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Items: 1 to 50 of 233

1.

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis.

Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE.

Elife. 2019 Mar 19;8. pii: e40529. doi: 10.7554/eLife.40529.

2.
3.

4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.

Meyers MJ, Liu J, Xu J, Leng F, Guan J, Liu Z, McNitt SA, Qin L, Dai L, Ma H, Adah D, Zhao S, Li X, Polino AJ, Nasamu AS, Goldberg DE, Liu X, Lu Y, Tu Z, Chen X, Tortorella MD.

J Med Chem. 2019 Apr 11;62(7):3503-3512. doi: 10.1021/acs.jmedchem.8b01972. Epub 2019 Mar 22.

PMID:
30856324
4.

Geodetic Observations of Weak Determinism in Rupture Evolution of Large Earthquakes.

Goldberg DE, Melgar D, Bock Y, Allen RM.

J Geophys Res Solid Earth. 2018 Nov;123(11):9950-9962. doi: 10.1029/2018JB015962. Epub 2018 Nov 27.

5.

Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis.

Bhatnagar S, Nicklas S, Morrisey JM, Goldberg DE, Vaidya AB.

ACS Infect Dis. 2019 Apr 12;5(4):550-558. doi: 10.1021/acsinfecdis.8b00277. Epub 2019 Jan 28.

6.

Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion.

Paing MM, Salinas ND, Adams Y, Oksman A, Jensen AT, Goldberg DE, Tolia NH.

Elife. 2018 Dec 17;7. pii: e43224. doi: 10.7554/eLife.43224.

7.

Fast-Acting Small Molecules Targeting Malarial Aspartyl Proteases, Plasmepsins, Inhibit Malaria Infection at Multiple Life Stages.

Singh S, Rajendran V, He J, Singh AK, Achieng AO, Vandana, Pant A, Nasamu AS, Pandit M, Singh J, Quadiri A, Gupta N, Poonam, Ghosh PC, Singh BK, Narayanan L, Kempaiah P, Chandra R, Dunn BM, Pandey KC, Goldberg DE, Singh AP, Rathi B.

ACS Infect Dis. 2019 Feb 8;5(2):184-198. doi: 10.1021/acsinfecdis.8b00197. Epub 2019 Jan 2.

PMID:
30554511
8.

Toward a chemical vaccine for malaria.

Phillips MA, Goldberg DE.

Science. 2018 Dec 7;362(6419):1112-1113. doi: 10.1126/science.aav7479. No abstract available.

PMID:
30523095
9.

Malaria parasite translocon structure and mechanism of effector export.

Ho CM, Beck JR, Lai M, Cui Y, Goldberg DE, Egea PF, Zhou ZH.

Nature. 2018 Sep;561(7721):70-75. doi: 10.1038/s41586-018-0469-4. Epub 2018 Aug 27.

10.

EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX.

Garten M, Nasamu AS, Niles JC, Zimmerberg J, Goldberg DE, Beck JR.

Nat Microbiol. 2018 Oct;3(10):1090-1098. doi: 10.1038/s41564-018-0222-7. Epub 2018 Aug 27.

11.

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro.

Radke JB, Burrows JN, Goldberg DE, Sibley LD.

ACS Infect Dis. 2018 Aug 10;4(8):1264-1274. doi: 10.1021/acsinfecdis.8b00113. Epub 2018 Jul 25.

PMID:
29998728
12.

Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes.

Glushakova S, Beck JR, Garten M, Busse BL, Nasamu AS, Tenkova-Heuser T, Heuser J, Goldberg DE, Zimmerberg J.

Cell Microbiol. 2018 Oct;20(10):e12868. doi: 10.1111/cmi.12868. Epub 2018 Jul 10.

PMID:
29900649
13.

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.

Lehmann C, Tan MSY, de Vries LE, Russo I, Sanchez MI, Goldberg DE, Deu E.

PLoS Pathog. 2018 May 16;14(5):e1007031. doi: 10.1371/journal.ppat.1007031. eCollection 2018 May.

14.

Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease.

Chance JP, Fejzic H, Hernandez O, Istvan ES, Andaya A, Maslov N, Aispuro R, Crisanto T, Nguyen H, Vidal B, Serrano W, Kuwahara B, Pugne Andanado C, Goldberg DE, Mallari JP.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1846-1848. doi: 10.1016/j.bmcl.2018.04.010. Epub 2018 Apr 19.

PMID:
29691139
15.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.

Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.

Science. 2018 Jan 12;359(6372):191-199. doi: 10.1126/science.aan4472.

16.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE.

Science. 2017 Oct 27;358(6362):518-522. doi: 10.1126/science.aan1478.

17.

Plasmodium heme biosynthesis: To be or not to be essential?

Goldberg DE, Sigala PA.

