: 10.1021/acs.jmedchem.6b01254. Epub 2017 Feb 14.

19.

Structure-guided design of purine-based probes for selective Nek2 inhibition.

Coxon CR, Wong C, Bayliss R, Boxall K, Carr KH, Fry AM, Hardcastle IR, Matheson CJ, Newell DR, Sivaprakasam M, Thomas H, Turner D, Yeoh S, Wang LZ, Griffin RJ, Golding BT, Cano C.

Oncotarget. 2017 Mar 21;8(12):19089-19124. doi: 10.18632/oncotarget.13249.

20.

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.

Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB.

Malar J. 2016 Nov 7;15(1):535.

21.

COST Action CM1201 "Biomimetic Radical Chemistry": free radical chemistry successfully meets many disciplines.

Ferreri C, Golding BT, Jahn U, Ravanat JL.

Free Radic Res. 2016 Nov;50(sup1):S112-S128. Review.

PMID:
27750460
22.

Development of a browser application to foster research on linking climate and health datasets: Challenges and opportunities.

Hajat S, Whitmore C, Sarran C, Haines A, Golding B, Gordon-Brown H, Kessel A, Fleming LE.

Sci Total Environ. 2017 Jan 1;575:79-86. doi: 10.1016/j.scitotenv.2016.09.162. Epub 2016 Oct 12.

23.

New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study.

Tommasino C, Gambardella L, Buoncervello M, Griffin RJ, Golding BT, Alberton M, Macchia D, Spada M, Cerbelli B, d'Amati G, Malorni W, Gabriele L, Giammarioli AM.

J Exp Clin Cancer Res. 2016 Sep 6;35(1):137. doi: 10.1186/s13046-016-0409-9.

24.

Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.

Beale G, Haagensen EJ, Thomas HD, Wang LZ, Revill CH, Payne SL, Golding BT, Hardcastle IR, Newell DR, Griffin RJ, Cano C.

Br J Cancer. 2016 Sep 6;115(6):682-90. doi: 10.1038/bjc.2016.238. Epub 2016 Aug 16.

25.

Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.

Huang LY, Stuart C, Takeda K, D'Agnillo F, Golding B.

PLoS One. 2016 Aug 9;11(8):e0160875. doi: 10.1371/journal.pone.0160875. eCollection 2016.

26.

Elucidating the Stereochemistry of Enzymatic Benzylsuccinate Synthesis with Chirally Labeled Toluene.

Seyhan D, Friedrich P, Szaleniec M, Hilberg M, Buckel W, Golding BT, Heider J.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11664-7. doi: 10.1002/anie.201605197. Epub 2016 Aug 9.

PMID:
27503670
27.

High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors.

Myers SM, Bawn RH, Bisset LC, Blackburn TJ, Cottyn B, Molyneux L, Wong AC, Cano C, Clegg W, Harrington RW, Leung H, Rigoreau L, Vidot S, Golding BT, Griffin RJ, Hammonds T, Newell DR, Hardcastle IR.

ACS Comb Sci. 2016 Aug 8;18(8):444-55. doi: 10.1021/acscombsci.5b00155. Epub 2016 Jul 20.

PMID:
27400250
28.

Synthesis and Biological Evaluation of N(2) -Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors.

Cortese D, Chegaev K, Guglielmo S, Wang LZ, Golding BT, Cano C, Fruttero R.

ChemMedChem. 2016 Aug 19;11(16):1705-8. doi: 10.1002/cmdc.201600108. Epub 2016 Jun 29.

PMID:
27355194
29.

Ageing and Learning in Australia: Arguing an Evidence Base for Informed and Equitable Policy.

Cuthill M, Buys L, Wilson B, Kimberley H, Reghenzani D, Kearns P, Thompson S, Golding B, Root J, Weston R.

Curr Aging Sci. 2016;9(3):196-202. Review.

PMID:
27151410
30.

Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases.

Reuillon T, Alhasan SF, Beale GS, Bertoli A, Brennan A, Cano C, Reeves HL, Newell DR, Golding BT, Miller DC, Griffin RJ.

Chem Sci. 2016 Apr 21;7(4):2821-2826. doi: 10.1039/c5sc03612g. Epub 2016 Jan 11.

31.

Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment.

Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck PM, Krüger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M, Wilkes H.

J Mol Microbiol Biotechnol. 2016;26(1-3):5-28. doi: 10.1159/000443997. Epub 2016 Mar 10. Review.

32.

Anaerobic Degradation of p-Alkylated Benzoates and Toluenes.

Rabus R, Boll M, Golding B, Wilkes H.

J Mol Microbiol Biotechnol. 2016;26(1-3):63-75. doi: 10.1159/000441144. Epub 2016 Mar 10. Review.

PMID:
26960059
33.

Structure and Function of 4-Hydroxyphenylacetate Decarboxylase and Its Cognate Activating Enzyme.

Selvaraj B, Buckel W, Golding BT, Ullmann GM, Martins BM.

J Mol Microbiol Biotechnol. 2016;26(1-3):76-91. doi: 10.1159/000440882. Epub 2016 Mar 10. Review.

PMID:
26959876
34.

Metabolism of Hydrocarbons in n-Alkane-Utilizing Anaerobic Bacteria.

Wilkes H, Buckel W, Golding BT, Rabus R.

J Mol Microbiol Biotechnol. 2016;26(1-3):138-51. doi: 10.1159/000442160. Epub 2016 Mar 10. Review.

PMID:
26959725
35.

Structure and Function of Benzylsuccinate Synthase and Related Fumarate-Adding Glycyl Radical Enzymes.