PLoS Pathog. 2017 Sep 28;13(9):e1006511. doi: 10.1371/journal.ppat.1006511. eCollection 2017 Sep. Review. No abstract available.

18.

Exploitation of a newly-identified entry pathway into the malaria parasite-infected erythrocyte to inhibit parasite egress.

Glushakova S, Busse BL, Garten M, Beck JR, Fairhurst RM, Goldberg DE, Zimmerberg J.

Sci Rep. 2017 Sep 25;7(1):12250. doi: 10.1038/s41598-017-12258-x.

19.

Plant Size and Competitive Dynamics along Nutrient Gradients.

Goldberg DE, Martina JP, Elgersma KJ, Currie WS.

Am Nat. 2017 Aug;190(2):229-243. doi: 10.1086/692438. Epub 2017 May 15.

PMID:
28731795
20.

Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice.

Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE.

PLoS One. 2017 May 5;12(5):e0177142. doi: 10.1371/journal.pone.0177142. eCollection 2017.

21.

Reply to "Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases".

Goldberg DE, Spillman NJ.

MBio. 2017 Mar 7;8(2). pii: e00235-17. doi: 10.1128/mBio.00235-17. No abstract available.

22.

Esterase mutation is a mechanism of resistance to antimalarial compounds.

Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg DE.

Nat Commun. 2017 Jan 20;8:14240. doi: 10.1038/ncomms14240.

23.

The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol.

Spillman NJ, Beck JR, Ganesan SM, Niles JC, Goldberg DE.

Cell Microbiol. 2017 Jun;19(6). doi: 10.1111/cmi.12719. Epub 2017 Jan 24.

24.

Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection.

Spillman NJ, Dalmia VK, Goldberg DE.

MBio. 2016 Oct 18;7(5). pii: e01538-16. doi: 10.1128/mBio.01538-16.

25.

In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis.

Sigala PA, Morante K, Tsumoto K, Caaveiro JM, Goldberg DE.

Biochemistry. 2016 Aug 30;55(34):4836-49. doi: 10.1021/acs.biochem.6b00562. Epub 2016 Aug 15.

26.

A broad analysis of resistance development in the malaria parasite.

Corey VC, Lukens AK, Istvan ES, Lee MCS, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, Prats S, Meister S, Tanaseichuk O, Wree M, Zhou Y, Willis PA, Gamo FJ, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.

Nat Commun. 2016 Jun 15;7:11901. doi: 10.1038/ncomms11901.

27.

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis.

Pal P, Daniels BP, Oskman A, Diamond MS, Klein RS, Goldberg DE.

MBio. 2016 Jun 7;7(3). pii: e00617-16. doi: 10.1128/mBio.00617-16.

28.

Erratum: Plasmepsin V shows its carnivorous side.

Goldberg DE.

Nat Struct Mol Biol. 2015 Nov;22(11):939. doi: 10.1038/nsmb1115-939a. No abstract available.

PMID:
26581524
29.

Plasmepsin V shows its carnivorous side.

Goldberg DE.

Nat Struct Mol Biol. 2015 Sep;22(9):647-8. doi: 10.1038/nsmb.3077. No abstract available. Erratum in: Nat Struct Mol Biol. 2015 Nov;22(11):939.

PMID:
26333709
30.

Deconvoluting heme biosynthesis to target blood-stage malaria parasites.

Sigala PA, Crowley JR, Henderson JP, Goldberg DE.

Elife. 2015 Jul 14;4. doi: 10.7554/eLife.09143.

31.

Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents.

Meyers MJ, Anderson EJ, McNitt SA, Krenning TM, Singh M, Xu J, Zeng W, Qin L, Xu W, Zhao S, Qin L, Eickhoff CS, Oliva J, Campbell MA, Arnett SD, Prinsen MJ, Griggs DW, Ruminski PG, Goldberg DE, Ding K, Liu X, Tu Z, Tortorella MD, Sverdrup FM, Chen X.

Bioorg Med Chem. 2015 Aug 15;23(16):5144-50. doi: 10.1016/j.bmc.2015.02.050. Epub 2015 Mar 4.

32.

Protein export into malaria parasite-infected erythrocytes: mechanisms and functional consequences.

Spillman NJ, Beck JR, Goldberg DE.

Annu Rev Biochem. 2015;84:813-41. doi: 10.1146/annurev-biochem-060614-034157. Epub 2015 Jan 26.

PMID:
25621510
33.

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

Ke H, Sigala PA, Miura K, Morrisey JM, Mather MW, Crowley JR, Henderson JP, Goldberg DE, Long CA, Vaidya AB.

J Biol Chem. 2014 Dec 12;289(50):34827-37. doi: 10.1074/jbc.M114.615831. Epub 2014 Oct 28.

34.

Kinase-associated endopeptidase 1 (Kae1) participates in an atypical ribosome-associated complex in the apicoplast of Plasmodium falciparum.

Mallari JP, Oksman A, Vaupel B, Goldberg DE.

J Biol Chem. 2014 Oct 24;289(43):30025-39. doi: 10.1074/jbc.M114.586735. Epub 2014 Sep 9.

35.

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes.

Beck JR, Muralidharan V, Oksman A, Goldberg DE.

Nature. 2014 Jul 31;511(7511):592-5. doi: 10.1038/nature13574. Epub 2014 Jul 16.

36.

The peculiarities and paradoxes of Plasmodium heme metabolism.

Sigala PA, Goldberg DE.

Annu Rev Microbiol. 2014;68:259-78. doi: 10.1146/annurev-micro-091313-103537. Epub 2014 Jun 16. Review.

PMID:
25002093
37.

Evaluation of aminohydantoins as a novel class of antimalarial agents.

Meyers MJ, Tortorella MD, Xu J, Qin L, He Z, Lang X, Zeng W, Xu W, Qin L, Prinsen MJ, Sverdrup FM, Eickhoff CS, Griggs DW, Oliva J, Ruminski PG, Jacobsen EJ, Campbell MA, Wood DC, Goldberg DE, Liu X, Lu Y, Lu X, Tu Z, Lu X, Ding K, Chen X.

ACS Med Chem Lett. 2013 Dec 6;5(1):89-93. doi: 10.1021/ml400412x. eCollection 2014 Jan 9.

38.

Asparagine repeats in Plasmodium falciparum proteins: good for nothing?

Muralidharan V, Goldberg DE.

PLoS Pathog. 2013;9(8):e1003488. doi: 10.1371/journal.ppat.1003488. Epub 2013 Aug 22. Review. No abstract available.

39.

Complex nature of malaria parasite hemoglobin degradation [corrected].

Goldberg DE.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5283-4. doi: 10.1073/pnas.1303299110. Epub 2013 Mar 19. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7097.

40.

Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers.

Muralidharan V, Oksman A, Pal P, Lindquist S, Goldberg DE.

Nat Commun. 2012;3:1310. doi: 10.1038/ncomms2306.

41.

Plasmodium protein export at higher PEXEL resolution.

Goldberg DE.

Cell Host Microbe. 2012 Nov 15;12(5):609-10. doi: 10.1016/j.chom.2012.11.001.

42.

The contrasting roles of growth traits and architectural traits in diversity maintenance in clonal plant communities.

Wildová R, Goldberg DE, Herben T.

Am Nat. 2012 Dec;180(6):693-706. doi: 10.1086/668013. Epub 2012 Oct 30.

PMID:
23149395
43.

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state.

Babbitt SE, Altenhofen L, Cobbold SA, Istvan ES, Fennell C, Doerig C, Llinás M, Goldberg DE.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3278-87. doi: 10.1073/pnas.1209823109. Epub 2012 Oct 29.

44.

Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum.

Sigala PA, Crowley JR, Hsieh S, Henderson JP, Goldberg DE.

J Biol Chem. 2012 Nov 2;287(45):37793-807. doi: 10.1074/jbc.M112.414078. Epub 2012 Sep 19.

45.

Early development of bacterial community diversity in emergently placed urinary catheters.

Foxman B, Wu J, Farrer EC, Goldberg DE, Younger JG, Xi C.

BMC Res Notes. 2012 Jun 27;5:332. doi: 10.1186/1756-0500-5-332.

46.

Outwitting evolution: fighting drug-resistant TB, malaria, and HIV.

Goldberg DE, Siliciano RF, Jacobs WR Jr.

Cell. 2012 Mar 16;148(6):1271-83. doi: 10.1016/j.cell.2012.02.021. Review.

47.
48.

New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: synthesis and analysis of structure-activity relationships.

Saify ZS, Azim MK, Ahmad W, Nisa M, Goldberg DE, Hussain SA, Akhtar S, Akram A, Arayne A, Oksman A, Khan IA.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1282-6. doi: 10.1016/j.bmcl.2011.10.018. Epub 2011 Oct 20.

PMID:
22204908
49.

Using previous models to bias structural learning in the hierarchical BOA.

Hauschild MW, Pelikan M, Sastry K, Goldberg DE.

Evol Comput. 2012 Spring;20(1):135-60. doi: 10.1162/EVCO_a_00056. Epub 2011 Dec 12.

PMID:
22082253
50.

Species-specific SSR alleles for studies of hybrid cattails (Typha latifolia x T. angustifolia; Typhaceae) in North America.

Snow AA, Travis SE, Wildová R, Fér T, Sweeney PM, Marburger JE, Windels S, Kubátová B, Goldberg DE, Mutegi E.

Am J Bot. 2010 Dec;97(12):2061-7. doi: 10.3732/ajb.1000187. Epub 2010 Nov 15.

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