Heider J, Szaleniec M, Martins BM, Seyhan D, Buckel W, Golding BT.

J Mol Microbiol Biotechnol. 2016;26(1-3):29-44. doi: 10.1159/000441656. Epub 2016 Mar 10. Review.

PMID:
26959246
36.

Versatile transformations of hydrocarbons in anaerobic bacteria: substrate ranges and regio- and stereo-chemistry of activation reactions.

Jarling R, Kühner S, Basílio Janke E, Gruner A, Drozdowska M, Golding BT, Rabus R, Wilkes H.

Front Microbiol. 2015 Sep 7;6:880. doi: 10.3389/fmicb.2015.00880. eCollection 2015.

37.

1918 pandemic influenza virus and Streptococcus pneumoniae co-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans.

Walters KA, D'Agnillo F, Sheng ZM, Kindrachuk J, Schwartzman LM, Kuestner RE, Chertow DS, Golding BT, Taubenberger JK, Kash JC.

J Pathol. 2016 Jan;238(1):85-97. doi: 10.1002/path.4638. Epub 2015 Oct 14.

38.

Identification and Characterization of an Irreversible Inhibitor of CDK2.

Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann M, Danielson UH, Stanley WA, Wang LZ, Reuillon T, Golding BT, Cano C, Newell DR, Noble ME, Wedge SR, Endicott JA, Griffin RJ.

Chem Biol. 2015 Sep 17;22(9):1159-64. doi: 10.1016/j.chembiol.2015.07.018. Epub 2015 Aug 27.

39.

Forensic science in the context of Islamic law: A review.

Alkahtani T, Aljerian K, Golding B, Alqahtani S.

J Forensic Leg Med. 2015 Aug;34:179-81. doi: 10.1016/j.jflm.2015.04.017. Epub 2015 May 21. Review.

PMID:
26165681
40.

Small-molecule MDM2-p53 inhibitors: recent advances.

Zhang B, Golding BT, Hardcastle IR.

Future Med Chem. 2015;7(5):631-45. doi: 10.4155/fmc.15.13. Review.

PMID:
25921402
41.

Academic medicinal chemistry: no country for young men (or women)?

Golding BT.

Future Med Chem. 2015;7(5):549-51. doi: 10.4155/fmc.15.10. No abstract available.

42.

Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases.

Miller DC, Carbain B, Beale GS, Alhasan SF, Reeves HL, Baisch U, Newell DR, Golding BT, Griffin RJ.

Org Biomol Chem. 2015 May 14;13(18):5279-84. doi: 10.1039/c5ob00211g.

PMID:
25858034
43.

Non-enzymatic ribonucleotide reduction in the prebiotic context.

Dragičević I, Barić D, Kovačević B, Golding BT, Smith DM.

Chemistry. 2015 Apr 13;21(16):6132-43. doi: 10.1002/chem.201405741. Epub 2015 Mar 6.

PMID:
25754795
44.

Fc fusion as a platform technology: potential for modulating immunogenicity.

Levin D, Golding B, Strome SE, Sauna ZE.

Trends Biotechnol. 2015 Jan;33(1):27-34. doi: 10.1016/j.tibtech.2014.11.001. Epub 2014 Dec 6. Review.

PMID:
25488117
45.

Developing a national mentorship scheme to enhance the contribution of clinical academics to health care.

Byrne G, Topping A, Kendall S, Golding B.

Nurse Res. 2014 Nov;22(2):23-8. doi: 10.7748/nr.22.2.23.e1288.

PMID:
25423938
46.

Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach.

Zaytsev A, Dodd B, Magnani M, Ghiron C, Golding BT, Griffin RJ, Liu J, Lu X, Micco I, Newell DR, Padova A, Robertson G, Lunec J, Hardcastle IR.

Chem Biol Drug Des. 2015 Aug;86(2):180-9. doi: 10.1111/cbdd.12474. Epub 2014 Dec 19.

PMID:
25388787
47.

Anaerobic activation of p-cymene in denitrifying betaproteobacteria: methyl group hydroxylation versus addition to fumarate.

Strijkstra A, Trautwein K, Jarling R, Wöhlbrand L, Dörries M, Reinhardt R, Drozdowska M, Golding BT, Wilkes H, Rabus R.

Appl Environ Microbiol. 2014 Dec;80(24):7592-603. doi: 10.1128/AEM.02385-14. Epub 2014 Sep 26.

48.

Immune globulins and same-day thrombotic events as recorded in a large health care database during 2008 to 2012.

Sridhar G, Ekezue BF, Izurieta HS, Selvam N, Ovanesov MV, Divan HA, Liang Y, Golding B, Forshee RA, Anderson SA, Menis M.

Transfusion. 2014 Oct;54(10):2553-65. doi: 10.1111/trf.12663. Epub 2014 May 8.

PMID:
24804899
49.

Retinal Input Directs the Recruitment of Inhibitory Interneurons into Thalamic Visual Circuits.

Golding B, Pouchelon G, Bellone C, Murthy S, Di Nardo AA, Govindan S, Ogawa M, Shimogori T, Lüscher C, Dayer A, Jabaudon D.

Neuron. 2014 Mar 19;81(6):1443. doi: 10.1016/j.neuron.2014.03.005. Epub 2014 Mar 19. No abstract available.

50.

Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits.

Golding B, Pouchelon G, Bellone C, Murthy S, Di Nardo AA, Govindan S, Ogawa M, Shimogori T, Lüscher C, Dayer A, Jabaudon D.

Neuron. 2014 Mar 5;81(5):1057-1069. doi: 10.1016/j.neuron.2014.01.032. Erratum in: Neuron. 2014 Mar 19;81(6):1443.

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